RPH3AL (rabphilin 3A like (without C2 domains))

Gene

• Entrez ID: 9501
• Gene name: Rabphilin 3A like (without C2 domains)
• Gene symbol: RPH3AL
• Synonyms: NOC2
• Chromosome: 17
• Chromosome location: 17p13.3
• Summary: The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative spl

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018406	hsa-miR-335-5p	Microarray	18185580
MIRT051146	hsa-miR-16-5p	CLASH	23622248
MIRT647348	hsa-miR-1288-5p	HITS-CLIP	23824327
MIRT647347	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT647346	hsa-miR-615-5p	HITS-CLIP	23824327
MIRT647345	hsa-miR-7704	HITS-CLIP	23824327
MIRT647344	hsa-miR-5100	HITS-CLIP	23824327
MIRT647343	hsa-miR-6737-5p	HITS-CLIP	23824327
MIRT647342	hsa-miR-6812-5p	HITS-CLIP	23824327
MIRT647341	hsa-miR-6819-5p	HITS-CLIP	23824327
MIRT647340	hsa-miR-3170	HITS-CLIP	23824327
MIRT647339	hsa-miR-6855-5p	HITS-CLIP	23824327
MIRT647338	hsa-miR-3942-3p	HITS-CLIP	23824327
MIRT647337	hsa-miR-5572	HITS-CLIP	23824327
MIRT647336	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT647335	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT647334	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT647333	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT647332	hsa-miR-7851-3p	HITS-CLIP	23824327
MIRT647331	hsa-miR-4798-3p	HITS-CLIP	23824327
MIRT647330	hsa-miR-3680-5p	HITS-CLIP	23824327
MIRT647329	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT647328	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT647327	hsa-miR-940	HITS-CLIP	23824327
MIRT647326	hsa-miR-3929	HITS-CLIP	23824327
MIRT647325	hsa-miR-4419b	HITS-CLIP	23824327
MIRT647324	hsa-miR-4478	HITS-CLIP	23824327
MIRT647323	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT647322	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT647321	hsa-miR-5690	HITS-CLIP	23824327
MIRT647320	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT647319	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT647318	hsa-miR-3192-5p	HITS-CLIP	23824327
MIRT647317	hsa-miR-1827	HITS-CLIP	23824327
MIRT647316	hsa-miR-3975	HITS-CLIP	23824327
MIRT647315	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT647314	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT647313	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT647312	hsa-miR-3188	HITS-CLIP	23824327
MIRT647311	hsa-miR-6804-3p	HITS-CLIP	23824327
MIRT647310	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT647309	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT647308	hsa-miR-6765-5p	HITS-CLIP	23824327
MIRT647307	hsa-miR-500a-3p	HITS-CLIP	23824327
MIRT647306	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT647305	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT647304	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT647303	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT647302	hsa-miR-3689c	HITS-CLIP	23824327
MIRT647301	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT647300	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT647299	hsa-miR-1304-5p	HITS-CLIP	23824327
MIRT489206	hsa-miR-1911-3p	PAR-CLIP	23592263
MIRT489205	hsa-miR-1226-3p	PAR-CLIP	23592263
MIRT489204	hsa-miR-4733-3p	PAR-CLIP	23592263
MIRT489202	hsa-miR-4704-3p	PAR-CLIP	23592263
MIRT489203	hsa-miR-544b	PAR-CLIP	23592263
MIRT489201	hsa-miR-6746-5p	PAR-CLIP	23592263
MIRT489200	hsa-miR-492	PAR-CLIP	23592263
MIRT489199	hsa-miR-3649	PAR-CLIP	23592263
MIRT489198	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT489197	hsa-miR-8085	PAR-CLIP	23592263
MIRT489196	hsa-miR-3144-5p	PAR-CLIP	23592263
MIRT647326	hsa-miR-3929	PAR-CLIP	27292025
MIRT647325	hsa-miR-4419b	PAR-CLIP	27292025
MIRT647324	hsa-miR-4478	PAR-CLIP	27292025
