RPL23 (ribosomal protein L23)

Gene

• Entrez ID: 9349
• Gene name: Ribosomal protein L23
• Gene symbol: RPL23
• Synonyms: L23, rpL17, uL14
• Chromosome: 17
• Chromosome location: 17q12
• Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal pro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022730	hsa-miR-124-3p	Microarray	18668037
MIRT047046	hsa-miR-183-5p	CLASH	23622248
MIRT041095	hsa-miR-503-5p	CLASH	23622248
MIRT041095	hsa-miR-503-5p	CLASH	23622248
MIRT039746	hsa-miR-615-3p	CLASH	23622248
MIRT052822	hsa-miR-3200-3p	CLASH	23622248
MIRT514899	hsa-miR-552-3p	PAR-CLIP	23446348
MIRT514898	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT514897	hsa-miR-3934-5p	PAR-CLIP	23446348
MIRT514896	hsa-miR-6872-3p	PAR-CLIP	23446348
MIRT514895	hsa-miR-5095	PAR-CLIP	23446348
MIRT514894	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT514893	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT514899	hsa-miR-552-3p	PAR-CLIP	23446348
MIRT514898	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT514897	hsa-miR-3934-5p	PAR-CLIP	23446348
MIRT514896	hsa-miR-6872-3p	PAR-CLIP	23446348
MIRT514895	hsa-miR-5095	PAR-CLIP	23446348
MIRT514894	hsa-miR-7151-3p	PAR-CLIP	23446348
MIRT514893	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT2318586	hsa-miR-1243	CLIP-seq
MIRT2318587	hsa-miR-3654	CLIP-seq
MIRT2318588	hsa-miR-4434	CLIP-seq
MIRT2318589	hsa-miR-4506	CLIP-seq
MIRT2318590	hsa-miR-4516	CLIP-seq
MIRT2318591	hsa-miR-4531	CLIP-seq
MIRT2318592	hsa-miR-520d-5p	CLIP-seq
MIRT2318593	hsa-miR-524-5p	CLIP-seq
MIRT2318594	hsa-miR-629	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	19160485
GO:0000184	Process	Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS
GO:0001223	Function	Transcription coactivator binding	IPI	19160485
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003735	Function	Structural constituent of ribosome	IBA	21873635
GO:0003735	Function	Structural constituent of ribosome	NAS	12962325
GO:0005515	Function	Protein binding	IPI	15314173, 16189514, 17110929, 17310983, 25416956, 32296183
GO:0005654	Component	Nucleoplasm	IDA	15314173
GO:0005730	Component	Nucleolus	IDA	15314173, 19160485
GO:0005737	Component	Cytoplasm	IDA	15314173
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	NAS	1874450
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006412	Process	Translation	NAS	12962325
GO:0006413	Process	Translational initiation	TAS
GO:0006610	Process	Ribosomal protein import into nucleus	NAS	1874450
GO:0006614	Process	SRP-dependent cotranslational protein targeting to membrane	TAS
GO:0008284	Process	Positive regulation of cell population proliferation	IMP	19160485
GO:0010628	Process	Positive regulation of gene expression	IMP	15314173
GO:0014069	Component	Postsynaptic density	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0019083	Process	Viral transcription	TAS
GO:0022625	Component	Cytosolic large ribosomal subunit	HDA	12962325
GO:0022625	Component	Cytosolic large ribosomal subunit	IBA	21873635
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	15314173
GO:0032986	Process	Protein-DNA complex disassembly	IDA	19160485
GO:0032991	Component	Protein-containing complex	IDA	19160485
GO:0032991	Component	Protein-containing complex	IMP	15314173
GO:0050821	Process	Protein stabilization	IMP	15314173, 19160485
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0070180	Function	Large ribosomal subunit rRNA binding	IBA	21873635
GO:0071157	Process	Negative regulation of cell cycle arrest	IMP	19160485
GO:0071158	Process	Positive regulation of cell cycle arrest	IMP	15314173
GO:0072717	Process	Cellular response to actinomycin D	IMP	15314173
GO:1901798	Process	Positive regulation of signal transduction by p53 class mediator	IMP	15314173
GO:1904667	Process	Negative regulation of ubiquitin protein ligase activity	IDA	15314173
GO:1990948	Function	Ubiquitin ligase inhibitor activity	IDA	15314173
GO:2000059	Process	Negative regulation of ubiquitin-dependent protein catabolic process	IDA	15314173

