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GPR55 (G protein-coupled receptor 55)

Gene

9290

G protein-coupled receptor 55

GPR55

LPIR1

2q37.1

This gene belongs to the G-protein-coupled receptor superfamily. The encoded integral membrane protein is a likely cannabinoid receptor. It may be involved in several physiological and pathological processes by activating a variety of signal transduction

Show/Hide all(142)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051125	hsa-miR-16-5p	CLASH	23622248
MIRT040844	hsa-miR-18a-3p	CLASH	23622248
MIRT040546	hsa-miR-92b-3p	CLASH	23622248
MIRT713265	hsa-miR-3620-3p	HITS-CLIP	19536157
MIRT713264	hsa-miR-4691-3p	HITS-CLIP	19536157
MIRT713263	hsa-miR-4286	HITS-CLIP	19536157
MIRT713262	hsa-miR-3157-5p	HITS-CLIP	19536157
MIRT713261	hsa-miR-2355-5p	HITS-CLIP	19536157
MIRT618470	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT618469	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT644690	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT644689	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT618466	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT618465	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT618464	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT644688	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT618460	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT618470	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT618469	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT618468	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT618467	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT618466	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT618465	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT618464	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT618463	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT618462	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT618461	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT618460	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT713265	hsa-miR-3620-3p	HITS-CLIP	19536157
MIRT713264	hsa-miR-4691-3p	HITS-CLIP	19536157
MIRT713263	hsa-miR-4286	HITS-CLIP	19536157
MIRT713262	hsa-miR-3157-5p	HITS-CLIP	19536157
MIRT713261	hsa-miR-2355-5p	HITS-CLIP	19536157
MIRT618470	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT618469	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT644690	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT644689	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT618466	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT618465	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT618464	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT644688	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT618460	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT618470	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT618469	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT618468	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT618467	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT618466	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT618465	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT618464	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT618463	hsa-miR-6780a-3p	HITS-CLIP	23824327
MIRT618462	hsa-miR-6881-3p	HITS-CLIP	23824327
MIRT618461	hsa-miR-670-3p	HITS-CLIP	23824327
MIRT618460	hsa-miR-1238-3p	HITS-CLIP	23824327
MIRT1031508	hsa-miR-1236	CLIP-seq
MIRT1031509	hsa-miR-1238	CLIP-seq
MIRT1031510	hsa-miR-1301	CLIP-seq
MIRT1031511	hsa-miR-1343	CLIP-seq
MIRT1031512	hsa-miR-3065-3p	CLIP-seq
MIRT1031513	hsa-miR-3140-3p	CLIP-seq
MIRT1031514	hsa-miR-3140-5p	CLIP-seq
MIRT1031515	hsa-miR-3617	CLIP-seq
MIRT1031516	hsa-miR-3620	CLIP-seq
MIRT1031517	hsa-miR-3684	CLIP-seq
MIRT1031518	hsa-miR-4660	CLIP-seq
MIRT1031519	hsa-miR-4691-5p	CLIP-seq
MIRT1031520	hsa-miR-5047	CLIP-seq
MIRT1031521	hsa-miR-600	CLIP-seq
MIRT1031522	hsa-miR-641	CLIP-seq
MIRT1549368	hsa-miR-296-5p	CLIP-seq
MIRT1549369	hsa-miR-4731-5p	CLIP-seq
MIRT1549370	hsa-miR-4758-3p	CLIP-seq
MIRT2005983	hsa-miR-1205	CLIP-seq
MIRT1031508	hsa-miR-1236	CLIP-seq
MIRT1031509	hsa-miR-1238	CLIP-seq
MIRT1031511	hsa-miR-1343	CLIP-seq
MIRT2005984	hsa-miR-3616-3p	CLIP-seq
MIRT2005985	hsa-miR-4436b-3p	CLIP-seq
MIRT1031518	hsa-miR-4660	CLIP-seq
MIRT1031519	hsa-miR-4691-5p	CLIP-seq
MIRT2005986	hsa-miR-498	CLIP-seq
MIRT2005987	hsa-miR-596	CLIP-seq
MIRT2005983	hsa-miR-1205	CLIP-seq
MIRT2238539	hsa-miR-3187-3p	CLIP-seq
MIRT2005984	hsa-miR-3616-3p	CLIP-seq
MIRT2238540	hsa-miR-3622a-3p	CLIP-seq
MIRT2238541	hsa-miR-3622b-3p	CLIP-seq
MIRT2238542	hsa-miR-3663-5p	CLIP-seq
MIRT2238543	hsa-miR-4276	CLIP-seq
MIRT2005985	hsa-miR-4436b-3p	CLIP-seq
MIRT2238544	hsa-miR-4527	CLIP-seq
MIRT2238545	hsa-miR-4529-5p	CLIP-seq
MIRT2238546	hsa-miR-4639-3p	CLIP-seq
MIRT1031518	hsa-miR-4660	CLIP-seq
MIRT1031519	hsa-miR-4691-5p	CLIP-seq
MIRT2238547	hsa-miR-4753-3p	CLIP-seq
MIRT2238548	hsa-miR-499-3p	CLIP-seq
MIRT2238549	hsa-miR-499a-3p	CLIP-seq
MIRT2005987	hsa-miR-596	CLIP-seq
MIRT2238550	hsa-miR-767-3p	CLIP-seq
MIRT1031508	hsa-miR-1236	CLIP-seq
MIRT1031509	hsa-miR-1238	CLIP-seq
MIRT2388668	hsa-miR-214	CLIP-seq
MIRT2388669	hsa-miR-3619-5p	CLIP-seq
MIRT2388670	hsa-miR-4530	CLIP-seq
MIRT1031519	hsa-miR-4691-5p	CLIP-seq
MIRT2388671	hsa-miR-634	CLIP-seq
MIRT2388672	hsa-miR-761	CLIP-seq
MIRT2450637	hsa-miR-1248	CLIP-seq
MIRT2450638	hsa-miR-128	CLIP-seq
MIRT2450639	hsa-miR-129-3p	CLIP-seq
MIRT1031510	hsa-miR-1301	CLIP-seq
MIRT2450640	hsa-miR-150	CLIP-seq
MIRT2450641	hsa-miR-197	CLIP-seq
MIRT1031512	hsa-miR-3065-3p	CLIP-seq
MIRT2450642	hsa-miR-3124-3p	CLIP-seq
MIRT1031515	hsa-miR-3617	CLIP-seq
MIRT2450643	hsa-miR-3667-3p	CLIP-seq
MIRT2450644	hsa-miR-3692	CLIP-seq
MIRT1031518	hsa-miR-4660	CLIP-seq
MIRT1031519	hsa-miR-4691-5p	CLIP-seq
MIRT1031520	hsa-miR-5047	CLIP-seq
MIRT1031521	hsa-miR-600	CLIP-seq
MIRT1031522	hsa-miR-641	CLIP-seq
MIRT1031510	hsa-miR-1301	CLIP-seq
MIRT1031512	hsa-miR-3065-3p	CLIP-seq
MIRT1031515	hsa-miR-3617	CLIP-seq
MIRT2450643	hsa-miR-3667-3p	CLIP-seq
MIRT1031518	hsa-miR-4660	CLIP-seq
MIRT1031519	hsa-miR-4691-5p	CLIP-seq
MIRT1031520	hsa-miR-5047	CLIP-seq
MIRT1031521	hsa-miR-600	CLIP-seq
MIRT1031522	hsa-miR-641	CLIP-seq
MIRT2238539	hsa-miR-3187-3p	CLIP-seq
MIRT2005984	hsa-miR-3616-3p	CLIP-seq
MIRT2005985	hsa-miR-4436b-3p	CLIP-seq
MIRT2238545	hsa-miR-4529-5p	CLIP-seq
MIRT2005987	hsa-miR-596	CLIP-seq
MIRT2238539	hsa-miR-3187-3p	CLIP-seq
MIRT2005984	hsa-miR-3616-3p	CLIP-seq
MIRT2005985	hsa-miR-4436b-3p	CLIP-seq
MIRT2238545	hsa-miR-4529-5p	CLIP-seq
MIRT2005987	hsa-miR-596	CLIP-seq