MIRT647320	hsa-miR-4768-3p	PAR-CLIP	27292025
MIRT647314	hsa-miR-485-5p	PAR-CLIP	27292025
MIRT489201	hsa-miR-6746-5p	PAR-CLIP	27292025
MIRT647313	hsa-miR-6884-5p	PAR-CLIP	27292025
MIRT647348	hsa-miR-1288-5p	HITS-CLIP	23824327
MIRT647347	hsa-miR-6793-3p	HITS-CLIP	23824327
MIRT647346	hsa-miR-615-5p	HITS-CLIP	23824327
MIRT647345	hsa-miR-7704	HITS-CLIP	23824327
MIRT647344	hsa-miR-5100	HITS-CLIP	23824327
MIRT647343	hsa-miR-6737-5p	HITS-CLIP	23824327
MIRT647342	hsa-miR-6812-5p	HITS-CLIP	23824327
MIRT647341	hsa-miR-6819-5p	HITS-CLIP	23824327
MIRT647340	hsa-miR-3170	HITS-CLIP	23824327
MIRT647339	hsa-miR-6855-5p	HITS-CLIP	23824327
MIRT647338	hsa-miR-3942-3p	HITS-CLIP	23824327
MIRT647337	hsa-miR-5572	HITS-CLIP	23824327
MIRT647336	hsa-miR-30a-3p	HITS-CLIP	23824327
MIRT647335	hsa-miR-30d-3p	HITS-CLIP	23824327
MIRT647334	hsa-miR-30e-3p	HITS-CLIP	23824327
MIRT647333	hsa-miR-34b-3p	HITS-CLIP	23824327
MIRT647332	hsa-miR-7851-3p	HITS-CLIP	23824327
MIRT647331	hsa-miR-4798-3p	HITS-CLIP	23824327
MIRT647330	hsa-miR-3680-5p	HITS-CLIP	23824327
MIRT647329	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT647328	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT647327	hsa-miR-940	HITS-CLIP	23824327
MIRT647326	hsa-miR-3929	HITS-CLIP	23824327
MIRT647325	hsa-miR-4419b	HITS-CLIP	23824327
MIRT647324	hsa-miR-4478	HITS-CLIP	23824327
MIRT647323	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT647322	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT647321	hsa-miR-5690	HITS-CLIP	23824327
MIRT647320	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT647319	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT647318	hsa-miR-3192-5p	HITS-CLIP	23824327
MIRT647317	hsa-miR-1827	HITS-CLIP	23824327
MIRT647316	hsa-miR-3975	HITS-CLIP	23824327
MIRT647315	hsa-miR-2467-5p	HITS-CLIP	23824327
MIRT647314	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT647313	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT647312	hsa-miR-3188	HITS-CLIP	23824327
MIRT647311	hsa-miR-6804-3p	HITS-CLIP	23824327
MIRT647310	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT647309	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT647308	hsa-miR-6765-5p	HITS-CLIP	23824327
MIRT647307	hsa-miR-500a-3p	HITS-CLIP	23824327
MIRT647306	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT647305	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT647304	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT647303	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT647302	hsa-miR-3689c	HITS-CLIP	23824327
MIRT647301	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT647300	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT647299	hsa-miR-1304-5p	HITS-CLIP	23824327
MIRT489206	hsa-miR-1911-3p	PAR-CLIP	23592263
MIRT489205	hsa-miR-1226-3p	PAR-CLIP	23592263
MIRT489204	hsa-miR-4733-3p	PAR-CLIP	23592263
MIRT489202	hsa-miR-4704-3p	PAR-CLIP	23592263
MIRT489203	hsa-miR-544b	PAR-CLIP	23592263
MIRT489201	hsa-miR-6746-5p	PAR-CLIP	23592263
MIRT489200	hsa-miR-492	PAR-CLIP	23592263
MIRT489199	hsa-miR-3649	PAR-CLIP	23592263
MIRT489198	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT489197	hsa-miR-8085	PAR-CLIP	23592263
MIRT489196	hsa-miR-3144-5p	PAR-CLIP	23592263
MIRT1315722	hsa-miR-1202	CLIP-seq
MIRT1315723	hsa-miR-1257	CLIP-seq
MIRT1315724	hsa-miR-1262	CLIP-seq
MIRT1315725	hsa-miR-15a	CLIP-seq
MIRT1315726	hsa-miR-15b	CLIP-seq
MIRT1315727	hsa-miR-16	CLIP-seq
MIRT1315728	hsa-miR-195	CLIP-seq
MIRT1315729	hsa-miR-3194-5p	CLIP-seq
MIRT1315730	hsa-miR-3609	CLIP-seq
MIRT1315731	hsa-miR-3972	CLIP-seq
MIRT1315732	hsa-miR-424	CLIP-seq
MIRT1315733	hsa-miR-4419a	CLIP-seq
MIRT1315734	hsa-miR-4447	CLIP-seq
MIRT1315735	hsa-miR-4472	CLIP-seq
