CD68 (CD68 molecule)

Gene

• Entrez ID: 968
• Gene name: CD68 molecule
• Gene symbol: CD68
• Synonyms: GP110, LAMP4, SCARD1
• Chromosome: 17
• Chromosome location: 17p13.1
• Summary: This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosome

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020775	hsa-miR-155-5p	Western blot	21030878
MIRT650254	hsa-miR-4282	HITS-CLIP	23824327
MIRT650253	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT650252	hsa-miR-3163	HITS-CLIP	23824327
MIRT650251	hsa-miR-1470	HITS-CLIP	23824327
MIRT650250	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT650249	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT650248	hsa-miR-4469	HITS-CLIP	23824327
MIRT650247	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT650246	hsa-miR-4287	HITS-CLIP	23824327
MIRT650245	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT650244	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT650243	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT650241	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT650242	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT650240	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT650239	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT650238	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT650254	hsa-miR-4282	HITS-CLIP	23824327
MIRT650253	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT650252	hsa-miR-3163	HITS-CLIP	23824327
MIRT650251	hsa-miR-1470	HITS-CLIP	23824327
MIRT650250	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT650249	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT650248	hsa-miR-4469	HITS-CLIP	23824327
MIRT650247	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT650246	hsa-miR-4287	HITS-CLIP	23824327
MIRT650245	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT650244	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT650243	hsa-miR-4713-5p	HITS-CLIP	23824327
MIRT650241	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT650242	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT650240	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT650239	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT650238	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT876125	hsa-miR-1245	CLIP-seq
MIRT876126	hsa-miR-1825	CLIP-seq
MIRT876127	hsa-miR-199a-5p	CLIP-seq
MIRT876128	hsa-miR-199b-5p	CLIP-seq
MIRT876129	hsa-miR-371-5p	CLIP-seq
MIRT876130	hsa-miR-371b-5p	CLIP-seq
MIRT876131	hsa-miR-3925-3p	CLIP-seq
MIRT876132	hsa-miR-640	CLIP-seq
MIRT876133	hsa-miR-1207-3p	CLIP-seq
MIRT876134	hsa-miR-1972	CLIP-seq
MIRT876135	hsa-miR-4438	CLIP-seq
MIRT876136	hsa-miR-5095	CLIP-seq
MIRT876137	hsa-miR-562	CLIP-seq
MIRT1959672	hsa-miR-150	CLIP-seq
MIRT1959673	hsa-miR-3187-3p	CLIP-seq
MIRT1959674	hsa-miR-3663-5p	CLIP-seq
MIRT876129	hsa-miR-371-5p	CLIP-seq
MIRT876130	hsa-miR-371b-5p	CLIP-seq
MIRT1959675	hsa-miR-4435	CLIP-seq
