RAPGEF5 (Rap guanine nucleotide exchange factor 5)

Gene

• Entrez ID: 9771
• Gene name: Rap guanine nucleotide exchange factor 5
• Gene symbol: RAPGEF5
• Synonyms: GFR, MR-GEF, MRGEF, REPAC
• Chromosome: 7
• Chromosome location: 7p15.3
• Summary: Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve a

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1290865	hsa-miR-101	CLIP-seq
MIRT1290866	hsa-miR-103a	CLIP-seq
MIRT1290867	hsa-miR-107	CLIP-seq
MIRT1290868	hsa-miR-1208	CLIP-seq
MIRT1290869	hsa-miR-1270	CLIP-seq
MIRT1290870	hsa-miR-144	CLIP-seq
MIRT1290871	hsa-miR-15a	CLIP-seq
MIRT1290872	hsa-miR-15b	CLIP-seq
MIRT1290873	hsa-miR-16	CLIP-seq
MIRT1290874	hsa-miR-1827	CLIP-seq
MIRT1290875	hsa-miR-195	CLIP-seq
MIRT1290876	hsa-miR-224	CLIP-seq
MIRT1290877	hsa-miR-3170	CLIP-seq
MIRT1290878	hsa-miR-3664-5p	CLIP-seq
MIRT1290879	hsa-miR-374c	CLIP-seq
MIRT1290880	hsa-miR-3929	CLIP-seq
MIRT1290881	hsa-miR-424	CLIP-seq
MIRT1290882	hsa-miR-4254	CLIP-seq
MIRT1290883	hsa-miR-4257	CLIP-seq
MIRT1290884	hsa-miR-4279	CLIP-seq
MIRT1290885	hsa-miR-4292	CLIP-seq
MIRT1290886	hsa-miR-4303	CLIP-seq
MIRT1290887	hsa-miR-4307	CLIP-seq
MIRT1290888	hsa-miR-4308	CLIP-seq
MIRT1290889	hsa-miR-4310	CLIP-seq
MIRT1290890	hsa-miR-4419b	CLIP-seq
MIRT1290891	hsa-miR-4422	CLIP-seq
MIRT1290892	hsa-miR-4468	CLIP-seq
MIRT1290893	hsa-miR-4477b	CLIP-seq
MIRT1290894	hsa-miR-4478	CLIP-seq
MIRT1290895	hsa-miR-4672	CLIP-seq
MIRT1290896	hsa-miR-4683	CLIP-seq
MIRT1290897	hsa-miR-4691-5p	CLIP-seq
MIRT1290898	hsa-miR-4698	CLIP-seq
MIRT1290899	hsa-miR-4714-5p	CLIP-seq
MIRT1290900	hsa-miR-4789-5p	CLIP-seq
MIRT1290901	hsa-miR-497	CLIP-seq
MIRT1290902	hsa-miR-590-3p	CLIP-seq
MIRT1290903	hsa-miR-615-5p	CLIP-seq
MIRT1290904	hsa-miR-620	CLIP-seq
MIRT1290905	hsa-miR-655	CLIP-seq
MIRT2086503	hsa-miR-1271	CLIP-seq
MIRT2086504	hsa-miR-1273g	CLIP-seq
MIRT2086505	hsa-miR-1276	CLIP-seq
MIRT2086506	hsa-miR-1323	CLIP-seq
MIRT2086507	hsa-miR-3148	CLIP-seq
MIRT2086508	hsa-miR-338-3p	CLIP-seq
MIRT2086509	hsa-miR-3607-5p	CLIP-seq
MIRT2086510	hsa-miR-3667-3p	CLIP-seq
MIRT2086511	hsa-miR-3973	CLIP-seq
MIRT2086512	hsa-miR-4530	CLIP-seq
MIRT1290895	hsa-miR-4672	CLIP-seq
MIRT2086513	hsa-miR-4717-3p	CLIP-seq
MIRT2086514	hsa-miR-520g	CLIP-seq
MIRT2086515	hsa-miR-520h	CLIP-seq
MIRT2086516	hsa-miR-548ac	CLIP-seq
MIRT2086517	hsa-miR-548ae	CLIP-seq
MIRT2086518	hsa-miR-548aj	CLIP-seq
MIRT2086519	hsa-miR-548am	CLIP-seq
MIRT2086520	hsa-miR-548d-3p	CLIP-seq
MIRT2086521	hsa-miR-548o	CLIP-seq
MIRT2086522	hsa-miR-548x	CLIP-seq
MIRT2086523	hsa-miR-548z	CLIP-seq
MIRT2086524	hsa-miR-601	CLIP-seq
MIRT2086525	hsa-miR-636	CLIP-seq
MIRT2086526	hsa-miR-96	CLIP-seq
