TNFRSF8 (TNF receptor superfamily member 8)

Gene

• Entrez ID: 943
• Gene name: TNF receptor superfamily member 8
• Gene symbol: TNFRSF8
• Synonyms: CD30, D1S166E, Ki-1
• Chromosome: 1
• Chromosome location: 1p36.22
• Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to th

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT719567	hsa-miR-4738-5p	HITS-CLIP	19536157
MIRT719566	hsa-miR-600	HITS-CLIP	19536157
MIRT719565	hsa-miR-4297	HITS-CLIP	19536157
MIRT719564	hsa-miR-5581-5p	HITS-CLIP	19536157
MIRT719563	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT719562	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT719567	hsa-miR-4738-5p	HITS-CLIP	19536157
MIRT719566	hsa-miR-600	HITS-CLIP	19536157
MIRT719565	hsa-miR-4297	HITS-CLIP	19536157
MIRT719564	hsa-miR-5581-5p	HITS-CLIP	19536157
MIRT719563	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT719562	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT719567	hsa-miR-4738-5p	HITS-CLIP	19536157
MIRT719566	hsa-miR-600	HITS-CLIP	19536157
MIRT719565	hsa-miR-4297	HITS-CLIP	19536157
MIRT719564	hsa-miR-5581-5p	HITS-CLIP	19536157
MIRT719563	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT719562	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT719567	hsa-miR-4738-5p	HITS-CLIP	19536157
MIRT719566	hsa-miR-600	HITS-CLIP	19536157
MIRT719565	hsa-miR-4297	HITS-CLIP	19536157
MIRT719564	hsa-miR-5581-5p	HITS-CLIP	19536157
MIRT719563	hsa-miR-6512-3p	HITS-CLIP	19536157
MIRT719562	hsa-miR-6720-5p	HITS-CLIP	19536157
MIRT1443128	hsa-miR-1207-3p	CLIP-seq
MIRT1443129	hsa-miR-1307	CLIP-seq
MIRT1443130	hsa-miR-1321	CLIP-seq
MIRT1443131	hsa-miR-147	CLIP-seq
MIRT1443132	hsa-miR-1470	CLIP-seq
MIRT1443133	hsa-miR-2117	CLIP-seq
MIRT1443134	hsa-miR-2681	CLIP-seq
MIRT1443135	hsa-miR-3145-5p	CLIP-seq
MIRT1443136	hsa-miR-3162-5p	CLIP-seq
MIRT1443137	hsa-miR-3178	CLIP-seq
MIRT1443138	hsa-miR-3179	CLIP-seq
MIRT1443139	hsa-miR-3194-5p	CLIP-seq
MIRT1443140	hsa-miR-34a	CLIP-seq
MIRT1443141	hsa-miR-34c-5p	CLIP-seq
MIRT1443142	hsa-miR-3611	CLIP-seq
MIRT1443143	hsa-miR-371b-3p	CLIP-seq
MIRT1443144	hsa-miR-382	CLIP-seq
MIRT1443145	hsa-miR-3921	CLIP-seq
MIRT1443146	hsa-miR-3943	CLIP-seq
MIRT1443147	hsa-miR-4273	CLIP-seq
MIRT1443148	hsa-miR-4323	CLIP-seq
MIRT1443149	hsa-miR-4432	CLIP-seq
MIRT1443150	hsa-miR-4435	CLIP-seq
MIRT1443151	hsa-miR-4455	CLIP-seq
MIRT1443152	hsa-miR-4494	CLIP-seq
MIRT1443153	hsa-miR-449a	CLIP-seq
MIRT1443154	hsa-miR-449b	CLIP-seq
MIRT1443155	hsa-miR-4506	CLIP-seq
MIRT1443156	hsa-miR-4638-5p	CLIP-seq
MIRT1443157	hsa-miR-4649-3p	CLIP-seq
MIRT1443158	hsa-miR-4653-5p	CLIP-seq
MIRT1443159	hsa-miR-4667-3p	CLIP-seq
MIRT1443160	hsa-miR-4690-3p	CLIP-seq
MIRT1443161	hsa-miR-4707-3p	CLIP-seq
MIRT1443162	hsa-miR-4739	CLIP-seq
MIRT1443163	hsa-miR-4756-5p	CLIP-seq
MIRT1443164	hsa-miR-4793-5p	CLIP-seq
MIRT1443165	hsa-miR-597	CLIP-seq
MIRT1443166	hsa-miR-609	CLIP-seq
MIRT2132623	hsa-miR-140-3p	CLIP-seq
MIRT2132624	hsa-miR-185	CLIP-seq
MIRT2132625	hsa-miR-3150b-3p	CLIP-seq
MIRT2132626	hsa-miR-4270	CLIP-seq
MIRT2132627	hsa-miR-4306	CLIP-seq
MIRT2132628	hsa-miR-4434	CLIP-seq
MIRT2132629	hsa-miR-4436a	CLIP-seq
MIRT2132630	hsa-miR-4441	CLIP-seq
MIRT2132631	hsa-miR-4514	CLIP-seq
MIRT2132632	hsa-miR-4516	CLIP-seq
MIRT2132633	hsa-miR-4522	CLIP-seq
MIRT2132634	hsa-miR-4531	CLIP-seq
MIRT2132635	hsa-miR-4644	CLIP-seq
MIRT2132636	hsa-miR-4645-5p	CLIP-seq
MIRT1443159	hsa-miR-4667-3p	CLIP-seq
MIRT2132637	hsa-miR-4673	CLIP-seq
MIRT2132638	hsa-miR-4685-5p	CLIP-seq
MIRT2132639	hsa-miR-4692	CLIP-seq
MIRT2132640	hsa-miR-4700-3p	CLIP-seq
MIRT2132641	hsa-miR-4784	CLIP-seq
MIRT2132642	hsa-miR-508-5p	CLIP-seq
MIRT2132643	hsa-miR-516b	CLIP-seq
MIRT2132644	hsa-miR-940	CLIP-seq
MIRT2353642	hsa-miR-1207-5p	CLIP-seq
MIRT2353643	hsa-miR-3176	CLIP-seq
MIRT2353644	hsa-miR-3922-3p	CLIP-seq
MIRT2132631	hsa-miR-4514	CLIP-seq
MIRT2132636	hsa-miR-4645-5p	CLIP-seq
MIRT2132637	hsa-miR-4673	CLIP-seq
MIRT2132639	hsa-miR-4692	CLIP-seq
MIRT2353645	hsa-miR-4717-5p	CLIP-seq
MIRT2353646	hsa-miR-4757-5p	CLIP-seq
MIRT2353647	hsa-miR-4763-3p	CLIP-seq
MIRT1443164	hsa-miR-4793-5p	CLIP-seq
MIRT2132644	hsa-miR-940	CLIP-seq
MIRT2353646	hsa-miR-4757-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	TAS	10192335
GO:0008285	Process	Negative regulation of cell population proliferation	TAS	10192335
GO:0016021	Component	Integral component of membrane	IEA
GO:0032759	Process	Positive regulation of TRAIL production	IDA	16108830
GO:0032760	Process	Positive regulation of tumor necrosis factor production	IDA	16108830
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	TAS
GO:0043065	Process	Positive regulation of apoptotic process	IDA	16108830
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0071260	Process	Cellular response to mechanical stimulus	IEP	19593445

