MAGED1 (MAGE family member D1)

Gene

• Entrez ID: 9500
• Gene name: MAGE family member D1
• Gene symbol: MAGED1
• Synonyms: DLXIN-1, NRAGE
• Chromosome: X
• Chromosome location: Xp11.22
• Summary: This gene is a member of the melanoma antigen gene (MAGE) family. Most of the genes of this family encode tumor specific antigens that are not expressed in normal adult tissues except testis. Although the protein encoded by this gene shares strong homolog

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT042443	hsa-miR-424-5p	CLASH	23622248
MIRT040341	hsa-miR-615-3p	CLASH	23622248
MIRT038660	hsa-let-7g-3p	CLASH	23622248
MIRT036791	hsa-miR-760	CLASH	23622248
MIRT1125718	hsa-miR-1251	CLIP-seq
MIRT1125719	hsa-miR-1252	CLIP-seq
MIRT1125720	hsa-miR-1265	CLIP-seq
MIRT1125721	hsa-miR-1323	CLIP-seq
MIRT1125722	hsa-miR-2277-3p	CLIP-seq
MIRT1125723	hsa-miR-3154	CLIP-seq
MIRT1125724	hsa-miR-421	CLIP-seq
MIRT1125725	hsa-miR-4252	CLIP-seq
MIRT1125726	hsa-miR-4457	CLIP-seq
MIRT1125727	hsa-miR-4474-3p	CLIP-seq
MIRT1125728	hsa-miR-4704-3p	CLIP-seq
MIRT1125729	hsa-miR-4709-5p	CLIP-seq
MIRT1125730	hsa-miR-4731-3p	CLIP-seq
MIRT1125731	hsa-miR-4764-5p	CLIP-seq
MIRT1125732	hsa-miR-4777-5p	CLIP-seq
MIRT1125733	hsa-miR-4801	CLIP-seq
MIRT1125734	hsa-miR-505	CLIP-seq
MIRT1125735	hsa-miR-548o	CLIP-seq
MIRT1125718	hsa-miR-1251	CLIP-seq
MIRT1125719	hsa-miR-1252	CLIP-seq
MIRT1125736	hsa-miR-3120-3p	CLIP-seq
MIRT1125737	hsa-miR-3153	CLIP-seq
MIRT1125723	hsa-miR-3154	CLIP-seq
MIRT1125738	hsa-miR-3200-5p	CLIP-seq
MIRT1125739	hsa-miR-377	CLIP-seq
MIRT1125740	hsa-miR-3908	CLIP-seq
MIRT1125741	hsa-miR-3942-5p	CLIP-seq
MIRT1125742	hsa-miR-411	CLIP-seq
MIRT1125727	hsa-miR-4474-3p	CLIP-seq
MIRT1125743	hsa-miR-4703-5p	CLIP-seq
MIRT1125731	hsa-miR-4764-5p	CLIP-seq
MIRT1125744	hsa-miR-4766-3p	CLIP-seq
MIRT1125732	hsa-miR-4777-5p	CLIP-seq
MIRT1125745	hsa-miR-513a-3p	CLIP-seq
MIRT1125746	hsa-miR-545	CLIP-seq
MIRT1125747	hsa-miR-548u	CLIP-seq
MIRT1125748	hsa-miR-936	CLIP-seq
MIRT1125718	hsa-miR-1251	CLIP-seq
MIRT1125719	hsa-miR-1252	CLIP-seq
MIRT1125720	hsa-miR-1265	CLIP-seq
MIRT1125721	hsa-miR-1323	CLIP-seq
MIRT1125722	hsa-miR-2277-3p	CLIP-seq
MIRT2035515	hsa-miR-2467-5p	CLIP-seq
MIRT1125736	hsa-miR-3120-3p	CLIP-seq
MIRT2035516	hsa-miR-3148	CLIP-seq
MIRT1125737	hsa-miR-3153	CLIP-seq
MIRT1125723	hsa-miR-3154	CLIP-seq
MIRT2035517	hsa-miR-3157-5p	CLIP-seq
MIRT2035518	hsa-miR-3188	CLIP-seq
MIRT1125738	hsa-miR-3200-5p	CLIP-seq
MIRT2035519	hsa-miR-342-3p	CLIP-seq
MIRT1125739	hsa-miR-377	CLIP-seq
MIRT1125740	hsa-miR-3908	CLIP-seq
MIRT1125741	hsa-miR-3942-5p	CLIP-seq
MIRT2035520	hsa-miR-3975	CLIP-seq
