PRDX6 (peroxiredoxin 6)

Gene

• Entrez ID: 9588
• Gene name: Peroxiredoxin 6
• Gene symbol: PRDX6
• Synonyms: 1-Cys, AOP2, HEL-S-128m, LPCAT-5, NSGPx, PRX, aiPLA2, p29
• Chromosome: 1
• Chromosome location: 1q25.1
• Summary: The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain org

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT004940	hsa-miR-632	qRT-PCR, Western blot	17980029
MIRT044389	hsa-miR-320a	CLASH	23622248
MIRT731962	hsa-miR-371a-3p	Luciferase reporter assay, Western blot	27484502
MIRT731962	hsa-miR-371a-3p	Luciferase reporter assay, Western blot	27484502
MIRT1260574	hsa-miR-10a	CLIP-seq
MIRT1260575	hsa-miR-10b	CLIP-seq
MIRT1260576	hsa-miR-1178	CLIP-seq
MIRT1260577	hsa-miR-1205	CLIP-seq
MIRT1260578	hsa-miR-122	CLIP-seq
MIRT1260579	hsa-miR-1226	CLIP-seq
MIRT1260580	hsa-miR-1228	CLIP-seq
MIRT1260581	hsa-miR-124	CLIP-seq
MIRT1260582	hsa-miR-1261	CLIP-seq
MIRT1260583	hsa-miR-1265	CLIP-seq
MIRT1260584	hsa-miR-1286	CLIP-seq
MIRT1260585	hsa-miR-1297	CLIP-seq
MIRT1260586	hsa-miR-1343	CLIP-seq
MIRT1260587	hsa-miR-137	CLIP-seq
MIRT1260588	hsa-miR-149	CLIP-seq
MIRT1260589	hsa-miR-183	CLIP-seq
MIRT1260590	hsa-miR-221	CLIP-seq
MIRT1260591	hsa-miR-222	CLIP-seq
MIRT1260592	hsa-miR-24	CLIP-seq
MIRT1260593	hsa-miR-2467-3p	CLIP-seq
MIRT1260594	hsa-miR-26a	CLIP-seq
MIRT1260595	hsa-miR-26b	CLIP-seq
MIRT1260596	hsa-miR-2964a-3p	CLIP-seq
MIRT1260597	hsa-miR-29a	CLIP-seq
MIRT1260598	hsa-miR-29b	CLIP-seq
MIRT1260599	hsa-miR-29c	CLIP-seq
MIRT1260600	hsa-miR-302f	CLIP-seq
MIRT1260601	hsa-miR-3064-5p	CLIP-seq
MIRT1260602	hsa-miR-3065-3p	CLIP-seq
MIRT1260603	hsa-miR-3125	CLIP-seq
MIRT1260604	hsa-miR-3134	CLIP-seq
MIRT1260605	hsa-miR-3145-3p	CLIP-seq
MIRT1260606	hsa-miR-3158-5p	CLIP-seq
MIRT1260607	hsa-miR-3171	CLIP-seq
MIRT1260608	hsa-miR-3173-5p	CLIP-seq
MIRT1260609	hsa-miR-3189-3p	CLIP-seq
MIRT1260610	hsa-miR-3201	CLIP-seq
MIRT1260611	hsa-miR-342-3p	CLIP-seq
MIRT1260612	hsa-miR-3545-3p	CLIP-seq
MIRT1260613	hsa-miR-361-3p	CLIP-seq
MIRT1260614	hsa-miR-3678-3p	CLIP-seq
MIRT1260615	hsa-miR-3679-3p	CLIP-seq
MIRT1260616	hsa-miR-3688-3p	CLIP-seq
MIRT1260617	hsa-miR-3689a-3p	CLIP-seq
MIRT1260618	hsa-miR-3689c	CLIP-seq
MIRT1260619	hsa-miR-3714	CLIP-seq
MIRT1260620	hsa-miR-378g	CLIP-seq
MIRT1260621	hsa-miR-3913-3p	CLIP-seq
MIRT1260622	hsa-miR-3916	CLIP-seq
MIRT1260623	hsa-miR-3921	CLIP-seq
MIRT1260624	hsa-miR-425	CLIP-seq
MIRT1260625	hsa-miR-4252	CLIP-seq
MIRT1260626	hsa-miR-4284	CLIP-seq
MIRT1260627	hsa-miR-4300	CLIP-seq
MIRT1260628	hsa-miR-4446-5p	CLIP-seq
MIRT1260629	hsa-miR-4457	CLIP-seq
MIRT1260630	hsa-miR-4465	CLIP-seq
MIRT1260631	hsa-miR-4493	CLIP-seq
MIRT1260632	hsa-miR-4502	CLIP-seq
MIRT1260633	hsa-miR-4530	CLIP-seq
MIRT1260634	hsa-miR-4534	CLIP-seq
MIRT1260635	hsa-miR-4653-5p	CLIP-seq
MIRT1260636	hsa-miR-4679	CLIP-seq
