ADAMTS4 (ADAM metallopeptidase with thrombospondin type 1 motif 4)
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Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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9507 |
Gene nameGene Name - the full gene name approved by the HGNC.
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ADAM metallopeptidase with thrombospondin type 1 motif 4 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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ADAMTS4 |
SynonymsGene synonyms aliases
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ADAMTS-2, ADAMTS-4, ADMP-1 |
ChromosomeChromosome number
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1 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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1q23.3 |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegr |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
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UniProt ID |
O75173 |
Protein name |
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4) (EC 3.4.24.82) (ADMP-1) (Aggrecanase-1) |
Protein function |
Cleaves aggrecan, a cartilage proteoglycan, at the '392-Glu-|-Ala-393' site and may be involved in its turnover (PubMed:10356395, PubMed:10827174). Also cleaves COMP (PubMed:39672391). May play an important role in the destruction of aggrecan in |
PDB |
2RJP
,
3B2Z
,
4WK7
,
4WKE
,
4WKI
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Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF01562 |
Pep_M12B_propep |
54 → 181 |
Reprolysin family propeptide |
Family |
PF01421 |
Reprolysin |
218 → 428 |
Reprolysin (M12B) family zinc metalloprotease |
Domain |
PF17771 |
ADAM_CR_2 |
439 → 507 |
ADAM cysteine-rich domain |
Domain |
PF00090 |
TSP_1 |
524 → 574 |
Thrombospondin type 1 domain |
Domain |
PF05986 |
ADAM_spacer1 |
686 → 803 |
ADAM-TS Spacer 1 |
Family |
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Sequence |
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Sequence length |
837 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Alzheimer disease |
Alzheimer`s Disease |
rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs145518263, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316 |
30617256 |
Asthma |
Asthma |
rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283 |
27182965 |
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