MIRT876135	hsa-miR-4438	CLIP-seq
MIRT1959676	hsa-miR-4701-5p	CLIP-seq
MIRT1959677	hsa-miR-4716-5p	CLIP-seq
MIRT1959678	hsa-miR-4727-5p	CLIP-seq
MIRT1959679	hsa-miR-4755-3p	CLIP-seq
MIRT1959680	hsa-miR-4781-3p	CLIP-seq
MIRT876136	hsa-miR-5095	CLIP-seq
MIRT1959681	hsa-miR-548s	CLIP-seq
MIRT1959682	hsa-miR-588	CLIP-seq
MIRT876125	hsa-miR-1245	CLIP-seq
MIRT2196679	hsa-miR-1343	CLIP-seq
MIRT876126	hsa-miR-1825	CLIP-seq
MIRT876127	hsa-miR-199a-5p	CLIP-seq
MIRT876128	hsa-miR-199b-5p	CLIP-seq
MIRT876131	hsa-miR-3925-3p	CLIP-seq
MIRT2196680	hsa-miR-4277	CLIP-seq
MIRT1959678	hsa-miR-4727-5p	CLIP-seq
MIRT2196681	hsa-miR-498	CLIP-seq
MIRT876132	hsa-miR-640	CLIP-seq
MIRT2385755	hsa-miR-106a	CLIP-seq
MIRT2385756	hsa-miR-106b	CLIP-seq
MIRT876125	hsa-miR-1245	CLIP-seq
MIRT1959672	hsa-miR-150	CLIP-seq
MIRT2385757	hsa-miR-17	CLIP-seq
MIRT876126	hsa-miR-1825	CLIP-seq
MIRT876127	hsa-miR-199a-5p	CLIP-seq
MIRT876128	hsa-miR-199b-5p	CLIP-seq
MIRT2385758	hsa-miR-20a	CLIP-seq
MIRT2385759	hsa-miR-20b	CLIP-seq
MIRT2385760	hsa-miR-302a	CLIP-seq
MIRT2385761	hsa-miR-302b	CLIP-seq
MIRT2385762	hsa-miR-302c	CLIP-seq
MIRT2385763	hsa-miR-302d	CLIP-seq
MIRT2385764	hsa-miR-302e	CLIP-seq
MIRT2385765	hsa-miR-372	CLIP-seq
MIRT2385766	hsa-miR-373	CLIP-seq
MIRT876131	hsa-miR-3925-3p	CLIP-seq
MIRT876135	hsa-miR-4438	CLIP-seq
MIRT2385767	hsa-miR-4731-5p	CLIP-seq
MIRT876136	hsa-miR-5095	CLIP-seq
MIRT2385768	hsa-miR-512-3p	CLIP-seq
MIRT2385769	hsa-miR-519d	CLIP-seq
MIRT2385770	hsa-miR-520a-3p	CLIP-seq
MIRT2385771	hsa-miR-520b	CLIP-seq
MIRT2385772	hsa-miR-520c-3p	CLIP-seq
MIRT2385773	hsa-miR-520d-3p	CLIP-seq
MIRT2385774	hsa-miR-520e	CLIP-seq
MIRT2385775	hsa-miR-520g	CLIP-seq
MIRT2385776	hsa-miR-520h	CLIP-seq
MIRT876132	hsa-miR-640	CLIP-seq
MIRT2385777	hsa-miR-93	CLIP-seq
MIRT2385755	hsa-miR-106a	CLIP-seq
MIRT2385756	hsa-miR-106b	CLIP-seq
MIRT876133	hsa-miR-1207-3p	CLIP-seq
MIRT2499881	hsa-miR-1228	CLIP-seq
MIRT876125	hsa-miR-1245	CLIP-seq
MIRT2196679	hsa-miR-1343	CLIP-seq
MIRT1959672	hsa-miR-150	CLIP-seq
MIRT2385757	hsa-miR-17	CLIP-seq
MIRT876126	hsa-miR-1825	CLIP-seq
MIRT2499882	hsa-miR-197	CLIP-seq
MIRT876134	hsa-miR-1972	CLIP-seq
MIRT876127	hsa-miR-199a-5p	CLIP-seq
MIRT876128	hsa-miR-199b-5p	CLIP-seq
MIRT2385758	hsa-miR-20a	CLIP-seq
MIRT2385759	hsa-miR-20b	CLIP-seq
MIRT2385760	hsa-miR-302a	CLIP-seq
MIRT2385761	hsa-miR-302b	CLIP-seq
MIRT2385762	hsa-miR-302c	CLIP-seq
MIRT2385763	hsa-miR-302d	CLIP-seq
MIRT2385764	hsa-miR-302e	CLIP-seq
MIRT2499883	hsa-miR-3160-5p	CLIP-seq
MIRT1959673	hsa-miR-3187-3p	CLIP-seq
MIRT1959674	hsa-miR-3663-5p	CLIP-seq
MIRT876129	hsa-miR-371-5p	CLIP-seq
MIRT876130	hsa-miR-371b-5p	CLIP-seq
MIRT2385765	hsa-miR-372	CLIP-seq
MIRT2385766	hsa-miR-373	CLIP-seq
MIRT2499884	hsa-miR-375	CLIP-seq
MIRT876131	hsa-miR-3925-3p	CLIP-seq
MIRT2499885	hsa-miR-411	CLIP-seq
MIRT2196680	hsa-miR-4277	CLIP-seq
MIRT1959675	hsa-miR-4435	CLIP-seq
MIRT876135	hsa-miR-4438	CLIP-seq