MIRT1260637	hsa-miR-4687-3p	CLIP-seq
MIRT1260638	hsa-miR-4698	CLIP-seq
MIRT1260639	hsa-miR-4699-3p	CLIP-seq
MIRT1260640	hsa-miR-4717-3p	CLIP-seq
MIRT1260641	hsa-miR-4722-5p	CLIP-seq
MIRT1260642	hsa-miR-4727-5p	CLIP-seq
MIRT1260643	hsa-miR-4733-3p	CLIP-seq
MIRT1260644	hsa-miR-4756-3p	CLIP-seq
MIRT1260645	hsa-miR-4764-5p	CLIP-seq
MIRT1260646	hsa-miR-4769-3p	CLIP-seq
MIRT1260647	hsa-miR-4777-5p	CLIP-seq
MIRT1260648	hsa-miR-4790-3p	CLIP-seq
MIRT1260649	hsa-miR-4791	CLIP-seq
MIRT1260650	hsa-miR-4794	CLIP-seq
MIRT1260651	hsa-miR-4797-5p	CLIP-seq
MIRT1260652	hsa-miR-488	CLIP-seq
MIRT1260653	hsa-miR-489	CLIP-seq
MIRT1260654	hsa-miR-506	CLIP-seq
MIRT1260655	hsa-miR-512-3p	CLIP-seq
MIRT1260656	hsa-miR-513b	CLIP-seq
MIRT1260657	hsa-miR-515-5p	CLIP-seq
MIRT1260658	hsa-miR-518a-3p	CLIP-seq
MIRT1260659	hsa-miR-518b	CLIP-seq
MIRT1260660	hsa-miR-518c	CLIP-seq
MIRT1260661	hsa-miR-518d-3p	CLIP-seq
MIRT1260662	hsa-miR-518d-5p	CLIP-seq
MIRT1260663	hsa-miR-518f	CLIP-seq
MIRT1260664	hsa-miR-519b-5p	CLIP-seq
MIRT1260665	hsa-miR-519c-5p	CLIP-seq
MIRT1260666	hsa-miR-520c-5p	CLIP-seq
MIRT1260667	hsa-miR-526a	CLIP-seq
MIRT1260668	hsa-miR-548an	CLIP-seq
MIRT1260669	hsa-miR-548v	CLIP-seq
MIRT1260670	hsa-miR-570	CLIP-seq
MIRT1260671	hsa-miR-607	CLIP-seq
MIRT1260672	hsa-miR-628-5p	CLIP-seq
MIRT1260673	hsa-miR-634	CLIP-seq
MIRT1260674	hsa-miR-647	CLIP-seq
MIRT1260675	hsa-miR-759	CLIP-seq
MIRT1260676	hsa-miR-890	CLIP-seq
MIRT1260677	hsa-miR-920	CLIP-seq
MIRT1260678	hsa-miR-922	CLIP-seq
MIRT1260577	hsa-miR-1205	CLIP-seq
MIRT1260583	hsa-miR-1265	CLIP-seq
MIRT1260584	hsa-miR-1286	CLIP-seq
MIRT1260588	hsa-miR-149	CLIP-seq
MIRT1260593	hsa-miR-2467-3p	CLIP-seq
MIRT1260596	hsa-miR-2964a-3p	CLIP-seq
MIRT1260600	hsa-miR-302f	CLIP-seq
MIRT1260601	hsa-miR-3064-5p	CLIP-seq
MIRT2076697	hsa-miR-3124-3p	CLIP-seq
MIRT1260606	hsa-miR-3158-5p	CLIP-seq
MIRT1260608	hsa-miR-3173-5p	CLIP-seq
MIRT1260614	hsa-miR-3678-3p	CLIP-seq
MIRT1260616	hsa-miR-3688-3p	CLIP-seq
MIRT1260621	hsa-miR-3913-3p	CLIP-seq
MIRT2076698	hsa-miR-412	CLIP-seq
MIRT1260624	hsa-miR-425	CLIP-seq
MIRT1260628	hsa-miR-4446-5p	CLIP-seq
MIRT1260638	hsa-miR-4698	CLIP-seq
MIRT1260641	hsa-miR-4722-5p	CLIP-seq
MIRT1260643	hsa-miR-4733-3p	CLIP-seq
MIRT2076699	hsa-miR-4753-3p	CLIP-seq
MIRT2076700	hsa-miR-4755-5p	CLIP-seq
MIRT1260644	hsa-miR-4756-3p	CLIP-seq
MIRT1260645	hsa-miR-4764-5p	CLIP-seq
MIRT1260650	hsa-miR-4794	CLIP-seq
MIRT1260653	hsa-miR-489	CLIP-seq
MIRT2076701	hsa-miR-548m	CLIP-seq
MIRT1260670	hsa-miR-570	CLIP-seq
MIRT2076702	hsa-miR-670	CLIP-seq
MIRT2076703	hsa-miR-885-3p	CLIP-seq
MIRT1260577	hsa-miR-1205	CLIP-seq
MIRT2303389	hsa-miR-1236	CLIP-seq
MIRT1260582	hsa-miR-1261	CLIP-seq
MIRT1260583	hsa-miR-1265	CLIP-seq
MIRT1260584	hsa-miR-1286	CLIP-seq
MIRT1260585	hsa-miR-1297	CLIP-seq