MIRT1315736	hsa-miR-4488	CLIP-seq
MIRT1315737	hsa-miR-4510	CLIP-seq
MIRT1315738	hsa-miR-452	CLIP-seq
MIRT1315739	hsa-miR-4530	CLIP-seq
MIRT1315740	hsa-miR-4676-3p	CLIP-seq
MIRT1315741	hsa-miR-4693-5p	CLIP-seq
MIRT1315742	hsa-miR-4697-5p	CLIP-seq
MIRT1315743	hsa-miR-4701-3p	CLIP-seq
MIRT1315744	hsa-miR-4776-3p	CLIP-seq
MIRT1315745	hsa-miR-4790-3p	CLIP-seq
MIRT1315746	hsa-miR-497	CLIP-seq
MIRT1315747	hsa-miR-541	CLIP-seq
MIRT1315748	hsa-miR-548ah	CLIP-seq
MIRT1315749	hsa-miR-548t	CLIP-seq
MIRT1315750	hsa-miR-654-5p	CLIP-seq
MIRT1315751	hsa-miR-1225-3p	CLIP-seq
MIRT1315752	hsa-miR-1227	CLIP-seq
MIRT1315753	hsa-miR-1233	CLIP-seq
MIRT1315754	hsa-miR-217	CLIP-seq
MIRT1315755	hsa-miR-299-3p	CLIP-seq
MIRT1315756	hsa-miR-3064-3p	CLIP-seq
MIRT1315757	hsa-miR-3117-5p	CLIP-seq
MIRT1315758	hsa-miR-3123	CLIP-seq
MIRT1315759	hsa-miR-3153	CLIP-seq
MIRT1315760	hsa-miR-3174	CLIP-seq
MIRT1315730	hsa-miR-3609	CLIP-seq
MIRT1315761	hsa-miR-3660	CLIP-seq
MIRT1315762	hsa-miR-3689d	CLIP-seq
MIRT1315763	hsa-miR-3940-3p	CLIP-seq
MIRT1315764	hsa-miR-4252	CLIP-seq
MIRT1315738	hsa-miR-452	CLIP-seq
MIRT1315765	hsa-miR-4526	CLIP-seq
MIRT1315766	hsa-miR-4537	CLIP-seq
MIRT1315767	hsa-miR-4648	CLIP-seq
MIRT1315768	hsa-miR-4654	CLIP-seq
MIRT1315769	hsa-miR-4668-5p	CLIP-seq
MIRT1315740	hsa-miR-4676-3p	CLIP-seq
MIRT1315741	hsa-miR-4693-5p	CLIP-seq
MIRT1315770	hsa-miR-4749-3p	CLIP-seq
MIRT1315771	hsa-miR-4769-5p	CLIP-seq
MIRT1315748	hsa-miR-548ah	CLIP-seq
MIRT1315751	hsa-miR-1225-3p	CLIP-seq
MIRT1315753	hsa-miR-1233	CLIP-seq
MIRT1315762	hsa-miR-3689d	CLIP-seq
MIRT1315763	hsa-miR-3940-3p	CLIP-seq
MIRT1315766	hsa-miR-4537	CLIP-seq
MIRT2093911	hsa-miR-3936	CLIP-seq
MIRT2093912	hsa-miR-4521	CLIP-seq
MIRT1315758	hsa-miR-3123	CLIP-seq
MIRT2318412	hsa-miR-3180-5p	CLIP-seq
MIRT2318413	hsa-miR-520a-5p	CLIP-seq
MIRT2318414	hsa-miR-525-5p	CLIP-seq
MIRT1315759	hsa-miR-3153	CLIP-seq
MIRT1315760	hsa-miR-3174	CLIP-seq
MIRT1315730	hsa-miR-3609	CLIP-seq
MIRT1315738	hsa-miR-452	CLIP-seq
MIRT1315740	hsa-miR-4676-3p	CLIP-seq
MIRT1315741	hsa-miR-4693-5p	CLIP-seq
MIRT1315748	hsa-miR-548ah	CLIP-seq
MIRT2458551	hsa-miR-1228	CLIP-seq
MIRT2458552	hsa-miR-3122	CLIP-seq
MIRT2458553	hsa-miR-3672	CLIP-seq
MIRT2458554	hsa-miR-3913-5p	CLIP-seq
MIRT2458555	hsa-miR-4691-5p	CLIP-seq
MIRT2458556	hsa-miR-4728-5p	CLIP-seq
MIRT2458557	hsa-miR-4786-5p	CLIP-seq
MIRT2458558	hsa-miR-769-5p	CLIP-seq
MIRT2458551	hsa-miR-1228	CLIP-seq
MIRT2614223	hsa-miR-1236	CLIP-seq
MIRT2458552	hsa-miR-3122	CLIP-seq
MIRT2458553	hsa-miR-3672	CLIP-seq
MIRT2458554	hsa-miR-3913-5p	CLIP-seq
MIRT2458556	hsa-miR-4728-5p	CLIP-seq
MIRT2458557	hsa-miR-4786-5p	CLIP-seq
MIRT2614224	hsa-miR-4799-5p	CLIP-seq
MIRT2614225	hsa-miR-548c-3p	CLIP-seq
MIRT2458558	hsa-miR-769-5p	CLIP-seq
MIRT2458551	hsa-miR-1228	CLIP-seq
MIRT2614223	hsa-miR-1236	CLIP-seq
MIRT2458552	hsa-miR-3122	CLIP-seq
MIRT2458553	hsa-miR-3672	CLIP-seq
MIRT2458554	hsa-miR-3913-5p	CLIP-seq
MIRT2458556	hsa-miR-4728-5p	CLIP-seq
MIRT2458557	hsa-miR-4786-5p	CLIP-seq
MIRT2614224	hsa-miR-4799-5p	CLIP-seq
MIRT2614225	hsa-miR-548c-3p	CLIP-seq
MIRT2458558	hsa-miR-769-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005737	Component	Cytoplasm	TAS	9367993
GO:0006886	Process	Intracellular protein transport	IEA
GO:0006887	Process	Exocytosis	IEA
GO:0008092	Function	Cytoskeletal protein binding	TAS	9367993
GO:0017157	Process	Regulation of exocytosis	IEA
GO:0030274	Function	LIM domain binding	IEA
GO:0030658	Component	Transport vesicle membrane	IEA
GO:0030667	Component	Secretory granule membrane	IEA
GO:0042493	Process	Response to drug	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0050714	Process	Positive regulation of protein secretion	IEA

