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NUMBL (NUMB like endocytic adaptor protein)

Gene

9253

NUMB like endocytic adaptor protein

NUMBL

CAG3A, CTG3a, NBL, NUMB-R, NUMBLIKE, NUMBR, TNRC23

19q13.2

Show/Hide all(184)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003111	hsa-miR-122-5p	Luciferase reporter assay, qRT-PCR	19296470
MIRT003111	hsa-miR-122-5p	Luciferase reporter assay, qRT-PCR	19296470
MIRT655687	hsa-miR-4269	HITS-CLIP	23824327
MIRT655686	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT655685	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT655684	hsa-miR-4673	HITS-CLIP	23824327
MIRT655683	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT655682	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT655681	hsa-miR-4258	HITS-CLIP	23824327
MIRT655680	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT655679	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT655678	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT655677	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT655676	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT655674	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT655687	hsa-miR-4269	HITS-CLIP	23824327
MIRT655686	hsa-miR-6715b-5p	HITS-CLIP	23824327
MIRT655685	hsa-miR-4645-5p	HITS-CLIP	23824327
MIRT655684	hsa-miR-4673	HITS-CLIP	23824327
MIRT655683	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT655682	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT655681	hsa-miR-4258	HITS-CLIP	23824327
MIRT655680	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT655679	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT655678	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT655677	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT655676	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT655674	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT1198945	hsa-miR-122	CLIP-seq
MIRT1198946	hsa-miR-1225-3p	CLIP-seq
MIRT1198947	hsa-miR-1245	CLIP-seq
MIRT1198948	hsa-miR-141	CLIP-seq
MIRT1198949	hsa-miR-200a	CLIP-seq
MIRT1198950	hsa-miR-3134	CLIP-seq
MIRT1198951	hsa-miR-3153	CLIP-seq
MIRT1198952	hsa-miR-3202	CLIP-seq
MIRT1198953	hsa-miR-3657	CLIP-seq
MIRT1198954	hsa-miR-3689d	CLIP-seq
MIRT1198955	hsa-miR-421	CLIP-seq
MIRT1198956	hsa-miR-4252	CLIP-seq
MIRT1198957	hsa-miR-4276	CLIP-seq
MIRT1198958	hsa-miR-4421	CLIP-seq
MIRT1198959	hsa-miR-4438	CLIP-seq
MIRT1198960	hsa-miR-4443	CLIP-seq
MIRT1198961	hsa-miR-4447	CLIP-seq
MIRT1198962	hsa-miR-4472	CLIP-seq
MIRT1198963	hsa-miR-4533	CLIP-seq
MIRT1198964	hsa-miR-4534	CLIP-seq
MIRT1198965	hsa-miR-4646-5p	CLIP-seq
MIRT1198966	hsa-miR-4668-5p	CLIP-seq
MIRT1198967	hsa-miR-4694-3p	CLIP-seq
MIRT1198968	hsa-miR-4709-5p	CLIP-seq
MIRT1198969	hsa-miR-4738-3p	CLIP-seq
MIRT1198970	hsa-miR-4761-3p	CLIP-seq
MIRT1198971	hsa-miR-4763-5p	CLIP-seq
MIRT1198972	hsa-miR-4768-3p	CLIP-seq
MIRT1198973	hsa-miR-4793-5p	CLIP-seq
MIRT1198974	hsa-miR-4802-5p	CLIP-seq
MIRT1198975	hsa-miR-505	CLIP-seq
MIRT1198976	hsa-miR-5095	CLIP-seq
MIRT1198977	hsa-miR-574-5p	CLIP-seq
MIRT2057652	hsa-miR-203	CLIP-seq
MIRT2057653	hsa-miR-3151	CLIP-seq
MIRT2057654	hsa-miR-3170	CLIP-seq
MIRT2057655	hsa-miR-342-5p	CLIP-seq
MIRT2057656	hsa-miR-34a	CLIP-seq
MIRT2057657	hsa-miR-34c-5p	CLIP-seq
MIRT2057658	hsa-miR-3650	CLIP-seq
MIRT2057659	hsa-miR-4260	CLIP-seq
MIRT2057660	hsa-miR-4433	CLIP-seq
MIRT1198959	hsa-miR-4438	CLIP-seq
MIRT1198961	hsa-miR-4447	CLIP-seq
MIRT1198962	hsa-miR-4472	CLIP-seq
MIRT2057661	hsa-miR-449a	CLIP-seq
MIRT2057662	hsa-miR-449b	CLIP-seq
MIRT2057663	hsa-miR-4651	CLIP-seq
MIRT2057664	hsa-miR-4664-5p	CLIP-seq
MIRT2057665	hsa-miR-4715-3p	CLIP-seq
MIRT2057666	hsa-miR-4722-3p	CLIP-seq