MIRT1260586	hsa-miR-1343	CLIP-seq
MIRT2303390	hsa-miR-142-5p	CLIP-seq
MIRT2303391	hsa-miR-23a	CLIP-seq
MIRT2303392	hsa-miR-23b	CLIP-seq
MIRT2303393	hsa-miR-23c	CLIP-seq
MIRT1260593	hsa-miR-2467-3p	CLIP-seq
MIRT1260594	hsa-miR-26a	CLIP-seq
MIRT1260595	hsa-miR-26b	CLIP-seq
MIRT1260596	hsa-miR-2964a-3p	CLIP-seq
MIRT1260600	hsa-miR-302f	CLIP-seq
MIRT2303394	hsa-miR-3065-5p	CLIP-seq
MIRT2076697	hsa-miR-3124-3p	CLIP-seq
MIRT1260603	hsa-miR-3125	CLIP-seq
MIRT1260605	hsa-miR-3145-3p	CLIP-seq
MIRT1260606	hsa-miR-3158-5p	CLIP-seq
MIRT1260608	hsa-miR-3173-5p	CLIP-seq
MIRT1260610	hsa-miR-3201	CLIP-seq
MIRT2303395	hsa-miR-340	CLIP-seq
MIRT1260612	hsa-miR-3545-3p	CLIP-seq
MIRT1260614	hsa-miR-3678-3p	CLIP-seq
MIRT1260616	hsa-miR-3688-3p	CLIP-seq
MIRT1260620	hsa-miR-378g	CLIP-seq
MIRT1260622	hsa-miR-3916	CLIP-seq
MIRT2076698	hsa-miR-412	CLIP-seq
MIRT1260624	hsa-miR-425	CLIP-seq
MIRT1260628	hsa-miR-4446-5p	CLIP-seq
MIRT1260629	hsa-miR-4457	CLIP-seq
MIRT1260630	hsa-miR-4465	CLIP-seq
MIRT2303396	hsa-miR-4494	CLIP-seq
MIRT2303397	hsa-miR-4499	CLIP-seq
MIRT2303398	hsa-miR-4506	CLIP-seq
MIRT2303399	hsa-miR-4517	CLIP-seq
MIRT1260636	hsa-miR-4679	CLIP-seq
MIRT1260637	hsa-miR-4687-3p	CLIP-seq
MIRT1260638	hsa-miR-4698	CLIP-seq
MIRT1260639	hsa-miR-4699-3p	CLIP-seq
MIRT1260640	hsa-miR-4717-3p	CLIP-seq
MIRT1260641	hsa-miR-4722-5p	CLIP-seq
MIRT1260643	hsa-miR-4733-3p	CLIP-seq
MIRT2076699	hsa-miR-4753-3p	CLIP-seq
MIRT2076700	hsa-miR-4755-5p	CLIP-seq
MIRT1260644	hsa-miR-4756-3p	CLIP-seq
MIRT1260645	hsa-miR-4764-5p	CLIP-seq
MIRT2303400	hsa-miR-4768-5p	CLIP-seq
MIRT1260647	hsa-miR-4777-5p	CLIP-seq
MIRT1260649	hsa-miR-4791	CLIP-seq
MIRT1260651	hsa-miR-4797-5p	CLIP-seq
MIRT2303401	hsa-miR-505	CLIP-seq
MIRT1260656	hsa-miR-513b	CLIP-seq
MIRT1260662	hsa-miR-518d-5p	CLIP-seq
MIRT1260664	hsa-miR-519b-5p	CLIP-seq
MIRT1260665	hsa-miR-519c-5p	CLIP-seq
MIRT1260666	hsa-miR-520c-5p	CLIP-seq
MIRT1260667	hsa-miR-526a	CLIP-seq
MIRT2076701	hsa-miR-548m	CLIP-seq
MIRT1260670	hsa-miR-570	CLIP-seq
MIRT2303402	hsa-miR-617	CLIP-seq
MIRT1260674	hsa-miR-647	CLIP-seq
MIRT2076702	hsa-miR-670	CLIP-seq
MIRT1260676	hsa-miR-890	CLIP-seq
MIRT2303403	hsa-miR-942	CLIP-seq
MIRT1260577	hsa-miR-1205	CLIP-seq
MIRT1260583	hsa-miR-1265	CLIP-seq
MIRT1260584	hsa-miR-1286	CLIP-seq
MIRT1260596	hsa-miR-2964a-3p	CLIP-seq
MIRT1260600	hsa-miR-302f	CLIP-seq
MIRT1260616	hsa-miR-3688-3p	CLIP-seq
MIRT1260641	hsa-miR-4722-5p	CLIP-seq
MIRT1260643	hsa-miR-4733-3p	CLIP-seq
MIRT1260645	hsa-miR-4764-5p	CLIP-seq
MIRT1260670	hsa-miR-570	CLIP-seq
MIRT2303389	hsa-miR-1236	CLIP-seq
MIRT2303391	hsa-miR-23a	CLIP-seq
MIRT2303392	hsa-miR-23b	CLIP-seq
MIRT2303393	hsa-miR-23c	CLIP-seq
MIRT2076698	hsa-miR-412	CLIP-seq
MIRT2457130	hsa-miR-4705	CLIP-seq
MIRT2076699	hsa-miR-4753-3p	CLIP-seq
MIRT2303400	hsa-miR-4768-5p	CLIP-seq