MIRT2499886	hsa-miR-4537	CLIP-seq
MIRT1959676	hsa-miR-4701-5p	CLIP-seq
MIRT1959677	hsa-miR-4716-5p	CLIP-seq
MIRT1959678	hsa-miR-4727-5p	CLIP-seq
MIRT2385767	hsa-miR-4731-5p	CLIP-seq
MIRT1959679	hsa-miR-4755-3p	CLIP-seq
MIRT1959680	hsa-miR-4781-3p	CLIP-seq
MIRT2499887	hsa-miR-4794	CLIP-seq
MIRT2196681	hsa-miR-498	CLIP-seq
MIRT876136	hsa-miR-5095	CLIP-seq
MIRT2499888	hsa-miR-5096	CLIP-seq
MIRT2385768	hsa-miR-512-3p	CLIP-seq
MIRT2385769	hsa-miR-519d	CLIP-seq
MIRT2385770	hsa-miR-520a-3p	CLIP-seq
MIRT2385771	hsa-miR-520b	CLIP-seq
MIRT2385772	hsa-miR-520c-3p	CLIP-seq
MIRT2385773	hsa-miR-520d-3p	CLIP-seq
MIRT2385774	hsa-miR-520e	CLIP-seq
MIRT2385775	hsa-miR-520g	CLIP-seq
MIRT2385776	hsa-miR-520h	CLIP-seq
MIRT1959681	hsa-miR-548s	CLIP-seq
MIRT876137	hsa-miR-562	CLIP-seq
MIRT1959682	hsa-miR-588	CLIP-seq
MIRT876132	hsa-miR-640	CLIP-seq
MIRT2385777	hsa-miR-93	CLIP-seq
MIRT2385755	hsa-miR-106a	CLIP-seq
MIRT2385756	hsa-miR-106b	CLIP-seq
MIRT876133	hsa-miR-1207-3p	CLIP-seq
MIRT2499881	hsa-miR-1228	CLIP-seq
MIRT876125	hsa-miR-1245	CLIP-seq
MIRT2196679	hsa-miR-1343	CLIP-seq
MIRT1959672	hsa-miR-150	CLIP-seq
MIRT2385757	hsa-miR-17	CLIP-seq
MIRT876126	hsa-miR-1825	CLIP-seq
MIRT2499882	hsa-miR-197	CLIP-seq
MIRT876134	hsa-miR-1972	CLIP-seq
MIRT876127	hsa-miR-199a-5p	CLIP-seq
MIRT876128	hsa-miR-199b-5p	CLIP-seq
MIRT2385758	hsa-miR-20a	CLIP-seq
MIRT2385759	hsa-miR-20b	CLIP-seq
MIRT2385760	hsa-miR-302a	CLIP-seq
MIRT2385761	hsa-miR-302b	CLIP-seq
MIRT2385762	hsa-miR-302c	CLIP-seq
MIRT2385763	hsa-miR-302d	CLIP-seq
MIRT2385764	hsa-miR-302e	CLIP-seq
MIRT1959673	hsa-miR-3187-3p	CLIP-seq
MIRT1959674	hsa-miR-3663-5p	CLIP-seq
MIRT876129	hsa-miR-371-5p	CLIP-seq
MIRT876130	hsa-miR-371b-5p	CLIP-seq
MIRT2385765	hsa-miR-372	CLIP-seq
MIRT2385766	hsa-miR-373	CLIP-seq
MIRT876131	hsa-miR-3925-3p	CLIP-seq
MIRT2196680	hsa-miR-4277	CLIP-seq
MIRT1959675	hsa-miR-4435	CLIP-seq
MIRT876135	hsa-miR-4438	CLIP-seq
MIRT2499886	hsa-miR-4537	CLIP-seq
MIRT1959676	hsa-miR-4701-5p	CLIP-seq
MIRT1959677	hsa-miR-4716-5p	CLIP-seq
MIRT1959678	hsa-miR-4727-5p	CLIP-seq
MIRT2385767	hsa-miR-4731-5p	CLIP-seq
MIRT1959679	hsa-miR-4755-3p	CLIP-seq
MIRT1959680	hsa-miR-4781-3p	CLIP-seq
MIRT2196681	hsa-miR-498	CLIP-seq
MIRT876136	hsa-miR-5095	CLIP-seq
MIRT2499888	hsa-miR-5096	CLIP-seq
MIRT2385768	hsa-miR-512-3p	CLIP-seq
MIRT2385769	hsa-miR-519d	CLIP-seq
MIRT2385770	hsa-miR-520a-3p	CLIP-seq
MIRT2385771	hsa-miR-520b	CLIP-seq
MIRT2385772	hsa-miR-520c-3p	CLIP-seq
MIRT2385773	hsa-miR-520d-3p	CLIP-seq
MIRT2385774	hsa-miR-520e	CLIP-seq
MIRT2385775	hsa-miR-520g	CLIP-seq
MIRT2385776	hsa-miR-520h	CLIP-seq
MIRT1959681	hsa-miR-548s	CLIP-seq
MIRT876137	hsa-miR-562	CLIP-seq
MIRT1959682	hsa-miR-588	CLIP-seq
MIRT876132	hsa-miR-640	CLIP-seq
MIRT2385777	hsa-miR-93	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ELF1	Activation	12676954
ESR2	Unknown	11517296
IRF4	Repression	12676954
IRF8	Repression	12676954
SPI1	Repression	12676954

