PLCH2 (phospholipase C eta 2)

Gene

• Entrez ID: 9651
• Gene name: Phospholipase C eta 2
• Gene symbol: PLCH2
• Synonyms: PLC-L4, PLC-eta2, PLCL4, PLCeta2
• Chromosome: 1
• Chromosome location: 1p36.32
• Summary: PLCH2 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave PtdIns(4,5) P2 to generate second messengers inositol 1,4,5-trisphosphate and diacylglycerol (Zhou et al., 2005 [PubMed 16107

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029064	hsa-miR-26b-5p	Microarray	19088304
MIRT043301	hsa-miR-331-3p	CLASH	23622248
MIRT2070585	hsa-miR-1321	CLIP-seq
MIRT2070586	hsa-miR-1909	CLIP-seq
MIRT2070587	hsa-miR-4419a	CLIP-seq
MIRT2070588	hsa-miR-4459	CLIP-seq
MIRT2070589	hsa-miR-4510	CLIP-seq
MIRT2070590	hsa-miR-4688	CLIP-seq
MIRT2070591	hsa-miR-4722-5p	CLIP-seq
MIRT2070592	hsa-miR-4739	CLIP-seq
MIRT2070593	hsa-miR-4756-5p	CLIP-seq
MIRT2070594	hsa-miR-4779	CLIP-seq
MIRT2070595	hsa-miR-486-3p	CLIP-seq
MIRT2297706	hsa-miR-1207-5p	CLIP-seq
MIRT2070585	hsa-miR-1321	CLIP-seq
MIRT2297707	hsa-miR-1827	CLIP-seq
MIRT2070586	hsa-miR-1909	CLIP-seq
MIRT2297708	hsa-miR-3612	CLIP-seq
MIRT2070587	hsa-miR-4419a	CLIP-seq
MIRT2070588	hsa-miR-4459	CLIP-seq
MIRT2070589	hsa-miR-4510	CLIP-seq
MIRT2297709	hsa-miR-4684-5p	CLIP-seq
MIRT2070590	hsa-miR-4688	CLIP-seq
MIRT2070591	hsa-miR-4722-5p	CLIP-seq
MIRT2070592	hsa-miR-4739	CLIP-seq
MIRT2070593	hsa-miR-4756-5p	CLIP-seq
MIRT2297710	hsa-miR-4763-3p	CLIP-seq
MIRT2297711	hsa-miR-4768-5p	CLIP-seq
MIRT2070594	hsa-miR-4779	CLIP-seq
MIRT2070595	hsa-miR-486-3p	CLIP-seq
MIRT2297712	hsa-miR-548ad	CLIP-seq
MIRT2297713	hsa-miR-650	CLIP-seq
MIRT2297714	hsa-miR-940	CLIP-seq
MIRT2297706	hsa-miR-1207-5p	CLIP-seq
MIRT2070585	hsa-miR-1321	CLIP-seq
MIRT2297707	hsa-miR-1827	CLIP-seq
MIRT2070586	hsa-miR-1909	CLIP-seq
MIRT2297708	hsa-miR-3612	CLIP-seq
MIRT2070587	hsa-miR-4419a	CLIP-seq
MIRT2070588	hsa-miR-4459	CLIP-seq
MIRT2070589	hsa-miR-4510	CLIP-seq
MIRT2070590	hsa-miR-4688	CLIP-seq
MIRT2070591	hsa-miR-4722-5p	CLIP-seq
MIRT2070592	hsa-miR-4739	CLIP-seq
MIRT2070593	hsa-miR-4756-5p	CLIP-seq
MIRT2297710	hsa-miR-4763-3p	CLIP-seq
MIRT2070594	hsa-miR-4779	CLIP-seq
MIRT2070595	hsa-miR-486-3p	CLIP-seq
MIRT2297713	hsa-miR-650	CLIP-seq
MIRT2297714	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004435	Function	Phosphatidylinositol phospholipase C activity	IBA	21873635
GO:0004435	Function	Phosphatidylinositol phospholipase C activity	IDA	18361507
GO:0005509	Function	Calcium ion binding	IEA
GO:0005575	Component	Cellular_component	ND
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0016042	Process	Lipid catabolic process	IEA
GO:0043647	Process	Inositol phosphate metabolic process	TAS
GO:0046488	Process	Phosphatidylinositol metabolic process	IEA
GO:0048015	Process	Phosphatidylinositol-mediated signaling	IBA	21873635
GO:0048015	Process	Phosphatidylinositol-mediated signaling	IDA	18361507

