SCARB1 (scavenger receptor class B member 1)

Gene

• Entrez ID: 949
• Gene name: Scavenger receptor class B member 1
• Gene symbol: SCARB1
• Synonyms: CD36L1, CLA-1, CLA1, HDLCQ6, HDLQTL6, SR-BI, SRB1
• Chromosome: 12
• Chromosome location: 12q24.31
• Summary: The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs74830677	G>A	Pathogenic	Missense variant, intron variant, non coding transcript variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT035549	hsa-miR-185-5p	Luciferase reporter assay	23459944
MIRT035549	hsa-miR-185-5p	Luciferase reporter assay	23459944
MIRT035549	hsa-miR-185-5p	Luciferase reporter assay	23459944
MIRT035550	hsa-miR-96-5p	Luciferase reporter assay	23459944
MIRT035551	hsa-miR-223-3p	Luciferase reporter assay	23459944
MIRT049705	hsa-miR-92a-3p	CLASH	23622248
MIRT043218	hsa-miR-324-5p	CLASH	23622248
MIRT040078	hsa-miR-615-3p	CLASH	23622248
MIRT037037	hsa-miR-877-3p	CLASH	23622248
MIRT646985	hsa-miR-3610	HITS-CLIP	23824327
MIRT646984	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT646983	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT646982	hsa-miR-5091	HITS-CLIP	23824327
MIRT646981	hsa-miR-5739	HITS-CLIP	23824327
MIRT646980	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT646979	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT646985	hsa-miR-3610	HITS-CLIP	23824327
MIRT646984	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT646983	hsa-miR-3121-5p	HITS-CLIP	23824327
MIRT646982	hsa-miR-5091	HITS-CLIP	23824327
MIRT646981	hsa-miR-5739	HITS-CLIP	23824327
MIRT646980	hsa-miR-106a-3p	HITS-CLIP	23824327
MIRT646979	hsa-miR-450b-5p	HITS-CLIP	23824327
MIRT035550	hsa-miR-96-5p	Microarray, qRT-PCR	35816043
MIRT1328450	hsa-miR-1227	CLIP-seq
MIRT1328451	hsa-miR-1268	CLIP-seq
MIRT1328452	hsa-miR-1268b	CLIP-seq
MIRT1328453	hsa-miR-19a	CLIP-seq
MIRT1328454	hsa-miR-19b	CLIP-seq
MIRT1328455	hsa-miR-297	CLIP-seq
MIRT1328456	hsa-miR-3665	CLIP-seq
MIRT1328457	hsa-miR-3934	CLIP-seq
MIRT1328458	hsa-miR-3944-5p	CLIP-seq
MIRT1328459	hsa-miR-4685-5p	CLIP-seq
MIRT1328460	hsa-miR-4755-3p	CLIP-seq
MIRT1328461	hsa-miR-567	CLIP-seq
MIRT1328462	hsa-miR-596	CLIP-seq
MIRT1328463	hsa-miR-657	CLIP-seq
MIRT2097484	hsa-miR-1207-5p	CLIP-seq
MIRT2097485	hsa-miR-125a-5p	CLIP-seq
MIRT2097486	hsa-miR-125b	CLIP-seq
MIRT2097487	hsa-miR-1265	CLIP-seq
MIRT2097488	hsa-miR-1910	CLIP-seq
MIRT2097489	hsa-miR-223	CLIP-seq
MIRT2097490	hsa-miR-2392	CLIP-seq
MIRT2097491	hsa-miR-24	CLIP-seq
MIRT2097492	hsa-miR-2964a-5p	CLIP-seq
MIRT2097493	hsa-miR-296-5p	CLIP-seq
MIRT2097494	hsa-miR-3200-5p	CLIP-seq
MIRT2097495	hsa-miR-339-3p	CLIP-seq
MIRT2097496	hsa-miR-3659	CLIP-seq
MIRT2097497	hsa-miR-3677-5p	CLIP-seq
MIRT2097498	hsa-miR-3682-5p	CLIP-seq
MIRT2097499	hsa-miR-3714	CLIP-seq
MIRT2097500	hsa-miR-3918	CLIP-seq
MIRT2097501	hsa-miR-4264	CLIP-seq
MIRT2097502	hsa-miR-4319	CLIP-seq
MIRT2097503	hsa-miR-4328	CLIP-seq
MIRT2097504	hsa-miR-455-3p	CLIP-seq
MIRT2097505	hsa-miR-4658	CLIP-seq
MIRT2097506	hsa-miR-4693-3p	CLIP-seq
MIRT2097507	hsa-miR-4697-3p	CLIP-seq
MIRT2097508	hsa-miR-4732-3p	CLIP-seq
MIRT2097509	hsa-miR-4743	CLIP-seq
MIRT2097510	hsa-miR-4763-3p	CLIP-seq
MIRT2097511	hsa-miR-556-3p	CLIP-seq
MIRT2097512	hsa-miR-574-5p	CLIP-seq
MIRT1328462	hsa-miR-596	CLIP-seq
MIRT2097513	hsa-miR-665	CLIP-seq
MIRT2097514	hsa-miR-670	CLIP-seq
MIRT2097515	hsa-miR-940	CLIP-seq
MIRT2321778	hsa-miR-10a	CLIP-seq
MIRT2321779	hsa-miR-10b	CLIP-seq
MIRT2321780	hsa-miR-1294	CLIP-seq
MIRT2321781	hsa-miR-3184	CLIP-seq
MIRT2097495	hsa-miR-339-3p	CLIP-seq
MIRT2321782	hsa-miR-423-5p	CLIP-seq
MIRT2321783	hsa-miR-4316	CLIP-seq
MIRT2321784	hsa-miR-4447	CLIP-seq
MIRT2321785	hsa-miR-4472	CLIP-seq
MIRT2321786	hsa-miR-4488	CLIP-seq
MIRT2321787	hsa-miR-4651	CLIP-seq
MIRT2321788	hsa-miR-4660	CLIP-seq
MIRT2321789	hsa-miR-4677-3p	CLIP-seq
MIRT2321790	hsa-miR-4680-3p	CLIP-seq
MIRT2321791	hsa-miR-4697-5p	CLIP-seq
MIRT2321792	hsa-miR-486-3p	CLIP-seq
MIRT2321793	hsa-miR-608	CLIP-seq
MIRT2097513	hsa-miR-665	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
NR1H4	Activation	20956002
SPI1	Unknown	8007948
STAT1	Unknown	17998316
STAT2	Unknown	17998316

