DLGAP1 (DLG associated protein 1)

Gene

• Entrez ID: 9229
• Gene name: DLG associated protein 1
• Gene symbol: DLGAP1
• Synonyms: DAP-1, DAP-1-ALPHA, DAP-1-BETA, DAP1, DLGAP1A, DLGAP1B, GKAP, SAPAP1
• Chromosome: 18
• Chromosome location: 18p11.31

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT938489	hsa-miR-125a-5p	CLIP-seq
MIRT938490	hsa-miR-125b	CLIP-seq
MIRT938491	hsa-miR-186	CLIP-seq
MIRT938492	hsa-miR-3140-3p	CLIP-seq
MIRT938493	hsa-miR-3942-3p	CLIP-seq
MIRT938494	hsa-miR-4319	CLIP-seq
MIRT938495	hsa-miR-4446-5p	CLIP-seq
MIRT938496	hsa-miR-4686	CLIP-seq
MIRT938497	hsa-miR-4732-3p	CLIP-seq
MIRT938498	hsa-miR-4755-5p	CLIP-seq
MIRT938499	hsa-miR-4775	CLIP-seq
MIRT938500	hsa-miR-670	CLIP-seq
MIRT938501	hsa-miR-3182	CLIP-seq
MIRT938502	hsa-miR-3672	CLIP-seq
MIRT938503	hsa-miR-4461	CLIP-seq
MIRT1977686	hsa-miR-3944-5p	CLIP-seq
MIRT2428266	hsa-miR-137	CLIP-seq
MIRT938493	hsa-miR-3942-3p	CLIP-seq
MIRT2428267	hsa-miR-3977	CLIP-seq
MIRT2448302	hsa-miR-1291	CLIP-seq
MIRT2448303	hsa-miR-328	CLIP-seq
MIRT2448304	hsa-miR-34a	CLIP-seq
MIRT2448305	hsa-miR-34c-5p	CLIP-seq
MIRT2448306	hsa-miR-449a	CLIP-seq
MIRT2448307	hsa-miR-449b	CLIP-seq
MIRT2448308	hsa-miR-4639-3p	CLIP-seq
MIRT2448309	hsa-miR-4715-5p	CLIP-seq
MIRT2448310	hsa-miR-4727-5p	CLIP-seq
MIRT2448311	hsa-miR-4769-3p	CLIP-seq
MIRT2448312	hsa-miR-4799-5p	CLIP-seq
MIRT2516876	hsa-miR-145	CLIP-seq
MIRT2516877	hsa-miR-181a	CLIP-seq
MIRT2516878	hsa-miR-181b	CLIP-seq
MIRT2516879	hsa-miR-181c	CLIP-seq
MIRT2516880	hsa-miR-181d	CLIP-seq
MIRT2516881	hsa-miR-4262	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17474147, 20936779, 22117215
GO:0005575	Component	Cellular_component	ND
GO:0005886	Component	Plasma membrane	TAS
GO:0007268	Process	Chemical synaptic transmission	NAS	9286858
GO:0014069	Component	Postsynaptic density	IEA
GO:0044877	Function	Protein-containing complex binding	ISS
GO:0060090	Function	Molecular adaptor activity	IBA	21873635
GO:0098962	Process	Regulation of postsynaptic neurotransmitter receptor activity	IBA	21873635
GO:0098978	Component	Glutamatergic synapse	IBA	21873635
GO:0099572	Component	Postsynaptic specialization	IBA	21873635

Other IDs

• MIM: 605445
• HGNC: 2905
• e!Ensembl: ENSG00000170579

Protein

• UniProt ID: O14490
• Protein name: Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (hGKAP) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1)
• Protein function: Part of the postsynaptic scaffold in neuronal cells.
• PDB: 5YPO, 6TNQ, 6TQ0
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03359	GKAP	645 → 977	Guanylate-kinase-associated protein (GKAP) protein	Family

• Sequence:

  MKGLSGSRSHHHGVTCDSACDSLSHHSDRKPYLLSPVEHHPADHPYYTQRNSFQAECVGP
  FSDPLASSTFPRRHYTSQQELKDECALVPRTLATKANRIPANLLDQFERQLPLSRDGYHT
  LQYKRTAVEHRSDSPGRIRHLVHSVQKLFTKSHSLEGPSKGSVNGGKASPDEAQAARYGK
  RSKSKERRAEPKARPSTSPGWWSSDDNLDGDMCIYHAPSGVMTMGRCPDRSASQYFLEAY
  NTISEQAVKASRSNNDVKCSTCANLPVSLDTPLLKKSAWSSTLTVSRAREVYQKASVNMD
  QAMVKSESCQQERSCQYLQVPQDEWTGYTPRGKDDEIPCRRMRSGSYIKAMGDEDSGDSD
  TSPKPSPKVAARRESYLKATQPSLTELTTLKISNEHSPKLQIRSHSYLRAVSEVSINRSL
  DSLDPAGLLTSPKFRSRNESYMRAMSTISQVSEMEVNGQFESVCESVFSELESQAVEALD
  LPMPGCFRMRSHSYVRAIEKGCSQDDECVSLRSSSPPRTTTTVRTIQSSTVSSCITTYKK
  TPPPVPPRTTTKPFISITAQSSTESAQDAYMDGQGQRGDIISQSGLSNSTESLDSMKALT
  AAIEAANAQIHGPASQHMGNNTATVTTTTTIATVTTEDRKKDHFKKNRCLSIGIQVDDAE
  EPDKTGENKAPSKFQSVGVQVEEEKCFRRFTRSNSVTTAVQADLDFHDNLENSLESIEDN
  SCPGPMARQFSRDASTSTVSIQGSGNHYHACAADDDFDTDFDPSILPPPDPWIDSITEDP
  LEAVQRSVCHRDGHWFLKLLQAERDRMEGWCQQMEREERENNLPEDILGKIRTAVGSAQL
  LMAQKFYQFRELCEENLNPNAHPRPTSQDLAGFWDMLQLSIENISMKFDELHQLKANNWK
  QMDPLDKKERRAPPPVPKKPAKGPAPLIRERSLESSQRQEARKRLMAAKRAASVRQNSAT
  ESAESIEIYIPEAQTRL

• Sequence length: 977

Pathways

KEGG:

Glutamatergic synapse

Reactome:

Neurexins and neuroligins

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Narcolepsy	Narcolepsy	rs104894574, rs387906655	19629137
Neurodevelopmental disorders	Neurodevelopmental Disorders	rs869312846, rs869312840, rs869312848, rs869312849, rs869312845, rs886041956, rs1064795110, rs1555762734, rs1555764992, rs1568512728, rs1568532361, rs1595472741, rs1595472764, rs1595476797, rs1016320330, rs1595127294, rs1600392059	28191889
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	12950712, 12784099, 22940546

Unknown
Disease name	Disease term	dbSNP ID	References
Eczema	Eczema		30595370