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002437	Process	Inflammatory response to antigenic stimulus	ISS
GO:0002605	Process	Negative regulation of dendritic cell antigen processing and presentation	ISS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005764	Component	Lysosome	ISS
GO:0005765	Component	Lysosomal membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	28601280
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0007568	Process	Aging	ISS
GO:0016020	Component	Membrane	TAS	7680921
GO:0016021	Component	Integral component of membrane	IEA
GO:0031669	Process	Cellular response to nutrient levels	ISS
GO:0031902	Component	Late endosome membrane	IBA	21873635
GO:0035425	Process	Autocrine signaling	IEA
GO:0035577	Component	Azurophil granule membrane	TAS
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0071222	Process	Cellular response to lipopolysaccharide	ISS
GO:0072594	Process	Establishment of protein localization to organelle	IBA	21873635
GO:0140052	Process	Cellular response to oxidised low-density lipoprotein particle stimulus	ISS

Other IDs

• MIM: 153634
• HGNC: 1693
• e!Ensembl: ENSG00000129226

Protein

• UniProt ID: P34810
• Protein name: Macrosialin (Gp110) (CD antigen CD68)
• Protein function: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01299	Lamp	155 → 303	Lysosome-associated membrane glycoprotein (Lamp)	Family

• Sequence:

  MRLAVLFSGALLGLLAAQGTGNDCPHKKSATLLPSFTVTPTVTESTGTTSHRTTKSHKTT
  THRTTTTGTTSHGPTTATHNPTTTSHGNVTVHPTSNSTATSQGPSTATHSPATTSHGNAT
  VHPTSNSTATSPGFTSSAHPEPPPPSPSPSPTSKETIGDYTWTNGSQPCVHLQAQIQIRV
  MYTTQGGGEAWGISVLNPNKTKVQGSCEGAHPHLLLSFPYGHLSFGFMQDLQQKVVYLSY
  MAVEYNVSFPHAAQWTFSAQNASLRDLQAPLGQSFSCSNSSIILSPAVHLDLLSLRLQAA
  QLPHTGVFGQSFSCPSDRSILLPLIIGLILLGLLALVLIAFCIIRRRPSAYQAL

• Sequence length: 354

Pathways

KEGG:

Lysosome

Reactome:

