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PTGES (prostaglandin E synthase)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9536
Gene nameGene Name - the full gene name approved by the HGNC.
Prostaglandin E synthase
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
PTGES
SynonymsGene synonyms aliases
MGST-IV, MGST1-L1, MGST1L1, MPGES, PGES, PIG12, PP102, PP1294, TP53I12, mPGES-1
ChromosomeChromosome number
9
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q34.11
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor pr
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT017384 hsa-miR-335-5p Microarray 18185580
MIRT022404 hsa-miR-124-3p Microarray 18668037
MIRT046064 hsa-miR-125b-5p CLASH 23622248
MIRT608918 hsa-miR-8485 HITS-CLIP 23824327
MIRT611037 hsa-miR-2355-5p HITS-CLIP 23824327
Transcription factors
Transcription factor Regulation Reference
CREB1 Unknown 20688046
EGR1 Activation 21983014
HDAC4 Unknown 19115247
HIF1A Activation 18050215
NFKB1 Activation 17928629
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001516 Process Prostaglandin biosynthetic process IBA 21873635
GO:0001516 Process Prostaglandin biosynthetic process IDA 18682561
GO:0002526 Process Acute inflammatory response IEA
GO:0002544 Process Chronic inflammatory response IEA
GO:0004364 Function Glutathione transferase activity IDA 12672824
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID O14684
Protein name Prostaglandin E synthase (EC 5.3.99.3) (Glutathione peroxidase PTGES) (EC 1.11.1.-) (Glutathione transferase PTGES) (EC 2.5.1.18) (Microsomal glutathione S-transferase 1-like 1) (MGST1-L1) (Microsomal prostaglandin E synthase 1) (MPGES-1) (p53-induced gen
Protein function Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammator
PDB 3DWW , 4AL0 , 4AL1 , 4BPM , 4WAB , 4YK5 , 4YL0 , 4YL1 , 4YL3 , 5BQG , 5BQH , 5BQI , 5K0I , 5T36 , 5T37 , 5TL9 , 6VL4 , 8PYV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01124 MAPEG
16 146
MAPEG family
Family
Sequence
Sequence length 152
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Arachidonic acid metabolism
Metabolic pathways
  Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Associated diseases
Causal
Disease name Disease term dbSNP ID References
Asthma Asthma rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283 27611488
Unknown
Disease name Disease term dbSNP ID References
Hydronephrosis Hydronephrosis 22430074, 25015655

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