DLGAP5 (DLG associated protein 5)

Gene

• Entrez ID: 9787
• Gene name: DLG associated protein 5
• Gene symbol: DLGAP5
• Synonyms: DLG7, HURP
• Chromosome: 14
• Chromosome location: 14q22.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024792	hsa-miR-215-5p	Microarray	19074876
MIRT026832	hsa-miR-192-5p	Microarray	19074876
MIRT042751	hsa-miR-339-5p	CLASH	23622248
MIRT527550	hsa-miR-7844-5p	PAR-CLIP	21572407
MIRT527549	hsa-miR-3133	PAR-CLIP	21572407
MIRT527548	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT527547	hsa-miR-302a-3p	PAR-CLIP	21572407
MIRT527546	hsa-miR-302b-3p	PAR-CLIP	21572407
MIRT527545	hsa-miR-302c-3p	PAR-CLIP	21572407
MIRT527544	hsa-miR-302d-3p	PAR-CLIP	21572407
MIRT527543	hsa-miR-302e	PAR-CLIP	21572407
MIRT527542	hsa-miR-372-3p	PAR-CLIP	21572407
MIRT527541	hsa-miR-373-3p	PAR-CLIP	21572407
MIRT527540	hsa-miR-520a-3p	PAR-CLIP	21572407
MIRT527539	hsa-miR-520b	PAR-CLIP	21572407
MIRT527538	hsa-miR-520c-3p	PAR-CLIP	21572407
MIRT527537	hsa-miR-520d-3p	PAR-CLIP	21572407
MIRT527536	hsa-miR-520e	PAR-CLIP	21572407
MIRT527535	hsa-miR-33a-3p	PAR-CLIP	21572407
MIRT527534	hsa-miR-374c-3p	PAR-CLIP	21572407
MIRT527533	hsa-miR-4744	PAR-CLIP	21572407
MIRT527550	hsa-miR-7844-5p	PAR-CLIP	22012620
MIRT527549	hsa-miR-3133	PAR-CLIP	22012620
MIRT527548	hsa-miR-186-5p	PAR-CLIP	22012620
MIRT527547	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT527546	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT527545	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT527544	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT527543	hsa-miR-302e	PAR-CLIP	22012620
MIRT527542	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT527541	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT527540	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT527539	hsa-miR-520b	PAR-CLIP	22012620
MIRT527538	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT527537	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT527536	hsa-miR-520e	PAR-CLIP	22012620
MIRT527535	hsa-miR-33a-3p	PAR-CLIP	22012620
MIRT527534	hsa-miR-374c-3p	PAR-CLIP	22012620
MIRT527533	hsa-miR-4744	PAR-CLIP	22012620
MIRT527550	hsa-miR-7844-5p	PAR-CLIP	21572407
MIRT527549	hsa-miR-3133	PAR-CLIP	21572407
MIRT527548	hsa-miR-186-5p	PAR-CLIP	21572407
MIRT527547	hsa-miR-302a-3p	PAR-CLIP	21572407
MIRT527546	hsa-miR-302b-3p	PAR-CLIP	21572407
MIRT527545	hsa-miR-302c-3p	PAR-CLIP	21572407
MIRT527544	hsa-miR-302d-3p	PAR-CLIP	21572407
MIRT527543	hsa-miR-302e	PAR-CLIP	21572407
MIRT527542	hsa-miR-372-3p	PAR-CLIP	21572407
MIRT527541	hsa-miR-373-3p	PAR-CLIP	21572407
MIRT527540	hsa-miR-520a-3p	PAR-CLIP	21572407
MIRT527539	hsa-miR-520b	PAR-CLIP	21572407
MIRT527538	hsa-miR-520c-3p	PAR-CLIP	21572407
MIRT527537	hsa-miR-520d-3p	PAR-CLIP	21572407
MIRT527536	hsa-miR-520e	PAR-CLIP	21572407
MIRT527535	hsa-miR-33a-3p	PAR-CLIP	21572407
MIRT527534	hsa-miR-374c-3p	PAR-CLIP	21572407
MIRT527533	hsa-miR-4744	PAR-CLIP	21572407
MIRT527550	hsa-miR-7844-5p	PAR-CLIP	22012620
MIRT527549	hsa-miR-3133	PAR-CLIP	22012620
MIRT527548	hsa-miR-186-5p	PAR-CLIP	22012620
MIRT527547	hsa-miR-302a-3p	PAR-CLIP	22012620
MIRT527546	hsa-miR-302b-3p	PAR-CLIP	22012620
MIRT527545	hsa-miR-302c-3p	PAR-CLIP	22012620
