CD151 (CD151 molecule (Raph blood group))

Gene

• Entrez ID: 977
• Gene name: CD151 molecule (Raph blood group)
• Gene symbol: CD151
• Synonyms: EBS7, GP27, MER2, PETA-3, RAPH, SFA1, TSPAN24
• Chromosome: 11
• Chromosome location: 11p15.5
• Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1565118389	->G	Pathogenic	Coding sequence variant, frameshift variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022976	hsa-miR-124-3p	Microarray	18668037
MIRT052276	hsa-let-7b-5p	CLASH	23622248
MIRT042936	hsa-miR-324-3p	CLASH	23622248
MIRT053753	hsa-miR-22-3p	Luciferase reporter assay, qRT-PCR, Western blot	24495805
MIRT053753	hsa-miR-22-3p	Luciferase reporter assay, qRT-PCR, Western blot	24495805
MIRT054136	hsa-miR-152-3p	Luciferase reporter assay, qRT-PCR, Western blot	25119599
MIRT054136	hsa-miR-152-3p	Luciferase reporter assay, qRT-PCR, Western blot	25119599
MIRT054566	hsa-miR-506-3p	Luciferase reporter assay, qRT-PCR, Western blot	23717581
MIRT054566	hsa-miR-506-3p	Luciferase reporter assay, qRT-PCR, Western blot	23717581
MIRT022976	hsa-miR-124-3p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	23816858
MIRT022976	hsa-miR-124-3p	Flow, Luciferase reporter assay, qRT-PCR, Western blot	23816858
MIRT737177	hsa-miR-199a-3p	Luciferase reporter assay, Western blotting, Immunofluorescence, qRT-PCR	32051735
MIRT873683	hsa-miR-1225-5p	CLIP-seq
MIRT873684	hsa-miR-124	CLIP-seq
MIRT873685	hsa-miR-127-5p	CLIP-seq
MIRT873686	hsa-miR-154	CLIP-seq
MIRT873687	hsa-miR-22	CLIP-seq
MIRT873688	hsa-miR-2355-5p	CLIP-seq
MIRT873689	hsa-miR-2467-3p	CLIP-seq
MIRT873690	hsa-miR-3120-3p	CLIP-seq
MIRT873691	hsa-miR-3136-3p	CLIP-seq
MIRT873692	hsa-miR-3170	CLIP-seq
MIRT873693	hsa-miR-3184	CLIP-seq
MIRT873694	hsa-miR-323b-5p	CLIP-seq
MIRT873695	hsa-miR-3622a-3p	CLIP-seq
MIRT873696	hsa-miR-3622b-3p	CLIP-seq
MIRT873697	hsa-miR-3670	CLIP-seq
MIRT873698	hsa-miR-3675-5p	CLIP-seq
MIRT873699	hsa-miR-3921	CLIP-seq
MIRT873700	hsa-miR-423-5p	CLIP-seq
MIRT873701	hsa-miR-4257	CLIP-seq
MIRT873702	hsa-miR-4466	CLIP-seq
MIRT873703	hsa-miR-4519	CLIP-seq
MIRT873704	hsa-miR-4635	CLIP-seq
MIRT873705	hsa-miR-4649-3p	CLIP-seq