Other IDs

• MIM: 612836
• HGNC: 29037
• e!Ensembl: ENSG00000149527

Protein

• UniProt ID: O75038
• Protein name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-eta-2) (Phosphoinositide phospholipase C-like 4) (PLC-L4) (Phospholipase C-like protein 4) (Phospholipase C-eta-2) (PLC-eta2)
• Protein function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:18361507). This phospholipase activity is very se
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16457	PH_12	41 → 155	Pleckstrin homology domain	Domain
  PF09279	EF-hand_like	234 → 319	Phosphoinositide-specific phospholipase C, efhand-like	Domain
  PF00388	PI-PLC-X	328 → 472	Phosphatidylinositol-specific phospholipase C, X domain	Family
  PF00387	PI-PLC-Y	626 → 738	Phosphatidylinositol-specific phospholipase C, Y domain	Family
  PF00168	C2	758 → 867	C2 domain	Domain

• Sequence:

  MSGPWPSPDSRTKGTVAWLAEVLLWVGGSVVLSSEWQLGPLVERCMGAMQEGMQMVKLRG
  GSKGLVRFYYLDEHRSCIRWRPSRKNEKAKISIDSIQEVSEGRQSEVFQRYPDGSFDPNC
  CFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDE
  ADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMST
  RRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESCQDIIEQFEPCPENKSKGLL
  GIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYA
  WVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIE
  NHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGKILVKGKKLPANISED
  AEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRKLDSLIKESKIRDCEDPNNFS
  VSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRKKKGSKLKKAASVEEGD
  EGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHDIEMEAASSWQVSSFSETKAH
  QILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLN
  RAKFSANGGCGYVLKPGCMCQGVFNPNSEDPLPGQLKKQLVLRIISGQQLPKPRDSMLGD
  RGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWEETLVFMVHMPEIALVRFLVWDH
  DPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQALGLKGLFLR
  GPKPGSLDSHAAGRPPARPSVSQRILRRTASAPTKSQKPGRRGFPELVLGTRDTGSKGVA
  DDVVPPGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLETIAEEPAPGPGPPPPA
  AVPTSSSQGRPPYPTGPGANVASPLEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRS
  QPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAPFPAPAVYSDATGSDPLWQRLEPCGHR
  DSVSSSSSMSSSDTVIDLSLPSLGLGRSRENLAGAHMGRLPPRPHSASAARPDLPPVTKS
  KSNPNLRATGQRPPIPDELQPRSLAPRMAGLPFRPPWGCLSLVGVQDCPVAAKSKSLGDL
  TADDFAPSFEGGSRRLSHSLGLPGGTRRVSGPGVRRDTLTEQLRWLTVFQQAGDITSPTS
  LGPAGEGVAGGPGFVRRSSSRSHSRVRAIASRARQAQERQQRLQGLGRQGPPEEERGTPE
  GACSVGHEGSVDAPAPSKGALGPASAAAENLVLLRL

• Sequence length: 1416

Pathways

KEGG:

Inositol phosphate metabolism
Metabolic pathways

Reactome:

Synthesis of IP3 and IP4 in the cytosol

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Azoospermia	Azoospermia	rs200969445, rs144567652, rs765353898	22197933
Non-obstructive azoospermia	Non-obstructive azoospermia	rs587777872, rs879253743, rs1600840291, rs1600877766, rs753462162, rs1588618614, rs1602684496, rs377712900	22197933
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	25056061, 26198764, 29483656, 31268507