SH3PXD2A (SH3 and PX domains 2A)
|
Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
9644 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
SH3 and PX domains 2A |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
SH3PXD2A |
SynonymsGene synonyms aliases
|
FISH, SH3MD1, TKS5 |
ChromosomeChromosome number
|
10 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
10q24.33 |
miRNAmiRNA information provided by mirtarbase database.
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|
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
Q5TCZ1 |
Protein name |
SH3 and PX domain-containing protein 2A (Adapter protein TKS5) (Five SH3 domain-containing protein) (SH3 multiple domains protein 1) (Tyrosine kinase substrate with five SH3 domains) |
Protein function |
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts |
PDB |
2DNU
,
2EGA
,
2EGC
,
2EKH
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00787 |
PX |
30 → 124 |
PX domain |
Domain |
PF00018 |
SH3_1 |
172 → 217 |
SH3 domain |
Domain |
PF00018 |
SH3_1 |
273 → 317 |
SH3 domain |
Domain |
PF00018 |
SH3_1 |
455 → 499 |
SH3 domain |
Domain |
PF00018 |
SH3_1 |
848 → 891 |
SH3 domain |
Domain |
|
Sequence |
|
Sequence length |
1133 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Asthma |
Asthma |
rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283 |
25918132 |
Atrial fibrillation |
Atrial Fibrillation |
rs120074192, rs121908590, rs121908593, rs121434558, rs587776851, rs387906612, rs387906613, rs387906614, rs387906615, rs199472687, rs199472705, rs199473324, rs587777336, rs587777339, rs587777557, rs587777558, rs587777559, rs587777560, rs886037778, rs769405762, rs770372675 |
28416822, 28416818, 30061737, 29892015, 29290336 |
Neurofibrosarcoma |
Neurofibrosarcoma |
rs137852604 |
27723760 |
Rheumatoid arthritis |
Rheumatoid Arthritis |
rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212 |
30891314 |
Schizophrenia |
Schizophrenia |
rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 |
24936775 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Malignant peripheral nerve sheath tumor |
Malignant Peripheral Nerve Sheath Tumor |
|
27723760 |
Paroxysmal atrial fibrillation |
Paroxysmal atrial fibrillation |
rs199865688, rs397515994, rs757096307 |
28416822 |
Stroke |
Cerebrovascular accident, Acute Cerebrovascular Accidents |
|
29531354 |
|
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