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MED7 (mediator complex subunit 7)

Gene

9443

Mediator complex subunit 7

MED7

ARC34, CRSP33, CRSP9

5q33.3

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. T

Show/Hide all(240)

miRTarBase ID	miRNA	Experiments	Reference
MIRT724206	hsa-miR-320e	HITS-CLIP	19536157
MIRT724205	hsa-miR-4318	HITS-CLIP	19536157
MIRT724204	hsa-miR-5693	HITS-CLIP	19536157
MIRT724203	hsa-miR-6499-3p	HITS-CLIP	19536157
MIRT724202	hsa-miR-6076	HITS-CLIP	19536157
MIRT724201	hsa-miR-6797-3p	HITS-CLIP	19536157
MIRT724200	hsa-miR-3135b	HITS-CLIP	19536157
MIRT724199	hsa-miR-504-3p	HITS-CLIP	19536157
MIRT724198	hsa-miR-122-5p	HITS-CLIP	19536157
MIRT724197	hsa-miR-3622b-5p	HITS-CLIP	19536157
MIRT724196	hsa-miR-143-5p	HITS-CLIP	19536157
MIRT724195	hsa-miR-943	HITS-CLIP	19536157
MIRT724194	hsa-miR-4474-3p	HITS-CLIP	19536157
MIRT724193	hsa-miR-5698	HITS-CLIP	19536157
MIRT711374	hsa-miR-25-3p	HITS-CLIP	19536157
MIRT711373	hsa-miR-32-5p	HITS-CLIP	19536157
MIRT711372	hsa-miR-363-3p	HITS-CLIP	19536157
MIRT711371	hsa-miR-367-3p	HITS-CLIP	19536157
MIRT711370	hsa-miR-92a-3p	HITS-CLIP	19536157
MIRT711369	hsa-miR-92b-3p	HITS-CLIP	19536157
MIRT711368	hsa-miR-1279	HITS-CLIP	19536157
MIRT711367	hsa-miR-5193	HITS-CLIP	19536157
MIRT711366	hsa-miR-6511a-3p	HITS-CLIP	19536157
MIRT711365	hsa-miR-6511b-3p	HITS-CLIP	19536157
MIRT711364	hsa-miR-4469	HITS-CLIP	19536157
MIRT711363	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT711374	hsa-miR-25-3p	HITS-CLIP	19536157
MIRT711373	hsa-miR-32-5p	HITS-CLIP	19536157
MIRT711372	hsa-miR-363-3p	HITS-CLIP	19536157
MIRT711371	hsa-miR-367-3p	HITS-CLIP	19536157
MIRT711370	hsa-miR-92a-3p	HITS-CLIP	19536157
MIRT711369	hsa-miR-92b-3p	HITS-CLIP	19536157
MIRT711368	hsa-miR-1279	HITS-CLIP	19536157
MIRT711367	hsa-miR-5193	HITS-CLIP	19536157
MIRT711366	hsa-miR-6511a-3p	HITS-CLIP	19536157
MIRT711365	hsa-miR-6511b-3p	HITS-CLIP	19536157
MIRT711364	hsa-miR-4469	HITS-CLIP	19536157
MIRT711363	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT626581	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT626580	hsa-miR-3189-3p	HITS-CLIP	23824327
MIRT626579	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT626578	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT626577	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT626576	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT626575	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT626574	hsa-miR-4284	HITS-CLIP	23824327
MIRT626573	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT626572	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT626571	hsa-miR-3940-5p	HITS-CLIP	23824327
MIRT626570	hsa-miR-4507	HITS-CLIP	23824327
MIRT626569	hsa-miR-6839-3p	HITS-CLIP	23824327
MIRT626580	hsa-miR-3189-3p	HITS-CLIP	23824327
MIRT626575	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT626573	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT626572	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT626571	hsa-miR-3940-5p	HITS-CLIP	23824327
MIRT626570	hsa-miR-4507	HITS-CLIP	23824327
MIRT626569	hsa-miR-6839-3p	HITS-CLIP	23824327
MIRT626581	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT626580	hsa-miR-3189-3p	HITS-CLIP	23824327
MIRT626579	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT626578	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT626577	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT626576	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT626575	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT626574	hsa-miR-4284	HITS-CLIP	23824327