Neutrophil degranulation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Amyotrophic lateral sclerosis	Amyotrophic Lateral Sclerosis, Familial	rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733, rs80356731, rs80356726, rs267606928, rs267606929, rs1885090126, rs121434591, rs121912431, rs121912432, rs121912433, rs121912434, rs121912435, rs121912440, rs121912436, rs121912437, rs121912438, rs121912439, rs74315452, rs121912442, rs121912443, rs121912444, rs121912446, rs121912447, rs1197141604, rs121912448, rs121912449, rs121912450, rs121912451, rs121912452, rs121912453, rs121912454, rs369600566, rs121912455, rs121912456, rs121912457, rs121912458, rs1555836889, rs121909667, rs121909668, rs121909669, rs121909671, rs121909535, rs121909537, rs121909538, rs121909539, rs121909540, rs121909542, rs121909544, rs80356734, rs367543041, rs80356740, rs80356719, rs80356721, rs80356723, rs80356725, rs387906627, rs387906628, rs387906709, rs387906710, rs387906711, rs387906829, rs387907264, rs387907265, rs387907266, rs312262739, rs312262709, rs312262749, rs200793464, rs147713329, rs312262788, rs397514262, rs63751180, rs587777132, rs730880025, rs730880026, rs730880027, rs368743618, rs730880029, rs730882255, rs730882256, rs786205611, rs121912441, rs199947197, rs780136067, rs772731615, rs879253926, rs879254294, rs764717219, rs886041390, rs750159428, rs753207473, rs267607087, rs767350733, rs778305085, rs1554707680, rs1554707622, rs1393363759, rs750959420, rs1555509569, rs1554716504, rs11556620, rs1247392012, rs142083484, rs140385286, rs749428135, rs371575563, rs1402429085, rs1218712729, rs1555179091, rs1555179087, rs746971952, rs1555836950, rs368276916, rs140376902, rs747220413, rs76731700, rs770684782, rs1200906022, rs1804449, rs1482760341, rs769898852, rs140599944, rs757972700, rs1555451521, rs1592362719, rs1555836803, rs763455928, rs1378590183, rs1583695322, rs1362178149, rs1197928094, rs368751524, rs1555509609, rs1574787779, rs1601157750, rs1301635320, rs1341055534, rs1402092579, rs1568809172, rs1555836170, rs1315541036, rs1339283341, rs1643659556, rs1644506661, rs1435710212, rs1553122918, rs1689580631, rs374047961, rs775935265, rs2076486420, rs1820836522, rs757260058, rs1844420892, rs1833371664, rs1833438306, rs1833451208, rs2083790483, rs1303294230, rs1226110412, rs2053207945, rs2053208751, rs2053501632, rs2053539304, rs1567479067, rs544088874, rs1228194239, rs1568807400, rs1169198442, rs2049594204, rs2049594311, rs1568810641, rs1568811372, rs2049618449, rs1476760624, rs2079347087	11796754
Cholestasis	Cholestasis, Extrahepatic	rs121909103, rs751511532, rs376368459, rs762702807, rs1578490102, rs1578499691, rs1578504946, rs1317656688, rs199791850, rs1452792080, rs1578491039	28789951
Hyperinsulinism	Hyperinsulinism	rs387906407, rs151344623, rs121913156, rs137853245, rs80356655, rs104894010, rs104894012, rs104894014, rs104894015, rs137852676, rs587783169, rs72559716, rs541269678, rs151344624, rs797045209, rs761749884, rs797045624, rs863225280, rs139964066, rs1057516281, rs1057516317, rs576684889, rs201682634, rs1350717554, rs768951263, rs1260178539, rs200670692, rs72559734, rs1400535021, rs372307320, rs1554923999, rs751279984, rs1008906426, rs367850779, rs1382448285, rs1564977373, rs750586210, rs1599937180	29035695
Lateral sclerosis	AMYOTROPHIC LATERAL SCLEROSIS 1, Amyotrophic Lateral Sclerosis, Sporadic	rs386134181, rs386134176, rs386134174, rs386134184, rs386134178, rs1693780539, rs1574698048	11796754
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	29035695

Unknown
Disease name	Disease term	dbSNP ID	References
Compensatory hyperinsulinemia	Compensatory Hyperinsulinemia		29035695
Endogenous hyperinsulinism	Endogenous Hyperinsulinism		29035695
Exogenous hyperinsulinism	Exogenous Hyperinsulinism		29035695
Kidney failure	Kidney Failure, Chronic		19539174
Miscarriage	Miscarriage		18539642
Psoriatic arthritis	Arthritis, Psoriatic		19732956