MIRT527544	hsa-miR-302d-3p	PAR-CLIP	22012620
MIRT527543	hsa-miR-302e	PAR-CLIP	22012620
MIRT527542	hsa-miR-372-3p	PAR-CLIP	22012620
MIRT527541	hsa-miR-373-3p	PAR-CLIP	22012620
MIRT527540	hsa-miR-520a-3p	PAR-CLIP	22012620
MIRT527539	hsa-miR-520b	PAR-CLIP	22012620
MIRT527538	hsa-miR-520c-3p	PAR-CLIP	22012620
MIRT527537	hsa-miR-520d-3p	PAR-CLIP	22012620
MIRT527536	hsa-miR-520e	PAR-CLIP	22012620
MIRT527535	hsa-miR-33a-3p	PAR-CLIP	22012620
MIRT527534	hsa-miR-374c-3p	PAR-CLIP	22012620
MIRT527533	hsa-miR-4744	PAR-CLIP	22012620
MIRT756189	hsa-miR-409-5p	Luciferase reporter assay, Western blotting, qRT-PCR	35765271
MIRT938730	hsa-miR-1252	CLIP-seq
MIRT938731	hsa-miR-1290	CLIP-seq
MIRT938732	hsa-miR-204	CLIP-seq
MIRT938733	hsa-miR-211	CLIP-seq
MIRT938734	hsa-miR-3167	CLIP-seq
MIRT938735	hsa-miR-3647-3p	CLIP-seq
MIRT938736	hsa-miR-4286	CLIP-seq
MIRT938737	hsa-miR-4517	CLIP-seq
MIRT938738	hsa-miR-4719	CLIP-seq
MIRT938739	hsa-miR-4755-5p	CLIP-seq
MIRT938740	hsa-miR-4778-5p	CLIP-seq
MIRT938741	hsa-miR-4780	CLIP-seq
MIRT938742	hsa-miR-515-5p	CLIP-seq
MIRT938743	hsa-miR-539	CLIP-seq
MIRT938744	hsa-miR-580	CLIP-seq
MIRT938745	hsa-miR-623	CLIP-seq
MIRT938746	hsa-miR-653	CLIP-seq
MIRT938747	hsa-miR-876-5p	CLIP-seq
MIRT1977726	hsa-miR-4282	CLIP-seq
MIRT938738	hsa-miR-4719	CLIP-seq
MIRT1977727	hsa-miR-513a-3p	CLIP-seq
MIRT938742	hsa-miR-515-5p	CLIP-seq
MIRT938732	hsa-miR-204	CLIP-seq
MIRT938733	hsa-miR-211	CLIP-seq
MIRT938736	hsa-miR-4286	CLIP-seq
MIRT938739	hsa-miR-4755-5p	CLIP-seq
MIRT938741	hsa-miR-4780	CLIP-seq
MIRT938744	hsa-miR-580	CLIP-seq
MIRT938745	hsa-miR-623	CLIP-seq
MIRT938732	hsa-miR-204	CLIP-seq
MIRT938733	hsa-miR-211	CLIP-seq
MIRT2516903	hsa-miR-410	CLIP-seq
MIRT938736	hsa-miR-4286	CLIP-seq
MIRT2516904	hsa-miR-4521	CLIP-seq
MIRT938739	hsa-miR-4755-5p	CLIP-seq
MIRT938741	hsa-miR-4780	CLIP-seq
MIRT938744	hsa-miR-580	CLIP-seq
MIRT938745	hsa-miR-623	CLIP-seq
MIRT938732	hsa-miR-204	CLIP-seq
MIRT938733	hsa-miR-211	CLIP-seq
MIRT2516903	hsa-miR-410	CLIP-seq
MIRT938736	hsa-miR-4286	CLIP-seq
MIRT2516904	hsa-miR-4521	CLIP-seq
MIRT938739	hsa-miR-4755-5p	CLIP-seq
MIRT938741	hsa-miR-4780	CLIP-seq
MIRT938744	hsa-miR-580	CLIP-seq
MIRT938745	hsa-miR-623	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15145941, 15987997, 25416956
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	12527899
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005739	Component	Mitochondrion	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0007052	Process	Mitotic spindle organization	IBA	21873635
GO:0007059	Process	Chromosome segregation	IBA	21873635
GO:0007079	Process	Mitotic chromosome movement towards spindle pole	NAS	12527899
GO:0007221	Process	Positive regulation of transcription of Notch receptor target	TAS
GO:0007346	Process	Regulation of mitotic cell cycle	IBA	21873635
GO:0008017	Function	Microtubule binding	IBA	21873635
GO:0031616	Component	Spindle pole centrosome	IBA	21873635
GO:0031616	Component	Spindle pole centrosome	IDA	12527899
GO:0034451	Component	Centriolar satellite	IDA
GO:0045842	Process	Positive regulation of mitotic metaphase/anaphase transition	NAS	12527899
GO:0051382	Process	Kinetochore assembly	IBA	21873635
GO:0051642	Process	Centrosome localization	IBA	21873635