MIRT1125742	hsa-miR-411	CLIP-seq
MIRT1125724	hsa-miR-421	CLIP-seq
MIRT1125725	hsa-miR-4252	CLIP-seq
MIRT1125726	hsa-miR-4457	CLIP-seq
MIRT1125727	hsa-miR-4474-3p	CLIP-seq
MIRT2035521	hsa-miR-450b-5p	CLIP-seq
MIRT2035522	hsa-miR-4649-3p	CLIP-seq
MIRT2035523	hsa-miR-4668-5p	CLIP-seq
MIRT1125743	hsa-miR-4703-5p	CLIP-seq
MIRT1125728	hsa-miR-4704-3p	CLIP-seq
MIRT1125729	hsa-miR-4709-5p	CLIP-seq
MIRT1125730	hsa-miR-4731-3p	CLIP-seq
MIRT2035524	hsa-miR-4762-3p	CLIP-seq
MIRT1125731	hsa-miR-4764-5p	CLIP-seq
MIRT1125744	hsa-miR-4766-3p	CLIP-seq
MIRT1125732	hsa-miR-4777-5p	CLIP-seq
MIRT1125733	hsa-miR-4801	CLIP-seq
MIRT2035525	hsa-miR-485-5p	CLIP-seq
MIRT1125734	hsa-miR-505	CLIP-seq
MIRT1125746	hsa-miR-545	CLIP-seq
MIRT1125735	hsa-miR-548o	CLIP-seq
MIRT1125747	hsa-miR-548u	CLIP-seq
MIRT1125748	hsa-miR-936	CLIP-seq
MIRT1125718	hsa-miR-1251	CLIP-seq
MIRT1125719	hsa-miR-1252	CLIP-seq
MIRT1125720	hsa-miR-1265	CLIP-seq
MIRT1125721	hsa-miR-1323	CLIP-seq
MIRT1125722	hsa-miR-2277-3p	CLIP-seq
MIRT1125736	hsa-miR-3120-3p	CLIP-seq
MIRT2035516	hsa-miR-3148	CLIP-seq
MIRT1125737	hsa-miR-3153	CLIP-seq
MIRT1125723	hsa-miR-3154	CLIP-seq
MIRT2035519	hsa-miR-342-3p	CLIP-seq
MIRT1125739	hsa-miR-377	CLIP-seq
MIRT1125740	hsa-miR-3908	CLIP-seq
MIRT1125741	hsa-miR-3942-5p	CLIP-seq
MIRT1125742	hsa-miR-411	CLIP-seq
MIRT1125724	hsa-miR-421	CLIP-seq
MIRT1125725	hsa-miR-4252	CLIP-seq
MIRT1125726	hsa-miR-4457	CLIP-seq
MIRT1125727	hsa-miR-4474-3p	CLIP-seq
MIRT2035523	hsa-miR-4668-5p	CLIP-seq
MIRT1125743	hsa-miR-4703-5p	CLIP-seq
MIRT1125728	hsa-miR-4704-3p	CLIP-seq
MIRT1125729	hsa-miR-4709-5p	CLIP-seq
MIRT1125730	hsa-miR-4731-3p	CLIP-seq
MIRT2035524	hsa-miR-4762-3p	CLIP-seq
MIRT1125731	hsa-miR-4764-5p	CLIP-seq
MIRT1125744	hsa-miR-4766-3p	CLIP-seq
MIRT1125732	hsa-miR-4777-5p	CLIP-seq
MIRT1125733	hsa-miR-4801	CLIP-seq
MIRT1125734	hsa-miR-505	CLIP-seq
MIRT1125746	hsa-miR-545	CLIP-seq
MIRT1125735	hsa-miR-548o	CLIP-seq
MIRT1125747	hsa-miR-548u	CLIP-seq
MIRT1125748	hsa-miR-936	CLIP-seq
MIRT1125721	hsa-miR-1323	CLIP-seq
MIRT1125722	hsa-miR-2277-3p	CLIP-seq
MIRT2035516	hsa-miR-3148	CLIP-seq
MIRT1125726	hsa-miR-4457	CLIP-seq
MIRT2035523	hsa-miR-4668-5p	CLIP-seq
MIRT1125730	hsa-miR-4731-3p	CLIP-seq
MIRT1125733	hsa-miR-4801	CLIP-seq
MIRT1125735	hsa-miR-548o	CLIP-seq
MIRT1125718	hsa-miR-1251	CLIP-seq
MIRT1125720	hsa-miR-1265	CLIP-seq
MIRT1125721	hsa-miR-1323	CLIP-seq
MIRT1125722	hsa-miR-2277-3p	CLIP-seq
MIRT1125736	hsa-miR-3120-3p	CLIP-seq
MIRT2035516	hsa-miR-3148	CLIP-seq
MIRT1125737	hsa-miR-3153	CLIP-seq
MIRT1125739	hsa-miR-377	CLIP-seq
MIRT1125740	hsa-miR-3908	CLIP-seq
MIRT1125741	hsa-miR-3942-5p	CLIP-seq
