CDYL (chromodomain Y like)

Gene

• Entrez ID: 9425
• Gene name: Chromodomain Y like
• Gene symbol: CDYL
• Synonyms: CDYL1
• Chromosome: 6
• Chromosome location: 6p25.1
• Summary: Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by r

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT006174	hsa-miR-141-3p	Luciferase reporter assay, Western blot	21867514
MIRT006174	hsa-miR-141-3p	Luciferase reporter assay, Western blot	21867514
MIRT006174	hsa-miR-141-3p	Luciferase reporter assay, Western blot	21867514
MIRT735364	hsa-miR-1180-3p	Luciferase reporter assay, Western blotting, qRT-PCR	32321304
MIRT882877	hsa-miR-3154	CLIP-seq
MIRT882878	hsa-miR-3179	CLIP-seq
MIRT882879	hsa-miR-4310	CLIP-seq
MIRT882877	hsa-miR-3154	CLIP-seq
MIRT882880	hsa-miR-3942-3p	CLIP-seq
MIRT882881	hsa-miR-548ae	CLIP-seq
MIRT882882	hsa-miR-548aj	CLIP-seq
MIRT882883	hsa-miR-548am	CLIP-seq
MIRT882884	hsa-miR-548x	CLIP-seq
MIRT882885	hsa-miR-1227	CLIP-seq
MIRT882886	hsa-miR-129-5p	CLIP-seq
MIRT882887	hsa-miR-186	CLIP-seq
MIRT882888	hsa-miR-196a	CLIP-seq
MIRT882889	hsa-miR-196b	CLIP-seq
MIRT882890	hsa-miR-2052	CLIP-seq
MIRT882891	hsa-miR-2467-3p	CLIP-seq
MIRT882892	hsa-miR-3168	CLIP-seq
MIRT882893	hsa-miR-329	CLIP-seq
MIRT882894	hsa-miR-33a	CLIP-seq
MIRT882895	hsa-miR-33b	CLIP-seq
MIRT882896	hsa-miR-340	CLIP-seq
MIRT882897	hsa-miR-362-3p	CLIP-seq
MIRT882898	hsa-miR-3941	CLIP-seq
MIRT882899	hsa-miR-409-3p	CLIP-seq
MIRT882900	hsa-miR-450b-5p	CLIP-seq
MIRT882901	hsa-miR-466	CLIP-seq
MIRT882902	hsa-miR-4672	CLIP-seq
MIRT882903	hsa-miR-4803	CLIP-seq
MIRT882904	hsa-miR-488	CLIP-seq
MIRT882905	hsa-miR-507	CLIP-seq
MIRT882906	hsa-miR-548ag	CLIP-seq
MIRT882907	hsa-miR-548ai	CLIP-seq
MIRT882908	hsa-miR-548c-3p	CLIP-seq
MIRT882909	hsa-miR-557	CLIP-seq
MIRT882910	hsa-miR-568	CLIP-seq
MIRT882911	hsa-miR-603	CLIP-seq
MIRT882912	hsa-miR-633	CLIP-seq
MIRT882913	hsa-miR-648	CLIP-seq
MIRT882914	hsa-miR-653	CLIP-seq
MIRT1961777	hsa-miR-101	CLIP-seq
MIRT1961778	hsa-miR-1290	CLIP-seq
MIRT1961779	hsa-miR-144	CLIP-seq
MIRT1961780	hsa-miR-200b	CLIP-seq
MIRT1961781	hsa-miR-200c	CLIP-seq
MIRT1961782	hsa-miR-429	CLIP-seq
MIRT1961783	hsa-miR-561	CLIP-seq
MIRT1961784	hsa-miR-582-5p	CLIP-seq
MIRT2198331	hsa-miR-4724-5p	CLIP-seq
MIRT882911	hsa-miR-603	CLIP-seq
MIRT2198332	hsa-miR-1231	CLIP-seq
MIRT1961778	hsa-miR-1290	CLIP-seq
MIRT2198333	hsa-miR-3170	CLIP-seq
MIRT2198334	hsa-miR-4260	CLIP-seq
MIRT2198335	hsa-miR-4268	CLIP-seq
MIRT2198336	hsa-miR-4448	CLIP-seq
MIRT2198337	hsa-miR-654-3p	CLIP-seq
MIRT2385899	hsa-miR-3654	CLIP-seq
MIRT2385900	hsa-miR-4511	CLIP-seq
MIRT2385901	hsa-miR-548b-3p	CLIP-seq
MIRT2385902	hsa-miR-555	CLIP-seq
MIRT2385903	hsa-miR-582-3p	CLIP-seq
MIRT2501432	hsa-miR-1204	CLIP-seq
MIRT2501433	hsa-miR-1252	CLIP-seq
MIRT2501434	hsa-miR-1323	CLIP-seq
MIRT2501435	hsa-miR-223	CLIP-seq
MIRT882877	hsa-miR-3154	CLIP-seq
MIRT882892	hsa-miR-3168	CLIP-seq