MIRT2303403	hsa-miR-942	CLIP-seq
MIRT1260574	hsa-miR-10a	CLIP-seq
MIRT1260575	hsa-miR-10b	CLIP-seq
MIRT1260577	hsa-miR-1205	CLIP-seq
MIRT1260579	hsa-miR-1226	CLIP-seq
MIRT1260580	hsa-miR-1228	CLIP-seq
MIRT1260581	hsa-miR-124	CLIP-seq
MIRT1260583	hsa-miR-1265	CLIP-seq
MIRT1260584	hsa-miR-1286	CLIP-seq
MIRT1260588	hsa-miR-149	CLIP-seq
MIRT1260590	hsa-miR-221	CLIP-seq
MIRT1260591	hsa-miR-222	CLIP-seq
MIRT2599985	hsa-miR-2276	CLIP-seq
MIRT1260592	hsa-miR-24	CLIP-seq
MIRT1260596	hsa-miR-2964a-3p	CLIP-seq
MIRT1260597	hsa-miR-29a	CLIP-seq
MIRT1260598	hsa-miR-29b	CLIP-seq
MIRT1260599	hsa-miR-29c	CLIP-seq
MIRT1260600	hsa-miR-302f	CLIP-seq
MIRT1260601	hsa-miR-3064-5p	CLIP-seq
MIRT1260602	hsa-miR-3065-3p	CLIP-seq
MIRT2076697	hsa-miR-3124-3p	CLIP-seq
MIRT1260609	hsa-miR-3189-3p	CLIP-seq
MIRT1260616	hsa-miR-3688-3p	CLIP-seq
MIRT1260617	hsa-miR-3689a-3p	CLIP-seq
MIRT1260618	hsa-miR-3689c	CLIP-seq
MIRT1260621	hsa-miR-3913-3p	CLIP-seq
MIRT2076698	hsa-miR-412	CLIP-seq
MIRT1260626	hsa-miR-4284	CLIP-seq
MIRT1260627	hsa-miR-4300	CLIP-seq
MIRT1260628	hsa-miR-4446-5p	CLIP-seq
MIRT2599986	hsa-miR-4476	CLIP-seq
MIRT2599987	hsa-miR-4719	CLIP-seq
MIRT1260641	hsa-miR-4722-5p	CLIP-seq
MIRT1260643	hsa-miR-4733-3p	CLIP-seq
MIRT2076699	hsa-miR-4753-3p	CLIP-seq
MIRT2076700	hsa-miR-4755-5p	CLIP-seq
MIRT1260645	hsa-miR-4764-5p	CLIP-seq
MIRT2599988	hsa-miR-4772-3p	CLIP-seq
MIRT1260650	hsa-miR-4794	CLIP-seq
MIRT1260652	hsa-miR-488	CLIP-seq
MIRT1260653	hsa-miR-489	CLIP-seq
MIRT1260654	hsa-miR-506	CLIP-seq
MIRT1260657	hsa-miR-515-5p	CLIP-seq
MIRT2599989	hsa-miR-544	CLIP-seq
MIRT1260668	hsa-miR-548an	CLIP-seq
MIRT2076701	hsa-miR-548m	CLIP-seq
MIRT2599990	hsa-miR-548p	CLIP-seq
MIRT1260669	hsa-miR-548v	CLIP-seq
MIRT1260670	hsa-miR-570	CLIP-seq
MIRT2076702	hsa-miR-670	CLIP-seq
MIRT2599991	hsa-miR-671-5p	CLIP-seq
MIRT2076703	hsa-miR-885-3p	CLIP-seq
MIRT1260677	hsa-miR-920	CLIP-seq
MIRT1260577	hsa-miR-1205	CLIP-seq
MIRT1260579	hsa-miR-1226	CLIP-seq
MIRT1260580	hsa-miR-1228	CLIP-seq
MIRT2303389	hsa-miR-1236	CLIP-seq
MIRT1260583	hsa-miR-1265	CLIP-seq
MIRT1260584	hsa-miR-1286	CLIP-seq
MIRT2688556	hsa-miR-1305	CLIP-seq
MIRT1260588	hsa-miR-149	CLIP-seq
MIRT1260590	hsa-miR-221	CLIP-seq
MIRT1260591	hsa-miR-222	CLIP-seq
MIRT2599985	hsa-miR-2276	CLIP-seq
MIRT1260592	hsa-miR-24	CLIP-seq
MIRT1260596	hsa-miR-2964a-3p	CLIP-seq
MIRT1260597	hsa-miR-29a	CLIP-seq
MIRT1260598	hsa-miR-29b	CLIP-seq
MIRT1260599	hsa-miR-29c	CLIP-seq
MIRT1260600	hsa-miR-302f	CLIP-seq
MIRT1260601	hsa-miR-3064-5p	CLIP-seq
MIRT1260602	hsa-miR-3065-3p	CLIP-seq
MIRT2076697	hsa-miR-3124-3p	CLIP-seq
MIRT1260609	hsa-miR-3189-3p	CLIP-seq
MIRT1260616	hsa-miR-3688-3p	CLIP-seq
MIRT1260617	hsa-miR-3689a-3p	CLIP-seq
MIRT1260618	hsa-miR-3689c	CLIP-seq
MIRT1260621	hsa-miR-3913-3p	CLIP-seq