MIRT873706	hsa-miR-4653-5p	CLIP-seq
MIRT873707	hsa-miR-4688	CLIP-seq
MIRT873708	hsa-miR-486-3p	CLIP-seq
MIRT873709	hsa-miR-506	CLIP-seq
MIRT873710	hsa-miR-545	CLIP-seq
MIRT873711	hsa-miR-548aa	CLIP-seq
MIRT873712	hsa-miR-548an	CLIP-seq
MIRT873713	hsa-miR-548p	CLIP-seq
MIRT873714	hsa-miR-584	CLIP-seq
MIRT873715	hsa-miR-615-5p	CLIP-seq
MIRT873716	hsa-miR-675	CLIP-seq
MIRT873717	hsa-miR-933	CLIP-seq
MIRT873718	hsa-miR-103a	CLIP-seq
MIRT873719	hsa-miR-107	CLIP-seq
MIRT873720	hsa-miR-1244	CLIP-seq
MIRT873721	hsa-miR-1262	CLIP-seq
MIRT873722	hsa-miR-15a	CLIP-seq
MIRT873723	hsa-miR-15b	CLIP-seq
MIRT873724	hsa-miR-16	CLIP-seq
MIRT873725	hsa-miR-195	CLIP-seq
MIRT873726	hsa-miR-3922-5p	CLIP-seq
MIRT873727	hsa-miR-3944-5p	CLIP-seq
MIRT873728	hsa-miR-424	CLIP-seq
MIRT873729	hsa-miR-4259	CLIP-seq
MIRT873730	hsa-miR-4701-3p	CLIP-seq
MIRT873731	hsa-miR-4703-3p	CLIP-seq
MIRT873732	hsa-miR-4708-3p	CLIP-seq
MIRT873733	hsa-miR-4715-5p	CLIP-seq
MIRT873734	hsa-miR-497	CLIP-seq
MIRT873720	hsa-miR-1244	CLIP-seq
MIRT1546251	hsa-miR-199b-3p	CLIP-seq
MIRT873689	hsa-miR-2467-3p	CLIP-seq
MIRT1546252	hsa-miR-3129-5p	CLIP-seq
MIRT1546253	hsa-miR-4797-3p	CLIP-seq
MIRT1546254	hsa-miR-936	CLIP-seq
MIRT873683	hsa-miR-1225-5p	CLIP-seq
MIRT873720	hsa-miR-1244	CLIP-seq
MIRT1959166	hsa-miR-1256	CLIP-seq
MIRT1959167	hsa-miR-128	CLIP-seq
MIRT1959168	hsa-miR-148a	CLIP-seq
MIRT1959169	hsa-miR-148b	CLIP-seq
MIRT1959170	hsa-miR-152	CLIP-seq
MIRT873686	hsa-miR-154	CLIP-seq
MIRT1959171	hsa-miR-1913	CLIP-seq
MIRT1546251	hsa-miR-199b-3p	CLIP-seq
MIRT873688	hsa-miR-2355-5p	CLIP-seq
MIRT873689	hsa-miR-2467-3p	CLIP-seq
MIRT873690	hsa-miR-3120-3p	CLIP-seq
MIRT1546252	hsa-miR-3129-5p	CLIP-seq
MIRT1959172	hsa-miR-3173-5p	CLIP-seq
MIRT1959173	hsa-miR-331-3p	CLIP-seq
MIRT1959174	hsa-miR-34a	CLIP-seq
MIRT1959175	hsa-miR-34c-5p	CLIP-seq
MIRT1959176	hsa-miR-3545-5p	CLIP-seq
MIRT873701	hsa-miR-4257	CLIP-seq
MIRT1959177	hsa-miR-4270	CLIP-seq
MIRT1959178	hsa-miR-4436b-3p	CLIP-seq
MIRT1959179	hsa-miR-4441	CLIP-seq
MIRT1959180	hsa-miR-4455	CLIP-seq
MIRT1959181	hsa-miR-449a	CLIP-seq
MIRT1959182	hsa-miR-449b	CLIP-seq
MIRT873703	hsa-miR-4519	CLIP-seq
