CD38 (CD38 molecule)

Gene

• Entrez ID: 952
• Gene name: CD38 molecule
• Gene symbol: CD38
• Synonyms: ADPRC 1, ADPRC1, cADPR1
• Chromosome: 4
• Chromosome location: 4p15.32
• Summary: The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5`-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018938	hsa-miR-335-5p	Microarray	18185580
MIRT053006	hsa-miR-140-3p	Luciferase reporter assay, qRT-PCR	22773691
MIRT504921	hsa-miR-5692a	PAR-CLIP	21572407
MIRT504920	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT504919	hsa-miR-203a-5p	PAR-CLIP	21572407
MIRT504918	hsa-miR-1273g-5p	PAR-CLIP	21572407
MIRT504917	hsa-miR-19a-5p	PAR-CLIP	21572407
MIRT504916	hsa-miR-19b-1-5p	PAR-CLIP	21572407
MIRT504915	hsa-miR-19b-2-5p	PAR-CLIP	21572407
MIRT504913	hsa-miR-5590-5p	PAR-CLIP	21572407
MIRT504914	hsa-miR-4659a-5p	PAR-CLIP	21572407
MIRT504912	hsa-miR-4659b-5p	PAR-CLIP	21572407
MIRT504911	hsa-miR-218-1-3p	PAR-CLIP	21572407
MIRT504910	hsa-miR-4776-3p	PAR-CLIP	21572407
MIRT504909	hsa-miR-659-3p	PAR-CLIP	21572407
MIRT504921	hsa-miR-5692a	PAR-CLIP	23446348
MIRT504920	hsa-miR-3613-3p	PAR-CLIP	23446348
MIRT504919	hsa-miR-203a-5p	PAR-CLIP	23446348
MIRT504918	hsa-miR-1273g-5p	PAR-CLIP	23446348
MIRT504917	hsa-miR-19a-5p	PAR-CLIP	23446348
MIRT504916	hsa-miR-19b-1-5p	PAR-CLIP	23446348
MIRT504915	hsa-miR-19b-2-5p	PAR-CLIP	23446348
MIRT504913	hsa-miR-5590-5p	PAR-CLIP	23446348
MIRT504914	hsa-miR-4659a-5p	PAR-CLIP	23446348
MIRT504912	hsa-miR-4659b-5p	PAR-CLIP	23446348
MIRT504911	hsa-miR-218-1-3p	PAR-CLIP	23446348
MIRT504910	hsa-miR-4776-3p	PAR-CLIP	23446348
MIRT504909	hsa-miR-659-3p	PAR-CLIP	23446348
MIRT504921	hsa-miR-5692a	PAR-CLIP	23446348
MIRT504920	hsa-miR-3613-3p	PAR-CLIP	23446348
MIRT504919	hsa-miR-203a-5p	PAR-CLIP	23446348
MIRT504918	hsa-miR-1273g-5p	PAR-CLIP	23446348
MIRT504917	hsa-miR-19a-5p	PAR-CLIP	23446348
MIRT504916	hsa-miR-19b-1-5p	PAR-CLIP	23446348
MIRT504915	hsa-miR-19b-2-5p	PAR-CLIP	23446348
MIRT504913	hsa-miR-5590-5p	PAR-CLIP	23446348
MIRT504914	hsa-miR-4659a-5p	PAR-CLIP	23446348
MIRT504912	hsa-miR-4659b-5p	PAR-CLIP	23446348
MIRT504911	hsa-miR-218-1-3p	PAR-CLIP	23446348
MIRT504910	hsa-miR-4776-3p	PAR-CLIP	23446348
MIRT504909	hsa-miR-659-3p	PAR-CLIP	23446348
MIRT734721	hsa-miR-26a-5p	Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), qRT-PCR, ELISA	31907356
MIRT053006	hsa-miR-140-3p	Western blotting	33121100
MIRT736433	hsa-miR-26b-5p	Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), qRT-PCR, ELISA	31907356
MIRT504921	hsa-miR-5692a	PAR-CLIP	21572407
MIRT504920	hsa-miR-3613-3p	PAR-CLIP	21572407
MIRT504919	hsa-miR-203a-5p	PAR-CLIP	21572407
MIRT504918	hsa-miR-1273g-5p	PAR-CLIP	21572407
MIRT504917	hsa-miR-19a-5p	PAR-CLIP	21572407
MIRT504916	hsa-miR-19b-1-5p	PAR-CLIP	21572407
MIRT504915	hsa-miR-19b-2-5p	PAR-CLIP	21572407
MIRT504913	hsa-miR-5590-5p	PAR-CLIP	21572407
MIRT504914	hsa-miR-4659a-5p	PAR-CLIP	21572407
MIRT504912	hsa-miR-4659b-5p	PAR-CLIP	21572407
MIRT504911	hsa-miR-218-1-3p	PAR-CLIP	21572407
MIRT504910	hsa-miR-4776-3p	PAR-CLIP	21572407
MIRT504909	hsa-miR-659-3p	PAR-CLIP	21572407
MIRT504921	hsa-miR-5692a	PAR-CLIP	23446348
MIRT504920	hsa-miR-3613-3p	PAR-CLIP	23446348
MIRT504919	hsa-miR-203a-5p	PAR-CLIP	23446348
MIRT504918	hsa-miR-1273g-5p	PAR-CLIP	23446348
MIRT504917	hsa-miR-19a-5p	PAR-CLIP	23446348
MIRT504916	hsa-miR-19b-1-5p	PAR-CLIP	23446348
MIRT504915	hsa-miR-19b-2-5p	PAR-CLIP	23446348
MIRT504913	hsa-miR-5590-5p	PAR-CLIP	23446348
MIRT504914	hsa-miR-4659a-5p	PAR-CLIP	23446348
MIRT504912	hsa-miR-4659b-5p	PAR-CLIP	23446348
MIRT504911	hsa-miR-218-1-3p	PAR-CLIP	23446348
MIRT504910	hsa-miR-4776-3p	PAR-CLIP	23446348
MIRT504909	hsa-miR-659-3p	PAR-CLIP	23446348
MIRT504921	hsa-miR-5692a	PAR-CLIP	23446348
MIRT504920	hsa-miR-3613-3p	PAR-CLIP	23446348
MIRT504919	hsa-miR-203a-5p	PAR-CLIP	23446348
MIRT504918	hsa-miR-1273g-5p	PAR-CLIP	23446348
MIRT504917	hsa-miR-19a-5p	PAR-CLIP	23446348
MIRT504916	hsa-miR-19b-1-5p	PAR-CLIP	23446348
MIRT504915	hsa-miR-19b-2-5p	PAR-CLIP	23446348
MIRT504913	hsa-miR-5590-5p	PAR-CLIP	23446348
MIRT504914	hsa-miR-4659a-5p	PAR-CLIP	23446348
MIRT504912	hsa-miR-4659b-5p	PAR-CLIP	23446348
MIRT504911	hsa-miR-218-1-3p	PAR-CLIP	23446348
MIRT504910	hsa-miR-4776-3p	PAR-CLIP	23446348
MIRT504909	hsa-miR-659-3p	PAR-CLIP	23446348
MIRT1959493	hsa-miR-1226	CLIP-seq
MIRT1959494	hsa-miR-214	CLIP-seq
MIRT1959495	hsa-miR-3130-3p	CLIP-seq
MIRT1959496	hsa-miR-3194-3p	CLIP-seq
MIRT1959497	hsa-miR-3619-5p	CLIP-seq
MIRT1959498	hsa-miR-4530	CLIP-seq
MIRT1959499	hsa-miR-4793-3p	CLIP-seq
MIRT1959500	hsa-miR-634	CLIP-seq
MIRT1959501	hsa-miR-761	CLIP-seq
MIRT1959502	hsa-miR-767-5p	CLIP-seq
MIRT2499500	hsa-miR-3137	CLIP-seq
MIRT2499501	hsa-miR-3202	CLIP-seq
MIRT2499502	hsa-miR-4476	CLIP-seq
MIRT2499503	hsa-miR-4670-3p	CLIP-seq
MIRT2499504	hsa-miR-584	CLIP-seq
MIRT2499505	hsa-miR-591	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
MYC	Activation	11519042
NFKB1	Unknown	17322278;18341691;18441094
RELA	Unknown	17322278;18341691;18441094

