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HERPUD1 (homocysteine inducible ER protein with ubiquitin like domain 1)

Gene

9709

Homocysteine inducible ER protein with ubiquitin like domain 1

HERPUD1

HERP, HERPUD1-IT1, Mif1, SUP

16q13

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This response includes the inhibition of translation to prevent further accumulation of unfolded proteins, the increased expression of proteins involv

Show/Hide all(254)

miRTarBase ID	miRNA	Experiments	Reference
MIRT002508	hsa-miR-373-3p	Microarray	15685193
MIRT018664	hsa-miR-335-5p	Microarray	18185580
MIRT019938	hsa-miR-375	Microarray	20215506
MIRT002508	hsa-miR-373-3p	Microarray;Other	15685193
MIRT029926	hsa-miR-26b-5p	Microarray	19088304
MIRT048869	hsa-miR-93-5p	CLASH	23622248
MIRT039770	hsa-miR-615-3p	CLASH	23622248
MIRT475747	hsa-miR-510-5p	HITS-CLIP	23706177
MIRT475746	hsa-miR-3927-3p	HITS-CLIP	23706177
MIRT475745	hsa-miR-6831-5p	HITS-CLIP	23706177
MIRT475744	hsa-miR-4768-3p	HITS-CLIP	23706177
MIRT475743	hsa-miR-4459	HITS-CLIP	23706177
MIRT475742	hsa-miR-4433a-3p	HITS-CLIP	23706177
MIRT475740	hsa-miR-3664-3p	HITS-CLIP	23706177
MIRT475739	hsa-miR-4680-5p	HITS-CLIP	23706177
MIRT475738	hsa-miR-4537	HITS-CLIP	23706177
MIRT475737	hsa-let-7a-5p	HITS-CLIP	23706177
MIRT475736	hsa-let-7b-5p	HITS-CLIP	23706177
MIRT475735	hsa-let-7c-5p	HITS-CLIP	23706177
MIRT475734	hsa-let-7d-5p	HITS-CLIP	23706177
MIRT475733	hsa-let-7e-5p	HITS-CLIP	23706177
MIRT475732	hsa-let-7f-5p	HITS-CLIP	23706177
MIRT475731	hsa-let-7g-5p	HITS-CLIP	23706177
MIRT475730	hsa-let-7i-5p	HITS-CLIP	23706177
MIRT475728	hsa-miR-4458	HITS-CLIP	23706177
MIRT475729	hsa-miR-4500	HITS-CLIP	23706177
MIRT475727	hsa-miR-98-5p	HITS-CLIP	23706177
MIRT475726	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT475725	hsa-miR-6086	HITS-CLIP	23706177
MIRT475724	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT475723	hsa-miR-4451	HITS-CLIP	23706177
MIRT682501	hsa-miR-7158-3p	HITS-CLIP	23706177
MIRT682500	hsa-miR-203b-3p	HITS-CLIP	23706177
MIRT475722	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT475721	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT475747	hsa-miR-510-5p	PAR-CLIP	23592263
MIRT475746	hsa-miR-3927-3p	PAR-CLIP	23592263
MIRT475745	hsa-miR-6831-5p	PAR-CLIP	23592263
MIRT475744	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT475743	hsa-miR-4459	PAR-CLIP	23592263
MIRT475742	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT475741	hsa-miR-1292-3p	PAR-CLIP	23592263
MIRT475740	hsa-miR-3664-3p	PAR-CLIP	23592263
MIRT475739	hsa-miR-4680-5p	PAR-CLIP	23592263
MIRT475738	hsa-miR-4537	PAR-CLIP	23592263
MIRT475737	hsa-let-7a-5p	PAR-CLIP	23592263
MIRT475736	hsa-let-7b-5p	PAR-CLIP	23592263
MIRT475735	hsa-let-7c-5p	PAR-CLIP	23592263
MIRT475734	hsa-let-7d-5p	PAR-CLIP	23592263
MIRT475733	hsa-let-7e-5p	PAR-CLIP	23592263
MIRT475732	hsa-let-7f-5p	PAR-CLIP	23592263
MIRT475731	hsa-let-7g-5p	PAR-CLIP	23592263
MIRT475730	hsa-let-7i-5p	PAR-CLIP	23592263
MIRT475728	hsa-miR-4458	PAR-CLIP	23592263
MIRT475729	hsa-miR-4500	PAR-CLIP	23592263
MIRT475727	hsa-miR-98-5p	PAR-CLIP	23592263
MIRT475726	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT475725	hsa-miR-6086	PAR-CLIP	23592263
MIRT475724	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT475723	hsa-miR-4451	PAR-CLIP	23592263
MIRT475722	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT475721	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT735042	hsa-miR-370-3p	Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), Immunofluorescence, qRT-PCR, In situ hybridization, Flow cytometry	32999631
MIRT475747	hsa-miR-510-5p	HITS-CLIP	23706177