MIRT2057667	hsa-miR-4735-5p	CLIP-seq
MIRT1198971	hsa-miR-4763-5p	CLIP-seq
MIRT2057668	hsa-miR-4775	CLIP-seq
MIRT2057669	hsa-miR-491-5p	CLIP-seq
MIRT1198976	hsa-miR-5095	CLIP-seq
MIRT2057670	hsa-miR-522	CLIP-seq
MIRT2057671	hsa-miR-541	CLIP-seq
MIRT2057672	hsa-miR-566	CLIP-seq
MIRT2057673	hsa-miR-590-3p	CLIP-seq
MIRT2057674	hsa-miR-608	CLIP-seq
MIRT2057675	hsa-miR-609	CLIP-seq
MIRT2057676	hsa-miR-654-5p	CLIP-seq
MIRT2286009	hsa-miR-1202	CLIP-seq
MIRT1198946	hsa-miR-1225-3p	CLIP-seq
MIRT2286010	hsa-miR-1231	CLIP-seq
MIRT2286011	hsa-miR-1254	CLIP-seq
MIRT2286012	hsa-miR-1256	CLIP-seq
MIRT2286013	hsa-miR-1911	CLIP-seq
MIRT2286014	hsa-miR-2110	CLIP-seq
MIRT2286015	hsa-miR-3116	CLIP-seq
MIRT2286016	hsa-miR-3120-3p	CLIP-seq
MIRT2286017	hsa-miR-3150a-3p	CLIP-seq
MIRT2057653	hsa-miR-3151	CLIP-seq
MIRT2057654	hsa-miR-3170	CLIP-seq
MIRT2286018	hsa-miR-3179	CLIP-seq
MIRT2286019	hsa-miR-3194-5p	CLIP-seq
MIRT1198952	hsa-miR-3202	CLIP-seq
MIRT2286020	hsa-miR-329	CLIP-seq
MIRT2057655	hsa-miR-342-5p	CLIP-seq
MIRT2057656	hsa-miR-34a	CLIP-seq
MIRT2057657	hsa-miR-34c-5p	CLIP-seq
MIRT2286021	hsa-miR-362-3p	CLIP-seq
MIRT2057658	hsa-miR-3650	CLIP-seq
MIRT2286022	hsa-miR-3664-3p	CLIP-seq
MIRT2286023	hsa-miR-3972	CLIP-seq
MIRT2057659	hsa-miR-4260	CLIP-seq
MIRT2286024	hsa-miR-4271	CLIP-seq
MIRT2286025	hsa-miR-4310	CLIP-seq
MIRT2286026	hsa-miR-4317	CLIP-seq
MIRT2057660	hsa-miR-4433	CLIP-seq
MIRT1198959	hsa-miR-4438	CLIP-seq
MIRT1198961	hsa-miR-4447	CLIP-seq
MIRT2286027	hsa-miR-4459	CLIP-seq
MIRT1198962	hsa-miR-4472	CLIP-seq
MIRT2057661	hsa-miR-449a	CLIP-seq
MIRT2057662	hsa-miR-449b	CLIP-seq
MIRT2057663	hsa-miR-4651	CLIP-seq
MIRT2057664	hsa-miR-4664-5p	CLIP-seq
MIRT2286028	hsa-miR-4667-5p	CLIP-seq
MIRT2286029	hsa-miR-4700-5p	CLIP-seq
MIRT2286030	hsa-miR-4711-3p	CLIP-seq
MIRT2057665	hsa-miR-4715-3p	CLIP-seq
MIRT2057666	hsa-miR-4722-3p	CLIP-seq
MIRT2286031	hsa-miR-4725-3p	CLIP-seq
MIRT2057667	hsa-miR-4735-5p	CLIP-seq
MIRT2286032	hsa-miR-4747-5p	CLIP-seq
MIRT1198971	hsa-miR-4763-5p	CLIP-seq
MIRT1198972	hsa-miR-4768-3p	CLIP-seq
MIRT2057669	hsa-miR-491-5p	CLIP-seq
MIRT2286033	hsa-miR-498	CLIP-seq
MIRT1198976	hsa-miR-5095	CLIP-seq
MIRT2286034	hsa-miR-510	CLIP-seq
MIRT2057671	hsa-miR-541	CLIP-seq
MIRT2286035	hsa-miR-550a	CLIP-seq
MIRT2057672	hsa-miR-566	CLIP-seq
MIRT2057674	hsa-miR-608	CLIP-seq
MIRT2286036	hsa-miR-637	CLIP-seq
MIRT2057676	hsa-miR-654-5p	CLIP-seq
MIRT2286037	hsa-miR-661	CLIP-seq
MIRT2286038	hsa-miR-665	CLIP-seq
MIRT1198952	hsa-miR-3202	CLIP-seq
MIRT2431735	hsa-miR-1273g	CLIP-seq
MIRT2431736	hsa-miR-1293	CLIP-seq
MIRT2431737	hsa-miR-1321	CLIP-seq
MIRT2431738	hsa-miR-140-5p	CLIP-seq
MIRT2431739	hsa-miR-142-3p	CLIP-seq
MIRT2431740	hsa-miR-3126-5p	CLIP-seq
MIRT2431741	hsa-miR-3137	CLIP-seq
MIRT2431742	hsa-miR-323b-5p	CLIP-seq
MIRT2431743	hsa-miR-3545-5p	CLIP-seq
MIRT2431744	hsa-miR-3686	CLIP-seq
MIRT2431745	hsa-miR-409-3p	CLIP-seq
MIRT2431746	hsa-miR-4419a	CLIP-seq
MIRT2431747	hsa-miR-4460	CLIP-seq
MIRT2431748	hsa-miR-4483	CLIP-seq
MIRT2431749	hsa-miR-4510	CLIP-seq
MIRT2057663	hsa-miR-4651	CLIP-seq
MIRT2431750	hsa-miR-4728-5p	CLIP-seq
MIRT2431751	hsa-miR-4739	CLIP-seq
MIRT2431752	hsa-miR-4756-5p	CLIP-seq
MIRT2431753	hsa-miR-4781-3p	CLIP-seq
MIRT2431754	hsa-miR-563	CLIP-seq
MIRT2057674	hsa-miR-608	CLIP-seq
MIRT2057675	hsa-miR-609	CLIP-seq
MIRT2431755	hsa-miR-659	CLIP-seq
MIRT2431756	hsa-miR-876-3p	CLIP-seq
MIRT2455548	hsa-miR-1267	CLIP-seq
MIRT2455549	hsa-miR-4423-5p	CLIP-seq
MIRT2455550	hsa-miR-4514	CLIP-seq
MIRT2455551	hsa-miR-4652-3p	CLIP-seq
MIRT2455552	hsa-miR-4692	CLIP-seq
MIRT2455553	hsa-miR-4722-5p	CLIP-seq
MIRT2455554	hsa-miR-4778-5p	CLIP-seq
MIRT2455555	hsa-miR-4797-5p	CLIP-seq
MIRT2455556	hsa-miR-940	CLIP-seq

