SLC16A7 (solute carrier family 16 member 7)

Gene

• Entrez ID: 9194
• Gene name: Solute carrier family 16 member 7
• Gene symbol: SLC16A7
• Synonyms: MCT2
• Chromosome: 12
• Chromosome location: 12q14.1
• Summary: This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024296	hsa-miR-215-5p	Microarray	19074876
MIRT026289	hsa-miR-192-5p	Microarray	19074876
MIRT467931	hsa-miR-4464	PAR-CLIP	23592263
MIRT467930	hsa-miR-4748	PAR-CLIP	23592263
MIRT467929	hsa-miR-329-5p	PAR-CLIP	23592263
MIRT467928	hsa-miR-892c-5p	PAR-CLIP	23592263
MIRT467927	hsa-miR-506-5p	PAR-CLIP	23592263
MIRT467926	hsa-miR-759	PAR-CLIP	23592263
MIRT467925	hsa-miR-4729	PAR-CLIP	23592263
MIRT467924	hsa-miR-20a-3p	PAR-CLIP	23592263
MIRT467923	hsa-miR-496	PAR-CLIP	23592263
MIRT467922	hsa-miR-4423-3p	PAR-CLIP	23592263
MIRT467931	hsa-miR-4464	PAR-CLIP	23592263
MIRT467930	hsa-miR-4748	PAR-CLIP	23592263
MIRT467929	hsa-miR-329-5p	PAR-CLIP	23592263
MIRT467928	hsa-miR-892c-5p	PAR-CLIP	23592263
MIRT467927	hsa-miR-506-5p	PAR-CLIP	23592263
MIRT467926	hsa-miR-759	PAR-CLIP	23592263
MIRT467925	hsa-miR-4729	PAR-CLIP	23592263
MIRT467924	hsa-miR-20a-3p	PAR-CLIP	23592263
MIRT467923	hsa-miR-496	PAR-CLIP	23592263
MIRT467922	hsa-miR-4423-3p	PAR-CLIP	23592263
MIRT1353213	hsa-miR-105	CLIP-seq
MIRT1353214	hsa-miR-1297	CLIP-seq
MIRT1353215	hsa-miR-132	CLIP-seq
MIRT1353216	hsa-miR-188-3p	CLIP-seq
MIRT1353217	hsa-miR-1915	CLIP-seq
MIRT1353218	hsa-miR-2053	CLIP-seq
MIRT1353219	hsa-miR-212	CLIP-seq
MIRT1353220	hsa-miR-224	CLIP-seq
MIRT1353221	hsa-miR-26a	CLIP-seq
MIRT1353222	hsa-miR-26b	CLIP-seq
MIRT1353223	hsa-miR-302a	CLIP-seq
MIRT1353224	hsa-miR-302b	CLIP-seq
MIRT1353225	hsa-miR-302c	CLIP-seq
MIRT1353226	hsa-miR-302d	CLIP-seq
MIRT1353227	hsa-miR-302e	CLIP-seq
MIRT1353228	hsa-miR-3145-3p	CLIP-seq
MIRT1353229	hsa-miR-3166	CLIP-seq
MIRT1353230	hsa-miR-331-5p	CLIP-seq
MIRT1353231	hsa-miR-372	CLIP-seq
MIRT1353232	hsa-miR-373	CLIP-seq
MIRT1353233	hsa-miR-409-3p	CLIP-seq
MIRT1353234	hsa-miR-4282	CLIP-seq
MIRT1353235	hsa-miR-4289	CLIP-seq
MIRT1353236	hsa-miR-4446-5p	CLIP-seq
MIRT1353237	hsa-miR-4465	CLIP-seq
MIRT1353238	hsa-miR-4726-3p	CLIP-seq
MIRT1353239	hsa-miR-4733-5p	CLIP-seq
MIRT1353240	hsa-miR-4735-5p	CLIP-seq
MIRT1353241	hsa-miR-4755-5p	CLIP-seq
MIRT1353242	hsa-miR-4769-3p	CLIP-seq
MIRT1353243	hsa-miR-4771	CLIP-seq
MIRT1353244	hsa-miR-4774-5p	CLIP-seq
MIRT1353245	hsa-miR-4799-5p	CLIP-seq
MIRT1353246	hsa-miR-499a-5p	CLIP-seq
MIRT1353247	hsa-miR-512-3p	CLIP-seq
MIRT1353248	hsa-miR-520a-3p	CLIP-seq
MIRT1353249	hsa-miR-520b	CLIP-seq
MIRT1353250	hsa-miR-520c-3p	CLIP-seq
MIRT1353251	hsa-miR-520d-3p	CLIP-seq
MIRT1353252	hsa-miR-520d-5p	CLIP-seq
MIRT1353253	hsa-miR-520e	CLIP-seq
MIRT1353254	hsa-miR-524-5p	CLIP-seq
MIRT1353255	hsa-miR-548c-3p	CLIP-seq
MIRT1353256	hsa-miR-7	CLIP-seq
MIRT1353257	hsa-miR-764	CLIP-seq
MIRT1353258	hsa-miR-944	CLIP-seq
MIRT2104570	hsa-miR-1246	CLIP-seq
MIRT2104571	hsa-miR-3122	CLIP-seq
MIRT2104572	hsa-miR-3607-5p	CLIP-seq
MIRT2104573	hsa-miR-3913-5p	CLIP-seq
MIRT2104574	hsa-miR-450b-3p	CLIP-seq
MIRT2104575	hsa-miR-490-5p	CLIP-seq
MIRT2104576	hsa-miR-769-3p	CLIP-seq
MIRT2623474	hsa-miR-1236	CLIP-seq
MIRT1353217	hsa-miR-1915	CLIP-seq
MIRT2623475	hsa-miR-200b	CLIP-seq
MIRT2623476	hsa-miR-200c	CLIP-seq
MIRT2623477	hsa-miR-3143	CLIP-seq
MIRT2623478	hsa-miR-3612	CLIP-seq
MIRT2623479	hsa-miR-3646	CLIP-seq
MIRT2623480	hsa-miR-3662	CLIP-seq
MIRT2623481	hsa-miR-3675-3p	CLIP-seq
MIRT2623482	hsa-miR-4263	CLIP-seq
MIRT2623483	hsa-miR-429	CLIP-seq
MIRT2623484	hsa-miR-4459	CLIP-seq
MIRT2623485	hsa-miR-4695-5p	CLIP-seq
MIRT2623486	hsa-miR-4698	CLIP-seq
MIRT1353238	hsa-miR-4726-3p	CLIP-seq
MIRT1353239	hsa-miR-4733-5p	CLIP-seq
MIRT1353242	hsa-miR-4769-3p	CLIP-seq
MIRT2623487	hsa-miR-495	CLIP-seq
MIRT2623488	hsa-miR-543	CLIP-seq
MIRT2623489	hsa-miR-548aa	CLIP-seq
MIRT2623490	hsa-miR-576-5p	CLIP-seq
MIRT2623491	hsa-miR-650	CLIP-seq
MIRT2623492	hsa-miR-665	CLIP-seq
MIRT2690902	hsa-miR-136	CLIP-seq
MIRT2623475	hsa-miR-200b	CLIP-seq
MIRT2623476	hsa-miR-200c	CLIP-seq
MIRT2690903	hsa-miR-3117-5p	CLIP-seq
MIRT2104571	hsa-miR-3122	CLIP-seq
MIRT2623477	hsa-miR-3143	CLIP-seq
MIRT2623479	hsa-miR-3646	CLIP-seq
MIRT2623480	hsa-miR-3662	CLIP-seq
MIRT2104573	hsa-miR-3913-5p	CLIP-seq
MIRT2690904	hsa-miR-410	CLIP-seq
MIRT2623482	hsa-miR-4263	CLIP-seq
MIRT2623483	hsa-miR-429	CLIP-seq
MIRT2104574	hsa-miR-450b-3p	CLIP-seq
MIRT2623486	hsa-miR-4698	CLIP-seq
MIRT2690905	hsa-miR-515-5p	CLIP-seq
MIRT2623488	hsa-miR-543	CLIP-seq
MIRT2623489	hsa-miR-548aa	CLIP-seq
MIRT2623490	hsa-miR-576-5p	CLIP-seq
MIRT2104576	hsa-miR-769-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005477	Function	Pyruvate secondary active transmembrane transporter activity	TAS	9786900
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	IDA	15505343
GO:0008028	Function	Monocarboxylic acid transmembrane transporter activity	IBA	21873635
GO:0015129	Function	Lactate transmembrane transporter activity	IDA	9786900
GO:0015293	Function	Symporter activity	IEA
GO:0015718	Process	Monocarboxylic acid transport	IBA	21873635
GO:0016021	Component	Integral component of membrane	IBA	21873635
GO:0035873	Process	Lactate transmembrane transport	IMP	9786900
GO:0050833	Function	Pyruvate transmembrane transporter activity	IDA	9786900
GO:0150104	Process	Transport across blood-brain barrier	NAS	26590417
GO:1901475	Process	Pyruvate transmembrane transport	IDA	9786900

