FEZ1 (fasciculation and elongation protein zeta 1)

Gene

• Entrez ID: 9638
• Gene name: Fasciculation and elongation protein zeta 1
• Gene symbol: FEZ1
• Synonyms: UNC-76
• Chromosome: 11
• Chromosome location: 11q24.2
• Summary: This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fascicu

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT994896	hsa-miR-1227	CLIP-seq
MIRT994897	hsa-miR-1228	CLIP-seq
MIRT994898	hsa-miR-1827	CLIP-seq
MIRT994899	hsa-miR-2114	CLIP-seq
MIRT994900	hsa-miR-25	CLIP-seq
MIRT994901	hsa-miR-2681	CLIP-seq
MIRT994902	hsa-miR-299-3p	CLIP-seq
MIRT994903	hsa-miR-3122	CLIP-seq
MIRT994904	hsa-miR-3138	CLIP-seq
MIRT994905	hsa-miR-3160-5p	CLIP-seq
MIRT994906	hsa-miR-3176	CLIP-seq
MIRT994907	hsa-miR-3192	CLIP-seq
MIRT994908	hsa-miR-32	CLIP-seq
MIRT994909	hsa-miR-3613-3p	CLIP-seq
MIRT994910	hsa-miR-361-3p	CLIP-seq
MIRT994911	hsa-miR-363	CLIP-seq
MIRT994912	hsa-miR-3664-3p	CLIP-seq
MIRT994913	hsa-miR-367	CLIP-seq
MIRT994914	hsa-miR-3689a-3p	CLIP-seq
MIRT994915	hsa-miR-3689c	CLIP-seq
MIRT994916	hsa-miR-3689d	CLIP-seq
MIRT994917	hsa-miR-3913-5p	CLIP-seq
MIRT994918	hsa-miR-3922-3p	CLIP-seq
MIRT994919	hsa-miR-3929	CLIP-seq
MIRT994920	hsa-miR-3934	CLIP-seq
MIRT994921	hsa-miR-4325	CLIP-seq
MIRT994922	hsa-miR-4419b	CLIP-seq
MIRT994923	hsa-miR-4428	CLIP-seq
MIRT994924	hsa-miR-4433	CLIP-seq
MIRT994925	hsa-miR-4453	CLIP-seq
MIRT994926	hsa-miR-4459	CLIP-seq
MIRT994927	hsa-miR-4478	CLIP-seq
MIRT994928	hsa-miR-4486	CLIP-seq
MIRT994929	hsa-miR-4491	CLIP-seq
MIRT994930	hsa-miR-4538	CLIP-seq
MIRT994931	hsa-miR-4640-5p	CLIP-seq
MIRT994932	hsa-miR-4649-3p	CLIP-seq
MIRT994933	hsa-miR-4649-5p	CLIP-seq
MIRT994934	hsa-miR-4657	CLIP-seq
MIRT994935	hsa-miR-4695-5p	CLIP-seq
MIRT994936	hsa-miR-4722-5p	CLIP-seq
MIRT994937	hsa-miR-4726-5p	CLIP-seq
MIRT994938	hsa-miR-4728-5p	CLIP-seq
MIRT994939	hsa-miR-4759	CLIP-seq
MIRT994940	hsa-miR-4760-5p	CLIP-seq
MIRT994941	hsa-miR-4768-3p	CLIP-seq
MIRT994942	hsa-miR-4775	CLIP-seq
MIRT994943	hsa-miR-4798-3p	CLIP-seq
MIRT994944	hsa-miR-4800-5p	CLIP-seq
MIRT994945	hsa-miR-485-5p	CLIP-seq
MIRT994946	hsa-miR-490-3p	CLIP-seq
MIRT994947	hsa-miR-508-5p	CLIP-seq
MIRT994948	hsa-miR-510	CLIP-seq
MIRT994949	hsa-miR-512-5p	CLIP-seq
MIRT994950	hsa-miR-590-3p	CLIP-seq
MIRT994951	hsa-miR-661	CLIP-seq
MIRT994952	hsa-miR-766	CLIP-seq
MIRT994953	hsa-miR-92a	CLIP-seq
MIRT994954	hsa-miR-92b	CLIP-seq
MIRT994955	hsa-miR-940	CLIP-seq
MIRT2465294	hsa-miR-3137	CLIP-seq
MIRT2465295	hsa-miR-3935	CLIP-seq
MIRT2465296	hsa-miR-577	CLIP-seq
MIRT2532762	hsa-miR-1226	CLIP-seq
MIRT2532763	hsa-miR-1284	CLIP-seq
MIRT2532764	hsa-miR-1291	CLIP-seq
MIRT2532765	hsa-miR-1913	CLIP-seq
MIRT2532766	hsa-miR-3173-5p	CLIP-seq
MIRT2532767	hsa-miR-3189-5p	CLIP-seq
MIRT2532768	hsa-miR-324-3p	CLIP-seq
MIRT2532769	hsa-miR-324-5p	CLIP-seq
MIRT2532770	hsa-miR-3612	CLIP-seq
MIRT2532771	hsa-miR-3676	CLIP-seq
MIRT2532772	hsa-miR-4661-5p	CLIP-seq
MIRT2532773	hsa-miR-4716-3p	CLIP-seq
MIRT2532774	hsa-miR-4723-5p	CLIP-seq
MIRT2532775	hsa-miR-4758-3p	CLIP-seq
MIRT2532776	hsa-miR-4786-3p	CLIP-seq
MIRT2532777	hsa-miR-4789-5p	CLIP-seq
MIRT2532778	hsa-miR-548al	CLIP-seq
MIRT2532779	hsa-miR-634	CLIP-seq
MIRT2532780	hsa-miR-650	CLIP-seq
MIRT2532781	hsa-miR-767-5p	CLIP-seq
MIRT2532762	hsa-miR-1226	CLIP-seq
MIRT2532763	hsa-miR-1284	CLIP-seq
MIRT2532764	hsa-miR-1291	CLIP-seq
MIRT2532765	hsa-miR-1913	CLIP-seq
MIRT2532766	hsa-miR-3173-5p	CLIP-seq
MIRT2532767	hsa-miR-3189-5p	CLIP-seq
MIRT2532768	hsa-miR-324-3p	CLIP-seq
MIRT2532769	hsa-miR-324-5p	CLIP-seq
MIRT2532770	hsa-miR-3612	CLIP-seq
MIRT2532771	hsa-miR-3676	CLIP-seq
MIRT2532772	hsa-miR-4661-5p	CLIP-seq
MIRT2532773	hsa-miR-4716-3p	CLIP-seq
MIRT2532774	hsa-miR-4723-5p	CLIP-seq
MIRT2532775	hsa-miR-4758-3p	CLIP-seq
MIRT2532776	hsa-miR-4786-3p	CLIP-seq
MIRT2532777	hsa-miR-4789-5p	CLIP-seq
MIRT2532778	hsa-miR-548al	CLIP-seq
MIRT2532779	hsa-miR-634	CLIP-seq
MIRT2532780	hsa-miR-650	CLIP-seq
MIRT2532781	hsa-miR-767-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005080	Function	Protein kinase C binding	IEA
GO:0005515	Function	Protein binding	IPI	14690447, 15383276, 16169070, 17500595, 20547877, 28514442
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005739	Component	Mitochondrion	IEA
GO:0005794	Component	Golgi apparatus	IDA	25495476
GO:0005813	Component	Centrosome	IEA
GO:0005874	Component	Microtubule	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0007155	Process	Cell adhesion	TAS	9096408
GO:0007399	Process	Nervous system development	TAS	9096408
GO:0007411	Process	Axon guidance	TAS	9096408
GO:0010976	Process	Positive regulation of neuron projection development	IEA
GO:0021766	Process	Hippocampus development	IEA
GO:0030010	Process	Establishment of cell polarity	IEA
GO:0030424	Component	Axon	IBA	21873635
GO:0030425	Component	Dendrite	IEA
GO:0030426	Component	Growth cone	IEA
GO:0043015	Function	Gamma-tubulin binding	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0045666	Process	Positive regulation of neuron differentiation	IEA
GO:0047485	Function	Protein N-terminus binding	IEA
GO:0051654	Process	Establishment of mitochondrion localization	IEA
GO:0061881	Process	Positive regulation of anterograde axonal transport of mitochondrion	IEA
GO:0070584	Process	Mitochondrion morphogenesis	IEA
GO:0071363	Process	Cellular response to growth factor stimulus	IEA
GO:1902902	Process	Negative regulation of autophagosome assembly	IMP	25495476