MIRT2076698	hsa-miR-412	CLIP-seq
MIRT1260626	hsa-miR-4284	CLIP-seq
MIRT1260627	hsa-miR-4300	CLIP-seq
MIRT1260628	hsa-miR-4446-5p	CLIP-seq
MIRT2599986	hsa-miR-4476	CLIP-seq
MIRT2457130	hsa-miR-4705	CLIP-seq
MIRT2599987	hsa-miR-4719	CLIP-seq
MIRT1260641	hsa-miR-4722-5p	CLIP-seq
MIRT1260643	hsa-miR-4733-3p	CLIP-seq
MIRT2076699	hsa-miR-4753-3p	CLIP-seq
MIRT2076700	hsa-miR-4755-5p	CLIP-seq
MIRT1260645	hsa-miR-4764-5p	CLIP-seq
MIRT2303400	hsa-miR-4768-5p	CLIP-seq
MIRT2599988	hsa-miR-4772-3p	CLIP-seq
MIRT1260650	hsa-miR-4794	CLIP-seq
MIRT1260653	hsa-miR-489	CLIP-seq
MIRT1260657	hsa-miR-515-5p	CLIP-seq
MIRT2599989	hsa-miR-544	CLIP-seq
MIRT2076701	hsa-miR-548m	CLIP-seq
MIRT2599990	hsa-miR-548p	CLIP-seq
MIRT1260669	hsa-miR-548v	CLIP-seq
MIRT1260670	hsa-miR-570	CLIP-seq
MIRT2076702	hsa-miR-670	CLIP-seq
MIRT2599991	hsa-miR-671-5p	CLIP-seq
MIRT2076703	hsa-miR-885-3p	CLIP-seq
MIRT1260677	hsa-miR-920	CLIP-seq
MIRT2303403	hsa-miR-942	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004602	Function	Glutathione peroxidase activity	IMP	10893423
GO:0004623	Function	Phospholipase A2 activity	IDA	26830860
GO:0005515	Function	Protein binding	IPI	16186110, 19188445, 20849852, 21044950, 21911577, 23164639, 26030842, 29128334, 32296183, 32814053
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	23580065
GO:0005634	Component	Nucleus	IDA	16186110
GO:0005737	Component	Cytoplasm	IDA	16186110, 19188445, 25468996
GO:0005739	Component	Mitochondrion	IBA	21873635
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	NAS	9497358
GO:0005829	Component	Cytosol	TAS
GO:0006979	Process	Response to oxidative stress	IMP	10893423
GO:0016020	Component	Membrane	HDA	19946888
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	19725078
GO:0034599	Process	Cellular response to oxidative stress	TAS
GO:0035578	Component	Azurophil granule lumen	TAS
GO:0042744	Process	Hydrogen peroxide catabolic process	IEA
GO:0042802	Function	Identical protein binding	IMP	9587003
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0045454	Process	Cell redox homeostasis	IBA	21873635
GO:0046475	Process	Glycerophospholipid catabolic process	IMP	10893423
GO:0047184	Function	1-acylglycerophosphocholine O-acyltransferase activity	IDA	26830860
GO:0047499	Function	Calcium-independent phospholipase A2 activity	IMP	10893423
GO:0048026	Process	Positive regulation of mRNA splicing, via spliceosome	IGI	16186110
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	16186110
GO:0051920	Function	Peroxiredoxin activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0098869	Process	Cellular oxidant detoxification	IMP	10893423
GO:0102567	Function	Phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)	IEA
GO:0102568	Function	Phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)	IEA