Other IDs

• MIM: 153243
• HGNC: 11923
• e!Ensembl: ENSG00000120949

Protein

• UniProt ID: P28908
• Protein name: Tumor necrosis factor receptor superfamily member 8 (CD30L receptor) (Ki-1 antigen) (Lymphocyte activation antigen CD30) (CD antigen CD30)
• Protein function: Receptor for TNFSF8/CD30L (PubMed:8391931). May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (PubMed:8999898). {ECO:0000269|PubMed:83919
• PDB: 1D01
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00020	TNFR_c6	108 → 149	TNFR/NGFR cysteine-rich region	Domain

• Sequence:

  MRVLLAALGLLFLGALRAFPQDRPFEDTCHGNPSHYYDKAVRRCCYRCPMGLFPTQQCPQ
  RPTDCRKQCEPDYYLDEADRCTACVTCSRDDLVEKTPCAWNSSRVCECRPGMFCSTSAVN
  SCARCFFHSVCPAGMIVKFPGTAQKNTVCEPASPGVSPACASPENCKEPSSGTIPQAKPT
  PVSPATSSASTMPVRGGTRLAQEAASKLTRAPDSPSSVGRPSSDPGLSPTQPCPEGSGDC
  RKQCEPDYYLDEAGRCTACVSCSRDDLVEKTPCAWNSSRTCECRPGMICATSATNSCARC
  VPYPICAAETVTKPQDMAEKDTTFEAPPLGTQPDCNPTPENGEAPASTSPTQSLLVDSQA
  SKTLPIPTSAPVALSSTGKPVLDAGPVLFWVILVLVVVVGSSAFLLCHRRACRKRIRQKL
  HLCYPVQTSQPKLELVDSRPRRSSTQLRSGASVTEPVAEERGLMSQPLMETCHSVGAAYL
  ESLPLQDASPAGGPSSPRDLPEPRVSTEHTNNKIEKIYIMKADTVIVGTVKAELPEGRGL
  AGPAEPELEEELEADHTPHYPEQETEPPLGSCSDVMLSVEEEGKEDPLPTAASGK

• Sequence length: 595

Pathways

KEGG:

Cytokine-cytokine receptor interaction

Reactome:

TNFs bind their physiological receptors

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Classical hodgkin lymphoma	Mixed Cellularity Hodgkin Lymphoma, Lymphocyte Rich Classical Hodgkin Lymphoma, Nodular Lymphocyte Predominant Hodgkin Lymphoma		16879607, 12453859
Eczema	Eczema		30595370
Hodgkin disease	Hodgkin Disease		12453859, 16879607
Hodgkin lymphoma	Adult Hodgkin Lymphoma	rs387906223, rs56391007, rs121913527, rs747694886	16879607, 12453859
Hodgkin lymphoma, lymphocyte depletion	Hodgkin lymphoma, lymphocyte depletion		12453859, 16879607
Malignant mesothelioma	Malignant mesothelioma		23056237