TGFBRAP1 (transforming growth factor beta receptor associated protein 1)

Gene

• Entrez ID: 9392
• Gene name: Transforming growth factor beta receptor associated protein 1
• Gene symbol: TGFBRAP1
• Synonyms: TRAP-1, TRAP1, VPS3
• Chromosome: 2
• Chromosome location: 2q12.1-q12.2
• Summary: This gene encodes a protein that binds to transforming growth factor-beta (TGF-beta) receptors and plays a role in TGF-beta signaling. The encoded protein acts as a chaprone in signaling downstream of TGF-beta. It is involved in signal-dependent associati

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023387	hsa-miR-122-5p	Microarray	17612493
MIRT049371	hsa-miR-92a-3p	CLASH	23622248
MIRT039586	hsa-miR-628-3p	CLASH	23622248
MIRT053662	hsa-miR-181a-5p	Microarray	22942087
MIRT053662	hsa-miR-181a-5p	Luciferase reporter assay, qRT-PCR, Western blot	22714950
MIRT053662	hsa-miR-181a-5p	Luciferase reporter assay, qRT-PCR, Western blot	22714950
MIRT709445	hsa-miR-2681-3p	HITS-CLIP	19536157
MIRT709444	hsa-miR-892c-5p	HITS-CLIP	19536157
MIRT709443	hsa-miR-6501-3p	HITS-CLIP	19536157
MIRT709442	hsa-miR-7112-3p	HITS-CLIP	19536157
MIRT709441	hsa-miR-4711-5p	HITS-CLIP	19536157
MIRT709440	hsa-miR-3945	HITS-CLIP	19536157
MIRT709439	hsa-miR-4253	HITS-CLIP	19536157
MIRT709438	hsa-miR-6862-5p	HITS-CLIP	19536157
MIRT709445	hsa-miR-2681-3p	HITS-CLIP	19536157
MIRT709444	hsa-miR-892c-5p	HITS-CLIP	19536157
MIRT709443	hsa-miR-6501-3p	HITS-CLIP	19536157
MIRT709442	hsa-miR-7112-3p	HITS-CLIP	19536157
MIRT709441	hsa-miR-4711-5p	HITS-CLIP	19536157
MIRT709440	hsa-miR-3945	HITS-CLIP	19536157
MIRT709439	hsa-miR-4253	HITS-CLIP	19536157
MIRT709438	hsa-miR-6862-5p	HITS-CLIP	19536157
MIRT652722	hsa-miR-4428	HITS-CLIP	23824327
MIRT652721	hsa-miR-4729	HITS-CLIP	23824327
MIRT652720	hsa-miR-5696	HITS-CLIP	23824327
MIRT652719	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT652718	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT652717	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT439464	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439464	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT709445	hsa-miR-2681-3p	HITS-CLIP	19536157
MIRT709444	hsa-miR-892c-5p	HITS-CLIP	19536157
MIRT709443	hsa-miR-6501-3p	HITS-CLIP	19536157
MIRT709442	hsa-miR-7112-3p	HITS-CLIP	19536157
MIRT709441	hsa-miR-4711-5p	HITS-CLIP	19536157
MIRT709440	hsa-miR-3945	HITS-CLIP	19536157
MIRT709439	hsa-miR-4253	HITS-CLIP	19536157
MIRT709438	hsa-miR-6862-5p	HITS-CLIP	19536157
MIRT709445	hsa-miR-2681-3p	HITS-CLIP	19536157
MIRT709444	hsa-miR-892c-5p	HITS-CLIP	19536157
MIRT709443	hsa-miR-6501-3p	HITS-CLIP	19536157
MIRT709442	hsa-miR-7112-3p	HITS-CLIP	19536157
MIRT709441	hsa-miR-4711-5p	HITS-CLIP	19536157
MIRT709440	hsa-miR-3945	HITS-CLIP	19536157
MIRT709439	hsa-miR-4253	HITS-CLIP	19536157
MIRT709438	hsa-miR-6862-5p	HITS-CLIP	19536157
MIRT652722	hsa-miR-4428	HITS-CLIP	23824327
MIRT652721	hsa-miR-4729	HITS-CLIP	23824327
MIRT652720	hsa-miR-5696	HITS-CLIP	23824327
MIRT652719	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT652718	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT652717	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT2126436	hsa-miR-125a-3p	CLIP-seq
MIRT2126437	hsa-miR-1289	CLIP-seq
MIRT2126438	hsa-miR-1290	CLIP-seq
MIRT2126439	hsa-miR-151-5p	CLIP-seq
MIRT2126440	hsa-miR-151b	CLIP-seq
MIRT2126441	hsa-miR-181a	CLIP-seq
MIRT2126442	hsa-miR-181b	CLIP-seq
MIRT2126443	hsa-miR-181c	CLIP-seq