Other IDs

• MIM: 602316
• HGNC: 16753
• e!Ensembl: ENSG00000117592

Protein

• UniProt ID: P30041
• Protein name: Peroxiredoxin-6 (EC 1.11.1.27) (1-Cys peroxiredoxin) (1-Cys PRX) (24 kDa protein) (Acidic calcium-independent phospholipase A2) (aiPLA2) (EC 3.1.1.4) (Antioxidant protein 2) (Glutathione-dependent peroxiredoxin) (Liver 2D page spot 40) (Lysophosphatidylch
• Protein function: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:10893423, PubMed:9497358). Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholip
• PDB: 1PRX, 5B6M, 5B6N
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00578	AhpC-TSA	7 → 146	AhpC/TSA family	Domain
  PF10417	1-cysPrx_C	166 → 205	C-terminal domain of 1-Cys peroxiredoxin	Domain

• Sequence:

  MPGGLLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPE
  FAKRNVKLIALSIDSVEDHLAWSKDINAYNCEEPTEKLPFPIIDDRNRELAILLGMLDPA
  EKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPVD
  WKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP

• Sequence length: 224

Pathways

KEGG:

Glutathione metabolism
Metabolic pathways

Reactome:

Detoxification of Reactive Oxygen Species
Neutrophil degranulation

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Dermatitis	Contact Dermatitis	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	25724174
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	23692979
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	19405953

Unknown
Disease name	Disease term	dbSNP ID	References
Down syndrome	Down Syndrome, Down Syndrome, Partial Trisomy 21		11771762
Liver carcinoma	Liver carcinoma		21472284
Lung neoplasms	Lung Neoplasms		23692979
Myocardial ischemia	Myocardial Ischemia		16214533
Respiratory distress syndrome	Respiratory Distress Syndrome, Adult		25070658
Trisomy 21	Trisomy 21, Meiotic Nondisjunction, Trisomy 21, Mitotic Nondisjunction		11771762