SPECC1 (sperm antigen with calponin homology and coiled-coil domains 1)

Gene

• Entrez ID: 92521
• Gene name: Sperm antigen with calponin homology and coiled-coil domains 1
• Gene symbol: SPECC1
• Synonyms: CYTSB, HCMOGT-1, HCMOGT1, NSP, NSP5
• Chromosome: 17
• Chromosome location: 17p11.2
• Summary: The protein encoded by this gene belongs to the cytospin-A family. It is localized in the nucleus, and highly expressed in testis and some cancer cell lines. A chromosomal translocation involving this gene and platelet-derived growth factor receptor, beta

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020795	hsa-miR-155-5p	Proteomics	18668040
MIRT047508	hsa-miR-10a-5p	CLASH	23622248
MIRT045245	hsa-miR-186-5p	CLASH	23622248
MIRT709375	hsa-miR-6768-5p	HITS-CLIP	19536157
MIRT709374	hsa-miR-4438	HITS-CLIP	19536157
MIRT709373	hsa-miR-103b	HITS-CLIP	19536157
MIRT709372	hsa-miR-6499-3p	HITS-CLIP	19536157
MIRT709371	hsa-miR-6847-3p	HITS-CLIP	19536157
MIRT709370	hsa-miR-3135b	HITS-CLIP	19536157
MIRT709369	hsa-miR-504-3p	HITS-CLIP	19536157
MIRT709368	hsa-miR-122-5p	HITS-CLIP	19536157
MIRT709367	hsa-miR-3652	HITS-CLIP	19536157
MIRT709366	hsa-miR-4430	HITS-CLIP	19536157
MIRT709365	hsa-miR-143-5p	HITS-CLIP	19536157
MIRT709364	hsa-miR-377-3p	HITS-CLIP	19536157
MIRT709363	hsa-miR-5698	HITS-CLIP	19536157
MIRT653191	hsa-miR-449b-3p	HITS-CLIP	23824327
MIRT653190	hsa-miR-6871-5p	HITS-CLIP	23824327
MIRT653189	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT618402	hsa-miR-5007-5p	HITS-CLIP	23824327
MIRT618401	hsa-miR-3976	HITS-CLIP	23824327
MIRT618400	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT709375	hsa-miR-6768-5p	HITS-CLIP	19536157
MIRT709374	hsa-miR-4438	HITS-CLIP	19536157
MIRT709373	hsa-miR-103b	HITS-CLIP	19536157
MIRT709372	hsa-miR-6499-3p	HITS-CLIP	19536157
MIRT709371	hsa-miR-6847-3p	HITS-CLIP	19536157
MIRT709370	hsa-miR-3135b	HITS-CLIP	19536157
MIRT709369	hsa-miR-504-3p	HITS-CLIP	19536157
MIRT709368	hsa-miR-122-5p	HITS-CLIP	19536157
MIRT709367	hsa-miR-3652	HITS-CLIP	19536157
MIRT709366	hsa-miR-4430	HITS-CLIP	19536157
MIRT709365	hsa-miR-143-5p	HITS-CLIP	19536157
MIRT709364	hsa-miR-377-3p	HITS-CLIP	19536157
MIRT709363	hsa-miR-5698	HITS-CLIP	19536157
MIRT653191	hsa-miR-449b-3p	HITS-CLIP	23824327
MIRT653190	hsa-miR-6871-5p	HITS-CLIP	23824327
MIRT653189	hsa-miR-4717-3p	HITS-CLIP	23824327
MIRT618402	hsa-miR-5007-5p	HITS-CLIP	23824327
MIRT618401	hsa-miR-3976	HITS-CLIP	23824327
MIRT618400	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT1383538	hsa-miR-1184	CLIP-seq
MIRT1383539	hsa-miR-1205	CLIP-seq
MIRT1383540	hsa-miR-1231	CLIP-seq
MIRT1383541	hsa-miR-1343	CLIP-seq
MIRT1383542	hsa-miR-2116	CLIP-seq
MIRT1383543	hsa-miR-3157-5p	CLIP-seq
MIRT1383544	hsa-miR-3158-5p	CLIP-seq
MIRT1383545	hsa-miR-378g	CLIP-seq
MIRT1383546	hsa-miR-4288	CLIP-seq
MIRT1383547	hsa-miR-4418	CLIP-seq
MIRT1383548	hsa-miR-4427	CLIP-seq
MIRT1383549	hsa-miR-4437	CLIP-seq
MIRT1383550	hsa-miR-4674	CLIP-seq
MIRT1383551	hsa-miR-4677-5p	CLIP-seq
MIRT1383552	hsa-miR-4680-3p	CLIP-seq
MIRT1383553	hsa-miR-4691-3p	CLIP-seq
MIRT1383554	hsa-miR-509-3-5p	CLIP-seq
MIRT1383555	hsa-miR-509-5p	CLIP-seq
MIRT1383556	hsa-miR-544	CLIP-seq
MIRT1383557	hsa-miR-632	CLIP-seq
MIRT1383558	hsa-miR-1273f	CLIP-seq
MIRT1383559	hsa-miR-150	CLIP-seq
MIRT1383560	hsa-miR-3138	CLIP-seq
MIRT1383561	hsa-miR-3942-3p	CLIP-seq
MIRT1383562	hsa-miR-4491	CLIP-seq
MIRT1383563	hsa-miR-4657	CLIP-seq
MIRT1383564	hsa-miR-4698	CLIP-seq
MIRT1383565	hsa-miR-4733-5p	CLIP-seq
MIRT1383566	hsa-miR-4800-5p	CLIP-seq
MIRT1383567	hsa-miR-515-5p	CLIP-seq
MIRT1383568	hsa-miR-518d-5p	CLIP-seq
MIRT1383569	hsa-miR-519b-5p	CLIP-seq
MIRT1383570	hsa-miR-519c-5p	CLIP-seq
MIRT1383571	hsa-miR-520c-5p	CLIP-seq
MIRT1383572	hsa-miR-526a	CLIP-seq
MIRT1383573	hsa-miR-579	CLIP-seq
MIRT1383574	hsa-miR-604	CLIP-seq
MIRT1383575	hsa-miR-647	CLIP-seq
MIRT2631087	hsa-miR-320e	CLIP-seq
MIRT2631087	hsa-miR-320e	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001650	Component	Fibrillar center	IDA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005815	Component	Microtubule organizing center	IBA	21873635
GO:0005829	Component	Cytosol	IDA
GO:0016020	Component	Membrane	IEA
GO:0030036	Process	Actin cytoskeleton organization	IBA	21873635
GO:0031941	Component	Filamentous actin	IBA	21873635
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA

Other IDs

• MIM: 608793
• HGNC: 30615
• e!Ensembl: ENSG00000128487

Protein

• UniProt ID: Q5M775
• Protein name: Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00307	CH	962 → 1068	Calponin homology (CH) domain	Domain

• Sequence:

  MRSAAKPWNPAIRAGGHGPDRVRPLPAASSGMKSSKSSTSLAFESRLSRLKRASSEDTLN
  KPGSTAASGVVRLKKTATAGAISELTESRLRSGTGAFTTTKRTGIPAPREFSVTVSRERS
  VPRGPSNPRKSVSSPTSSNTPTPTKHLRTPSTKPKQENEGGEKAALESQVRELLAEAKAK
  DSEINRLRSELKKYKEKRTLNAEGTDALGPNVDGTSVSPGDTEPMIRALEEKNKNFQKEL
  SDLEEENRVLKEKLIYLEHSPNSEGAASHTGDSSCPTSITQESSFGSPTGNQMSSDIDEY
  KKNIHGNALRTSGSSSSDVTKASLSPDASDFEHITAETPSRPLSSTSNPFKSSKCSTAGS
  SPNSVSELSLASLTEKIQKMEENHHSTAEELQATLQELSDQQQMVQELTAENEKLVDEKT
  ILETSFHQHRERAEQLSQENEKLMNLLQERVKNEEPTTQEGKIIELEQKCTGILEQGRFE
  REKLLNIQQQLTCSLRKVEEENQGALEMIKRLKEENEKLNEFLELERHNNNMMAKTLEEC
  RVTLEGLKMENGSLKSHLQGEKQKATEASAVEQTAESCEVQEMLKVARAEKDLLELSCNE
  LRQELLKANGEIKHVSSLLAKVEKDYSYLKEICDHQAEQLSRTSLKLQEKASESDAEIKD
  MKETIFELEDQVEQHRAVKLHNNQLISELESSVIKLEEQKSDLERQLKTLTKQMKEETEE
  WRRFQADLQTAVVVANDIKCEAQQELRTVKRKLLEEEEKNARLQKELGDVQGHGRVVTSR
  AAPPPVDEEPESSEVDAAGRWPGVCVSRTSPTPPESATTVKSLIKSFDLGRPGGAGQNIS
  VHKTPRSPLSGIPVRTAPAAAVSPMQRHSTYSSVRPASRGVTQRLDLPDLPLSDILKGRT
  ETLKPDPHLRKSPSLESLSRPPSLGFGDTRLLSASTRAWKPQSKLSVERKDPLAALAREY
  GGSKRNALLKWCQKKTQGYANIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELNSQEKK
  RNLLLAFEAAESVGIKPSLELSEMLYTDRPDWQSVMQYVAQIYKYFET

• Sequence length: 1068

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	28991256, 30285260, 26198764