MIRT626573	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT626572	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT626571	hsa-miR-3940-5p	HITS-CLIP	23824327
MIRT626570	hsa-miR-4507	HITS-CLIP	23824327
MIRT626569	hsa-miR-6839-3p	HITS-CLIP	23824327
MIRT724206	hsa-miR-320e	HITS-CLIP	19536157
MIRT724205	hsa-miR-4318	HITS-CLIP	19536157
MIRT724204	hsa-miR-5693	HITS-CLIP	19536157
MIRT724203	hsa-miR-6499-3p	HITS-CLIP	19536157
MIRT724202	hsa-miR-6076	HITS-CLIP	19536157
MIRT724201	hsa-miR-6797-3p	HITS-CLIP	19536157
MIRT724200	hsa-miR-3135b	HITS-CLIP	19536157
MIRT724199	hsa-miR-504-3p	HITS-CLIP	19536157
MIRT724198	hsa-miR-122-5p	HITS-CLIP	19536157
MIRT724197	hsa-miR-3622b-5p	HITS-CLIP	19536157
MIRT724196	hsa-miR-143-5p	HITS-CLIP	19536157
MIRT724195	hsa-miR-943	HITS-CLIP	19536157
MIRT724194	hsa-miR-4474-3p	HITS-CLIP	19536157
MIRT724193	hsa-miR-5698	HITS-CLIP	19536157
MIRT711374	hsa-miR-25-3p	HITS-CLIP	19536157
MIRT711373	hsa-miR-32-5p	HITS-CLIP	19536157
MIRT711372	hsa-miR-363-3p	HITS-CLIP	19536157
MIRT711371	hsa-miR-367-3p	HITS-CLIP	19536157
MIRT711370	hsa-miR-92a-3p	HITS-CLIP	19536157
MIRT711369	hsa-miR-92b-3p	HITS-CLIP	19536157
MIRT711368	hsa-miR-1279	HITS-CLIP	19536157
MIRT711367	hsa-miR-5193	HITS-CLIP	19536157
MIRT711366	hsa-miR-6511a-3p	HITS-CLIP	19536157
MIRT711365	hsa-miR-6511b-3p	HITS-CLIP	19536157
MIRT711364	hsa-miR-4469	HITS-CLIP	19536157
MIRT711363	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT711374	hsa-miR-25-3p	HITS-CLIP	19536157
MIRT711373	hsa-miR-32-5p	HITS-CLIP	19536157
MIRT711372	hsa-miR-363-3p	HITS-CLIP	19536157
MIRT711371	hsa-miR-367-3p	HITS-CLIP	19536157
MIRT711370	hsa-miR-92a-3p	HITS-CLIP	19536157
MIRT711369	hsa-miR-92b-3p	HITS-CLIP	19536157
MIRT711368	hsa-miR-1279	HITS-CLIP	19536157
MIRT711367	hsa-miR-5193	HITS-CLIP	19536157
MIRT711366	hsa-miR-6511a-3p	HITS-CLIP	19536157
MIRT711365	hsa-miR-6511b-3p	HITS-CLIP	19536157
MIRT711364	hsa-miR-4469	HITS-CLIP	19536157
MIRT711363	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT626581	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT626580	hsa-miR-3189-3p	HITS-CLIP	23824327
MIRT626579	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT626578	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT626577	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT626576	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT626575	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT626574	hsa-miR-4284	HITS-CLIP	23824327
MIRT626573	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT626572	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT626571	hsa-miR-3940-5p	HITS-CLIP	23824327
MIRT626570	hsa-miR-4507	HITS-CLIP	23824327
MIRT626569	hsa-miR-6839-3p	HITS-CLIP	23824327
MIRT626580	hsa-miR-3189-3p	HITS-CLIP	23824327
MIRT626575	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT626573	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT626572	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT626571	hsa-miR-3940-5p	HITS-CLIP	23824327
MIRT626570	hsa-miR-4507	HITS-CLIP	23824327
MIRT626569	hsa-miR-6839-3p	HITS-CLIP	23824327
MIRT626581	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT626580	hsa-miR-3189-3p	HITS-CLIP	23824327
MIRT626579	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT626578	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT626577	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT626576	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT626575	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT626574	hsa-miR-4284	HITS-CLIP	23824327
