MAGI1 (membrane associated guanylate kinase, WW and PDZ domain containing 1)

Gene

• Entrez ID: 9223
• Gene name: Membrane associated guanylate kinase, WW and PDZ domain containing 1
• Gene symbol: MAGI1
• Synonyms: AIP-3, AIP3, BAIAP1, BAP-1, BAP1, MAGI-1, MAGI-1b, Magi1d, TNRC19, WWP3
• Chromosome: 3
• Chromosome location: 3p14.1
• Summary: The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell con

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017415	hsa-miR-335-5p	Microarray	18185580
MIRT025370	hsa-miR-34a-5p	Sequencing	20371350
MIRT030459	hsa-miR-24-3p	Sequencing	20371350
MIRT042831	hsa-miR-324-3p	CLASH	23622248
MIRT1125832	hsa-miR-101	CLIP-seq
MIRT1125833	hsa-miR-1179	CLIP-seq
MIRT1125834	hsa-miR-1272	CLIP-seq
MIRT1125835	hsa-miR-1292	CLIP-seq
MIRT1125836	hsa-miR-1321	CLIP-seq
MIRT1125837	hsa-miR-139-5p	CLIP-seq
MIRT1125838	hsa-miR-140-3p	CLIP-seq
MIRT1125839	hsa-miR-140-5p	CLIP-seq
MIRT1125840	hsa-miR-142-3p	CLIP-seq
MIRT1125841	hsa-miR-144	CLIP-seq
MIRT1125842	hsa-miR-1470	CLIP-seq
MIRT1125843	hsa-miR-1827	CLIP-seq
MIRT1125844	hsa-miR-186	CLIP-seq
MIRT1125845	hsa-miR-1914	CLIP-seq
MIRT1125846	hsa-miR-2054	CLIP-seq
MIRT1125847	hsa-miR-224	CLIP-seq
MIRT1125848	hsa-miR-24	CLIP-seq
MIRT1125849	hsa-miR-2682	CLIP-seq
MIRT1125850	hsa-miR-27a	CLIP-seq
MIRT1125851	hsa-miR-27b	CLIP-seq
MIRT1125852	hsa-miR-298	CLIP-seq
MIRT1125853	hsa-miR-3123	CLIP-seq
MIRT1125854	hsa-miR-3145-3p	CLIP-seq
MIRT1125855	hsa-miR-3155	CLIP-seq
MIRT1125856	hsa-miR-3155b	CLIP-seq
MIRT1125857	hsa-miR-3160-5p	CLIP-seq
MIRT1125858	hsa-miR-3163	CLIP-seq
MIRT1125859	hsa-miR-3189-5p	CLIP-seq
MIRT1125860	hsa-miR-320a	CLIP-seq
MIRT1125861	hsa-miR-320b	CLIP-seq
MIRT1125862	hsa-miR-320c	CLIP-seq
MIRT1125863	hsa-miR-320d	CLIP-seq
MIRT1125864	hsa-miR-34c-3p	CLIP-seq
MIRT1125865	hsa-miR-3545-5p	CLIP-seq
MIRT1125866	hsa-miR-3613-3p	CLIP-seq
MIRT1125867	hsa-miR-3662	CLIP-seq
MIRT1125868	hsa-miR-3671	CLIP-seq
MIRT1125869	hsa-miR-3682-3p	CLIP-seq
MIRT1125870	hsa-miR-376a	CLIP-seq
MIRT1125871	hsa-miR-376b	CLIP-seq
MIRT1125872	hsa-miR-380	CLIP-seq
MIRT1125873	hsa-miR-3925-5p	CLIP-seq
MIRT1125874	hsa-miR-421	CLIP-seq
MIRT1125875	hsa-miR-4253	CLIP-seq
MIRT1125876	hsa-miR-4272	CLIP-seq
MIRT1125877	hsa-miR-4284	CLIP-seq
MIRT1125878	hsa-miR-4323	CLIP-seq
MIRT1125879	hsa-miR-4429	CLIP-seq
MIRT1125880	hsa-miR-4436b-5p	CLIP-seq
MIRT1125881	hsa-miR-4438	CLIP-seq
MIRT1125882	hsa-miR-4446-5p	CLIP-seq
MIRT1125883	hsa-miR-4460	CLIP-seq
MIRT1125884	hsa-miR-4471	CLIP-seq
MIRT1125885	hsa-miR-449c	CLIP-seq
MIRT1125886	hsa-miR-450b-3p	CLIP-seq
MIRT1125887	hsa-miR-4645-3p	CLIP-seq
MIRT1125888	hsa-miR-4648	CLIP-seq
MIRT1125889	hsa-miR-4654	CLIP-seq
MIRT1125890	hsa-miR-4667-3p	CLIP-seq