MIRT1125742	hsa-miR-411	CLIP-seq
MIRT1125724	hsa-miR-421	CLIP-seq
MIRT1125725	hsa-miR-4252	CLIP-seq
MIRT1125726	hsa-miR-4457	CLIP-seq
MIRT1125727	hsa-miR-4474-3p	CLIP-seq
MIRT2035523	hsa-miR-4668-5p	CLIP-seq
MIRT1125743	hsa-miR-4703-5p	CLIP-seq
MIRT1125728	hsa-miR-4704-3p	CLIP-seq
MIRT1125729	hsa-miR-4709-5p	CLIP-seq
MIRT1125730	hsa-miR-4731-3p	CLIP-seq
MIRT1125731	hsa-miR-4764-5p	CLIP-seq
MIRT1125744	hsa-miR-4766-3p	CLIP-seq
MIRT1125732	hsa-miR-4777-5p	CLIP-seq
MIRT1125733	hsa-miR-4801	CLIP-seq
MIRT1125734	hsa-miR-505	CLIP-seq
MIRT1125745	hsa-miR-513a-3p	CLIP-seq
MIRT1125746	hsa-miR-545	CLIP-seq
MIRT1125735	hsa-miR-548o	CLIP-seq
MIRT1125747	hsa-miR-548u	CLIP-seq
MIRT1125748	hsa-miR-936	CLIP-seq
MIRT1125718	hsa-miR-1251	CLIP-seq
MIRT1125719	hsa-miR-1252	CLIP-seq
MIRT1125720	hsa-miR-1265	CLIP-seq
MIRT1125721	hsa-miR-1323	CLIP-seq
MIRT1125722	hsa-miR-2277-3p	CLIP-seq
MIRT2035515	hsa-miR-2467-5p	CLIP-seq
MIRT1125736	hsa-miR-3120-3p	CLIP-seq
MIRT2035516	hsa-miR-3148	CLIP-seq
MIRT1125737	hsa-miR-3153	CLIP-seq
MIRT1125723	hsa-miR-3154	CLIP-seq
MIRT2035518	hsa-miR-3188	CLIP-seq
MIRT1125738	hsa-miR-3200-5p	CLIP-seq
MIRT1125739	hsa-miR-377	CLIP-seq
MIRT2035520	hsa-miR-3975	CLIP-seq
MIRT1125742	hsa-miR-411	CLIP-seq
MIRT1125724	hsa-miR-421	CLIP-seq
MIRT1125725	hsa-miR-4252	CLIP-seq
MIRT1125726	hsa-miR-4457	CLIP-seq
MIRT1125727	hsa-miR-4474-3p	CLIP-seq
MIRT2035522	hsa-miR-4649-3p	CLIP-seq
MIRT2035523	hsa-miR-4668-5p	CLIP-seq
MIRT1125728	hsa-miR-4704-3p	CLIP-seq
MIRT1125729	hsa-miR-4709-5p	CLIP-seq
MIRT1125730	hsa-miR-4731-3p	CLIP-seq
MIRT1125731	hsa-miR-4764-5p	CLIP-seq
MIRT1125732	hsa-miR-4777-5p	CLIP-seq
MIRT1125733	hsa-miR-4801	CLIP-seq
MIRT2035525	hsa-miR-485-5p	CLIP-seq
MIRT1125734	hsa-miR-505	CLIP-seq
MIRT1125745	hsa-miR-513a-3p	CLIP-seq
MIRT1125746	hsa-miR-545	CLIP-seq
MIRT1125735	hsa-miR-548o	CLIP-seq
MIRT1125747	hsa-miR-548u	CLIP-seq
MIRT1125748	hsa-miR-936	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISS
GO:0005515	Function	Protein binding	IPI	15930293, 16000308, 20864041, 21516116, 24722188, 25416956, 25910212, 26871637, 31515488, 32296183, 32814053
GO:0005634	Component	Nucleus	ISS
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0006355	Process	Regulation of transcription, DNA-templated	TAS	15930293
GO:0032922	Process	Circadian regulation of gene expression	ISS
GO:0032991	Component	Protein-containing complex	IDA	15930293
GO:0042802	Function	Identical protein binding	IPI	25416956, 32296183
GO:0042981	Process	Regulation of apoptotic process	TAS	15930293
GO:0050680	Process	Negative regulation of epithelial cell proliferation	IDA	15930293

