BCAR1 (BCAR1 scaffold protein, Cas family member)

Gene

• Entrez ID: 9564
• Gene name: BCAR1 scaffold protein, Cas family member
• Gene symbol: BCAR1
• Synonyms: CAS, CAS1, CASS1, CRKAS, P130Cas
• Chromosome: 16
• Chromosome location: 16q23.1
• Summary: The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded p

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT697058	hsa-miR-548aa	HITS-CLIP	23313552
MIRT697057	hsa-miR-548ap-3p	HITS-CLIP	23313552
MIRT697056	hsa-miR-548t-3p	HITS-CLIP	23313552
MIRT697055	hsa-miR-4694-3p	HITS-CLIP	23313552
MIRT697054	hsa-miR-224-3p	HITS-CLIP	23313552
MIRT697053	hsa-miR-522-3p	HITS-CLIP	23313552
MIRT697052	hsa-miR-580-5p	HITS-CLIP	23313552
MIRT697051	hsa-miR-105-5p	HITS-CLIP	23313552
MIRT697050	hsa-miR-7853-5p	HITS-CLIP	23313552
MIRT697049	hsa-miR-509-3p	HITS-CLIP	23313552
MIRT697048	hsa-miR-3148	HITS-CLIP	23313552
MIRT697047	hsa-miR-6124	HITS-CLIP	23313552
MIRT697046	hsa-miR-139-3p	HITS-CLIP	23313552
MIRT697045	hsa-miR-3978	HITS-CLIP	23313552
MIRT697058	hsa-miR-548aa	HITS-CLIP	23313552
MIRT697057	hsa-miR-548ap-3p	HITS-CLIP	23313552
MIRT697056	hsa-miR-548t-3p	HITS-CLIP	23313552
MIRT697055	hsa-miR-4694-3p	HITS-CLIP	23313552
MIRT697054	hsa-miR-224-3p	HITS-CLIP	23313552
MIRT697053	hsa-miR-522-3p	HITS-CLIP	23313552
MIRT697052	hsa-miR-580-5p	HITS-CLIP	23313552
MIRT697051	hsa-miR-105-5p	HITS-CLIP	23313552
MIRT697050	hsa-miR-7853-5p	HITS-CLIP	23313552
MIRT697049	hsa-miR-509-3p	HITS-CLIP	23313552
MIRT697048	hsa-miR-3148	HITS-CLIP	23313552
MIRT697047	hsa-miR-6124	HITS-CLIP	23313552
MIRT697046	hsa-miR-139-3p	HITS-CLIP	23313552
MIRT697045	hsa-miR-3978	HITS-CLIP	23313552
MIRT817503	hsa-miR-3649	CLIP-seq
MIRT817504	hsa-miR-4270	CLIP-seq
MIRT817505	hsa-miR-4300	CLIP-seq
MIRT817506	hsa-miR-4421	CLIP-seq
MIRT817507	hsa-miR-4441	CLIP-seq
MIRT817508	hsa-miR-4487	CLIP-seq
MIRT817509	hsa-miR-4731-5p	CLIP-seq
MIRT817510	hsa-miR-615-5p	CLIP-seq
MIRT817511	hsa-miR-920	CLIP-seq
MIRT1941695	hsa-miR-1197	CLIP-seq
MIRT1941696	hsa-miR-1291	CLIP-seq
MIRT1941697	hsa-miR-146b-3p	CLIP-seq
MIRT1941698	hsa-miR-1470	CLIP-seq
MIRT1941699	hsa-miR-193a-3p	CLIP-seq
MIRT1941700	hsa-miR-193b	CLIP-seq
MIRT1941701	hsa-miR-328	CLIP-seq
MIRT1941702	hsa-miR-329	CLIP-seq
MIRT1941703	hsa-miR-331-3p	CLIP-seq
MIRT1941704	hsa-miR-339-5p	CLIP-seq
MIRT1941705	hsa-miR-342-3p	CLIP-seq
MIRT817503	hsa-miR-3649	CLIP-seq
MIRT1941706	hsa-miR-3688-5p	CLIP-seq
MIRT1941707	hsa-miR-4299	CLIP-seq
MIRT817506	hsa-miR-4421	CLIP-seq
MIRT1941708	hsa-miR-4431	CLIP-seq
MIRT1941709	hsa-miR-4456	CLIP-seq
MIRT1941710	hsa-miR-4469	CLIP-seq
MIRT817508	hsa-miR-4487	CLIP-seq
MIRT1941711	hsa-miR-4651	CLIP-seq
MIRT1941712	hsa-miR-4667-3p	CLIP-seq
MIRT1941713	hsa-miR-4687-5p	CLIP-seq
MIRT817509	hsa-miR-4731-5p	CLIP-seq
MIRT1941714	hsa-miR-4793-3p	CLIP-seq
MIRT1941715	hsa-miR-489	CLIP-seq
MIRT1941716	hsa-miR-508-5p	CLIP-seq
MIRT1941717	hsa-miR-548q	CLIP-seq
MIRT1941718	hsa-miR-564	CLIP-seq
MIRT1941719	hsa-miR-608	CLIP-seq
MIRT817510	hsa-miR-615-5p	CLIP-seq
MIRT1941720	hsa-miR-658	CLIP-seq
MIRT1941721	hsa-miR-766	CLIP-seq
MIRT817510	hsa-miR-615-5p	CLIP-seq
MIRT1941702	hsa-miR-329	CLIP-seq
MIRT1941706	hsa-miR-3688-5p	CLIP-seq
MIRT817506	hsa-miR-4421	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
EGR1	Activation	22431919
NAB2	Activation	22431919

