RIMS2 (regulating synaptic membrane exocytosis 2)

Gene

• Entrez ID: 9699
• Gene name: Regulating synaptic membrane exocytosis 2
• Gene symbol: RIMS2
• Synonyms: CRSDS, OBOE, RAB3IP3, RIM2
• Chromosome: 8
• Chromosome location: 8q22.3
• Summary: The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacti

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023538	hsa-miR-1-3p	Microarray	18668037
MIRT654254	hsa-miR-3065-3p	HITS-CLIP	23824327
MIRT654253	hsa-miR-376a-3p	HITS-CLIP	23824327
MIRT654252	hsa-miR-376b-3p	HITS-CLIP	23824327
MIRT654251	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT654254	hsa-miR-3065-3p	HITS-CLIP	23824327
MIRT654253	hsa-miR-376a-3p	HITS-CLIP	23824327
MIRT654252	hsa-miR-376b-3p	HITS-CLIP	23824327
MIRT654251	hsa-miR-335-3p	HITS-CLIP	23824327
MIRT1306978	hsa-miR-1301	CLIP-seq
MIRT1306979	hsa-miR-135a	CLIP-seq
MIRT1306980	hsa-miR-135b	CLIP-seq
MIRT1306981	hsa-miR-3168	CLIP-seq
MIRT1306982	hsa-miR-3185	CLIP-seq
MIRT1306983	hsa-miR-3619-3p	CLIP-seq
MIRT1306984	hsa-miR-3646	CLIP-seq
MIRT1306985	hsa-miR-3942-3p	CLIP-seq
MIRT1306986	hsa-miR-4323	CLIP-seq
MIRT1306987	hsa-miR-4452	CLIP-seq
MIRT1306988	hsa-miR-4503	CLIP-seq
MIRT1306989	hsa-miR-4535	CLIP-seq
MIRT1306990	hsa-miR-4762-5p	CLIP-seq
MIRT1306991	hsa-miR-4776-5p	CLIP-seq
MIRT1306992	hsa-miR-5047	CLIP-seq
MIRT1306993	hsa-miR-577	CLIP-seq
MIRT1306994	hsa-miR-616	CLIP-seq
MIRT1306995	hsa-miR-1253	CLIP-seq
MIRT1306996	hsa-miR-1298	CLIP-seq
MIRT1306979	hsa-miR-135a	CLIP-seq
MIRT1306980	hsa-miR-135b	CLIP-seq
MIRT1306997	hsa-miR-200b	CLIP-seq
MIRT1306998	hsa-miR-200c	CLIP-seq
MIRT1306999	hsa-miR-27a	CLIP-seq
MIRT1307000	hsa-miR-27b	CLIP-seq
MIRT1306981	hsa-miR-3168	CLIP-seq
MIRT1306982	hsa-miR-3185	CLIP-seq
MIRT1307001	hsa-miR-3194-3p	CLIP-seq
MIRT1306983	hsa-miR-3619-3p	CLIP-seq
MIRT1306984	hsa-miR-3646	CLIP-seq
MIRT1307002	hsa-miR-3682-3p	CLIP-seq
MIRT1307003	hsa-miR-369-3p	CLIP-seq
MIRT1306985	hsa-miR-3942-3p	CLIP-seq
MIRT1307004	hsa-miR-412	CLIP-seq
MIRT1307005	hsa-miR-4258	CLIP-seq
MIRT1307006	hsa-miR-4280	CLIP-seq
MIRT1307007	hsa-miR-429	CLIP-seq
MIRT1307008	hsa-miR-4419a	CLIP-seq
MIRT1307009	hsa-miR-4434	CLIP-seq
MIRT1307010	hsa-miR-4446-3p	CLIP-seq
MIRT1306987	hsa-miR-4452	CLIP-seq
MIRT1307011	hsa-miR-4502	CLIP-seq
MIRT1307012	hsa-miR-4510	CLIP-seq
MIRT1307013	hsa-miR-4516	CLIP-seq
MIRT1306989	hsa-miR-4535	CLIP-seq
MIRT1307014	hsa-miR-4656	CLIP-seq
MIRT1307015	hsa-miR-4721	CLIP-seq
MIRT1306990	hsa-miR-4762-5p	CLIP-seq
MIRT1306991	hsa-miR-4776-5p	CLIP-seq
MIRT1307016	hsa-miR-4779	CLIP-seq
MIRT1307017	hsa-miR-513a-5p	CLIP-seq
MIRT1306993	hsa-miR-577	CLIP-seq