MIRT1546253	hsa-miR-4797-3p	CLIP-seq
MIRT1959183	hsa-miR-510	CLIP-seq
MIRT1959184	hsa-miR-512-5p	CLIP-seq
MIRT873714	hsa-miR-584	CLIP-seq
MIRT1959185	hsa-miR-609	CLIP-seq
MIRT873717	hsa-miR-933	CLIP-seq
MIRT1546254	hsa-miR-936	CLIP-seq
MIRT873720	hsa-miR-1244	CLIP-seq
MIRT1959166	hsa-miR-1256	CLIP-seq
MIRT1959167	hsa-miR-128	CLIP-seq
MIRT2196119	hsa-miR-1291	CLIP-seq
MIRT2196120	hsa-miR-134	CLIP-seq
MIRT1959168	hsa-miR-148a	CLIP-seq
MIRT1959169	hsa-miR-148b	CLIP-seq
MIRT1959170	hsa-miR-152	CLIP-seq
MIRT1959171	hsa-miR-1913	CLIP-seq
MIRT1546251	hsa-miR-199b-3p	CLIP-seq
MIRT873689	hsa-miR-2467-3p	CLIP-seq
MIRT2196121	hsa-miR-3118	CLIP-seq
MIRT873690	hsa-miR-3120-3p	CLIP-seq
MIRT1546252	hsa-miR-3129-5p	CLIP-seq
MIRT1959172	hsa-miR-3173-5p	CLIP-seq
MIRT1959173	hsa-miR-331-3p	CLIP-seq
MIRT1959174	hsa-miR-34a	CLIP-seq
MIRT1959175	hsa-miR-34c-5p	CLIP-seq
MIRT1959176	hsa-miR-3545-5p	CLIP-seq
MIRT1959177	hsa-miR-4270	CLIP-seq
MIRT1959178	hsa-miR-4436b-3p	CLIP-seq
MIRT1959179	hsa-miR-4441	CLIP-seq
MIRT2196122	hsa-miR-4476	CLIP-seq
MIRT2196123	hsa-miR-4493	CLIP-seq
MIRT1959181	hsa-miR-449a	CLIP-seq
MIRT1959182	hsa-miR-449b	CLIP-seq
MIRT873703	hsa-miR-4519	CLIP-seq
MIRT1546253	hsa-miR-4797-3p	CLIP-seq
MIRT1959183	hsa-miR-510	CLIP-seq
MIRT1959184	hsa-miR-512-5p	CLIP-seq
MIRT873711	hsa-miR-548aa	CLIP-seq
MIRT1546254	hsa-miR-936	CLIP-seq
MIRT873720	hsa-miR-1244	CLIP-seq
MIRT1959166	hsa-miR-1256	CLIP-seq
MIRT2196119	hsa-miR-1291	CLIP-seq
MIRT1959171	hsa-miR-1913	CLIP-seq
MIRT1546251	hsa-miR-199b-3p	CLIP-seq
MIRT873689	hsa-miR-2467-3p	CLIP-seq
MIRT1546252	hsa-miR-3129-5p	CLIP-seq
MIRT1959172	hsa-miR-3173-5p	CLIP-seq
MIRT1959176	hsa-miR-3545-5p	CLIP-seq
MIRT873729	hsa-miR-4259	CLIP-seq
MIRT873731	hsa-miR-4703-3p	CLIP-seq
MIRT873733	hsa-miR-4715-5p	CLIP-seq
MIRT1546253	hsa-miR-4797-3p	CLIP-seq
MIRT1959183	hsa-miR-510	CLIP-seq
MIRT1959184	hsa-miR-512-5p	CLIP-seq
MIRT1546254	hsa-miR-936	CLIP-seq
MIRT2499222	hsa-miR-3127-3p	CLIP-seq
MIRT2499223	hsa-miR-4256	CLIP-seq
MIRT2499222	hsa-miR-3127-3p	CLIP-seq
MIRT2499223	hsa-miR-4256	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SP1	Activation	20149781