Other IDs

• MIM: 604881
• HGNC: 10296
• e!Ensembl: ENSG00000181031

Protein

• UniProt ID: Q9UNE2
• Protein name: Rab effector Noc2 (No C2 domains protein) (Rabphilin-3A-like protein)
• Protein function: Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02318	FYVE_2	45 → 159	FYVE-type zinc finger	Family

• Sequence:

  MADTIFGSGNDQWVCPNDRQLALRAKLQTGWSVHTYQTEKQRRKQHLSPAEVEAILQVIQ
  RAERLDVLEQQRIGRLVERLETMRRNVMGNGLSQCLLCGEVLGFLGSSSVFCKDCRKKVC
  TKCGIEASPGQKRPLWLCKICSEQREVWKRSGAWFYKGLPKYILPLKTPGRADDPHFRPL
  PTEPAEREPRSSETSRIYTWARGRVVSSDSDSDSDLSSSSLEDRLPSTGVRDRKGDKPWK
  ESGGSVEAPRMGFTHPPGHLSGCQSSLASGETGTGSADPPGGPRPGLTRRAPVKDTPGRA
  PAADAAPAGPSSCLG

• Sequence length: 315

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Autism	Autistic Disorder	rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634	22843504

Unknown
Disease name	Disease term	dbSNP ID	References
Intracranial hypertension	Pseudotumor Cerebri		29608535