MIRT475746	hsa-miR-3927-3p	HITS-CLIP	23706177
MIRT475745	hsa-miR-6831-5p	HITS-CLIP	23706177
MIRT475744	hsa-miR-4768-3p	HITS-CLIP	23706177
MIRT475743	hsa-miR-4459	HITS-CLIP	23706177
MIRT475742	hsa-miR-4433a-3p	HITS-CLIP	23706177
MIRT475740	hsa-miR-3664-3p	HITS-CLIP	23706177
MIRT475739	hsa-miR-4680-5p	HITS-CLIP	23706177
MIRT475738	hsa-miR-4537	HITS-CLIP	23706177
MIRT475737	hsa-let-7a-5p	HITS-CLIP	23706177
MIRT475736	hsa-let-7b-5p	HITS-CLIP	23706177
MIRT475735	hsa-let-7c-5p	HITS-CLIP	23706177
MIRT475734	hsa-let-7d-5p	HITS-CLIP	23706177
MIRT475733	hsa-let-7e-5p	HITS-CLIP	23706177
MIRT475732	hsa-let-7f-5p	HITS-CLIP	23706177
MIRT475731	hsa-let-7g-5p	HITS-CLIP	23706177
MIRT475730	hsa-let-7i-5p	HITS-CLIP	23706177
MIRT475728	hsa-miR-4458	HITS-CLIP	23706177
MIRT475729	hsa-miR-4500	HITS-CLIP	23706177
MIRT475727	hsa-miR-98-5p	HITS-CLIP	23706177
MIRT475726	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT475725	hsa-miR-6086	HITS-CLIP	23706177
MIRT475724	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT475723	hsa-miR-4451	HITS-CLIP	23706177
MIRT682501	hsa-miR-7158-3p	HITS-CLIP	23706177
MIRT682500	hsa-miR-203b-3p	HITS-CLIP	23706177
MIRT475722	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT475721	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT475747	hsa-miR-510-5p	PAR-CLIP	23592263
MIRT475746	hsa-miR-3927-3p	PAR-CLIP	23592263
MIRT475745	hsa-miR-6831-5p	PAR-CLIP	23592263
MIRT475744	hsa-miR-4768-3p	PAR-CLIP	23592263
MIRT475743	hsa-miR-4459	PAR-CLIP	23592263
MIRT475742	hsa-miR-4433a-3p	PAR-CLIP	23592263
MIRT475741	hsa-miR-1292-3p	PAR-CLIP	23592263
MIRT475740	hsa-miR-3664-3p	PAR-CLIP	23592263
MIRT475739	hsa-miR-4680-5p	PAR-CLIP	23592263
MIRT475738	hsa-miR-4537	PAR-CLIP	23592263
MIRT475737	hsa-let-7a-5p	PAR-CLIP	23592263
MIRT475736	hsa-let-7b-5p	PAR-CLIP	23592263
MIRT475735	hsa-let-7c-5p	PAR-CLIP	23592263
MIRT475734	hsa-let-7d-5p	PAR-CLIP	23592263
MIRT475733	hsa-let-7e-5p	PAR-CLIP	23592263
MIRT475732	hsa-let-7f-5p	PAR-CLIP	23592263
MIRT475731	hsa-let-7g-5p	PAR-CLIP	23592263
MIRT475730	hsa-let-7i-5p	PAR-CLIP	23592263
MIRT475728	hsa-miR-4458	PAR-CLIP	23592263
MIRT475729	hsa-miR-4500	PAR-CLIP	23592263
MIRT475727	hsa-miR-98-5p	PAR-CLIP	23592263
MIRT475726	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT475725	hsa-miR-6086	PAR-CLIP	23592263
MIRT475724	hsa-miR-6499-3p	PAR-CLIP	23592263
MIRT475723	hsa-miR-4451	PAR-CLIP	23592263
MIRT475722	hsa-miR-455-3p	PAR-CLIP	23592263
MIRT475721	hsa-miR-6516-5p	PAR-CLIP	23592263
MIRT1044434	hsa-miR-1253	CLIP-seq
MIRT1044435	hsa-miR-3120-3p	CLIP-seq
MIRT1044436	hsa-miR-3148	CLIP-seq
MIRT1044437	hsa-miR-3166	CLIP-seq
MIRT1044438	hsa-miR-3617	CLIP-seq
MIRT1044439	hsa-miR-3978	CLIP-seq
MIRT1044440	hsa-miR-4326	CLIP-seq
MIRT1044441	hsa-miR-4643	CLIP-seq
MIRT1044442	hsa-miR-4771	CLIP-seq
MIRT1044443	hsa-miR-548u	CLIP-seq
MIRT1044444	hsa-miR-548v	CLIP-seq
MIRT1044445	hsa-miR-641	CLIP-seq
MIRT1044446	hsa-miR-126	CLIP-seq
MIRT1044447	hsa-miR-198	CLIP-seq
MIRT1044448	hsa-miR-3149	CLIP-seq
MIRT1044449	hsa-miR-4317	CLIP-seq
MIRT1044450	hsa-miR-4530	CLIP-seq
MIRT1044451	hsa-miR-4659a-5p	CLIP-seq
MIRT1044452	hsa-miR-4659b-5p	CLIP-seq
MIRT1044453	hsa-miR-4762-5p	CLIP-seq
MIRT1044454	hsa-miR-4776-3p	CLIP-seq
MIRT1044455	hsa-miR-487b	CLIP-seq
MIRT1044456	hsa-miR-544	CLIP-seq
MIRT1044457	hsa-miR-548ac	CLIP-seq
MIRT1044458	hsa-miR-548ae	CLIP-seq
MIRT1044459	hsa-miR-548aj	CLIP-seq
MIRT1044460	hsa-miR-548am	CLIP-seq
MIRT1044461	hsa-miR-548d-3p	CLIP-seq
MIRT1044462	hsa-miR-548x	CLIP-seq
MIRT1044463	hsa-miR-548z	CLIP-seq
MIRT1044464	hsa-miR-617	CLIP-seq
MIRT1044465	hsa-miR-634	CLIP-seq