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001530	Function	Lipopolysaccharide binding	IDA	12651854
GO:0001540	Function	Amyloid-beta binding	IEA
GO:0001618	Function	Virus receptor activity	IEA
GO:0001786	Function	Phosphatidylserine binding	ISS
GO:0001875	Function	Lipopolysaccharide immune receptor activity	IDA	12651854
GO:0001935	Process	Endothelial cell proliferation	IEA
GO:0005044	Function	Scavenger receptor activity	IBA	21873635
GO:0005044	Function	Scavenger receptor activity	TAS	11240025
GO:0005215	Function	Transporter activity	TAS	9211901
GO:0005515	Function	Protein binding	IPI	12356718, 25416956, 30024968, 32814053, 32900848
GO:0005545	Function	1-phosphatidylinositol binding	TAS	9211901
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005764	Component	Lysosome	IDA
GO:0005765	Component	Lysosomal membrane	HDA	17897319
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	9211901
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IEA
GO:0005901	Component	Caveola	IBA	21873635
GO:0005901	Component	Caveola	TAS	12651854
GO:0006702	Process	Androgen biosynthetic process	IEA
GO:0006707	Process	Cholesterol catabolic process	IEA
GO:0006898	Process	Receptor-mediated endocytosis	TAS
GO:0008035	Function	High-density lipoprotein particle binding	IEA
GO:0008289	Function	Lipid binding	IBA	21873635
GO:0009986	Component	Cell surface	ISS	21481393
GO:0010595	Process	Positive regulation of endothelial cell migration	TAS	17574123
GO:0010867	Process	Positive regulation of triglyceride biosynthetic process	ISS
GO:0010886	Process	Positive regulation of cholesterol storage	IDA	9211901
GO:0010899	Process	Regulation of phosphatidylcholine catabolic process	ISS
GO:0015914	Process	Phospholipid transport	ISS
GO:0015920	Process	Lipopolysaccharide transport	IDA	12651854
GO:0030169	Function	Low-density lipoprotein particle binding	IBA	21873635
GO:0030169	Function	Low-density lipoprotein particle binding	IDA	9211901
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0031528	Component	Microvillus membrane	IEA
GO:0031663	Process	Lipopolysaccharide-mediated signaling pathway	IEA
GO:0032497	Process	Detection of lipopolysaccharide	IDA	12651854
GO:0033344	Process	Cholesterol efflux	IBA	21873635
GO:0033344	Process	Cholesterol efflux	IMP	12202492
GO:0033344	Process	Cholesterol efflux	ISS	14718538
GO:0034185	Function	Apolipoprotein binding	IPI	10764676
GO:0034186	Function	Apolipoprotein A-I binding	IPI	10764676, 12651854
GO:0034375	Process	High-density lipoprotein particle remodeling	ISS
GO:0034381	Process	Plasma lipoprotein particle clearance	IBA	21873635
GO:0034383	Process	Low-density lipoprotein particle clearance	ISS
GO:0034384	Process	High-density lipoprotein particle clearance	IDA	9211901
GO:0034384	Process	High-density lipoprotein particle clearance	TAS
GO:0035461	Process	Vitamin transmembrane transport	IMP	11208913
GO:0042060	Process	Wound healing	TAS	17574123
GO:0042632	Process	Cholesterol homeostasis	ISS
GO:0042802	Function	Identical protein binding	IEA
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0043534	Process	Blood vessel endothelial cell migration	IEA
GO:0043654	Process	Recognition of apoptotic cell	IBA	21873635
GO:0043654	Process	Recognition of apoptotic cell	IDA	9211901
GO:0043691	Process	Reverse cholesterol transport	IEP	9211901
GO:0044406	Process	Adhesion of symbiont to host	IMP	19087225
GO:0046718	Process	Viral entry into host cell	IEA
GO:0050764	Process	Regulation of phagocytosis	IC	9211901
GO:0050892	Process	Intestinal absorption	IEA
GO:0051000	Process	Positive regulation of nitric-oxide synthase activity	IDA	11792700
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070328	Process	Triglyceride homeostasis	ISS
GO:0070506	Function	High-density lipoprotein particle receptor activity	IDA	9211901
GO:0070506	Function	High-density lipoprotein particle receptor activity	IMP	11208913
GO:0070508	Process	Cholesterol import	IBA	21873635
GO:0070508	Process	Cholesterol import	IMP	11208913, 26965621
GO:0070508	Process	Cholesterol import	ISS	14718538