Other IDs

• MIM: 603662
• HGNC: 10316
• e!Ensembl: ENSG00000125691

Protein

• UniProt ID: P62829
• Protein name: Large ribosomal subunit protein uL14 (60S ribosomal protein L17) (60S ribosomal protein L23)
• Protein function: Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
• PDB: 4UG0, 4V6X, 5AJ0, 5LKS, 5T2C, 6IP5, 6IP6, 6IP8, 6LQM, 6LSR, 6LSS, 6LU8, 6OLE, 6OLF, 6OLG, 6OLI, 6OLZ, 6OM0, 6OM7, 6QZP, 6XA1, 6Y0G, 6Y2L, 6Y57, 6Y6X, 6Z6L, 6Z6M, 6Z6N, 6ZM7, 6ZME, 6ZMI, 6ZMO, 7F5S, 7OW7, 7XNX, 7XNY, 8A3D, 8FKP, 8FKQ, 8FKR, 8FKS, 8FKT, 8FKU, 8FKV, 8FKW, 8FKX, 8FKY, 8FKZ, 8FL0, 8FL2, 8FL3
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00238	Ribosomal_L14	20 → 140	Ribosomal protein L14p/L23e	Domain

• Sequence:

  MSKRGRGGSSGAKFRISLGLPVGAVINCADNTGAKNLYIISVKGIKGRLNRLPAAGVGDM
  VMATVKKGKPELRKKVHPAVVIRQRKSYRRKDGVFLYFEDNAGVIVNNKGEMKGSAITGP
  VAKECADLWPRIASNAGSIA

• Sequence length: 140

Pathways

KEGG:

Ribosome
Coronavirus disease - COVID-19

Reactome:

L13a-mediated translational silencing of Ceruloplasmin expression
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Anemia	Anemia, Diamond-Blackfan	rs118204044, rs118204045, rs118204046, rs121918330, rs869320719, rs869312029, rs121918332, rs869320724, rs767094129, rs786205058, rs786205059, rs137853119, rs137853120, rs137853121, rs1384933966, rs137853122, rs137853123, rs786205060, rs267607121, rs121908584, rs80338697, rs80338699, rs120074166, rs120074167, rs1050828, rs74575103, rs137852314, rs5030868, rs137852316, rs137852317, rs137852318, rs137852319, rs137852320, rs137852321, rs137852322, rs137852323, rs137852324, rs72554665, rs387906468, rs5030872, rs137852326, rs137852333, rs137852327, rs137852328, rs137852329, rs137852330, rs137852331, rs137852332, rs137852334, rs137852335, rs137852336, rs137852339, rs76645461, rs137852340, rs137852341, rs78478128, rs137852343, rs137852344, rs137852345, rs587776730, rs137852346, rs137852347, rs137852349, rs2070404412, rs2070350038, rs2070350009, rs137852303, rs137852304, rs33946267, rs34378160, rs33933298, rs11549407, rs35724775, rs34598529, rs41469945, rs267607201, rs80338694, rs80338696, rs387907018, rs398123546, rs78365220, rs587777100, rs587777101, rs483352840, rs869312752, rs765487627, rs1557229599, rs1557230040, rs1555524842, rs782090947, rs1358275550, rs1557229736, rs1557230573, rs1556323334, rs1233124208, rs1293528130, rs146864395, rs1595503440, rs1603411214, rs137852325, rs1575247302, rs1603411177, rs1336651679, rs782322505	28297620