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005178	Function	Integrin binding	IDA	17716972, 27993971
GO:0005178	Function	Integrin binding	IPI	24220332
GO:0005515	Function	Protein binding	IPI	10811835, 14557253, 14676841, 25416956, 25910212, 29892012, 32296183
GO:0005604	Component	Basement membrane	IDA	23302890
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0007155	Process	Cell adhesion	NAS	9602068
GO:0009986	Component	Cell surface	IDA	17716972
GO:0016020	Component	Membrane	TAS	8627808
GO:0016032	Process	Viral process	IEA
GO:0016477	Process	Cell migration	IBA	21873635
GO:0030335	Process	Positive regulation of cell migration	IDA	17716972
GO:0030335	Process	Positive regulation of cell migration	IMP	17716972
GO:0031581	Process	Hemidesmosome assembly	TAS
GO:0042098	Process	T cell proliferation	IEA
GO:0044319	Process	Wound healing, spreading of cells	IDA	17716972
GO:0044319	Process	Wound healing, spreading of cells	IMP	17716972
GO:0045807	Process	Positive regulation of endocytosis	IDA	17716972
GO:0045807	Process	Positive regulation of endocytosis	IMP	17716972

Other IDs

• MIM: 602243
• HGNC: 1630
• e!Ensembl: ENSG00000177697

Protein

• UniProt ID: P48509
• Protein name: CD151 antigen (GP27) (Membrane glycoprotein SFA-1) (Platelet-endothelial tetraspan antigen 3) (PETA-3) (Tetraspanin-24) (Tspan-24) (CD antigen CD151)
• Protein function: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Plays a role in various cellular and molecular mechanism through its asso
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00335	Tetraspanin	16 → 247	Tetraspanin family	Family

• Sequence:

  MGEFNEKKTTCGTVCLKYLLFTYNCCFWLAGLAVMAVGIWTLALKSDYISLLASGTYLAT
  AYILVVAGTVVMVTGVLGCCATFKERRNLLRLYFILLLIIFLLEIIAGILAYAYYQQLNT
  ELKENLKDTMTKRYHQPGHEAVTSAVDQLQQEFHCCGSNNSQDWRDSEWIRSQEAGGRVV
  PDSCCKTVVALCGQRDHASNIYKVEGGCITKLETFIQEHLRVIGAVGIGIACVQVFGMIF
  TCCLYRSLKLEHY

• Sequence length: 253

Pathways

Reactome:

Assembly of collagen fibrils and other multimeric structures
Type I hemidesmosome assembly