MIRT1125891	hsa-miR-4709-5p	CLIP-seq
MIRT1125892	hsa-miR-4713-3p	CLIP-seq
MIRT1125893	hsa-miR-4718	CLIP-seq
MIRT1125894	hsa-miR-4728-5p	CLIP-seq
MIRT1125895	hsa-miR-4739	CLIP-seq
MIRT1125896	hsa-miR-4755-5p	CLIP-seq
MIRT1125897	hsa-miR-4756-5p	CLIP-seq
MIRT1125898	hsa-miR-4769-5p	CLIP-seq
MIRT1125899	hsa-miR-484	CLIP-seq
MIRT1125900	hsa-miR-499-3p	CLIP-seq
MIRT1125901	hsa-miR-499a-3p	CLIP-seq
MIRT1125902	hsa-miR-499a-5p	CLIP-seq
MIRT1125903	hsa-miR-503	CLIP-seq
MIRT1125904	hsa-miR-513a-5p	CLIP-seq
MIRT1125905	hsa-miR-548ae	CLIP-seq
MIRT1125906	hsa-miR-548aj	CLIP-seq
MIRT1125907	hsa-miR-548am	CLIP-seq
MIRT1125908	hsa-miR-548x	CLIP-seq
MIRT1125909	hsa-miR-551a	CLIP-seq
MIRT1125910	hsa-miR-551b	CLIP-seq
MIRT1125911	hsa-miR-582-5p	CLIP-seq
MIRT1125912	hsa-miR-600	CLIP-seq
MIRT1125913	hsa-miR-638	CLIP-seq
MIRT1125914	hsa-miR-642a	CLIP-seq
MIRT1125915	hsa-miR-664	CLIP-seq
MIRT1125916	hsa-miR-769-3p	CLIP-seq
MIRT1125917	hsa-miR-940	CLIP-seq
MIRT1125834	hsa-miR-1272	CLIP-seq
MIRT1125918	hsa-miR-3663-3p	CLIP-seq
MIRT1125919	hsa-miR-433	CLIP-seq
MIRT1125920	hsa-miR-4646-5p	CLIP-seq
MIRT1125874	hsa-miR-421	CLIP-seq
MIRT1125891	hsa-miR-4709-5p	CLIP-seq
MIRT1125832	hsa-miR-101	CLIP-seq
MIRT1125833	hsa-miR-1179	CLIP-seq
MIRT2035547	hsa-miR-1228	CLIP-seq
MIRT2035548	hsa-miR-1245b-3p	CLIP-seq
MIRT2035549	hsa-miR-125a-3p	CLIP-seq
MIRT2035550	hsa-miR-1271	CLIP-seq
MIRT2035551	hsa-miR-1273d	CLIP-seq
MIRT1125842	hsa-miR-1470	CLIP-seq
MIRT2035552	hsa-miR-182	CLIP-seq
MIRT1125846	hsa-miR-2054	CLIP-seq
MIRT1125847	hsa-miR-224	CLIP-seq
MIRT1125850	hsa-miR-27a	CLIP-seq
MIRT1125851	hsa-miR-27b	CLIP-seq
MIRT2035553	hsa-miR-3074-3p	CLIP-seq
MIRT1125855	hsa-miR-3155	CLIP-seq
MIRT1125856	hsa-miR-3155b	CLIP-seq
MIRT2035554	hsa-miR-3157-5p	CLIP-seq
MIRT1125860	hsa-miR-320a	CLIP-seq
MIRT1125861	hsa-miR-320b	CLIP-seq
MIRT1125862	hsa-miR-320c	CLIP-seq
MIRT1125863	hsa-miR-320d	CLIP-seq
MIRT2035555	hsa-miR-331-5p	CLIP-seq
MIRT2035556	hsa-miR-342-3p	CLIP-seq
MIRT1125867	hsa-miR-3662	CLIP-seq
MIRT1125868	hsa-miR-3671	CLIP-seq
MIRT1125870	hsa-miR-376a	CLIP-seq
MIRT1125871	hsa-miR-376b	CLIP-seq
MIRT1125872	hsa-miR-380	CLIP-seq
MIRT2035557	hsa-miR-3934	CLIP-seq
MIRT2035558	hsa-miR-3977	CLIP-seq
MIRT2035559	hsa-miR-4269	CLIP-seq
MIRT1125877	hsa-miR-4284	CLIP-seq
MIRT1125879	hsa-miR-4429	CLIP-seq
MIRT1125882	hsa-miR-4446-5p	CLIP-seq
MIRT1125887	hsa-miR-4645-3p	CLIP-seq
MIRT2035560	hsa-miR-4661-3p	CLIP-seq
MIRT1125890	hsa-miR-4667-3p	CLIP-seq
MIRT1125891	hsa-miR-4709-5p	CLIP-seq
MIRT2035561	hsa-miR-4733-3p	CLIP-seq
MIRT1125896	hsa-miR-4755-5p	CLIP-seq
MIRT2035562	hsa-miR-4762-3p	CLIP-seq
MIRT2035563	hsa-miR-4796-5p	CLIP-seq
MIRT1125899	hsa-miR-484	CLIP-seq
MIRT1125900	hsa-miR-499-3p	CLIP-seq