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001666	Process	Response to hypoxia	IEA
GO:0003953	Function	NAD+ nucleosidase activity	IBA	21873635
GO:0003953	Function	NAD+ nucleosidase activity	TAS
GO:0005634	Component	Nucleus	IEA
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	NAS	8253715
GO:0007204	Process	Positive regulation of cytosolic calcium ion concentration	IEA
GO:0007565	Process	Female pregnancy	IEA
GO:0009986	Component	Cell surface	IEA
GO:0010977	Process	Negative regulation of neuron projection development	IEA
GO:0014824	Process	Artery smooth muscle contraction	IEA
GO:0016020	Component	Membrane	TAS	8253715
GO:0016021	Component	Integral component of membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016849	Function	Phosphorus-oxygen lyase activity	IBA	21873635
GO:0019674	Process	NAD metabolic process	TAS
GO:0030307	Process	Positive regulation of cell growth	IEA
GO:0030667	Component	Secretory granule membrane	IEA
GO:0030890	Process	Positive regulation of B cell proliferation	IBA	21873635
GO:0030890	Process	Positive regulation of B cell proliferation	IMP	17875758
GO:0032024	Process	Positive regulation of insulin secretion	IEA
GO:0032355	Process	Response to estradiol	IEA
GO:0032526	Process	Response to retinoic acid	IEA
GO:0032570	Process	Response to progesterone	IEA
GO:0033194	Process	Response to hydroperoxide	IEA
GO:0042493	Process	Response to drug	IMP	17875758
GO:0042802	Function	Identical protein binding	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IMP	17875758
GO:0045779	Process	Negative regulation of bone resorption	IEA
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IMP	17875758
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IMP	17875758
GO:0045907	Process	Positive regulation of vasoconstriction	IEA
GO:0050135	Function	NAD(P)+ nucleosidase activity	IEA
GO:0050853	Process	B cell receptor signaling pathway	IMP	17875758
GO:0060292	Process	Long-term synaptic depression	IEA
GO:0061809	Function	NAD+ nucleotidase, cyclic ADP-ribose generating	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0070555	Process	Response to interleukin-1	IEA
GO:0097190	Process	Apoptotic signaling pathway	TAS	10777496