Other IDs

• MIM: 300224
• HGNC: 6813
• e!Ensembl: ENSG00000179222

Protein

• UniProt ID: Q9Y5V3
• Protein name: Melanoma-associated antigen D1 (MAGE tumor antigen CCF) (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog)
• Protein function: Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubi
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01454	MAGE	478 → 645	MAGE family	Family

• Sequence:

  MAQKMDCGAGLLGFQAEASVEDSALLMQTLMEAIQISEAPPTNQATAAASPQSSQPPTAN
  EMADIQVSAAAARPKSAFKVQNATTKGPNGVYDFSQAHNAKDVPNTQPKAAFKSQNATPK
  GPNAAYDFSQAATTGELAANKSEMAFKAQNATTKVGPNATYNFSQSLNANDLANSRPKTP
  FKAWNDTTKAPTADTQTQNVNQAKMATSQADIETDPGISEPDGATAQTSADGSQAQNLES
  RTIIRGKRTRKINNLNVEENSSGDQRRAPLAAGTWRSAPVPVTTQNPPGAPPNVLWQTPL
  AWQNPSGWQNQTARQTPPARQSPPARQTPPAWQNPVAWQNPVIWPNPVIWQNPVIWPNPI
  VWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPDWQGPPDWPLPPDWPLPPDWPLPT
  DWPLPPDWIPADWPIPPDWQNLRPSPNLRPSPNSRASQNPGAAQPRDVALLQERANKLVK
  YLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYIL
  ISTPESLAGILGTTKDTPKLGLLLVILGVIFMNGNRASEAVLWEALRKMGLRPGVRHPLL
  GDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPR
  DWTAQFMEAADEALDALDAAAAEAEARAEARTRMGIGDEAVSGPWSWDDIEFELLTWDEE
  GDFGDPWSRIPFTFWARYHQNARSRFPQTFAGPIIGPGGTASANFAANFGAIGFFWVE

• Sequence length: 778

Pathways

KEGG:

Neurotrophin signaling pathway

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	18264097