Other IDs

• MIM: 601040
• HGNC: 1664
• e!Ensembl: ENSG00000073060

Protein

• UniProt ID: Q8WTV0
• Protein name: Scavenger receptor class B member 1 (SRB1) (CD36 and LIMPII analogous 1) (CLA-1) (CD36 antigen-like 1) (Collagen type I receptor, thrombospondin receptor-like 1) (SR-BI) (CD antigen CD36)
• Protein function: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579). Receptor for HDL, mediating selective uptake of cholesteryl ether
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01130	CD36	16 → 463	CD36 family	Family

• Sequence:

  MGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKNVRIDPSSLSFNMWKEIP
  IPFYLSVYFFDVMNPSEILKGEKPQVRERGPYVYREFRHKSNITFNNNDTVSFLEYRTFQ
  FQPSKSHGSESDYIVMPNILVLGAAVMMENKPMTLKLIMTLAFTTLGERAFMNRTVGEIM
  WGYKDPLVNLINKYFPGMFPFKDKFGLFAELNNSDSGLFTVFTGVQNISRIHLVDKWNGL
  SKVDFWHSDQCNMINGTSGQMWPPFMTPESSLEFYSPEACRSMKLMYKESGVFEGIPTYR
  FVAPKTLFANGSIYPPNEGFCPCLESGIQNVSTCRFSAPLFLSHPHFLNADPVLAEAVTG
  LHPNQEAHSLFLDIHPVTGIPMNCSVKLQLSLYMKSVAGIGQTGKIEPVVLPLLWFAESG
  AMEGETLHTFYTQLVLMPKVMHYAQYVLLALGCVLLLVPVICQIRSQVGAGQRAARADSH
  SLACWGKGASDRTLWPTAAWSPPPAAVLRLCRSGSGHCWGLRSTLASFACRVATTLPVLE
  GLGPSLGGGTGS