MIRT1044466	hsa-miR-922	CLIP-seq
MIRT1549480	hsa-miR-376c	CLIP-seq
MIRT1549481	hsa-miR-4477a	CLIP-seq
MIRT1549482	hsa-miR-4753-5p	CLIP-seq
MIRT1549483	hsa-miR-520f	CLIP-seq
MIRT1044449	hsa-miR-4317	CLIP-seq
MIRT1044451	hsa-miR-4659a-5p	CLIP-seq
MIRT1044452	hsa-miR-4659b-5p	CLIP-seq
MIRT1044454	hsa-miR-4776-3p	CLIP-seq
MIRT1044457	hsa-miR-548ac	CLIP-seq
MIRT1044458	hsa-miR-548ae	CLIP-seq
MIRT1044459	hsa-miR-548aj	CLIP-seq
MIRT1044460	hsa-miR-548am	CLIP-seq
MIRT1044461	hsa-miR-548d-3p	CLIP-seq
MIRT1044462	hsa-miR-548x	CLIP-seq
MIRT1044463	hsa-miR-548z	CLIP-seq
MIRT1044437	hsa-miR-3166	CLIP-seq
MIRT2009683	hsa-miR-370	CLIP-seq
MIRT2009684	hsa-miR-3908	CLIP-seq
MIRT2009685	hsa-miR-3942-5p	CLIP-seq
MIRT1044441	hsa-miR-4643	CLIP-seq
MIRT2009686	hsa-miR-4703-5p	CLIP-seq
MIRT2009687	hsa-miR-4766-3p	CLIP-seq
MIRT1044442	hsa-miR-4771	CLIP-seq
MIRT1044456	hsa-miR-544	CLIP-seq
MIRT1044464	hsa-miR-617	CLIP-seq
MIRT2241973	hsa-miR-1178	CLIP-seq
MIRT2241974	hsa-miR-1208	CLIP-seq
MIRT2241975	hsa-miR-1245b-5p	CLIP-seq
MIRT1044434	hsa-miR-1253	CLIP-seq
MIRT1044446	hsa-miR-126	CLIP-seq
MIRT2241976	hsa-miR-142-5p	CLIP-seq
MIRT1044435	hsa-miR-3120-3p	CLIP-seq
MIRT2241977	hsa-miR-3142	CLIP-seq
MIRT1044436	hsa-miR-3148	CLIP-seq
MIRT1044437	hsa-miR-3166	CLIP-seq
MIRT2241978	hsa-miR-3189-3p	CLIP-seq
MIRT2241979	hsa-miR-320a	CLIP-seq
MIRT2241980	hsa-miR-320b	CLIP-seq
MIRT2241981	hsa-miR-320c	CLIP-seq
MIRT2241982	hsa-miR-320d	CLIP-seq
MIRT2241983	hsa-miR-330-3p	CLIP-seq
MIRT2241984	hsa-miR-340	CLIP-seq
MIRT2241985	hsa-miR-3591-3p	CLIP-seq
MIRT2241986	hsa-miR-3591-5p	CLIP-seq
MIRT1044438	hsa-miR-3617	CLIP-seq
MIRT1549480	hsa-miR-376c	CLIP-seq
MIRT2241987	hsa-miR-3945	CLIP-seq
MIRT1044439	hsa-miR-3978	CLIP-seq
MIRT2241988	hsa-miR-410	CLIP-seq
MIRT2241989	hsa-miR-4253	CLIP-seq
MIRT2241990	hsa-miR-4280	CLIP-seq
MIRT1044449	hsa-miR-4317	CLIP-seq
MIRT1044440	hsa-miR-4326	CLIP-seq
MIRT2241991	hsa-miR-4421	CLIP-seq
MIRT2241992	hsa-miR-4422	CLIP-seq
MIRT2241993	hsa-miR-4429	CLIP-seq
MIRT1549481	hsa-miR-4477a	CLIP-seq
MIRT2241994	hsa-miR-452	CLIP-seq
MIRT1044450	hsa-miR-4530	CLIP-seq
MIRT1044441	hsa-miR-4643	CLIP-seq
MIRT1044451	hsa-miR-4659a-5p	CLIP-seq
MIRT1044452	hsa-miR-4659b-5p	CLIP-seq
MIRT2241995	hsa-miR-4676-3p	CLIP-seq
MIRT2241996	hsa-miR-4719	CLIP-seq
MIRT1549482	hsa-miR-4753-5p	CLIP-seq
MIRT1044453	hsa-miR-4762-5p	CLIP-seq
MIRT1044442	hsa-miR-4771	CLIP-seq
MIRT1044454	hsa-miR-4776-3p	CLIP-seq
MIRT1044455	hsa-miR-487b	CLIP-seq
MIRT1549483	hsa-miR-520f	CLIP-seq
MIRT2241997	hsa-miR-543	CLIP-seq
MIRT1044456	hsa-miR-544	CLIP-seq
MIRT2241998	hsa-miR-548a-5p	CLIP-seq
MIRT2241999	hsa-miR-548ab	CLIP-seq
MIRT1044457	hsa-miR-548ac	CLIP-seq
MIRT1044458	hsa-miR-548ae	CLIP-seq
MIRT1044459	hsa-miR-548aj	CLIP-seq
MIRT2242000	hsa-miR-548ak	CLIP-seq
MIRT1044460	hsa-miR-548am	CLIP-seq
MIRT2242001	hsa-miR-548b-5p	CLIP-seq
MIRT2242002	hsa-miR-548c-5p	CLIP-seq
MIRT1044461	hsa-miR-548d-3p	CLIP-seq
MIRT2242003	hsa-miR-548d-5p	CLIP-seq
MIRT2242004	hsa-miR-548h	CLIP-seq
MIRT2242005	hsa-miR-548i	CLIP-seq
MIRT2242006	hsa-miR-548j	CLIP-seq
MIRT2242007	hsa-miR-548k	CLIP-seq
MIRT2242008	hsa-miR-548l	CLIP-seq
MIRT1044443	hsa-miR-548u	CLIP-seq
MIRT1044444	hsa-miR-548v	CLIP-seq
MIRT2242009	hsa-miR-548w	CLIP-seq
MIRT1044462	hsa-miR-548x	CLIP-seq
MIRT2242010	hsa-miR-548y	CLIP-seq
MIRT1044463	hsa-miR-548z	CLIP-seq
MIRT2242011	hsa-miR-559	CLIP-seq
MIRT1044464	hsa-miR-617	CLIP-seq
MIRT1044465	hsa-miR-634	CLIP-seq
MIRT2242012	hsa-miR-635	CLIP-seq
MIRT1044445	hsa-miR-641	CLIP-seq
MIRT2242013	hsa-miR-656	CLIP-seq
MIRT1044466	hsa-miR-922	CLIP-seq
MIRT1044441	hsa-miR-4643	CLIP-seq
MIRT1044464	hsa-miR-617	CLIP-seq