MIRT1290868	hsa-miR-1208	CLIP-seq
MIRT2311579	hsa-miR-1253	CLIP-seq
MIRT2311580	hsa-miR-125a-5p	CLIP-seq
MIRT2311581	hsa-miR-125b	CLIP-seq
MIRT1290874	hsa-miR-1827	CLIP-seq
MIRT2311582	hsa-miR-194	CLIP-seq
MIRT2311583	hsa-miR-196a	CLIP-seq
MIRT2311584	hsa-miR-196b	CLIP-seq
MIRT2311585	hsa-miR-2114	CLIP-seq
MIRT2311586	hsa-miR-218	CLIP-seq
MIRT2311587	hsa-miR-2276	CLIP-seq
MIRT2311588	hsa-miR-3064-5p	CLIP-seq
MIRT2311589	hsa-miR-3119	CLIP-seq
MIRT2311590	hsa-miR-3128	CLIP-seq
MIRT2311591	hsa-miR-3129-3p	CLIP-seq
MIRT2086507	hsa-miR-3148	CLIP-seq
MIRT2311592	hsa-miR-331-5p	CLIP-seq
MIRT2311593	hsa-miR-3529	CLIP-seq
MIRT2086509	hsa-miR-3607-5p	CLIP-seq
MIRT2311594	hsa-miR-3620	CLIP-seq
MIRT2311595	hsa-miR-3622a-3p	CLIP-seq
MIRT2311596	hsa-miR-3622b-3p	CLIP-seq
MIRT1290878	hsa-miR-3664-5p	CLIP-seq
MIRT2311597	hsa-miR-379	CLIP-seq
MIRT2311598	hsa-miR-3927	CLIP-seq
MIRT2086511	hsa-miR-3973	CLIP-seq
MIRT2311599	hsa-miR-4251	CLIP-seq
MIRT1290883	hsa-miR-4257	CLIP-seq
MIRT2311600	hsa-miR-4280	CLIP-seq
MIRT2311601	hsa-miR-4319	CLIP-seq
MIRT2311602	hsa-miR-4324	CLIP-seq
MIRT2311603	hsa-miR-4329	CLIP-seq
MIRT2311604	hsa-miR-4420	CLIP-seq
MIRT2311605	hsa-miR-4470	CLIP-seq
MIRT2311606	hsa-miR-4522	CLIP-seq
MIRT2311607	hsa-miR-4540	CLIP-seq
MIRT2311608	hsa-miR-4670-3p	CLIP-seq
MIRT1290895	hsa-miR-4672	CLIP-seq
MIRT1290897	hsa-miR-4691-5p	CLIP-seq
MIRT2311609	hsa-miR-4693-3p	CLIP-seq
MIRT1290898	hsa-miR-4698	CLIP-seq
MIRT2311610	hsa-miR-4718	CLIP-seq
MIRT2311611	hsa-miR-4732-3p	CLIP-seq
MIRT2311612	hsa-miR-4735-5p	CLIP-seq
MIRT2311613	hsa-miR-4753-3p	CLIP-seq
MIRT1290900	hsa-miR-4789-5p	CLIP-seq
MIRT2311614	hsa-miR-495	CLIP-seq
MIRT2311615	hsa-miR-5096	CLIP-seq
MIRT2311616	hsa-miR-592	CLIP-seq
MIRT2311617	hsa-miR-597	CLIP-seq
MIRT2311618	hsa-miR-604	CLIP-seq
MIRT1290903	hsa-miR-615-5p	CLIP-seq
MIRT2311619	hsa-miR-616	CLIP-seq
MIRT2311620	hsa-miR-626	CLIP-seq
MIRT2311621	hsa-miR-647	CLIP-seq
MIRT2311622	hsa-miR-656	CLIP-seq
MIRT2311623	hsa-miR-670	CLIP-seq
MIRT2311624	hsa-miR-892b	CLIP-seq
MIRT2311620	hsa-miR-626	CLIP-seq
MIRT2457757	hsa-miR-1279	CLIP-seq
MIRT2457758	hsa-miR-4277	CLIP-seq
MIRT2457759	hsa-miR-4699-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IDA	10486569
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS	10934204
GO:0005634	Component	Nucleus	IDA	10486569
GO:0005654	Component	Nucleoplasm	IDA
GO:0007264	Process	Small GTPase mediated signal transduction	NAS	10486569
GO:0007399	Process	Nervous system development	NAS	10486569
GO:0016604	Component	Nuclear body	IDA
GO:0030742	Function	GTP-dependent protein binding	IPI	10934204
GO:0050790	Process	Regulation of catalytic activity	IEA