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001558	Process	Regulation of cell growth	TAS	11607844
GO:0001726	Component	Ruffle	IDA	9472046
GO:0005515	Function	Protein binding	IPI	9285683, 9360983, 9407132, 9418872, 9748234, 10339567, 10542110, 10587647, 10889023, 11158326, 11782456, 12799422, 14657239, 14688263, 15866871, 16105984, 16245368, 17038317, 17474147, 18164686, 18722344, 19086031, 19732724, 20534451, 21034468, 22081014, 28007913, 31413325, 31980649
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	8070403
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	21245381
GO:0005925	Component	Focal adhesion	IBA	21873635
GO:0005925	Component	Focal adhesion	IDA	21245381
GO:0005925	Component	Focal adhesion	ISS
GO:0007015	Process	Actin filament organization	IDA	16105984
GO:0007155	Process	Cell adhesion	IEA
GO:0007169	Process	Transmembrane receptor protein tyrosine kinase signaling pathway	IBA	21873635
GO:0007173	Process	Epidermal growth factor receptor signaling pathway	ISS
GO:0007186	Process	G protein-coupled receptor signaling pathway	ISS
GO:0007186	Process	G protein-coupled receptor signaling pathway	NAS	10092204
GO:0007229	Process	Integrin-mediated signaling pathway	IDA	8649368
GO:0008286	Process	Insulin receptor signaling pathway	ISS
GO:0010595	Process	Positive regulation of endothelial cell migration	IDA	21245381
GO:0015629	Component	Actin cytoskeleton	IEA
GO:0016477	Process	Cell migration	IBA	21873635
GO:0016477	Process	Cell migration	IDA	9425168
GO:0017124	Function	SH3 domain binding	IEA
GO:0019901	Function	Protein kinase binding	IPI	8070403, 8649368, 9020138, 9472046, 10026197
GO:0030027	Component	Lamellipodium	IEA
GO:0030335	Process	Positive regulation of cell migration	IDA	9472046
GO:0030424	Component	Axon	IEA
GO:0035729	Process	Cellular response to hepatocyte growth factor stimulus	IMP	21245381
GO:0042981	Process	Regulation of apoptotic process	TAS	11607844
GO:0048008	Process	Platelet-derived growth factor receptor signaling pathway	ISS
GO:0048010	Process	Vascular endothelial growth factor receptor signaling pathway	IMP	21245381
GO:0048010	Process	Vascular endothelial growth factor receptor signaling pathway	TAS
GO:0048011	Process	Neurotrophin TRK receptor signaling pathway	ISS
GO:0048012	Process	Hepatocyte growth factor receptor signaling pathway	IMP	21245381
GO:0050851	Process	Antigen receptor-mediated signaling pathway	IDA	10587647
GO:0050852	Process	T cell receptor signaling pathway	NAS	9295052
GO:0050853	Process	B cell receptor signaling pathway	IDA	9020138
GO:0051301	Process	Cell division	NAS	10675905
GO:0060326	Process	Cell chemotaxis	IMP	21245381
GO:0086100	Process	Endothelin receptor signaling pathway	IDA	19086031
GO:0090527	Process	Actin filament reorganization	IBA	21873635