MIRT1125901	hsa-miR-499a-3p	CLIP-seq
MIRT1125902	hsa-miR-499a-5p	CLIP-seq
MIRT1125904	hsa-miR-513a-5p	CLIP-seq
MIRT2035564	hsa-miR-518a-5p	CLIP-seq
MIRT2035565	hsa-miR-527	CLIP-seq
MIRT2035566	hsa-miR-561	CLIP-seq
MIRT2035567	hsa-miR-568	CLIP-seq
MIRT2035568	hsa-miR-586	CLIP-seq
MIRT2035569	hsa-miR-607	CLIP-seq
MIRT1125914	hsa-miR-642a	CLIP-seq
MIRT1125915	hsa-miR-664	CLIP-seq
MIRT2035570	hsa-miR-764	CLIP-seq
MIRT2035571	hsa-miR-96	CLIP-seq
MIRT1125832	hsa-miR-101	CLIP-seq
MIRT1125841	hsa-miR-144	CLIP-seq
MIRT2266058	hsa-miR-148a	CLIP-seq
MIRT2266059	hsa-miR-148b	CLIP-seq
MIRT2266060	hsa-miR-152	CLIP-seq
MIRT2266061	hsa-miR-323-3p	CLIP-seq
MIRT2266062	hsa-miR-4659a-5p	CLIP-seq
MIRT2266063	hsa-miR-4659b-5p	CLIP-seq
MIRT2266064	hsa-miR-4776-3p	CLIP-seq
MIRT1125911	hsa-miR-582-5p	CLIP-seq
MIRT1125832	hsa-miR-101	CLIP-seq
MIRT1125841	hsa-miR-144	CLIP-seq
MIRT2266061	hsa-miR-323-3p	CLIP-seq
MIRT1125911	hsa-miR-582-5p	CLIP-seq
MIRT1125838	hsa-miR-140-3p	CLIP-seq
MIRT1125844	hsa-miR-186	CLIP-seq
MIRT1125845	hsa-miR-1914	CLIP-seq
MIRT2565327	hsa-miR-193a-5p	CLIP-seq
MIRT1125866	hsa-miR-3613-3p	CLIP-seq
MIRT2565328	hsa-miR-4489	CLIP-seq
MIRT2565329	hsa-miR-4506	CLIP-seq
MIRT2565330	hsa-miR-4508	CLIP-seq
MIRT1125886	hsa-miR-450b-3p	CLIP-seq
MIRT2565331	hsa-miR-4532	CLIP-seq
MIRT1125888	hsa-miR-4648	CLIP-seq
MIRT1125889	hsa-miR-4654	CLIP-seq
MIRT1125892	hsa-miR-4713-3p	CLIP-seq
MIRT1125898	hsa-miR-4769-5p	CLIP-seq
MIRT2565332	hsa-miR-548c-3p	CLIP-seq
MIRT1125909	hsa-miR-551a	CLIP-seq
MIRT1125910	hsa-miR-551b	CLIP-seq
MIRT1125913	hsa-miR-638	CLIP-seq
MIRT1125916	hsa-miR-769-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	9647693, 11168587, 12097473, 12444549, 14627983, 16464232, 17267502, 22662192, 23873930
GO:0005524	Function	ATP binding	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	16464232, 20298433
GO:0005886	Component	Plasma membrane	IDA	20298433
GO:0005911	Component	Cell-cell junction	IBA	21873635
GO:0005911	Component	Cell-cell junction	IDA	20298433
GO:0005912	Component	Adherens junction	ISS
GO:0005923	Component	Bicellular tight junction	IEA
GO:0007155	Process	Cell adhesion	TAS	9647739
GO:0007165	Process	Signal transduction	IBA	21873635
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	9647739
GO:0008022	Function	Protein C-terminus binding	TAS	9647739
GO:0022409	Process	Positive regulation of cell-cell adhesion	IDA	20298433
GO:0030054	Component	Cell junction	IDA
GO:0042995	Component	Cell projection	IDA	16464232
GO:0051393	Function	Alpha-actinin binding	IPI	16464232
GO:0060090	Function	Molecular adaptor activity	IEA
GO:0065003	Process	Protein-containing complex assembly	NAS	9647739
GO:0071944	Component	Cell periphery	IDA	20298433

