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FHL5 (four and a half LIM domains 5)
Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
9457
Gene nameGene Name - the full gene name approved by the HGNC.
Four and a half LIM domains 5
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
FHL5
SynonymsGene synonyms aliases
1700027G07Rik, ACT, FHL-5, dJ393D12.2
ChromosomeChromosome number
6
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q16.1
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene. Polymorphisms in this gene may be associated with susceptibility for migraine headaches. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Apr 2016]
miRNAmiRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
miRTarBase ID miRNA Experiments Reference
MIRT029004 hsa-miR-26b-5p Microarray 19088304
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Transcription factor Regulation Reference
CREM Unknown 16687568
NFIC Activation 16565071
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
GO ID Ontology Definition Evidence Reference
GO:0003712 Function Transcription coregulator activity IBA 21873635
GO:0003713 Function Transcription coactivator activity IBA 21873635
GO:0005515 Function Protein binding IPI 16189514, 21516116, 23088713, 25910212, 26871637, 28514442, 31515488, 32296183, 32814053
GO:0005634 Component Nucleus IBA 21873635
GO:0030018 Component Z disc IBA 21873635
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
MIM
HGNC
e!Ensembl
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
UniProt ID Q5TD97
Protein name Four and a half LIM domains protein 5 (FHL-5) (Activator of cAMP-responsive element modulator in testis) (Activator of CREM in testis)
Protein function May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.
PDB 1X68
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00412 LIM
41 → 98
LIM domain
 Domain
PF00412 LIM
102 → 159
LIM domain
 Domain
PF00412 LIM
163 → 218
LIM domain
 Domain
PF00412 LIM
222 → 279
LIM domain
 Domain
Sequence
Sequence length 284
Interactions View interactions
Associated diseases
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Causal
Disease name Disease term dbSNP ID References
Coronary artery disease Coronary Artery Disease rs137852988, rs121918313, rs-1, rs121918529, rs121918531, rs137852340, rs405509, rs1555800701, rs1215189537 29212778
Migraine Cervical Migraine Syndrome, Migraine Disorders rs794727411 23793025, 27182965, 27322543
Unknown
Disease name Disease term dbSNP ID References
Abdominal migraine Abdominal Migraine 23793025
Common migraine Common Migraine 27322543
Confusional migraine Acute Confusional Migraine 23793025
Hemicrania migraine Hemicrania migraine 23793025

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