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EI24 (EI24 autophagy associated transmembrane protein)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9538
Gene nameGene Name - the full gene name approved by the HGNC.
EI24 autophagy associated transmembrane protein
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
EI24
SynonymsGene synonyms aliases
EPG4, PIG8, TP53I8
ChromosomeChromosome number
11
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q24.2
SummarySummary of gene provided in NCBI Entrez Gene.
This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT029332 hsa-miR-26b-5p Microarray 19088304
MIRT638786 hsa-miR-129-5p HITS-CLIP 23824327
MIRT638785 hsa-miR-6499-3p HITS-CLIP 23824327
MIRT638784 hsa-miR-6081 HITS-CLIP 23824327
MIRT638783 hsa-miR-455-3p HITS-CLIP 23824327
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183
GO:0005783 Component Endoplasmic reticulum IBA 21873635
GO:0005783 Component Endoplasmic reticulum IDA
GO:0005789 Component Endoplasmic reticulum membrane IEA
GO:0005794 Component Golgi apparatus IDA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID O14681
Protein name Etoposide-induced protein 2.4 homolog (p53-induced gene 8 protein)
Protein function Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07264 EI24
59 271
Family
Sequence
Sequence length 340
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
  p53 signaling pathway  
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 17013881
Unknown
Disease name Disease term dbSNP ID References
Prostatic neoplasms Prostatic Neoplasms 17013881

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