Other IDs

• MIM: 603654
• HGNC: 10928
• e!Ensembl: ENSG00000118596

Protein

• UniProt ID: O60669
• Protein name: Monocarboxylate transporter 2 (MCT 2) (Solute carrier family 16 member 7)
• Protein function: Proton-coupled monocarboxylate symporter. Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate (PubMed:32415067, PubMed:9786900
• PDB: 7BP3
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07690	MFS_1	21 → 390	Major Facilitator Superfamily	Family

• Sequence:

  MPPMPSAPPVHPPPDGGWGWIVVGAAFISIGFSYAFPKAVTVFFKEIQQIFHTTYSEIAW
  ISSIMLAVMYAGGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFIT
  GLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLI
  LGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFS
  LFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSV
  GLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFE
  TLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVW
  LLIGNAINYRLLAKERKEENARQKTRESEPLSKSKHSEDVNVKVSNAQSVTSERETNI

• Sequence length: 478

Pathways

Reactome:

Proton-coupled monocarboxylate transport

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs145518263, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316	20885792
Asthma	Asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	26031901
Obesity	Obesity	rs34911341, rs74315349, rs1474810899, rs2282440, rs2491132, rs121918111, rs796065034, rs753856820, rs796065035, rs121918112, rs104894023, rs137852821, rs1580764441, rs137852822, rs137852823, rs137852824, rs13447324, rs121913562, rs121913564, rs74315393, rs121913556, rs2989924, rs193922650, rs193922685, rs193922687, rs751160202, rs1421085, rs747681609, rs1553400259, rs13447339, rs370479598, rs1554394014, rs1553174844, rs756232889, rs369841551, rs1557670950, rs1571321748, rs148538980, rs1572820988, rs1591461970, rs1419374563, rs745921568, rs144159890, rs1570714352, rs779783209, rs1573250294, rs1573254045, rs1580744791, rs1580746829, rs6548238, rs7138803, rs7754840	20882379

Unknown
Disease name	Disease term	dbSNP ID	References
Proliferative diabetic retinopathy	Proliferative diabetic retinopathy		30487263