MIRT626573	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT626572	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT626571	hsa-miR-3940-5p	HITS-CLIP	23824327
MIRT626570	hsa-miR-4507	HITS-CLIP	23824327
MIRT626569	hsa-miR-6839-3p	HITS-CLIP	23824327
MIRT1141863	hsa-miR-106a	CLIP-seq
MIRT1141864	hsa-miR-106b	CLIP-seq
MIRT1141865	hsa-miR-1289	CLIP-seq
MIRT1141866	hsa-miR-130a	CLIP-seq
MIRT1141867	hsa-miR-130b	CLIP-seq
MIRT1141868	hsa-miR-141	CLIP-seq
MIRT1141869	hsa-miR-17	CLIP-seq
MIRT1141870	hsa-miR-1909	CLIP-seq
MIRT1141871	hsa-miR-200a	CLIP-seq
MIRT1141872	hsa-miR-20a	CLIP-seq
MIRT1141873	hsa-miR-20b	CLIP-seq
MIRT1141874	hsa-miR-301a	CLIP-seq
MIRT1141875	hsa-miR-301b	CLIP-seq
MIRT1141876	hsa-miR-3140-3p	CLIP-seq
MIRT1141877	hsa-miR-3198	CLIP-seq
MIRT1141878	hsa-miR-320a	CLIP-seq
MIRT1141879	hsa-miR-320b	CLIP-seq
MIRT1141880	hsa-miR-320c	CLIP-seq
MIRT1141881	hsa-miR-320d	CLIP-seq
MIRT1141882	hsa-miR-3591-5p	CLIP-seq
MIRT1141883	hsa-miR-3606	CLIP-seq
MIRT1141884	hsa-miR-3609	CLIP-seq
MIRT1141885	hsa-miR-3666	CLIP-seq
MIRT1141886	hsa-miR-4294	CLIP-seq
MIRT1141887	hsa-miR-4295	CLIP-seq
MIRT1141888	hsa-miR-4309	CLIP-seq
MIRT1141889	hsa-miR-4429	CLIP-seq
MIRT1141890	hsa-miR-4473	CLIP-seq
MIRT1141891	hsa-miR-454	CLIP-seq
MIRT1141892	hsa-miR-4659a-3p	CLIP-seq
MIRT1141893	hsa-miR-4659b-3p	CLIP-seq
MIRT1141894	hsa-miR-4671-3p	CLIP-seq
MIRT1141895	hsa-miR-4738-3p	CLIP-seq
MIRT1141896	hsa-miR-4778-3p	CLIP-seq
MIRT1141897	hsa-miR-4796-3p	CLIP-seq
MIRT1141898	hsa-miR-4796-5p	CLIP-seq
MIRT1141899	hsa-miR-519d	CLIP-seq
MIRT1141900	hsa-miR-548ah	CLIP-seq
MIRT1141901	hsa-miR-579	CLIP-seq
MIRT1141902	hsa-miR-646	CLIP-seq
MIRT1141903	hsa-miR-921	CLIP-seq
MIRT1141904	hsa-miR-93	CLIP-seq
MIRT1141905	hsa-miR-1	CLIP-seq
MIRT1141906	hsa-miR-206	CLIP-seq
MIRT1141907	hsa-miR-613	CLIP-seq
MIRT1141902	hsa-miR-646	CLIP-seq
MIRT2270112	hsa-miR-4789-5p	CLIP-seq
MIRT1141901	hsa-miR-579	CLIP-seq
MIRT1141863	hsa-miR-106a	CLIP-seq
MIRT1141864	hsa-miR-106b	CLIP-seq
MIRT2569156	hsa-miR-1272	CLIP-seq
MIRT1141866	hsa-miR-130a	CLIP-seq
MIRT1141867	hsa-miR-130b	CLIP-seq
MIRT2569157	hsa-miR-1322	CLIP-seq
MIRT1141869	hsa-miR-17	CLIP-seq
MIRT2569158	hsa-miR-208a	CLIP-seq
MIRT2569159	hsa-miR-208b	CLIP-seq
MIRT1141872	hsa-miR-20a	CLIP-seq
MIRT1141873	hsa-miR-20b	CLIP-seq
MIRT1141874	hsa-miR-301a	CLIP-seq
MIRT1141875	hsa-miR-301b	CLIP-seq
MIRT2569160	hsa-miR-3129-3p	CLIP-seq
MIRT1141876	hsa-miR-3140-3p	CLIP-seq
MIRT1141884	hsa-miR-3609	CLIP-seq
MIRT2569161	hsa-miR-3646	CLIP-seq
MIRT2569162	hsa-miR-3662	CLIP-seq
MIRT1141885	hsa-miR-3666	CLIP-seq
MIRT2569163	hsa-miR-3913-3p	CLIP-seq
MIRT2569164	hsa-miR-425	CLIP-seq
MIRT1141887	hsa-miR-4295	CLIP-seq
MIRT2569165	hsa-miR-4432	CLIP-seq
MIRT1141890	hsa-miR-4473	CLIP-seq
MIRT1141891	hsa-miR-454	CLIP-seq
MIRT1141892	hsa-miR-4659a-3p	CLIP-seq
MIRT1141893	hsa-miR-4659b-3p	CLIP-seq
MIRT1141894	hsa-miR-4671-3p	CLIP-seq
MIRT1141895	hsa-miR-4738-3p	CLIP-seq
MIRT2569166	hsa-miR-4753-3p	CLIP-seq
MIRT1141896	hsa-miR-4778-3p	CLIP-seq
MIRT1141897	hsa-miR-4796-3p	CLIP-seq
MIRT2569167	hsa-miR-489	CLIP-seq
MIRT2569168	hsa-miR-499-5p	CLIP-seq
MIRT1141899	hsa-miR-519d	CLIP-seq
MIRT1141900	hsa-miR-548ah	CLIP-seq
MIRT1141904	hsa-miR-93	CLIP-seq
MIRT2569169	hsa-miR-942	CLIP-seq
MIRT2569156	hsa-miR-1272	CLIP-seq
MIRT2569157	hsa-miR-1322	CLIP-seq
MIRT2569158	hsa-miR-208a	CLIP-seq
MIRT2569159	hsa-miR-208b	CLIP-seq
MIRT2569160	hsa-miR-3129-3p	CLIP-seq
MIRT2569161	hsa-miR-3646	CLIP-seq
MIRT2569162	hsa-miR-3662	CLIP-seq
MIRT2569165	hsa-miR-4432	CLIP-seq
MIRT1141895	hsa-miR-4738-3p	CLIP-seq
MIRT2569166	hsa-miR-4753-3p	CLIP-seq
MIRT2569168	hsa-miR-499-5p	CLIP-seq
MIRT2569169	hsa-miR-942	CLIP-seq