MIRT2501436	hsa-miR-3180-5p	CLIP-seq
MIRT2501437	hsa-miR-323-5p	CLIP-seq
MIRT882893	hsa-miR-329	CLIP-seq
MIRT882897	hsa-miR-362-3p	CLIP-seq
MIRT2501438	hsa-miR-3689d	CLIP-seq
MIRT2501439	hsa-miR-3915	CLIP-seq
MIRT2501440	hsa-miR-3928	CLIP-seq
MIRT882898	hsa-miR-3941	CLIP-seq
MIRT2501441	hsa-miR-4263	CLIP-seq
MIRT2501442	hsa-miR-4277	CLIP-seq
MIRT2501443	hsa-miR-4652-3p	CLIP-seq
MIRT882901	hsa-miR-466	CLIP-seq
MIRT882902	hsa-miR-4672	CLIP-seq
MIRT2501444	hsa-miR-4743	CLIP-seq
MIRT2501445	hsa-miR-4760-5p	CLIP-seq
MIRT2501446	hsa-miR-4777-5p	CLIP-seq
MIRT2501447	hsa-miR-4778-5p	CLIP-seq
MIRT2501448	hsa-miR-495	CLIP-seq
MIRT2501449	hsa-miR-499a-5p	CLIP-seq
MIRT2501450	hsa-miR-518d-5p	CLIP-seq
MIRT2501451	hsa-miR-519b-5p	CLIP-seq
MIRT2501452	hsa-miR-519c-5p	CLIP-seq
MIRT2501453	hsa-miR-520a-5p	CLIP-seq
MIRT2501454	hsa-miR-520c-5p	CLIP-seq
MIRT2501455	hsa-miR-525-5p	CLIP-seq
MIRT2501456	hsa-miR-526a	CLIP-seq
MIRT2501457	hsa-miR-548a-3p	CLIP-seq
MIRT2501458	hsa-miR-548e	CLIP-seq
MIRT2501459	hsa-miR-548f	CLIP-seq
MIRT2501460	hsa-miR-548g	CLIP-seq
MIRT2501461	hsa-miR-548o	CLIP-seq
MIRT2501462	hsa-miR-570	CLIP-seq
MIRT882911	hsa-miR-603	CLIP-seq
MIRT2501432	hsa-miR-1204	CLIP-seq
MIRT2501434	hsa-miR-1323	CLIP-seq
MIRT2501435	hsa-miR-223	CLIP-seq
MIRT882892	hsa-miR-3168	CLIP-seq
MIRT2501437	hsa-miR-323-5p	CLIP-seq
MIRT882893	hsa-miR-329	CLIP-seq
MIRT882897	hsa-miR-362-3p	CLIP-seq
MIRT2501438	hsa-miR-3689d	CLIP-seq
MIRT882898	hsa-miR-3941	CLIP-seq
MIRT2501441	hsa-miR-4263	CLIP-seq
MIRT2501442	hsa-miR-4277	CLIP-seq
MIRT882901	hsa-miR-466	CLIP-seq
MIRT882902	hsa-miR-4672	CLIP-seq
MIRT2501444	hsa-miR-4743	CLIP-seq
MIRT2501457	hsa-miR-548a-3p	CLIP-seq
MIRT2501458	hsa-miR-548e	CLIP-seq
MIRT2501459	hsa-miR-548f	CLIP-seq
MIRT2501460	hsa-miR-548g	CLIP-seq
MIRT2501461	hsa-miR-548o	CLIP-seq
MIRT882911	hsa-miR-603	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003682	Function	Chromatin binding	ISS
GO:0003714	Function	Transcription corepressor activity	IBA	21873635
GO:0003714	Function	Transcription corepressor activity	IMP	19061646
GO:0005515	Function	Protein binding	IPI	16415788, 19061646, 22009739
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	18450745
GO:0005694	Component	Chromosome	ISS
GO:0005737	Component	Cytoplasm	ISS
GO:0007283	Process	Spermatogenesis	TAS	10192397
GO:0007286	Process	Spermatid development	ISS
GO:0016607	Component	Nuclear speck	IDA
GO:0030674	Function	Protein-macromolecule adaptor activity	IPI	19061646
GO:0035064	Function	Methylated histone binding	IDA	22009739
GO:0035064	Function	Methylated histone binding	IDA	18450745
GO:0045892	Process	Negative regulation of transcription, DNA-templated	IEA
GO:0060816	Process	Random inactivation of X chromosome	ISS
GO:0120092	Function	Crotonyl-CoA hydratase activity	IDA	28803779
GO:0120094	Process	Negative regulation of peptidyl-lysine crotonylation	IDA	28803779