Show/Hide all(16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA	21873635
GO:0004949	Function	Cannabinoid receptor activity	IBA	21873635
GO:0004949	Function	Cannabinoid receptor activity	IDA	19723626
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	IDA	18757503
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007202	Process	Activation of phospholipase C activity	IBA	21873635
GO:0007202	Process	Activation of phospholipase C activity	IDA	18757503
GO:0035025	Process	Positive regulation of Rho protein signal transduction	IBA	21873635
GO:0035025	Process	Positive regulation of Rho protein signal transduction	IDA	18757503, 19805329
GO:0038171	Process	Cannabinoid signaling pathway	IEA
GO:0045453	Process	Bone resorption	IDA	19805329
GO:0045671	Process	Negative regulation of osteoclast differentiation	IDA	19805329
GO:0051482	Process	Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	IBA	21873635
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IDA	19805329

MIM	HGNC	e!Ensembl
604107	4511	ENSG00000135898

Protein

UniProt ID

Q9Y2T6

Protein name

G-protein coupled receptor 55

Protein function

G-protein coupled receptor that binds to several ligands including 2-arachidonoyl lysophosphatidylinositol or lysophosphatidylglucoside with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways (P

PDB

8ZX4 , 8ZX5 , 9GE2 , 9GE3 , 9IY8 , 9IYA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	37 → 288	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MSQQNTSGDCLFDGVNELMKTLQFAVHIPTFVLGLLLNLLAIHGFSTFLKNRWPDYAATS
IYMINLAVFDLLLVLSLPFKMVLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRF
LAIRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSFHGKVEKYMCFHNMSDDTWSAK
VFFPLEVFGFLLPMGIMGFCCSRSIHILLGRRDHTQDWVQQKACIYSIAASLAVFVVSFL
PVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVIKEFRMNIR
AHRPSRVQLVLQDTTISRG

Sequence length

319

Interactions

View interactions

	Reactome
			Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs4402960, rs1362648752, rs3745368, rs3792267, rs3842570, rs5030952, rs2975760, rs119489103, rs7903146, rs12255372, rs11196205, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs137852740, rs137852786, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs80356663, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356666, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs387906779, rs141804752, rs182349376, rs184917682, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs61736969, rs587783673, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs797045623, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs1553638903, rs1553638909, rs948820149, rs371977235, rs1553784995, rs76474829, rs200998587, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs776793516, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	29221444

Show/Hide Unknown Diseases (3)

Unknown
Disease name	Disease term	dbSNP ID	References
Benign neoplasm	Benign Neoplasm		27423937
Malignant neoplasm	Malignant Neoplasms		27423937
Neoplasms	Neoplasms		27423937

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