Other IDs

• MIM: 107270
• HGNC: 1667
• e!Ensembl: ENSG00000004468

Protein

• UniProt ID: P28907
• Protein name: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (EC 3.2.2.-) (EC 3.2.2.6) (2'-phospho-ADP-ribosyl cyclase) (2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase) (EC 2.4.99.20) (2'-phospho-cyclic-ADP-ribose transferase) (ADP-ribosyl c
• Protein function: Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion (PubMed:7961800, PubMed:8253715). Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nic
• PDB: 1YH3, 1ZVM, 2EF1, 2HCT, 2I65, 2I66, 2I67, 2O3Q, 2O3R, 2O3S, 2O3T, 2O3U, 2PGJ, 2PGL, 3DZF, 3DZG, 3DZH, 3DZI, 3DZJ, 3DZK, 3F6Y, 3I9M, 3I9N, 3OFS, 3RAJ, 3ROK, 3ROM, 3ROP, 3ROQ, 3U4H, 3U4I, 4CMH, 4F45, 4F46, 4OGW, 4TMF, 4XJS, 4XJT, 5F1K, 5F1O, 5F21, 6EDR, 6VUA, 7DHA, 7DUO, 7VKE, 8BYU, 8D0M, 8IL3, 8P8C, 8VAU
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02267	Rib_hydrolayse	56 → 296	ADP-ribosyl cyclase	Domain

• Sequence:

  MANCEFSPVSGDKPCCRLSRRAQLCLGVSILVLILVVVLAVVVPRWRQQWSGPGTTKRFP
  ETVLARCVKYTEIHPEMRHVDCQSVWDAFKGAFISKHPCNITEEDYQPLMKLGTQTVPCN
  KILLWSRIKDLAHQFTQVQRDMFTLEDTLLGYLADDLTWCGEFNTSKINYQSCPDWRKDC
  SNNPVSVFWKTVSRRFAEAACDVVHVMLNGSRSKIFDKNSTFGSVEVHNLQPEKVQTLEA
  WVIHGGREDSRDLCQDPTIKELESIISKRNIQFSCKNIYRPDKFLQCVKNPEDSSCTSEI
  

• Sequence length: 300

Pathways

KEGG:

Nicotinate and nicotinamide metabolism
Metabolic pathways
Calcium signaling pathway
Hematopoietic cell lineage
Oxytocin signaling pathway
Salivary secretion
Pancreatic secretion

Reactome:

Nicotinate metabolism

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Myocardial ischemia	Myocardial Ischemia		16214533