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Epidermolysis bullosa	Epidermolysis bullosa, pretibial	rs137852757, rs80356682, rs80356680, rs786205094, rs121912482, rs786205095, rs587776813, rs121912487, rs587776814, rs1558092501, rs80356683, rs118203899, rs118203900, rs1558095794, rs118203901, rs1558088792, rs121912466, rs2147483647, rs746056280, rs121912832, rs121912833, rs121912834, rs121912836, rs121912837, rs759990189, rs121912839, rs121912844, rs121912845, rs1575495784, rs121912848, rs121912849, rs121912851, rs121912852, rs121912853, rs121912854, rs121912855, rs121912769, rs1564673127, rs121912770, rs753898533, rs121912771, rs1589562891, rs2134563935, rs2134581672, rs121912772, rs121912773, rs121912774, rs121912856, rs201551805, rs769967565, rs786204774, rs797045084, rs886039330, rs886039412, rs1553277702, rs886041187, rs368007918, rs886041186, rs766902987, rs886041555, rs752657203, rs757415879, rs886058642, rs752317971, rs201307156, rs1057517096, rs774133746, rs772421306, rs758886532, rs144023803, rs1057517723, rs760063197, rs916512411, rs772381373, rs768128088, rs374718902, rs762162799, rs1064793916, rs780623622, rs747522386, rs1064793760, rs775196743, rs1131691385, rs201940939, rs200972872, rs139318843, rs1368134215, rs1203706188, rs772038362, rs1553281335, rs1181742615, rs1553853022, rs1553612928, rs1055680335, rs1057517023, rs760094345, rs1560241522, rs199527325, rs751535193, rs767539005, rs775244527, rs769808745, rs1032335328, rs1478395810, rs777672897, rs1575466699, rs776841521, rs1589572214, rs761388039, rs769294243, rs761927109, rs754621187
Hearing loss	Sensorineural Hearing Loss (disorder)	rs267607135, rs267606855, rs779841884, rs267606854, rs28942097, rs121908073, rs121908076, rs74315289, rs121908144, rs111033313, rs74315437, rs121908348, rs121908349, rs121908350, rs397515359, rs180177151, rs180177154, rs180177153, rs35689081, rs35887622, rs80338944, rs104894396, rs104894398, rs80338947, rs80338948, rs80338942, rs104894402, rs104894403, rs80338945, rs28931594, rs80338940, rs80338941, rs80356590, rs80338950, rs387906706, rs387906707, rs387906708, rs398122848, rs387907016, rs587776894, rs387907088, rs397515411, rs370965183, rs398122930, rs199897298, rs111033187, rs111033448, rs199606180, rs111033284, rs397516413, rs111033305, rs111033220, rs111033256, rs111033297, rs111033253, rs104894408, rs111033295, rs397516874, rs76434661, rs111033335, rs397517323, rs111033247, rs367928692, rs374793617, rs143939430, rs397515605, rs80338939, rs200656442, rs779748859, rs587781261, rs587781262, rs143343083, rs200147906, rs730880338, rs797044491, rs146281367, rs756484720, rs869025593, rs201306709, rs540895576, rs777777359, rs879255246, rs1554358720, rs142498437, rs377145777, rs1057517519, rs779077039, rs952741388, rs1060499797, rs764139009, rs1060499590, rs1064794012, rs1064797115, rs756790858, rs775633137, rs1554952443, rs1554952193, rs782063761, rs1199012623, rs756147087, rs1555648043, rs1555661490, rs1553196233, rs781546107, rs111033190, rs775428246, rs782539587, rs537227442, rs148695069, rs1554835827, rs953422571, rs1554834186, rs1554834161, rs1554835103, rs1554577339, rs1554577402, rs768471577, rs782279338, rs781951909, rs998045226, rs375759781, rs755804651, rs1557458426, rs767797828, rs538027448, rs1559366084, rs367688416, rs1558480402, rs1558490542, rs1559870857, rs1560690591, rs1561299289, rs1562817224, rs1562817529, rs1562822565, rs1562835391, rs1564113368, rs1564554255, rs773851192, rs1564555240, rs761261855, rs1564805114, rs1565522273, rs1565127413, rs781790246, rs1565430886, rs1565469959, rs746667217, rs1565819402, rs1565855932, rs150529554, rs1567939793, rs201866631, rs754472294, rs1559372512, rs1558464965, rs1558488902, rs775062249, rs1226171550, rs1561590396, rs765574676, rs762876554, rs757327146, rs1564949059, rs1565519673, rs368050948, rs1565541888, rs781989117, rs1565402473, rs750358148, rs1386887007, rs1209665716, rs1567641234, rs1237955948, rs1569042782, rs752672077, rs146689036, rs1560070780, rs149712664, rs1564556995, rs762226905, rs773573968, rs1568528171, rs1198256157, rs377267777, rs370564476, rs1577876794, rs747787770, rs759432278, rs1043716893, rs1581138934, rs2033773650, rs1421964916, rs771766431, rs780917129, rs1895773215, rs1895769400, rs761543680, rs1565920060
Kidney disease	Kidney Diseases, Chronic kidney disease stage 5	rs74315342, rs749740335, rs757649673, rs112417755, rs35138315
Nephropathy with pretibial epidermolysis bullosa and deafness	Nephropathy with Pretibial Epidermolysis Bullosa and Deafness	rs121908681, rs587784343, rs587784353, rs121908685, rs121908686, rs200075782, rs587784350, rs149712244, rs535486098, rs587784330, rs797045888, rs1555978219, rs1554292444, rs1569243771	29138120, 15265795

Unknown
Disease name	Disease term	dbSNP ID	References
Nail dystrophy	Dystrophia unguium
Nephritis	Nephritis
Nephrotic syndrome-epidermolysis bullosa-sensorineural deafness syndrome	Nephrotic syndrome-epidermolysis bullosa-sensorineural deafness syndrome