INTS4 (integrator complex subunit 4)

Gene

• Entrez ID: 92105
• Gene name: Integrator complex subunit 4
• Gene symbol: INTS4
• Synonyms: INT4, MST093
• Chromosome: 11
• Chromosome location: 11q14.1
• Summary: INTS4 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Ba

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020869	hsa-miR-155-5p	Proteomics	18668040
MIRT048141	hsa-miR-197-3p	CLASH	23622248
MIRT037855	hsa-miR-455-3p	CLASH	23622248
MIRT2016593	hsa-miR-3154	CLIP-seq
MIRT2016594	hsa-miR-3653	CLIP-seq
MIRT2016595	hsa-miR-4425	CLIP-seq
MIRT2016596	hsa-miR-452	CLIP-seq
MIRT2016597	hsa-miR-4676-3p	CLIP-seq
MIRT2016598	hsa-miR-4717-5p	CLIP-seq
MIRT2016599	hsa-miR-4747-5p	CLIP-seq
MIRT2016600	hsa-miR-645	CLIP-seq
MIRT2016601	hsa-miR-7	CLIP-seq
MIRT2016593	hsa-miR-3154	CLIP-seq
MIRT2016594	hsa-miR-3653	CLIP-seq
MIRT2016598	hsa-miR-4717-5p	CLIP-seq
MIRT2016600	hsa-miR-645	CLIP-seq
MIRT2016593	hsa-miR-3154	CLIP-seq
MIRT2016594	hsa-miR-3653	CLIP-seq
MIRT2016598	hsa-miR-4717-5p	CLIP-seq
MIRT2016600	hsa-miR-645	CLIP-seq
MIRT2016593	hsa-miR-3154	CLIP-seq
MIRT2016594	hsa-miR-3653	CLIP-seq
MIRT2016598	hsa-miR-4717-5p	CLIP-seq
MIRT2016600	hsa-miR-645	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16239144, 25416956, 31515488
GO:0005634	Component	Nucleus	IDA	23904267
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA
GO:0016180	Process	SnRNA processing	IBA	21873635
GO:0016180	Process	SnRNA processing	IDA	16239144
GO:0032039	Component	Integrator complex	IBA	21873635
GO:0032039	Component	Integrator complex	IDA	16239144
GO:0042795	Process	SnRNA transcription by RNA polymerase II	TAS

Other IDs

• MIM: 611348
• HGNC: 25048
• e!Ensembl: ENSG00000149262

Protein

• UniProt ID: Q96HW7
• Protein name: Integrator complex subunit 4 (Int4)
• Protein function: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:29471365, PubMed:33243860, PubMed:33548203, PubMed:38570683). The integrator co
• PDB: 7BFP, 7BFQ, 7CUN, 7PKS, 7YCX, 8R2D, 8RBX, 8RBZ, 8RC4, 8YJB
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12765	Cohesin_HEAT	178 → 218	HEAT repeat associated with sister chromatid cohesion	Family

• Sequence:

  MAAHLKKRVYEEFTKVVQPQEEIATKKLRLTKPSKSAALHIDLCKATSPADALQYLLQFA
  RKPVEAESVEGVVRILLEHYYKENDPSVRLKIASLLGLLSKTAGFSPDCIMDDAINILQN
  EKSHQVLAQLLDTLLAIGTKLPENQAIQMRLVDVACKHLTDTSHGVRNKCLQLLGNLGSL
  EKSVTKDAEGLAARDVQKIIGDYFSDQDPRVRTAAIKAMLQLHERGLKLHQTIYNQACKL
  LSDDYEQVRSAAVQLIWVVSQLYPESIVPIPSSNEEIRLVDDAFGKICHMVSDGSWVVRV
  QAAKLLGSMEQVSSHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPK
  EEVDTGAVNLIESGACGAFVHGLEDEMYEVRIAAVEALCMLAQSSPSFAEKCLDFLVDMF
  NDEIEEVRLQSIHTMRKISNNITLREDQLDTVLAVLEDSSRDIREALHELLCCTNVSTKE
  GIHLALVELLKNLTKYPTDRDSIWKCLKFLGSRHPTLVLPLVPELLSTHPFFDTAEPDMD
  DPAYIAVLVLIFNAAKTCPTMPALFSDHTFRHYAYLRDSLSHLVPALRLPGRKLVSSAVS
  PSIIPQEDPSQQFLQQSLERVYSLQHLDPQGAQELLEFTIRDLQRLGELQSELAGVADFS
  ATYLRCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVENKQVV
  IIHHMRLQAKALQLIVTARTTRGLDPLFGMCEKFLQEVDFFQRYFIADLPHLQDSFVDKL
  LDLMPRLMTSKPAEVVKILQTMLRQSAFLHLPLPEQIHKASATIIEPAGESDNPLRFTSG
  LVVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLITQVYLSH
  TAWTEACQVEVRLLLAYNSSARIPKCPWMEGGEMSPQVETSIEGTIPFSKPVKVYIMPKP
  ARR

• Sequence length: 963

Pathways

Reactome:

RNA polymerase II transcribes snRNA genes

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	24763052

Unknown
Disease name	Disease term	dbSNP ID	References
Prostatic neoplasms	Prostatic Neoplasms		24763052