Other IDs

• MIM: 609527
• HGNC: 16862
• e!Ensembl: ENSG00000136237

Protein

• UniProt ID: Q92565
• Protein name: Rap guanine nucleotide exchange factor 5 (Guanine nucleotide exchange factor for Rap1) (M-Ras-regulated Rap GEF) (MR-GEF) (Related to Epac) (Repac)
• Protein function: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation.
• PDB: 1WGY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00618	RasGEF_N	71 → 176	RasGEF N-terminal motif	Domain
  PF00617	RasGEF	348 → 525	RasGEF domain	Family

• Sequence:

  MGSSRLRVFDPHLERKDSAAALSDRELPLPTFDVPYFKYIDEEDEDDEWSSRSQSSTEDD
  SVDSLLSDRYVVVSGTPEKILEHLLNDLHLEEVQDKETETLLDDFLLTYTVFMTTDDLCQ
  ALLRHYSAKKYQGKEENSDVPRRKRKVLHLVSQWIALYKDWLPEDEHSKMFLKTIYRNVL
  DDVYEYPILEKELKEFQKILGMHRRHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVTET
  EEIFCHVYITEHSYVSVKAKVSSIAQEILKVVAEKIQYAEEDLALVAITFSGEKHELQPN
  DLVISKSLEASGRIYVYRKDLADTLNPFAENEESQQRSMRILGMNTWDLALELMNFDWSL
  FNSIHEQELIYFTFSRQGSGEHTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKF
  IKIAAHCKAQRNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHK
  AYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTN
  QFGDLSPKEHQELKSYVNHLYVIDSQQALFELSHRIEPRV

• Sequence length: 580

Pathways

KEGG:

Ras signaling pathway
Rap1 signaling pathway

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Glaucoma	Glaucoma	rs121918355, rs1566660365, rs1566635134, rs121918356, rs1566634475, rs28936700, rs55771538, rs28936701, rs104893622, rs55989760, rs72549387, rs104893628, rs2125316417, rs104893629, rs74315328, rs121909193, rs74315330, rs74315329, rs74315332, rs74315334, rs74315336, rs74315338, rs74315341, rs121909194, rs74315331, rs1558603396, rs387907175, rs587778873, rs587778875, rs104894979, rs137854895, rs766425037, rs72549380, rs148542782, rs541217363, rs753021890, rs771076928, rs56010818, rs777678299, rs1446110883, rs1573274915, rs1587545234, rs751768343, rs944452644	30104761

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		20436929
Mental depression	Unipolar Depression, Major Depressive Disorder	rs587778876, rs587778877	20436929, 20436929, 30219690