CADPS2 (calcium dependent secretion activator 2)

Gene

• Entrez ID: 93664
• Gene name: Calcium dependent secretion activator 2
• Gene symbol: CADPS2
• Synonyms: CAPS2
• Chromosome: 7
• Chromosome location: 7q31.32
• Summary: This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this ge

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018754	hsa-miR-335-5p	Microarray	18185580
MIRT024929	hsa-miR-215-5p	Microarray	19074876
MIRT026747	hsa-miR-192-5p	Microarray	19074876
MIRT047976	hsa-miR-30c-5p	CLASH	23622248
MIRT858692	hsa-miR-1228	CLIP-seq
MIRT858693	hsa-miR-3129-3p	CLIP-seq
MIRT858694	hsa-miR-4450	CLIP-seq
MIRT858695	hsa-miR-4667-5p	CLIP-seq
MIRT858696	hsa-miR-4700-5p	CLIP-seq
MIRT1954960	hsa-miR-4762-5p	CLIP-seq
MIRT1954961	hsa-miR-4778-3p	CLIP-seq
MIRT2192570	hsa-miR-1243	CLIP-seq
MIRT2192571	hsa-miR-2276	CLIP-seq
MIRT2192572	hsa-miR-329	CLIP-seq
MIRT2192573	hsa-miR-362-3p	CLIP-seq
MIRT2192574	hsa-miR-3654	CLIP-seq
MIRT2192575	hsa-miR-374a	CLIP-seq
MIRT2192576	hsa-miR-374b	CLIP-seq
MIRT2192577	hsa-miR-3941	CLIP-seq
MIRT2192578	hsa-miR-548ag	CLIP-seq
MIRT2192579	hsa-miR-548ai	CLIP-seq
MIRT2192580	hsa-miR-603	CLIP-seq
MIRT2426866	hsa-miR-3605-5p	CLIP-seq
MIRT2426867	hsa-miR-4731-3p	CLIP-seq
MIRT2426868	hsa-miR-4801	CLIP-seq
MIRT2426869	hsa-miR-583	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005654	Component	Nucleoplasm	IDA
GO:0006887	Process	Exocytosis	IBA	21873635
GO:0008289	Function	Lipid binding	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016079	Process	Synaptic vesicle exocytosis	IEA
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0045921	Process	Positive regulation of exocytosis	IBA	21873635
GO:0046872	Function	Metal ion binding	IEA
GO:0098793	Component	Presynapse	IEA
GO:0098978	Component	Glutamatergic synapse	IBA	21873635
GO:1990504	Process	Dense core granule exocytosis	IEA

Other IDs

• MIM: 609978
• HGNC: 16018
• e!Ensembl: ENSG00000081803

Protein

• UniProt ID: Q86UW7
• Protein name: Calcium-dependent secretion activator 2 (Calcium-dependent activator protein for secretion 2) (CAPS-2)
• Protein function: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granu
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00169	PH	488 → 590	PH domain	Domain
  PF06292	DUF1041	801 → 894	Domain of Unknown Function (DUF1041)	Domain

• Sequence:

  MLDPSSSEEESDEGLEEESRDVLVAAGSSQRAPPAPTREGRRDAPGRAGGGGAARSVSPS
  PSVLSEGRDEPQRQLDDEQERRIRLQLYVFVVRCIAYPFNAKQPTDMARRQQKLNKQQLQ
  LLKERFQAFLNGETQIVADEAFCNAVRSYYEVFLKSDRVARMVQSGGCSANDFREVFKKN
  IEKRVRSLPEIDGLSKETVLSSWIAKYDAIYRGEEDLCKQPNRMALSAVSELILSKEQLY
  EMFQQILGIKKLEHQLLYNACQLDNADEQAAQIRRELDGRLQLADKMAKERKFPKFIAKD
  MENMYIEELRSSVNLLMANLESLPVSKGGPEFKLQKLKRSQNSAFLDIGDENEIQLSKSD
  VVLSFTLEIVIMEVQGLKSVAPNRIVYCTMEVEGEKLQTDQAEASRPQWGTQGDFTTTHP
  RPVVKVKLFTESTGVLALEDKELGRVILYPTSNSSKSAELHRMVVPKNSQDSDLKIKLAV
  RMDKPAHMKHSGYLYALGQKVWKRWKKRYFVLVQVSQYTFAMCSYREKKSEPQELMQLEG
  YTVDYTDPHPGLQGGCMFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSYKPVPAIQ
  TQKLNPKGGTLHADAQLSGKDADRFQKHGMDEFISANPCKLDHAFLFRILQRQTLDHRLN
  DSYSCLGWFSPGQVFVLDEYCARYGVRGCHRHLCYLAELMEHSENGAVIDPTLLHYSFAF
  CASHVHGNRPDGIGTVSVEEKERFEEIKERLSSLLENQISHFRYCFPFGRPEGALKATLS
  LLERVLMKDIATPIPAEEVKKVVRKCLEKAALINYTRLTEYAKIEETMNQASPARKLEEI
  LHLAELCIEVLQQNEEHHAEGREAFAWWPDLLAEHAEKFWALFTVDMDTALEAQPQDSWD
  SFPLFQLLNNFLRNDTLLCNGKFHKHLQEIFVPLVVRYVDLMESSIAQSIHRGFEQETWQ
  PVKNIANSLPNVALPKVPSLPLNLPQIPNISTASWMPSLYESTNGSATSEDLFWKLDALQ
  MFVFDLHWPEQEFAHHLEQRLKLMASDMLEACVKRTRTAFELKLQKASKTTDLRIPASVC
  TMFNVLVDAKKQSTKLCALDGGQEQQYHSKIDDLIDNSVKEIISLLVSKFVSVLEGVLSK
  LSRYDEGTFFSSILSFTVKAAAKYVDVPKPGMDLADTYIMFVRQNQDILREKVNEEMYIE
  KLFDQWYSSSMKVICVWLTDRLDLQLHIYQLKTLIKIVKKTYRDFRLQGVLEGTLNSKTY
  DTVHRRLTVEEATASVSEGGGLQGITMKDSDEEEEG

• Sequence length: 1296

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs145518263, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316	26830138
Autism	Autistic Disorder	rs121964908, rs121912597, rs2710102, rs7794745, rs142990298, rs62643608, rs181327458, rs797046134, rs869312704, rs1555013332, rs876657679, rs1057518999, rs1057518658, rs771827120, rs1555187899, rs773080572, rs753871454, rs1684130791, rs1684180699, rs1553510219, rs1684182454, rs1559060428, rs1553510677, rs1576352885, rs1574152522, rs1574152672, rs1696658542, rs1751123722, rs1750373491, rs1751075634	17380209
Cholestasis	Cholestasis	rs121909103, rs751511532, rs376368459, rs762702807, rs1578490102, rs1578499691, rs1578504946, rs1317656688, rs199791850, rs1452792080, rs1578491039	26881866
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	21601610

Unknown
Disease name	Disease term	dbSNP ID	References
Cardiovascular diseases	Cardiovascular Diseases		30595370