MIRT2126444	hsa-miR-181d	CLIP-seq
MIRT2126445	hsa-miR-184	CLIP-seq
MIRT2126446	hsa-miR-2052	CLIP-seq
MIRT2126447	hsa-miR-2110	CLIP-seq
MIRT2126448	hsa-miR-214	CLIP-seq
MIRT2126449	hsa-miR-2909	CLIP-seq
MIRT2126450	hsa-miR-297	CLIP-seq
MIRT2126451	hsa-miR-3149	CLIP-seq
MIRT2126452	hsa-miR-3150a-3p	CLIP-seq
MIRT2126453	hsa-miR-3619-5p	CLIP-seq
MIRT2126454	hsa-miR-3690	CLIP-seq
MIRT2126455	hsa-miR-376a	CLIP-seq
MIRT2126456	hsa-miR-376b	CLIP-seq
MIRT2126457	hsa-miR-4260	CLIP-seq
MIRT2126458	hsa-miR-4262	CLIP-seq
MIRT2126459	hsa-miR-4278	CLIP-seq
MIRT2126460	hsa-miR-4291	CLIP-seq
MIRT2126461	hsa-miR-4307	CLIP-seq
MIRT2126462	hsa-miR-4450	CLIP-seq
MIRT2126463	hsa-miR-4520a-3p	CLIP-seq
MIRT2126464	hsa-miR-4638-3p	CLIP-seq
MIRT2126465	hsa-miR-4652-3p	CLIP-seq
MIRT2126466	hsa-miR-4680-5p	CLIP-seq
MIRT2126467	hsa-miR-4716-5p	CLIP-seq
MIRT2126468	hsa-miR-4804-5p	CLIP-seq
MIRT2126469	hsa-miR-503	CLIP-seq
MIRT2126470	hsa-miR-552	CLIP-seq
MIRT2126471	hsa-miR-567	CLIP-seq
MIRT2126472	hsa-miR-587	CLIP-seq
MIRT2126473	hsa-miR-619	CLIP-seq
MIRT2126474	hsa-miR-642b	CLIP-seq
MIRT2126475	hsa-miR-643	CLIP-seq
MIRT2126476	hsa-miR-761	CLIP-seq
MIRT2126477	hsa-miR-922	CLIP-seq
MIRT2641325	hsa-miR-198	CLIP-seq
MIRT2126448	hsa-miR-214	CLIP-seq
MIRT2641326	hsa-miR-24	CLIP-seq
MIRT2641327	hsa-miR-3133	CLIP-seq
MIRT2641328	hsa-miR-3155	CLIP-seq
MIRT2641329	hsa-miR-3155b	CLIP-seq
MIRT2641330	hsa-miR-323-5p	CLIP-seq
MIRT2641331	hsa-miR-338-3p	CLIP-seq
MIRT2126453	hsa-miR-3619-5p	CLIP-seq
MIRT2641332	hsa-miR-4511	CLIP-seq
MIRT2641333	hsa-miR-4530	CLIP-seq
MIRT2641334	hsa-miR-4686	CLIP-seq
MIRT2641335	hsa-miR-4690-5p	CLIP-seq
MIRT2641336	hsa-miR-484	CLIP-seq
MIRT2126474	hsa-miR-642b	CLIP-seq
MIRT2126476	hsa-miR-761	CLIP-seq
MIRT2641337	hsa-miR-767-3p	CLIP-seq
MIRT2641338	hsa-miR-876-3p	CLIP-seq
MIRT2641325	hsa-miR-198	CLIP-seq
MIRT2126448	hsa-miR-214	CLIP-seq
MIRT2641326	hsa-miR-24	CLIP-seq
MIRT2641327	hsa-miR-3133	CLIP-seq
MIRT2641328	hsa-miR-3155	CLIP-seq
MIRT2641329	hsa-miR-3155b	CLIP-seq
MIRT2641330	hsa-miR-323-5p	CLIP-seq
MIRT2641331	hsa-miR-338-3p	CLIP-seq
MIRT2126453	hsa-miR-3619-5p	CLIP-seq
MIRT2641332	hsa-miR-4511	CLIP-seq
MIRT2641333	hsa-miR-4530	CLIP-seq
MIRT2641334	hsa-miR-4686	CLIP-seq
MIRT2641335	hsa-miR-4690-5p	CLIP-seq
MIRT2641336	hsa-miR-484	CLIP-seq
MIRT2126474	hsa-miR-642b	CLIP-seq
MIRT2126476	hsa-miR-761	CLIP-seq
MIRT2641337	hsa-miR-767-3p	CLIP-seq
MIRT2641338	hsa-miR-876-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005160	Function	Transforming growth factor beta receptor binding	IDA	11278302
GO:0005515	Function	Protein binding	IPI	11278302, 25266290, 26496610, 28514442
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005769	Component	Early endosome	IDA	25266290
GO:0006355	Process	Regulation of transcription, DNA-templated	IDA	11278302
GO:0006886	Process	Intracellular protein transport	IEA
GO:0006914	Process	Autophagy	IBA	21873635
GO:0007165	Process	Signal transduction	IDA	11278302
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	TAS	9545258
GO:0008333	Process	Endosome to lysosome transport	IMP	25266290
GO:0016020	Component	Membrane	IBA	21873635
GO:0016020	Component	Membrane	IDA	11278302
GO:0033263	Component	CORVET complex	IEA
GO:0034058	Process	Endosomal vesicle fusion	IBA	21873635
GO:0034058	Process	Endosomal vesicle fusion	IMP	25266290
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0046332	Function	SMAD binding	IDA	11278302