Show/Hide all(32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005515	Function	Protein binding	IPI	18307982, 28827405
GO:0005783	Component	Endoplasmic reticulum	IDA	15102845, 19788048, 22045699
GO:0005789	Component	Endoplasmic reticulum membrane	IBA	21873635
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	10922362
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA	21873635
GO:0006986	Process	Response to unfolded protein	IEP	10708769, 10922362
GO:0016020	Component	Membrane	HDA	19946888
GO:0016021	Component	Integral component of membrane	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0030433	Process	Ubiquitin-dependent ERAD pathway	IMP	28827405
GO:0030968	Process	Endoplasmic reticulum unfolded protein response	IBA	21873635
GO:0030970	Process	Retrograde protein transport, ER to cytosol	IMP	25660456
GO:0031396	Process	Regulation of protein ubiquitination	IEA
GO:0032469	Process	Endoplasmic reticulum calcium ion homeostasis	IBA	21873635
GO:0032469	Process	Endoplasmic reticulum calcium ion homeostasis	IDA	15102845, 22045699
GO:0034976	Process	Response to endoplasmic reticulum stress	TAS	19788048
GO:0036499	Process	PERK-mediated unfolded protein response	TAS
GO:0043154	Process	Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA
GO:0044322	Component	Endoplasmic reticulum quality control compartment	IEA
GO:0044325	Function	Ion channel binding	IBA	21873635
GO:0044325	Function	Ion channel binding	IPI	22045699
GO:0045047	Process	Protein targeting to ER	IEA
GO:1902236	Process	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IBA	21873635
GO:1902236	Process	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IDA	15102845
GO:1903069	Process	Regulation of ER-associated ubiquitin-dependent protein catabolic process	IBA	21873635
GO:1903071	Process	Positive regulation of ER-associated ubiquitin-dependent protein catabolic process	IDA	22045699
GO:1903071	Process	Positive regulation of ER-associated ubiquitin-dependent protein catabolic process	IMP	18307982
GO:1990037	Component	Lewy body core	IDA	19788048
GO:1990756	Function	Ubiquitin ligase-substrate adaptor activity	IEA
GO:2001243	Process	Negative regulation of intrinsic apoptotic signaling pathway	IGI	22045699

