TP53I3 (tumor protein p53 inducible protein 3)

Gene

• Entrez ID: 9540
• Gene name: Tumor protein p53 inducible protein 3
• Gene symbol: TP53I3
• Synonyms: PIG3
• Chromosome: 2
• Chromosome location: 2p23.3
• Summary: The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell dea

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016254	hsa-miR-504-5p	qRT-PCR	20542001
MIRT029187	hsa-miR-26b-5p	Microarray	19088304
MIRT1448270	hsa-miR-1257	CLIP-seq
MIRT1448271	hsa-miR-1299	CLIP-seq
MIRT1448272	hsa-miR-3194-3p	CLIP-seq
MIRT1448273	hsa-miR-3611	CLIP-seq
MIRT1448274	hsa-miR-3925-3p	CLIP-seq
MIRT1448275	hsa-miR-3978	CLIP-seq
MIRT1448276	hsa-miR-4421	CLIP-seq
MIRT1448277	hsa-miR-4464	CLIP-seq
MIRT1448278	hsa-miR-4748	CLIP-seq
MIRT1448279	hsa-miR-4796-5p	CLIP-seq
MIRT1448280	hsa-miR-515-5p	CLIP-seq
MIRT1448281	hsa-miR-578	CLIP-seq
MIRT1448282	hsa-miR-766	CLIP-seq
MIRT1448283	hsa-miR-875-3p	CLIP-seq
MIRT1448284	hsa-miR-942	CLIP-seq
MIRT1448276	hsa-miR-4421	CLIP-seq
MIRT1448279	hsa-miR-4796-5p	CLIP-seq
MIRT1448281	hsa-miR-578	CLIP-seq
MIRT2462179	hsa-miR-516b	CLIP-seq
MIRT2462180	hsa-miR-760	CLIP-seq
MIRT2462181	hsa-miR-765	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
TP53	Activation	10101800;14695213
TP53	Unknown	12851404

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003960	Function	NADPH:quinone reductase activity	IBA	21873635
GO:0003960	Function	NADPH:quinone reductase activity	IDA	19349281
GO:0005829	Component	Cytosol	TAS
GO:0006739	Process	NADP metabolic process	IDA	19349281
GO:0042803	Function	Protein homodimerization activity	IPI	19349281
GO:0042981	Process	Regulation of apoptotic process	TAS
GO:0048038	Function	Quinone binding	IBA	21873635
GO:0048038	Function	Quinone binding	IDA	19349281
GO:0070402	Function	NADPH binding	IBA	21873635
GO:0070402	Function	NADPH binding	IDA	19349281

Other IDs

• MIM: 605171
• HGNC: 19373
• e!Ensembl: ENSG00000115129

Protein

• UniProt ID: Q53FA7
• Protein name: Quinone oxidoreductase PIG3 (EC 1.6.5.5) (NADPH:quinone reductase PIG3) (Tumor protein p53-inducible protein 3) (Protein PIG3) (p53-induced gene 3 protein)
• Protein function: Catalyzes the NADPH-dependent reduction of quinones (PubMed:19349281). Exhibits a low enzymatic activity with beta-naphthoquinones, with a strong preference for the ortho-quinone isomer (1,2-beta-naphthoquinone) over the para isomer (1,4-beta-na
• PDB: 2J8Z, 2OBY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08240	ADH_N	27 → 91	Alcohol dehydrogenase GroES-like domain	Domain
  PF00107	ADH_zinc_N	152 → 283	Zinc-binding dehydrogenase	Family

• Sequence:

  MLAVHFDKPGGPENLYVKEVAKPSPGEGEVLLKVAASALNRADLMQRQGQYDPPPGASNI
  LGLEASGHVAELGPGCQGHWKIGDTAMALLPGGGQAQYVTVPEGLLMPIPEGLTLTQAAA
  IPEAWLTAFQLLHLVGNVQAGDYVLIHAGLSGVGTAAIQLTRMAGAIPLVTAGSQKKLQM
  AEKLGAAAGFNYKKEDFSEATLKFTKGAGVNLILDCIGGSYWEKNVNCLALDGRWVLYGL
  MGGGDINGPLFSKLLFKRGSLITSLLRSRDNKYKQMLVNAFTEQILPHFSTEGPQRLLPV
  LDRIYPVTEIQEAHKYMEANKNIGKIVLELPQ

• Sequence length: 332

Pathways

KEGG:

p53 signaling pathway

Reactome:

TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243
Carcinoma	Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	21489049

Unknown
Disease name	Disease term	dbSNP ID	References
Anaplastic carcinoma	Anaplastic carcinoma		21489049