Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
9706 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Unc-51 like autophagy activating kinase 2 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
ULK2 |
SynonymsGene synonyms aliases
|
ATG1B, Unc51.2 |
ChromosomeChromosome number
|
17 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
17p11.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a cen |
SNPsSNP information provided by dbSNP.
|
SNP ID |
Visualize variation |
Clinical significance |
Consequence |
rs1060499754 |
T>C |
Likely-pathogenic |
Coding sequence variant, non coding transcript variant, missense variant |
|
miRNAmiRNA information provided by mirtarbase database.
|
|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
|
|
Protein
|
UniProt ID |
Q8IYT8 |
Protein name |
Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) |
Protein function |
Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback lo |
PDB |
6QAT
,
6QAU
,
6QAV
,
6YID
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00069 |
Pkinase |
9 → 271 |
Protein kinase domain |
Domain |
PF12063 |
DUF3543 |
842 → 1032 |
Domain of unknown function (DUF3543) |
Family |
|
Sequence |
|
Sequence length |
1036 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
|
|
Associated diseases
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Malignant mesothelioma |
Malignant mesothelioma |
|
26928227 |
Metastatic melanoma |
Metastatic melanoma |
|
|
|