Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
940 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
CD28 molecule |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
CD28 |
SynonymsGene synonyms aliases
|
IMD123, Tp44 |
ChromosomeChromosome number
|
2 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
2q33.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
|
The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provide |
miRNAmiRNA information provided by mirtarbase database.
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Transcription factors
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0001772 |
Component |
Immunological synapse |
IEA |
|
GO:0001816 |
Process |
Cytokine production |
TAS |
8717514 |
GO:0002020 |
Function |
Protease binding |
IPI |
12777399 |
GO:0002863 |
Process |
Positive regulation of inflammatory response to antigenic stimulus |
IEA |
|
GO:0005515 |
Function |
Protein binding |
IPI |
7568038, 7584133, 7807015, 8146197, 8183372, 9417079, 9784967, 10820259, 11285224, 15067037, 15554700, 18641334 |
GO:0005829 |
Component |
Cytosol |
TAS |
|
GO:0005886 |
Component |
Plasma membrane |
IDA |
11390434 |
GO:0005886 |
Component |
Plasma membrane |
TAS |
|
GO:0005887 |
Component |
Integral component of plasma membrane |
TAS |
9784967 |
GO:0006959 |
Process |
Humoral immune response |
TAS |
8717514 |
GO:0007166 |
Process |
Cell surface receptor signaling pathway |
TAS |
9784967 |
GO:0009897 |
Component |
External side of plasma membrane |
IBA |
21873635 |
GO:0009897 |
Component |
External side of plasma membrane |
IDA |
11390434 |
GO:0009986 |
Component |
Cell surface |
IDA |
15067037 |
GO:0010628 |
Process |
Positive regulation of gene expression |
IMP |
23817958 |
GO:0010629 |
Process |
Negative regulation of gene expression |
IMP |
23817958 |
GO:0014068 |
Process |
Positive regulation of phosphatidylinositol 3-kinase signaling |
IEA |
|
GO:0015026 |
Function |
Coreceptor activity |
TAS |
9784967 |
GO:0019901 |
Function |
Protein kinase binding |
IEA |
|
GO:0031295 |
Process |
T cell costimulation |
IBA |
21873635 |
GO:0031295 |
Process |
T cell costimulation |
TAS |
8617933 |
GO:0032733 |
Process |
Positive regulation of interleukin-10 production |
IDA |
8617933 |
GO:0032743 |
Process |
Positive regulation of interleukin-2 production |
IDA |
3875683 |
GO:0032753 |
Process |
Positive regulation of interleukin-4 production |
IDA |
8617933 |
GO:0042102 |
Process |
Positive regulation of T cell proliferation |
IBA |
21873635 |
GO:0042102 |
Process |
Positive regulation of T cell proliferation |
IDA |
3159820, 8617933 |
GO:0042102 |
Process |
Positive regulation of T cell proliferation |
TAS |
9784967 |
GO:0042110 |
Process |
T cell activation |
IBA |
21873635 |
GO:0042110 |
Process |
T cell activation |
IGI |
18337562 |
GO:0042802 |
Function |
Identical protein binding |
NAS |
3159820 |
GO:0043066 |
Process |
Negative regulation of apoptotic process |
TAS |
8717514 |
GO:0045060 |
Process |
Negative thymic T cell selection |
IEA |
|
GO:0045066 |
Process |
Regulatory T cell differentiation |
IDA |
18641304 |
GO:0045070 |
Process |
Positive regulation of viral genome replication |
NAS |
7492435 |
GO:0045589 |
Process |
Regulation of regulatory T cell differentiation |
IEA |
|
GO:0045727 |
Process |
Positive regulation of translation |
NAS |
12028592 |
GO:0045840 |
Process |
Positive regulation of mitotic nuclear division |
IDA |
3159820 |
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
IEA |
|
GO:0046641 |
Process |
Positive regulation of alpha-beta T cell proliferation |
IEA |
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GO:0048304 |
Process |
Positive regulation of isotype switching to IgG isotypes |
IEA |
|
GO:0050690 |
Process |
Regulation of defense response to virus by virus |
TAS |
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GO:0050852 |
Process |
T cell receptor signaling pathway |
IBA |
21873635 |
GO:0051897 |
Process |
Positive regulation of protein kinase B signaling |
TAS |
|
GO:0097190 |
Process |
Apoptotic signaling pathway |
IEA |
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GO:0098636 |
Component |
Protein complex involved in cell adhesion |
IDA |
7544393 |
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
P10747 |
Protein name |
T-cell-specific surface glycoprotein CD28 (TP44) (CD antigen CD28) |
Protein function |
Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis (PubMed:1650475, PubMed:7568038). Functions not only as an amplifier of TCR signals but delivers unique signals that control intra |
PDB |
1YJD
,
3WA4
,
5AUL
,
5GJH
,
5GJI
,
6O8D
,
7PPN
,
7VU5
,
8S6Z
,
8W2V
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF15910 |
V-set_2 |
23 → 139 |
ICOS V-set domain |
Domain |
|
Sequence |
|
Sequence length |
220 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Autoimmune diseases |
Autoimmune Diseases |
rs41285370, rs869025224 |
15494542, 19077085 |
Inflammatory bowel disease |
Inflammatory Bowel Diseases |
rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs139868987, rs750447828, rs368138379, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468 |
26192919 |
Lymphoma |
Lymphoma, T-Cell, Cutaneous |
rs11540652, rs1592119138, rs1592123162, rs1599367044 |
26192916, 26258847 |
Palmoplantar keratoderma |
Keratoderma, Palmoplantar |
rs59616921, rs1568039793, rs746488412, rs200564757, rs1567027297, rs781596375, rs1567027610, rs398123054, rs398123055, rs398123056, rs398123057, rs398122949, rs398122950, rs397515639, rs398122951, rs397515640, rs397515641, rs142859678, rs797044479, rs577442939, rs672601344, rs568609861, rs1057518846, rs1182196436, rs1567037561 |
|
Rheumatoid arthritis |
Rheumatoid Arthritis |
rs3766379, rs3792876, rs2071592, rs3087456, rs587776843, rs1566328963, rs2240340, rs1557787212 |
19898481, 23143596, 20453842 |
Sezary syndrome |
Sezary Syndrome |
rs587776632 |
26258847 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Alopecia |
Alopecia |
|
|
Celiac disease |
Celiac Disease |
rs2305764, rs35218876 |
25920553 |
Ectropion |
Ectropion |
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Eczema |
Eczema |
|
30595370 |
Exfoliative dermatitis |
Exfoliative dermatitis |
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Gangrene |
Gangrene |
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Granulomatous slack skin |
Granulomatous Slack Skin |
|
26192916, 26258847 |
Hyperkeratosis |
Hyperkeratosis |
|
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Immunologic deficiency syndromes |
Immunologic Deficiency Syndromes |
|
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Nail dystrophy |
Dystrophia unguium |
|
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Nervous system diseases |
Peripheral Nervous System Diseases |
|
|
Poikiloderma |
Poikiloderma |
|
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Skin neoplasms |
Skin Neoplasms |
|
|
T-cell lymphoma |
Peripheral T-Cell Lymphoma |
|
26192916 |
T-cell lymphoma/leukemia |
Adult T-Cell Lymphoma/Leukemia |
|
26437031 |
Ulcerative colitis |
Ulcerative Colitis |
|
26192919 |
|