MIM	HGNC	e!Ensembl
608070	13744	ENSG00000051108

Protein

UniProt ID

Q15011

Protein name

Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (Methyl methanesulfonate (MMF)-inducible fragment protein 1)

Protein function

Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16289116, PubMed:28827405). Could e

PDB

1WGD

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00240	ubiquitin	12 → 89	Ubiquitin family	Domain

Sequence

MESETEPEPVTLLVKSPNQRHRDLELSGDRGWSVGHLKAHLSRVYPERPRPEDQRLIYSG
KLLLDHQCLRDLLPKQEKRHVLHLVCNVKSPSKMPEINAKVAESTEEPAGSNRGQYPEDS
SSDGLRQREVLRNLSSPGWENISRPEAAQQAFQGLGPGFSGYTPYGWLQLSWFQQIYARQ
YYMQYLAATAASGAFVPPPSAQEIPVVSAPAPAPIHNQFPAENQPANQNAAPQVVVNPGA
NQNLRMNAQGGPIVEEDDEINRDWLDWTYSAATFSVFLSILYFYSSLSRFLMVMGATVVM
YLHHVGWFPFRPRPVQNFPNDGPPPDVVNQDPNNNLQEGTDPETEDPNHLPPDRDVLDGE
QTSPSFMSTAWLVFKTFFASLLPEGPPAIAN

Sequence length

391

Interactions

View interactions

	KEGG		Reactome
	Protein processing in endoplasmic reticulum		ATF4 activates genes in response to endoplasmic reticulum stress

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	17013881

Show/Hide Unknown Diseases (1)

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		17013881

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