Other IDs

• MIM: 603778
• HGNC: 1811
• e!Ensembl: ENSG00000153046

Protein

• UniProt ID: Q9Y232
• Protein name: Chromodomain Y-like protein (CDY-like) (Crotonyl-CoA hydratase) (EC 4.2.1.-)
• Protein function: [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) (PubMed:19808672, PubMed:28402439). Part o
• PDB: 2DNT, 2GTR, 7N27
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00385	Chromo	61 → 112	Chromo (CHRromatin Organisation MOdifier) domain	Domain
  PF00378	ECH_1	347 → 598	Enoyl-CoA hydratase/isomerase	Domain

• Sequence:

  MTFQASHRSAWGKSRKKNWQYEGPTQKLFLKRNNVSAPDGPSDPSISVSSEQSGAQQPPA
  LQVERIVDKRKNKKGKTEYLVRWKGYDSEDDTWEPEQHLVNCEEYIHDFNRRHTEKQKES
  TLTRTNRTSPNNARKQISRSTNSNFSKTSPKALVIGKDHESKNSQLFAASQKFRKNTAPS
  LSSRKNMDLAKSGIKILVPKSPVKSRTAVDGFQSESPEKLDPVEQGQEDTVAPEVAAEKP
  VGALLGPGAERARMGSRPRIHPLVPQVPGPVTAAMATGLAVNGKGTSPFMDALTANGTTN
  IQTSVTGVTASKRKFIDDRRDQPFDKRLRFSVRQTESAYRYRDIVVRKQDGFTHILLSTK
  SSENNSLNPEVMREVQSALSTAAADDSKLVLLSAVGSVFCCGLDFIYFIRRLTDDRKRES
  TKMAEAIRNFVNTFIQFKKPIIVAVNGPAIGLGASILPLCDVVWANEKAWFQTPYTTFGQ
  SPDGCSTVMFPKIMGGASANEMLLSGRKLTAQEACGKGLVSQVFWPGTFTQEVMVRIKEL
  ASCNPVVLEESKALVRCNMKMELEQANERECEVLKKIWGSAQGMDSMLKYLQRKIDEF

• Sequence length: 598

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Chronic obstructive pulmonary disease	Chronic Obstructive Airway Disease	rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928	21685187
Lung carcinoma	Small cell carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	22941189