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SLC25A27 (solute carrier family 25 member 27)
Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9481
Gene nameGene Name - the full gene name approved by the HGNC.
Solute carrier family 25 member 27
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
SLC25A27
SynonymsGene synonyms aliases
UCP4
ChromosomeChromosome number
6
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p12.3
SummarySummary of gene provided in NCBI Entrez Gene.
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proto
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT509160 hsa-miR-369-3p HITS-CLIP 21572407
MIRT509159 hsa-miR-5692b HITS-CLIP 21572407
MIRT509158 hsa-miR-5692c HITS-CLIP 21572407
MIRT509157 hsa-miR-410-3p HITS-CLIP 21572407
MIRT509156 hsa-miR-5011-5p HITS-CLIP 21572407
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Transcription factor Regulation Reference
NFKB1 Activation 20385226
RELA Activation 20385226
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0005739 Component Mitochondrion IDA 10025957
GO:0005743 Component Mitochondrial inner membrane TAS
GO:0008284 Process Positive regulation of cell population proliferation IEA
GO:0009409 Process Response to cold IBA 21873635
GO:0010917 Process Negative regulation of mitochondrial membrane potential IEA
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID O95847
Protein name Mitochondrial uncoupling protein 4 (UCP 4) (Solute carrier family 25 member 27)
Protein function Facilitates proton transport across the inner mitochondrial membrane and may dissipate excessive proton gradient associated with oxidative and metabolic stress at neuronal synapses. Regulates glutamate-induced proton conductance in astrocytes, s
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00153 Mito_carr
16 → 120
Mitochondrial carrier protein
 Family
PF00153 Mito_carr
123 → 222
Mitochondrial carrier protein
 Family
PF00153 Mito_carr
225 → 320
Mitochondrial carrier protein
 Family
Sequence
Sequence length 323
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
 
Reactome
    The fatty acid cycling model
The proton buffering model
Associated diseases
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Causal
Disease name Disease term dbSNP ID References
Schizophrenia Schizophrenia rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 21332312, 17066476
Unknown
Disease name Disease term dbSNP ID References
Autoimmune thyroiditis Autoimmune thyroiditis 25429627
Graves disease Graves Disease 25429627
Hashimoto disease Hashimoto Disease 25429627

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