Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
9536 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Prostaglandin E synthase |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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PTGES |
SynonymsGene synonyms aliases
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MGST-IV, MGST1-L1, MGST1L1, MPGES, PGES, PIG12, PP102, PP1294, TP53I12, mPGES-1 |
ChromosomeChromosome number
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9 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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9q34.11 |
SummarySummary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor pr |
miRNAmiRNA information provided by mirtarbase database.
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Transcription factors
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
O14684 |
Protein name |
Prostaglandin E synthase (EC 5.3.99.3) (Glutathione peroxidase PTGES) (EC 1.11.1.-) (Glutathione transferase PTGES) (EC 2.5.1.18) (Microsomal glutathione S-transferase 1-like 1) (MGST1-L1) (Microsomal prostaglandin E synthase 1) (MPGES-1) (p53-induced gen |
Protein function |
Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammator |
PDB |
3DWW
,
4AL0
,
4AL1
,
4BPM
,
4WAB
,
4YK5
,
4YL0
,
4YL1
,
4YL3
,
5BQG
,
5BQH
,
5BQI
,
5K0I
,
5T36
,
5T37
,
5TL9
,
6VL4
,
8PYV
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF01124 |
MAPEG |
16 → 146 |
MAPEG family |
Family |
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Sequence |
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Sequence length |
152 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Hydronephrosis |
Hydronephrosis |
|
22430074, 25015655 |
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