MIRT1307018	hsa-miR-583	CLIP-seq
MIRT1306994	hsa-miR-616	CLIP-seq
MIRT1307019	hsa-miR-767-3p	CLIP-seq
MIRT2091006	hsa-miR-3671	CLIP-seq
MIRT2091007	hsa-miR-4307	CLIP-seq
MIRT2315763	hsa-miR-1248	CLIP-seq
MIRT2315764	hsa-miR-1296	CLIP-seq
MIRT2315765	hsa-miR-146a	CLIP-seq
MIRT2315766	hsa-miR-146b-5p	CLIP-seq
MIRT2315767	hsa-miR-2909	CLIP-seq
MIRT2315768	hsa-miR-3149	CLIP-seq
MIRT2315769	hsa-miR-3545-3p	CLIP-seq
MIRT2315770	hsa-miR-3622a-3p	CLIP-seq
MIRT2315771	hsa-miR-3622b-3p	CLIP-seq
MIRT2315772	hsa-miR-3921	CLIP-seq
MIRT1306985	hsa-miR-3942-3p	CLIP-seq
MIRT2315773	hsa-miR-4251	CLIP-seq
MIRT2315774	hsa-miR-4329	CLIP-seq
MIRT2315775	hsa-miR-4436b-3p	CLIP-seq
MIRT2315776	hsa-miR-4653-5p	CLIP-seq
MIRT2315777	hsa-miR-4761-3p	CLIP-seq
MIRT2315778	hsa-miR-507	CLIP-seq
MIRT2315779	hsa-miR-5096	CLIP-seq
MIRT2315780	hsa-miR-557	CLIP-seq
MIRT2315781	hsa-miR-568	CLIP-seq
MIRT2315782	hsa-miR-589	CLIP-seq
MIRT2315783	hsa-miR-759	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17474147
GO:0006886	Process	Intracellular protein transport	IEA
GO:0010628	Process	Positive regulation of gene expression	ISS
GO:0017156	Process	Calcium-ion regulated exocytosis	ISS
GO:0017157	Process	Regulation of exocytosis	ISS
GO:0019933	Process	CAMP-mediated signaling	ISS
GO:0030073	Process	Insulin secretion	ISS
GO:0030154	Process	Cell differentiation	IEA
GO:0042391	Process	Regulation of membrane potential	IBA	21873635
GO:0042391	Process	Regulation of membrane potential	ISS
GO:0042734	Component	Presynaptic membrane	IBA	21873635
GO:0042995	Component	Cell projection	IEA
GO:0044325	Function	Ion channel binding	IBA	21873635
GO:0044325	Function	Ion channel binding	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0048167	Process	Regulation of synaptic plasticity	IBA	21873635
GO:0048786	Component	Presynaptic active zone	TAS	15217342
GO:0048788	Component	Cytoskeleton of presynaptic active zone	IBA	21873635
GO:0048791	Process	Calcium ion-regulated exocytosis of neurotransmitter	IBA	21873635
GO:0048791	Process	Calcium ion-regulated exocytosis of neurotransmitter	ISS
GO:0050806	Process	Positive regulation of synaptic transmission	IBA	21873635
GO:0061669	Process	Spontaneous neurotransmitter secretion	ISS
GO:0070062	Component	Extracellular exosome	HDA	18570454
GO:0097151	Process	Positive regulation of inhibitory postsynaptic potential	ISS
GO:1903861	Process	Positive regulation of dendrite extension	IDA	23999003
GO:2000300	Process	Regulation of synaptic vesicle exocytosis	IBA	21873635
GO:2000463	Process	Positive regulation of excitatory postsynaptic potential	ISS

