CD6 (CD6 molecule)

Gene

• Entrez ID: 923
• Gene name: CD6 molecule
• Gene symbol: CD6
• Synonyms: TP120
• Chromosome: 11
• Chromosome location: 11q12.2
• Summary: This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion mol

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT876092	hsa-let-7a	CLIP-seq
MIRT876093	hsa-let-7b	CLIP-seq
MIRT876094	hsa-let-7c	CLIP-seq
MIRT876095	hsa-let-7d	CLIP-seq
MIRT876096	hsa-let-7e	CLIP-seq
MIRT876097	hsa-let-7f	CLIP-seq
MIRT876098	hsa-let-7g	CLIP-seq
MIRT876099	hsa-let-7i	CLIP-seq
MIRT876100	hsa-miR-103a	CLIP-seq
MIRT876101	hsa-miR-107	CLIP-seq
MIRT876102	hsa-miR-1184	CLIP-seq
MIRT876103	hsa-miR-1226	CLIP-seq
MIRT876104	hsa-miR-1470	CLIP-seq
MIRT876105	hsa-miR-15a	CLIP-seq
MIRT876106	hsa-miR-15b	CLIP-seq
MIRT876107	hsa-miR-16	CLIP-seq
MIRT876108	hsa-miR-1915	CLIP-seq
MIRT876109	hsa-miR-195	CLIP-seq
MIRT876110	hsa-miR-1976	CLIP-seq
MIRT876111	hsa-miR-324-5p	CLIP-seq
MIRT876112	hsa-miR-335	CLIP-seq
MIRT876113	hsa-miR-3622b-5p	CLIP-seq
MIRT876114	hsa-miR-424	CLIP-seq
MIRT876115	hsa-miR-4290	CLIP-seq
MIRT876116	hsa-miR-4458	CLIP-seq
MIRT876117	hsa-miR-4500	CLIP-seq
MIRT876118	hsa-miR-4667-3p	CLIP-seq
MIRT876119	hsa-miR-4720-5p	CLIP-seq
MIRT876120	hsa-miR-4726-3p	CLIP-seq
MIRT876121	hsa-miR-4799-3p	CLIP-seq
MIRT876122	hsa-miR-497	CLIP-seq
MIRT876123	hsa-miR-665	CLIP-seq
MIRT876124	hsa-miR-98	CLIP-seq
MIRT876123	hsa-miR-665	CLIP-seq
MIRT876118	hsa-miR-4667-3p	CLIP-seq
MIRT876100	hsa-miR-103a	CLIP-seq
MIRT876101	hsa-miR-107	CLIP-seq
MIRT876102	hsa-miR-1184	CLIP-seq
MIRT876105	hsa-miR-15a	CLIP-seq
MIRT876106	hsa-miR-15b	CLIP-seq
MIRT876107	hsa-miR-16	CLIP-seq
MIRT876109	hsa-miR-195	CLIP-seq
MIRT876110	hsa-miR-1976	CLIP-seq
MIRT2385754	hsa-miR-296-5p	CLIP-seq
MIRT876114	hsa-miR-424	CLIP-seq
MIRT876115	hsa-miR-4290	CLIP-seq
MIRT876118	hsa-miR-4667-3p	CLIP-seq
MIRT876122	hsa-miR-497	CLIP-seq
MIRT876092	hsa-let-7a	CLIP-seq
MIRT876093	hsa-let-7b	CLIP-seq
MIRT876094	hsa-let-7c	CLIP-seq
MIRT876095	hsa-let-7d	CLIP-seq
MIRT876096	hsa-let-7e	CLIP-seq
MIRT876097	hsa-let-7f	CLIP-seq
MIRT876098	hsa-let-7g	CLIP-seq
MIRT876099	hsa-let-7i	CLIP-seq
MIRT876103	hsa-miR-1226	CLIP-seq
MIRT876112	hsa-miR-335	CLIP-seq
MIRT876116	hsa-miR-4458	CLIP-seq
MIRT876117	hsa-miR-4500	CLIP-seq
MIRT876124	hsa-miR-98	CLIP-seq
MIRT2677759	hsa-miR-3195	CLIP-seq
MIRT2677760	hsa-miR-330-3p	CLIP-seq
MIRT2677761	hsa-miR-4269	CLIP-seq
MIRT2677762	hsa-miR-4514	CLIP-seq
MIRT2677763	hsa-miR-4692	CLIP-seq
MIRT2677764	hsa-miR-4742-5p	CLIP-seq
MIRT2677765	hsa-miR-510	CLIP-seq
MIRT2677766	hsa-miR-518a-3p	CLIP-seq
MIRT2677767	hsa-miR-518b	CLIP-seq
MIRT2677768	hsa-miR-518c	CLIP-seq
MIRT2677769	hsa-miR-518d-3p	CLIP-seq
MIRT2677770	hsa-miR-518f	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ETS1	Unknown	19446338
RUNX1	Unknown	19446338
RUNX3	Unknown	19446338