Show/Hide all(10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16713569, 20079715, 32296183, 32814053
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0007399	Process	Nervous system development	TAS	9303539
GO:0007409	Process	Axonogenesis	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	IDA	18299187
GO:0019538	Process	Protein metabolic process	IDA	20079715
GO:0021670	Process	Lateral ventricle development	ISS
GO:0021849	Process	Neuroblast division in subventricular zone	ISS
GO:0034332	Process	Adherens junction organization	IEA
GO:0050769	Process	Positive regulation of neurogenesis	ISS

MIM	HGNC	e!Ensembl
604018	8061	ENSG00000105245

Protein

UniProt ID

Q9Y6R0

Protein name

Numb-like protein (Numb-related protein) (Numb-R)

Protein function

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. No

PDB

3F0W

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00640	PID	80 → 202	Phosphotyrosine interaction domain (PTB/PID)	Domain
PF06311	NumbF	287 → 371	NUMB domain	Family

Sequence

MSRSAAASGGPRRPERHLPPAPCGAPGPPETCRTEPDGAGTMNKLRQSLRRRKPAYVPEA
SRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWV
SADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDS
GERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAPD
KKKAEAAAAPTVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQL
VRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGAGDSDSI
NALCTQISSSFASAGAPAPGPPPATTGTSAWGEPSVPPAAAFQPGHKRTPSEAERWLEEV
SQVAKAQQQQQQQQQQQQQQQQQQQQAASVAPVPTMPPALQPFPAPVGPFDAAPAQVAVF
LPPPHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAF
PPPAIPSAPGSQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKATVEKPSNPFSGD
LQKTFEIEL

Sequence length

609

Interactions

View interactions

	KEGG
	Notch signaling pathway

Associated diseases

Show/Hide Causal Diseases (3)

Causal
Disease name	Disease term	dbSNP ID	References
Lung carcinoma	Carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	28604730
Prostate cancer	Prostate carcinoma	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	27515689
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	16899352

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