• Sequence length: 552

Pathways

KEGG:

Virion - Hepatitis viruses
Phagosome
Ovarian steroidogenesis
Aldosterone synthesis and secretion
Cortisol synthesis and secretion
Cushing syndrome
Fat digestion and absorption
Bile secretion
Vitamin digestion and absorption
Cholesterol metabolism
Hepatitis C

Reactome:

Scavenging by Class B Receptors
HDL clearance

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs145518263, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316	30805717
Carcinoma	Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma	rs121912654, rs555607708, rs786202962, rs1564055259	12376462
Coronary artery disease	Coronary Artery Disease	rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537	28714975, 23202125, 29212778
Hypercholesterolemia	Hypercholesterolemia	rs28942111, rs28942112, rs137852912, rs121908025, rs28942082, rs28942083, rs121908028, rs121908030, rs28942079, rs28942084, rs121908032, rs387906302, rs387906303, rs121908033, rs121908034, rs387906304, rs387906305, rs121908036, rs387906306, rs121908037, rs200238879, rs121908040, rs267607213, rs121908041, rs121908042, rs145787161, rs121908043, rs121908044, rs121908324, rs1557703339, rs121908325, rs1553170279, rs755104973, rs1461905374, rs781585299, rs751141, rs121918386, rs587776886, rs193922566, rs137943601, rs193922567, rs193922569, rs193922571, rs144467873, rs137853966, rs137853965, rs377271627, rs144172724, rs139043155, rs368657165, rs146200173, rs368562025, rs139624145, rs370777955, rs373646964, rs137929307, rs374045590, rs139617694, rs730880131, rs730880130, rs730882080, rs200727689, rs557344672, rs730882085, rs730882086, rs730882090, rs544453230, rs730882098, rs570942190, rs193922568, rs730882102, rs730882109, rs201102492, rs730882110, rs793888522, rs793888517, rs146651743, rs794728683, rs794728585, rs376459828, rs768563000, rs794728584, rs375009082, rs869025453, rs869025454, rs758194385, rs769446356, rs869320649, rs869320652, rs875989888, rs551747280, rs544203837, rs875989889, rs875989890, rs875989891, rs875989893, rs875989894, rs771019366, rs563390335, rs875989895, rs875989896, rs875989897, rs875989898, rs769383881, rs875989900, rs537484504, rs875989901, rs199774121, rs875989902, rs875989903, rs121908027, rs875989905, rs875989906, rs577934998, rs121908029, rs875989907, rs875989908, rs875989909, rs11547917, rs875989911, rs875989910, rs875989912, rs761954844, rs875989914, rs767767730, rs875989915, rs875989916, rs875989917, rs765696008, rs552422789, rs28942078, rs875989919, rs875989920, rs875989921, rs875989922, rs875989925, rs875989926, rs875989927, rs875989928, rs875989929, rs875989930, rs875989932, rs370245937, rs875989934, rs875989935, rs875989936, rs875989937, rs775092314, rs875989938, rs875989941, rs875989943, rs750518671, rs28942085, rs876657697, rs756039188, rs878854026, rs878854028, rs878854027, rs879254363, rs879254368, rs879254374, rs879254382, rs879254383, rs879254384, rs201016593, rs879254386, rs879254385, rs879254387, rs879254388, rs879254390, rs879254393, rs879254394, rs879254395, rs879254396, rs879254397, rs879254398, rs879254399, rs879254400, rs2228671, rs879254401, rs776421777, rs879254402, rs879254403, rs879254404, rs879254405, rs879254406, rs879254407, rs879254408, rs879254409, rs879254410, rs879254411, rs879254412, rs879254413, rs879254414, rs879254415, rs754676104, rs387906301, rs879254417, rs879254418, rs879254419, rs879254423, rs879254422, rs879254424, rs879254425, rs879254426, rs879254428, rs879254430, rs879254432, rs879254433, rs879254434, rs1555802710, rs879254435, rs879254436, rs879254437, rs879254438, rs879254439, rs758927662, rs879254440, rs879254442, rs879254443, rs879254445, rs879254447, rs879254446, rs879254448, rs879254452, rs199570811, rs879254453, rs879254455, rs777640882, rs749038326, rs372828849, rs745776977, rs879254456, rs879254457, rs139400379, rs372845091, rs879254458, rs879254459, rs879254460, rs879254461, rs764797225, rs879254464, rs879254463, rs879254465, rs112029328, rs879254466, rs879254467, rs879254470, rs879254471, rs879254472, rs879254475, rs879254476, rs879254477, rs879254478, rs879254479, rs879254480, rs879254481, rs774723292, rs879254482, rs879254485, rs879254483, rs879254484, rs879254487, rs879254488, rs879254489, rs879254490, rs879254491, rs879254492, rs879254493, rs879254494, rs879254496, rs879254497, rs879254499, rs875989899, rs879254500, rs879254501, rs879254502, rs879254503, rs879254505, rs879254504, rs879254506, rs879254507, rs879254509, rs879254510, rs879254512, rs879254514, rs879254515, rs879254516, rs755799528, rs879254517, rs879254518, rs748944640, rs879254519, rs879254520, rs879254521, rs879254522, rs879254523, rs879254524, rs879254525, rs879254526, rs879254528, rs879254530, rs879254531, rs879254532, rs879254533, rs879254534, rs879254535, rs879254536, rs766094434, rs879254537, rs879254538, rs763998635, rs879254540, rs879254542, rs879254543, rs879254545, rs879254546, rs879254547, rs879254548, rs752596535, rs879254549, rs879254550, rs879254551, rs879254552, rs879254554, rs879254555, rs879254557, rs879254556, rs879254558, rs879254560, rs879254559, rs769318035, rs879254561, rs879254562, rs879254563, rs879254565, rs879254564, rs879254566, rs879254567, rs879254568, rs879254569, rs879254570, rs879254572, rs879254571, rs879254573, rs879254574, rs879254575, rs879254577, rs879254579, rs879254580, rs879254581, rs879254582, rs879254584, rs748672083, rs879254588, rs879254591, rs879254592, rs879254593, rs879254594, rs879254595, rs879254596, rs879254597, rs879254598, rs879254599, rs879254600, rs771917370, rs879254602, rs879254605, rs879254606, rs764042910, rs879254607, rs879254608, rs879254610, rs879254609, rs879254611, rs879254612, rs879254613, rs879254614, rs879254615, rs879254616, rs879254358, rs1555803428, rs879254619, rs373822756, rs879254620, rs879254622, rs756613387, rs879254623, rs879254624, rs1555803424, rs879254627, rs879254625, rs879254626, rs879254628, rs879254629, rs879254630, rs1555803414, rs879254631, rs1555803423, rs1555803426, rs879254632, rs879254633, rs879254635, rs879254634, rs879254636, rs879254638, rs1555803427, rs879254639, rs879254640, rs879254641, rs879254642, rs746091400, rs879254644, rs121908035, rs879254645, rs879254646, rs879254647, rs879254651, rs879254652, rs1555803643, rs1555803644, rs879254653, rs879254655, rs879254656, rs879254658, rs879254659, rs879254660, rs879254662, rs879254663, rs879254664, rs879254666, rs759109699, rs879254667, rs879254668, rs879254669, rs879254670, rs879254671, rs879254672, rs879254673, rs879254674, rs879254675, rs879254677, rs879254678, rs879254681, rs879254682, rs879254683, rs773328511, rs879254684, rs879254685, rs879254686, rs879254688, rs879254689, rs879254691, rs879254692, rs730882089, rs879254693, rs140241383, rs375495026, rs879254697, rs879254696, rs879254699, rs879254700, rs879254701, rs879254702, rs879254703, rs879254704, rs879254705, rs879254706, rs879254708, rs879254710, rs879254712, rs767618089, rs879254713, rs879254