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001530	Function	Lipopolysaccharide binding	IDA	17601777
GO:0001771	Process	Immunological synapse formation	IMP	15294938
GO:0001772	Component	Immunological synapse	IDA	15294938
GO:0002250	Process	Adaptive immune response	IEA
GO:0002438	Process	Acute inflammatory response to antigenic stimulus	IDA	17601777
GO:0005044	Function	Scavenger receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	24584089, 24945728, 26146185
GO:0005576	Component	Extracellular region	IEA
GO:0005887	Component	Integral component of plasma membrane	TAS	1919444
GO:0006897	Process	Endocytosis	IEA
GO:0007157	Process	Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP	16352806
GO:0009897	Component	External side of plasma membrane	IBA	21873635
GO:0031226	Component	Intrinsic component of plasma membrane	IDA	15294938
GO:0031663	Process	Lipopolysaccharide-mediated signaling pathway	IDA	17601777
GO:0032496	Process	Response to lipopolysaccharide	IDA	17601777
GO:0042101	Component	T cell receptor complex	IDA	15294938
GO:0042102	Process	Positive regulation of T cell proliferation	IMP	15294938
GO:0042802	Function	Identical protein binding	IPI	26146185
GO:0045087	Process	Innate immune response	IEA
GO:0070891	Function	Lipoteichoic acid binding	IMP	17601777
GO:1900017	Process	Positive regulation of cytokine production involved in inflammatory response	IDA	17601777

Other IDs

• MIM: 186720
• HGNC: 1691
• e!Ensembl: ENSG00000013725

Protein

• UniProt ID: P30203
• Protein name: T-cell differentiation antigen CD6 (T12) (TP120) (CD antigen CD6) [Cleaved into: Soluble CD6]
• Protein function: Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24584089, PubMed:24945728). Contributes to si
• PDB: 5A2E
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00530	SRCR	48 → 156	Scavenger receptor cysteine-rich domain	Domain
  PF00530	SRCR	164 → 260	Scavenger receptor cysteine-rich domain	Domain
  PF00530	SRCR	268 → 361	Scavenger receptor cysteine-rich domain	Domain

• Sequence:

  MWLFFGITGLLTAALSGHPSPAPPDQLNTSSAESELWEPGERLPVRLTNGSSSCSGTVEV
  RLEASWEPACGALWDSRAAEAVCRALGCGGAEAASQLAPPTPELPPPPAAGNTSVAANAT
  LAGAPALLCSGAEWRLCEVVEHACRSDGRRARVTCAENRALRLVDGGGACAGRVEMLEHG
  EWGSVCDDTWDLEDAHVVCRQLGCGWAVQALPGLHFTPGRGPIHRDQVNCSGAEAYLWDC
  PGLPGQHYCGHKEDAGAVCSEHQSWRLTGGADRCEGQVEVHFRGVWNTVCDSEWYPSEAK
  VLCQSLGCGTAVERPKGLPHSLSGRMYYSCNGEELTLSNCSWRFNNSNLCSQSLAARVLC
  SASRSLHNLSTPEVPASVQTVTIESSVTVKIENKESRELMLLIPSIVLGILLLGSLIFIA
  FILLRIKGKYALPVMVNHQHLPTTIPAGSNSYQPVPITIPKEVFMLPIQVQAPPPEDSDS
  GSDSDYEHYDFSAQPPVALTTFYNSQRHRVTDEEVQQSRFQMPPLEEGLEELHASHIPTA
  NPGHCITDPPSLGPQYHPRSNSESSTSSGEDYCNSPKSKLPPWNPQVFSSERSSFLEQPP
  NLELAGTQPAFSAGPPADDSSSTSSGEWYQNFQPPPQPPSEEQFGCPGSPSPQPDSTDND
  DYDDISAA

• Sequence length: 668

Pathways

KEGG:

Cell adhesion molecules

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Inflammatory bowel disease	Inflammatory Bowel Diseases	rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs139868987, rs750447828, rs368138379, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468	23128233, 26192919
Multiple sclerosis	Multiple Sclerosis, Multiple Sclerosis, Acute Fulminating	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039, rs483353038, rs61731956, rs568165874, rs767480544	24076602, 19525953, 21833088, 24076602, 19525953
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	26974007

Unknown
Disease name	Disease term	dbSNP ID	References
Ankylosing spondylitis	Ankylosing spondylitis		26974007
Cholangitis	Cholangitis, Sclerosing		26974007
Crohn disease	Crohn Disease	rs2066847, rs2066844, rs886052047, rs5743265, rs111608429, rs104895438	26192919, 26974007
Ulcerative colitis	Ulcerative Colitis		26974007, 26192919