Other IDs

• MIM: 617859
• HGNC: 16864
• e!Ensembl: ENSG00000126787

Protein

• UniProt ID: Q15398
• Protein name: Disks large-associated protein 5 (DAP-5) (Discs large homolog 7) (Disks large-associated protein DLG7) (Hepatoma up-regulated protein) (HURP)
• Protein function: Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in
• PDB: 7ZX4, 8X9P, 9DUQ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03359	GKAP	318 → 602	Guanylate-kinase-associated protein (GKAP) protein	Family

• Sequence:

  MSSSHFASRHRKDISTEMIRTKIAHRKSLSQKENRHKEYERNRHFGLKDVNIPTLEGRIL
  VELDETSQGLVPEKTNVKPRAMKTILGDQRKQMLQKYKEEKQLQKLKEQREKAKRGIFKV
  GRYRPDMPCFLLSNQNAVKAEPKKAIPSSVRITRSKAKDQMEQTKIDNESDVRAIRPGPR
  QTSEKKVSDKEKKVVQPVMPTSLRMTRSATQAAKQVPRTVSSTTARKPVTRAANENEPEG
  KVPSKGRPAKNVETKPDKGISCKVDSEENTLNSQTNATSGMNPDGVLSKMENLPEINTAK
  IKGKNSFAPKDFMFQPLDGLKTYQVTPMTPRSANAFLTPSYTWTPLKTEVDESQATKEIL
  AQKCKTYSTKTIQQDSNKLPCPLGPLTVWHEEHVLNKNEATTKNLNGLPIKEVPSLERNE
  GRIAQPHHGVPYFRNILQSETEKLTSHCFEWDRKLELDIPDDAKDLIRTAVGQTRLLMKE
  RFKQFEGLVDDCEYKRGIKETTCTDLDGFWDMVSFQIEDVIHKFNNLIKLEESGWQVNNN
  MNHNMNKNVFRKKVVSGIASKPKQDDAGRIAARNRLAAIKNAMRERIRQEECAETAVSVI
  PKEVDKIVFDAGFFRVESPVKLFSGLSVSSEGPSQRLGTPKSVNKAVSQSRNEMGIPQQT
  TSPENAGPQNTKSEHVKKTLFLSIPESRSSIEDAQCPGLPDLIEENHVVNKTDLKVDCLS
  SERMSLPLLAGGVADDINTNKKEGISDVVEGMELNSSITSQDVLMSSPEKNTASQNSILE
  EGETKISQSELFDNKSLTTECHLLDSPGLNCSNPFTQLERRHQEHARHISFGGNLITFSP
  LQPGEF

• Sequence length: 846

Pathways

Reactome:

NOTCH3 Intracellular Domain Regulates Transcription

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		28284560