Other IDs

• MIM: 602625
• HGNC: 946
• e!Ensembl: ENSG00000151276

Protein

• UniProt ID: Q96QZ7
• Protein name: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (Atrophin-1-interacting protein 3) (AIP-3) (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Trinucleotide repeat-containing gene 19
• Protein function: Plays a role in coupling actin fibers to cell junctions in endothelial cells, via its interaction with AMOTL2 and CDH5 (By similarity). May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). {E
• PDB: 1WBP, 2KPK, 2KPL, 2Q9V, 2R4H, 2YSD, 2YSE, 2ZAJ, 3BPU, 5N7D, 5N7F, 5N7G, 6TWU, 6TWX, 6TWY, 7P71
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00625	Guanylate_kin	126 → 200	Guanylate kinase	Domain
  PF16663	MAGI_u1	202 → 261		Disordered
  PF00397	WW	302 → 331	WW domain	Domain
  PF00397	WW	361 → 390	WW domain	Domain
  PF00595	PDZ	472 → 552	PDZ domain	Domain
  PF00595	PDZ	642 → 720	PDZ domain	Domain
  PF16666	MAGI_u5	722 → 840		Disordered
  PF00595	PDZ	841 → 922	PDZ domain	Domain
  PF00595	PDZ	998 → 1091	PDZ domain	Domain
  PF00595	PDZ	1152 → 1231	PDZ domain	Domain

• Sequence:

  MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGE
  GPRLGEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRF
  QKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYNFLTVKEFLDLEQSGTLLEVG
  TYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEE
  EDDVPEMNSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLG
  PLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELE
  LPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQ
  QTEEWTEDHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSR
  GFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQ
  SIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTG
  KVNGMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADS
  PGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLVQ
  RGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQ
  TDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQ
  DIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKS
  HQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQ
  GSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRP
  EAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIK
  EAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFK
  APQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEIL
  EINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQGVPEVR
  AGPDRRQHPSLESSYPPDLHKSSPHGEKRAHARDPKGSREYSRQPNEHHTWNGTSRKPDS
  GACRPKDRAPEGRRDAQAERAAAANGPKRRSPEKRREGTRSADNTLERREKHEKRRDVSP
  ERRRERSPTRRRDGSPSRRRRSLERLLEQRRSPERRRGGSPERRAKSTDRRRARSPERRR
  ERSLDKRNREDRASHREREEANLKQDAGRSSRHPPEQRRRPYKECSTDLSI

• Sequence length: 1491

Pathways

KEGG:

Rap1 signaling pathway
PI3K-Akt signaling pathway
Tight junction
Human papillomavirus infection

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Adenocarcinoma	Adenoid Cystic Carcinoma	rs121913530, rs886039394, rs121913474	23685749
Narcolepsy	Narcolepsy	rs104894574, rs387906655	19629137
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	22381734

Unknown
Disease name	Disease term	dbSNP ID	References
Anxiety disorder	Anxiety		29942085
Bipolar disorder	Bipolar Disorder		22381734, 24215895
Crohn disease	Crohn Disease	rs2066847, rs2066844, rs886052047, rs5743265, rs111608429, rs104895438	25557950
Knee osteoarthritis	Osteoarthritis, Knee		28916551
Major affective disorder	MAJOR AFFECTIVE DISORDER 2	rs1601436804	22381734