Other IDs

• MIM: 602941
• HGNC: 971
• e!Ensembl: ENSG00000050820

Protein

• UniProt ID: P56945
• Protein name: Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)
• Protein function: Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (PubMed:12432078, PubMed:12832404). Implicated in induction of cell migration and cell branching (PubMed:12432078, PubMed:128324
• PDB: 1WYX, 3T6G, 5O2M, 5O2P, 5O2Q
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00018	SH3_1	9 → 57	SH3 domain	Domain
  PF08824	Serine_rich	454 → 608	Serine rich protein interaction domain	Domain
  PF12026	CAS_C	654 → 864	Crk-Associated Substrate C-terminal domain	Domain

• Sequence:

  MNHLNVLAKALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVPGNRL
  KILVGMYDKKPAGPGPGPPATPAQPQPGLHAPAPPASQYTPMLPNTYQPQPDSVYLVPTP
  SKAQQGLYQVPGPSPQFQSPPAKQTSTFSKQTPHHPFPSPATDLYQVPPGPGGPAQDIYQ
  VPPSAGMGHDIYQVPPSMDTRSWEGTKPPAKVVVPTRVGQGYVYEAAQPEQDEYDIPRHL
  LAPGPQDIYDVPPVRGLLPSQYGQEVYDTPPMAVKGPNGRDPLLEVYDVPPSVEKGLPPS
  NHHAVYDVPPSVSKDVPDGPLLREETYDVPPAFAKAKPFDPARTPLVLAAPPPDSPPAED
  VYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADGGVVDSGVYAVPPPAEREA
  PAEGKRLSASSTGSTRSSQSASSLEVAGPGREPLELEVAVEALARLQQGVSATVAHLLDL
  AGSAGATGSWRSPSEPQEPLVQDLQAAVAAVQSAVHELLEFARSAVGNAAHTSDRALHAK
  LSRQLQKMEDVHQTLVAHGQALDAGRGGSGATLEDLDRLVACSRAVPEDAKQLASFLHGN
  ASLLFRRTKATAPGPEGGGTLHPNPTDKTSSIQSRPLPSPPKFTSQDSPDGQYENSEGGW
  MEDYDYVHLQGKEEFEKTQKELLEKGSITRQGKSQLELQQLKQFERLEQEVSRPIDHDLA
  NWTPAQPLAPGRTGGLGPSDRQLLLFYLEQCEANLTTLTNAVDAFFTAVATNQPPKIFVA
  HSKFVILSAHKLVFIGDTLSRQAKAADVRSQVTHYSNLLCDLLRGIVATTKAAALQYPSP
  SAAQDMVERVKELGHSTQQFRRVLGQLAAA

• Sequence length: 870

Pathways

KEGG:

Rap1 signaling pathway
Chemokine signaling pathway
Efferocytosis
Focal adhesion
Leukocyte transendothelial migration
Regulation of actin cytoskeleton
Growth hormone synthesis, secretion and action
Bacterial invasion of epithelial cells
Shigellosis
Yersinia infection
Human cytomegalovirus infection

Reactome:

Downstream signal transduction
p130Cas linkage to MAPK signaling for integrins
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243
Pancreatic cancer	Malignant neoplasm of pancreas	rs118203998, rs180177143, rs587776417, rs587776527, rs864622498, rs876659571, rs587778587, rs886039619, rs745533713, rs1555460431, rs200612497	26098869
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29295717

Unknown
Disease name	Disease term	dbSNP ID	References
Ductal carcinoma	Ductal Carcinoma		29295717
Pancreatic neoplasm	Pancreatic Neoplasm		26098869
Pancreatic carcinoma	Pancreatic carcinoma		29422604, 25086665
Prostatic neoplasms	Prostatic Neoplasms		29295717