714, rs879254716, rs879254717, rs757252110, rs879254718, rs879254719, rs879254720, rs879254721, rs879254723, rs879254725, rs879254727, rs879254728, rs13306512, rs879254729, rs879254734, rs112366278, rs879254735, rs879254736, rs746834464, rs879254737, rs879254738, rs879254739, rs879254740, rs879254743, rs879254744, rs879254745, rs879254746, rs879254747, rs879254748, rs879254749, rs767024374, rs879254751, rs879254752, rs879254753, rs879254754, rs879254755, rs879254757, rs755757866, rs879254758, rs777524402, rs730882096, rs879254760, rs879254761, rs879254762, rs879254763, rs879254764, rs748300548, rs879254765, rs879254767, rs879254768, rs879254769, rs13306515, rs879254770, rs879254771, rs879254773, rs879254774, rs755449669, rs879254775, rs879254777, rs879254778, rs879254781, rs879254780, rs879254782, rs879254783, rs879254784, rs879254786, rs879254788, rs879254789, rs746982741, rs879254791, rs768430352, rs113669610, rs879254792, rs879254794, rs879254796, rs879254797, rs879254799, rs1555804777, rs879254800, rs773064328, rs879254801, rs879254802, rs1555804793, rs879254804, rs879254805, rs879254807, rs879254806, rs879254811, rs879254812, rs879254814, rs879254813, rs879254815, rs879254816, rs879254817, rs879254820, rs879254819, rs879254821, rs879254823, rs879254824, rs879254826, rs879254827, rs879254828, rs879254829, rs879254830, rs879254832, rs879254833, rs879254835, rs879254837, rs879254838, rs879254839, rs879254840, rs879254841, rs879254842, rs879254844, rs879254846, rs773658037, rs869320651, rs774439908, rs879254848, rs879254849, rs879254850, rs879254851, rs879254854, rs879254855, rs879254856, rs745343524, rs879254857, rs879254858, rs779732323, rs879254859, rs879254862, rs879254863, rs879254864, rs879254865, rs879254866, rs879254867, rs879254868, rs879254869, rs879254872, rs879254873, rs879254874, rs775924858, rs879254875, rs531005522, rs879254879, rs879254880, rs879254881, rs879254882, rs879254883, rs879254884, rs879254885, rs879254886, rs879254887, rs879254888, rs879254892, rs879254893, rs201967266, rs879254896, rs879254898, rs879254899, rs879254901, rs879254902, rs879254904, rs879254907, rs879254906, rs879254913, rs879254915, rs879254916, rs879254918, rs879254919, rs751603969, rs879254921, rs879254922, rs879254923, rs755667663, rs879254924, rs730882103, rs879254927, rs879254929, rs879254930, rs879254931, rs879254932, rs879254933, rs879254935, rs879254939, rs879254941, rs755389753, rs879254945, rs879254947, rs879254948, rs879254949, rs879254950, rs879254951, rs746939188, rs879254952, rs879254955, rs879254956, rs879254957, rs879254958, rs879254959, rs769370816, rs879254962, rs879254963, rs879254964, rs879254965, rs759876319, rs879254966, rs28942081, rs879254967, rs879254970, rs879254969, rs879254971, rs28941776, rs879254973, rs879254972, rs879254975, rs879254976, rs879254977, rs879254978, rs879254979, rs879254980, rs879254981, rs879254982, rs879254985, rs879254984, rs879254986, rs879254988, rs879254989, rs746959386, rs879254990, rs879254991, rs879254994, rs879254996, rs879254998, rs879254999, rs879255000, rs138947766, rs879255001, rs879255003, rs879255004, rs879255005, rs879255006, rs879255007, rs879255009, rs879255008, rs879255011, rs879255012, rs879255013, rs879255014, rs879255015, rs879255016, rs875989931, rs879255019, rs879255020, rs879255021, rs879255022, rs879255026, rs753707206, rs879255027, rs879255028, rs879255029, rs879255031, rs879255032, rs879255033, rs879255034, rs879255035, rs879255038, rs879255037, rs879255039, rs879255041, rs879255044, rs879255046, rs879255049, rs879255050, rs879255051, rs879255052, rs747134711, rs879255053, rs879255054, rs879255055, rs875989933, rs879255057, rs879255058, rs879255059, rs879255060, rs879255061, rs879255063, rs879255065, rs879255066, rs879255069, rs879255068, rs879255070, rs754536745, rs879255073, rs879255076, rs879255077, rs879255078, rs879255079, rs879255082, rs1555807275, rs879255088, rs879255089, rs879255090, rs879255092, rs773693079, rs879255093, rs879255096, rs879255097, rs879255098, rs1555807306, rs879255101, rs879255102, rs879255104, rs752935814, rs879255106, rs150021927, rs879255107, rs879255109, rs879255108, rs879255110, rs879255112, rs770744861, rs745753810, rs879255113, rs879255114, rs879255115, rs879255116, rs879255117, rs760436036, rs879255118, rs201637900, rs121908031, rs879255120, rs879255121, rs2569548, rs879255122, rs879255123, rs879255124, rs879255126, rs879255125, rs879255127, rs751228587, rs879255128, rs879255130, rs369943481, rs879255131, rs879255132, rs879255133, rs879255134, rs112954220, rs776217028, rs879255135, rs879255136, rs879255138, rs879255139, rs879255140, rs879255141, rs879255142, rs879255144, rs879255145, rs879255146, rs879255147, rs879255153, rs879255155, rs879255156, rs879255157, rs879255158, rs879255159, rs879255160, rs879255161, rs879255163, rs879255164, rs370018159, rs879255166, rs879255167, rs879255168, rs879255169, rs879255172, rs879255174, rs763625913, rs879255175, rs879255176, rs879255177, rs879255178, rs879255181, rs879255185, rs879255186, rs879255188, rs879255187, rs767790696, rs879255193, rs879255194, rs879255196, rs879255197, rs879255198, rs879255200, rs879255202, rs879255204, rs773618064, rs879255207, rs879255209, rs879255210, rs879255212, rs879255213, rs879255215, rs879255217, rs747344293, rs879255218, rs879255219, rs879255222, rs377437226, rs879255224, rs879255227, rs879255229, rs1555803632, rs886039829, rs886039830, rs886039831, rs1057515537, rs774615547, rs1057516129, rs1057516132, rs1057516133, rs1057516135, rs777326720, rs751122998, rs1057516130, rs774069731, rs879254847, rs1057516134, rs867272973, rs1057516127, rs763147599, rs1057519647, rs1057519648, rs1057519649, rs1057519650, rs751317621, rs774016801, rs1057519652, rs1057519653, rs1057519654, rs1555803257, rs1057519655, rs879254601, rs1057519657, rs1057519662, rs879254618, rs1057519659, rs1057519660, rs1057519661, rs1057519663, rs1057519664, rs1057519665, rs1057519666, rs373869746, rs879254803, rs1057519668, rs1057519669, rs1057519670, rs1057519671, rs1057519672, rs1057519673, rs1057519674, rs879254993, rs1057519676, rs1057519679, rs1057519682, rs1057519683, rs1057519685, rs1057519687, rs1057519690, rs1060499931, rs1060499919, rs1064792905, rs1060499921, rs1060499922, rs1555805127, rs1060499923, rs1060499924, rs1060499926, rs1060499927, rs1555808044, rs1555808111, rs1060499930, rs770696696, rs1060500988, rs1060500987, rs879254637, rs1064794259, rs1555800611, rs1131692189, rs1555802312, rs1131692191, rs1131692192, rs1555803259, rs1131692193, rs1131692194, rs121908039, rs1131692195, rs1131692197, rs1131692198, rs148698650, rs1131692201, rs1131692202, rs879254715, rs370471092, rs1131692203, rs1131692204, rs1131692205, rs1131692206, rs1131692207, rs1131692208, rs1131692209, rs1131692210, rs1131692211, rs1131692214, rs1131692215, rs1131692217, rs1555806546, rs1131692219, rs879255095, rs1131692220, rs1131692221, rs200793488, rs1131692223, rs1131692224, rs1131692225, rs1131