Show/Hide all(14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000151	Component	Ubiquitin ligase complex	IEA
GO:0003713	Function	Transcription coactivator activity	TAS	9989412
GO:0005515	Function	Protein binding	IPI	14576168, 15175163, 16189514, 18391015, 21729782, 22458338, 24882805, 24981860, 26871637, 28514442, 32296183
GO:0005654	Component	Nucleoplasm	TAS
GO:0005667	Component	Transcription regulator complex	IDA	9989412
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA	21873635
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IDA	9989412
GO:0006367	Process	Transcription initiation from RNA polymerase II promoter	TAS
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016592	Component	Mediator complex	IBA	21873635
GO:0016604	Component	Nuclear body	IDA
GO:0019827	Process	Stem cell population maintenance	IEA
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA

MIM	HGNC	e!Ensembl
605045	2378	ENSG00000155868

Protein

UniProt ID

O43513

Protein name

Mediator of RNA polymerase II transcription subunit 7 (hMED7) (Activator-recruited cofactor 34 kDa component) (ARC34) (Cofactor required for Sp1 transcriptional activation subunit 9) (CRSP complex subunit 9) (Mediator complex subunit 7) (RNA polymerase tr

Protein function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RN

PDB

7EMF , 7ENA , 7ENC , 7ENJ , 7LBM , 7NVR , 8GXQ , 8GXS , 8T9D , 8TQW , 8TRH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05983	Med7	7 → 164	MED7 protein	Family

Sequence

MGEPQQVSALPPPPMQYIKEYTDENIQEGLAPKPPPPIKDSYMMFGNQFQCDDLIIRPLE
SQGIERLHPMQFDHKKELRKLNMSILINFLDLLDILIRSPGSIKREEKLEDLKLLFVHVH
HLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERVIEMIQNCLASLPDDLPHSEA
GMRVKTEPMDADDSNNCTGQNEHQRENSGHRRDQIIEKDAALCVLIDEMNERP

Sequence length

233

Interactions

View interactions

	Reactome
			PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Hypothyroidism	Hypothyroidism	rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912, rs121917847, rs104893655, rs104893657, rs104893658, rs104893659, rs104893660, rs104893656, rs121917719, rs786204790, rs189261858, rs879255608, rs868197660, rs879255609, rs1586744173, rs1586182837, rs771222349, rs1587618417, rs1601844140, rs760832986, rs780982673, rs1603336347, rs1691155605	30595370

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