Other IDs

• MIM: 604825
• HGNC: 3659
• e!Ensembl: ENSG00000149557

Protein

• UniProt ID: Q99689
• Protein name: Fasciculation and elongation protein zeta-1 (Zygin I) (Zygin-1)
• Protein function: May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline trans
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07763	FEZ	58 → 297	FEZ-like protein	Family

• Sequence:

  MEAPLVSLDEEFEDLRPSCSEDPEEKPQCFYGSSPHHLEDPSLSELENFSSEIISFKSME
  DLVNEFDEKLNVCFRNYNAKTENLAPVKNQLQIQEEEETLQDEEVWDALTDNYIPSLSED
  WRDPNIEALNGNCSDTEIHEKEEEEFNEKSENDSGINEEPLLTADQVIEEIEEMMQNSPD
  PEEEEEVLEEEDGGETSSQADSVLLQEMQALTQTFNNNWSYEGLRHMSGSELTELLDQVE
  GAIRDFSEELVQQLARRDELEFEKEVKNSFITVLIEVQNKQKEQRELMKKRRKEKGLSLQ
  SSRIEKGNQMPLKRFSMEGISNILQSGIRQTFGSSGTDKQYLNTVIPYEKKASPPSVEDL
  QMLTNILFAMKEDNEKVPTLLTDYILKVLCPT

• Sequence length: 392

Pathways

KEGG:

Viral life cycle - HIV-1

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Attention deficit hyperactivity disorder	Attention deficit hyperactivity disorder	rs120074176, rs786205019	23453885
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	23453885, 16936715, 22099459, 22688191, 18647754, 21926974

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		23453885
Development disorder	Child Development Disorders, Pervasive		23453885
Mental depression	Major Depressive Disorder	rs587778876, rs587778877	23453885
Psychosis	Psychotic Disorders		22099459
Vascular diseases	Peripheral Arterial Diseases		27082954