692226, rs1135402767, rs1555805507, rs1553137543, rs1382988295, rs1555802270, rs934496989, rs1555806455, rs1555807335, rs1555803481, rs1555804717, rs1372204035, rs1553135930, rs1057519691, rs1254346075, rs1553137693, rs1553137699, rs886046435, rs1553382295, rs1553382319, rs1553382325, rs1442815965, rs747606537, rs5742904, rs1553385404, rs1553385715, rs1555800620, rs1555800631, rs1555800632, rs1555800648, rs1555800724, rs1555802242, rs1555802245, rs1555802258, rs1555802287, rs200660051, rs1398808477, rs1555802822, rs752191968, rs1555803191, rs1555803213, rs879254529, rs754933794, rs1555803327, rs1555803337, rs1555803354, rs1013147010, rs1555803383, rs1555803391, rs753319170, rs1555803409, rs1555803432, rs1555803449, rs1555803641, rs1555803701, rs1555803837, rs1555803841, rs1555803879, rs1555803891, rs1555804443, rs1555804700, rs730882099, rs1225797407, rs879254871, rs1555805337, rs1555805348, rs1555805360, rs1555805380, rs1555805490, rs1555805530, rs1555805531, rs1555805985, rs1555806110, rs1555806448, rs1555806467, rs1555806582, rs778408161, rs1555807261, rs1555807390, rs1555807388, rs1555807421, rs1555807465, rs1555807475, rs1555808008, rs1555808107, rs1555808114, rs1555808118, rs1555808120, rs1555808139, rs875989942, rs1555809471, rs1555809490, rs1555809520, rs1555800701, rs762417023, rs1555802259, rs1555802291, rs1555803186, rs1555803254, rs1555803280, rs879254541, rs1555803455, rs1555803439, rs1555803471, rs1555803912, rs1555804467, rs1555804545, rs1555805947, rs879254992, rs1555807356, rs1555808143, rs1555805930, rs1201229554, rs1555806529, rs779921498, rs1555807206, rs753151497, rs1208216597, rs1555803908, rs1323416354, rs1555805409, rs1555805413, rs774467219, rs1555806088, rs1568600415, rs777903106, rs1568606711, rs1568610747, rs1568600459, rs1568592055, rs1568582652, rs1568591929, rs1568594903, rs1568600328, rs1600743301, rs750383461, rs1600683731, rs1600704961, rs1600715039, rs1600720921, rs1555804729, rs1600727337, rs1600727715, rs1600732894, rs1600726930, rs1600742966, rs1600762098, rs1600765031, rs1600715089, rs879255149, rs1600715567, rs1600732566, rs1257344396, rs1572802096, rs763778803, rs2044384127, rs2077272442, rs2077276411, rs2077276612, rs2077282480, rs2077297994, rs879254707, rs2077361078, rs2077408020, rs2077409930, rs2077412367, rs2077417709, rs2077419273, rs2077459772, rs2077475503, rs2077534881, rs762148512, rs140807148, rs2077460968, rs2077315885, rs2077271255
Papillary renal carcinoma	Papillary Renal Cell Carcinoma	rs5030823, rs2137087134, rs121913668, rs121913669, rs121913670, rs121913671, rs121913673, rs121913243, rs786202724	21131975
Renal carcinoma	Renal Cell Carcinoma, Conventional (Clear Cell) Renal Cell Carcinoma, Sarcomatoid Renal Cell Carcinoma, Collecting Duct Carcinoma of the Kidney	rs121913668, rs121913670, rs121913243, rs786202724	28598434, 21131975, 21131975

Unknown
Disease name	Disease term	dbSNP ID	References
Anaplastic carcinoma	Anaplastic carcinoma		12376462
Chromophobe carcinoma	Chromophobe Renal Cell Carcinoma	rs137853247	21131975
Coronary heart disease	Coronary heart disease	rs9289231, rs281864746	28753643
Coronary syndrome	Acute Coronary Syndrome	rs4986893	28753643
Follicular cyst	Follicular cyst		20404351
Kidney failure	Kidney Failure, Chronic		19878707
Lupus erythematosus	Lupus Erythematosus, Systemic		26980576
Lupus nephritis	Lupus Nephritis		26980576
Non-alcoholic fatty liver disease	Non-alcoholic Fatty Liver Disease, Nonalcoholic Steatohepatitis		23127599