Other IDs

• MIM: 606630
• HGNC: 17283
• e!Ensembl: ENSG00000176406

Protein

• UniProt ID: Q9UQ26
• Protein name: Regulating synaptic membrane exocytosis protein 2 (Rab-3-interacting molecule 2) (RIM 2) (Rab-3-interacting protein 3)
• Protein function: Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003).
• PDB: 1V27, 1WFG
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02318	FYVE_2	67 → 185	FYVE-type zinc finger	Family
  PF17820	PDZ_6	697 → 754	PDZ domain	Domain
  PF00168	C2	820 → 930	C2 domain	Domain
  PF00168	C2	1270 → 1377	C2 domain	Domain

• Sequence:

  MSAPVGPRGRLAPIPAASQPPLQPEMPDLSHLTEEERKIILAVMDRQKKKVKEEHKPQLT
  QWFPFSGITELVNNVLQPQQKQQNEKEPQTKLHQQFEMYKEQVKKMGEESQQQQEQKGDA
  PTCGICHKTKFADGCGHNCSYCQTKFCARCGGRVSLRSNKVMWVCNLCRKQQEILTKSGA
  WFYNSGSNTPQQPDQKVLRGLRNEEAPQEKKPKLHEQTQFQGPSGDLSVPAVEKSRSHGL
  TRQHSIKNGSGVKHHIASDIASDRKRSPSVSRDQNRRYDQREEREEYSQYATSDTAMPRS
  PSDYADRRSQHEPQFYEDSDHLSYRDSNRRSHRHSKEYIVDDEDVESRDEYERQRREEEY
  QSRYRSDPNLARYPVKPQPYEEQMRIHAEVSRARHERRHSDVSLANADLEDSRISMLRMD
  RPSRQRSISERRAAMENQRSYSMERTREAQGPSSYAQRTTNHSPPTPRRSPLPIDRPDLR
  RTDSLRKQHHLDPSSAVRKTKREKMETMLRNDSLSSDQSESVRPPPPKPHKSKKGGKMRQ
  ISLSSSEEELASTPEYTSCDDVEIESESVSEKGDSQKGKRKTSEQAVLSDSNTRSERQKE
  MMYFGGHSLEEDLEWSEPQIKDSGVDTCSSTTLNEEHSHSDKHPVTWQPSKDGDRLIGRI
  LLNKRLKDGSVPRDSGAMLGLKVVGGKMTESGRLCAFITKVKKGSLADTVGHLRPGDEVL
  EWNGRLLQGATFEEVYNIILESKPEPQVELVVSRPIGDIPRIPDSTHAQLESSSSSFESQ
  KMDRPSISVTSPMSPGMLRDVPQFLSGQLSIKLWFDKVGHQLIVTILGAKDLPSREDGRP
  RNPYVKIYFLPDRSDKNKRRTKTVKKTLEPKWNQTFIYSPVHRREFRERMLEITLWDQAR
  VREEESEFLGEILIELETALLDDEPHWYKLQTHDVSSLPLPHPSPYMPRRQLHGESPTRR
  LQRSKRISDSEVSDYDCDDGIGVVSDYRHDGRDLQSSTLSVPEQVMSSNHCSPSGSPHRV
  DVIGRTRSWSPSVPPPQSRNVEQGLRGTRTMTGHYNTISRMDRHRVMDDHYSPDRDRDCE
  AADRQPYHRSRSTEQRPLLERTTTRSRSTERPDTNLMRSMPSLMTGRSAPPSPALSRSHP
  RTGSVQTSPSSTPVAGRRGRQLPQLPPKGTLDRKAGGKKLRSTVQRSTETGLAVEMRNWM
  TRQASRESTDGSMNSYSSEGNLIFPGVRLASDSQFSDFLDGLGPAQLVGRQTLATPAMGD
  IQVGMMDKKGQLEVEIIRARGLVVKPGSKTLPAPYVKVYLLDNGVCIAKKKTKVARKTLE
  PLYQQLLSFEESPQGKVLQIIVWGDYGRMDHKSFMGVAQILLDELELSNMVIGWFKLFPP
  SSLVDPTLAPLTRRASQSSLESSTGPSYSRS

• Sequence length: 1411

Pathways

KEGG:

Insulin secretion

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Lung carcinoma	Small cell carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	22941189
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	18490030