Other IDs

• MIM: 606237
• HGNC: 16836
• e!Ensembl: ENSG00000135966

Protein

• UniProt ID: Q8WUH2
• Protein name: Transforming growth factor-beta receptor-associated protein 1 (TGF-beta receptor-associated protein 1) (TRAP-1) (TRAP1)
• Protein function: Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00780	CNH	34 → 292	CNH domain	Family
  PF10366	Vps39_1	448 → 550	Vacuolar sorting protein 39 domain 1	Family
  PF00637	Clathrin	569 → 729	Region in Clathrin and VPS	Family
  PF10367	Vps39_2	738 → 846	Vacuolar sorting protein 39 domain 2	Domain

• Sequence:

  MMSIKAFTLVSAVERELLMGDKERVNIECVECCGRDLYVGTNDCFVYHFLLEERPVPAGP
  ATFTATKQLQRHLGFKKPVNELRAASALNRLLVLCDNSISLVNMLNLEPVPSGARIKGAA
  TFALNENPVSGDPFCVEVCIISVKRRTIQMFLVYEDRVQIVKEVSTAEQPLAVAVDGHFL
  CLALTTQYIIHNYSTGVSQDLFPYCSEERPPIVKRIGRQEFLLAGPGGLGMFATVAGISQ
  RAPVHWSENVIGAAVSFPYVIALDDEFITVHSMLDQQQKQTLPFKEGHILQDFEGRVIVA
  TSKGVYILVPLPLEKQIQDLLASRRVEEALVLAKGARRNIPKEKFQVMYRRILQQAGFIQ
  FAQLQFLEAKELFRSGQLDVRELISLYPFLLPTSSSFTRSHPPLHEYADLNQLTQGDQEK
  MAKCKRFLMSYLNEVRSTEVANGYKEDIDTALLKLYAEADHDSLLDLLVTENFCLLTDSA
  AWLEKHKKYFALGLLYHYNNQDAAAVQLWVNIVNGDVQDSTRSDLYEYIVDFLTYCLDEE
  LVWAYADWVLQKSEEVGVQVFTKRPLDEQQKNSFNPDDIINCLKKYPKALVKYLEHLVID
  KRLQKEEYHTHLAVLYLEEVLLQRASASGKGAEATETQAKLRRLLQKSDLYRVHFLLERL
  QGAGLPMESAILHGKLGEHEKALHILVHELQDFAAAEDYCLWCSEGRDPPHRQQLFHTLL
  AIYLHAGPTAHELAVAAVDLLNRHATEFDAAQVLQMLPDTWSVQLLCPFLMGAMRDSIHA
  RRTMQVALGLARSENLIYTYDKMKLKGSSIQLSDKKLCQICQNPFCEPVFVRYPNGGLVH
  THCAASRHTNPSSSSPGTRT

• Sequence length: 860

Pathways

KEGG:

Efferocytosis

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	31374203