Gene
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
9189 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Zinc finger BED-type containing 1 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
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ZBED1 |
SynonymsGene synonyms aliases
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ALTE, DREF, TRAMP, hDREF |
ChromosomeChromosome number
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X|Y |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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X;Y |
SummarySummary of gene provided in NCBI Entrez Gene.
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This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene pro |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0000785 |
Component |
Chromatin |
ISA |
|
GO:0000978 |
Function |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
IDA |
17220279 |
GO:0000981 |
Function |
DNA-binding transcription factor activity, RNA polymerase II-specific |
ISA |
|
GO:0001228 |
Function |
DNA-binding transcription activator activity, RNA polymerase II-specific |
IDA |
17220279 |
GO:0003712 |
Function |
Transcription coregulator activity |
IDA |
25210186 |
GO:0003713 |
Function |
Transcription coactivator activity |
IDA |
27068747 |
GO:0003713 |
Function |
Transcription coactivator activity |
IMP |
17209048 |
GO:0005515 |
Function |
Protein binding |
IPI |
16713569, 17209048, 21516116, 25210186, 25416956, 25910212, 27068747, 32296183 |
GO:0005634 |
Component |
Nucleus |
IBA |
21873635 |
GO:0005634 |
Component |
Nucleus |
IDA |
17209048 |
GO:0005654 |
Component |
Nucleoplasm |
IDA |
|
GO:0005654 |
Component |
Nucleoplasm |
TAS |
|
GO:0005813 |
Component |
Centrosome |
IDA |
|
GO:0006355 |
Process |
Regulation of transcription, DNA-templated |
IDA |
25210186, 27068747 |
GO:0006357 |
Process |
Regulation of transcription by RNA polymerase II |
IBA |
21873635 |
GO:0016032 |
Process |
Viral process |
IEA |
|
GO:0016605 |
Component |
PML body |
IDA |
25210186, 27068747 |
GO:0019789 |
Function |
SUMO transferase activity |
EXP |
27068747 |
GO:0031965 |
Component |
Nuclear membrane |
IDA |
|
GO:0042802 |
Function |
Identical protein binding |
IPI |
17209048, 25416956, 32296183 |
GO:0043565 |
Function |
Sequence-specific DNA binding |
IDA |
23332764 |
GO:0044828 |
Process |
Negative regulation by host of viral genome replication |
IDA |
25210186 |
GO:0045944 |
Process |
Positive regulation of transcription by RNA polymerase II |
IDA |
17220279 |
GO:0046872 |
Function |
Metal ion binding |
IEA |
|
GO:0046983 |
Function |
Protein dimerization activity |
IEA |
|
GO:0061665 |
Function |
SUMO ligase activity |
IDA |
27068747 |
GO:1990466 |
Process |
Protein autosumoylation |
IMP |
27068747 |
GO:1990837 |
Function |
Sequence-specific double-stranded DNA binding |
IDA |
28473536 |
|
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
O96006 |
Protein name |
E3 SUMO-protein ligase ZBED1 (EC 2.3.2.-) (DNA replication-related element-binding factor) (Putative Ac-like transposable element) (Zinc finger BED domain-containing protein 1) (dREF homolog) |
Protein function |
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA (PubMed:27068747). This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of |
PDB |
2CT5
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF02892 |
zf-BED |
23 → 72 |
BED zinc finger |
Domain |
PF05699 |
Dimer_Tnp_hAT |
571 → 651 |
hAT family C-terminal dimerisation region |
Domain |
|
Sequence |
MENKSLESSQTDLKLVAHPRAKSKVWKYFGFDTNAEGCILQWKKIYCRICMAQIAYSGNT SNLSYHLEKNHPEEFCEFVKSNTEQMREAFATAFSKLKPESSQQPGQDALAVKAGHGYDS KKQQELTAAVLGLICEGLYPASIVDEPTFKVLLKTADPRYELPSRKYISTKAIPEKYGAV REVILKELAEATWCGISTDMWRSENQNRAYVTLAAHFLGLGAPNCLSMGSRCLKTFEVPE ENTAETITRVLYEVFIEWGISAKVFGATTNYGKDIVKACSLLDVAVHMPCLGHTFNAGIQ QAFQLPKLGALLSRCRKLVEYFQQSAVAMYMLYEKQKQQNVAHCMLVSNRVSWWGSTLAM LQRLKEQQFVIAGVLVEDSNNHHLMLEASEWATIEGLVELLQPFKQVAEMLSASRYPTIS MVKPLLHMLLNTTLNIKETDSKELSMAKEVIAKELSKTYQETPEIDMFLNVATFLDPRYK RLPFLSAFERQQVENRVVEEAKGLLDKVKDGGYRPAEDKIFPVPEEPPVKKLMRTSTPPP ASVINNMLAEIFCQTGGVEDQEEWHAQVVEELSNFKSQKVLGLNEDPLKWWSDRLALFPL LPKVLQKYWCVTATRVAPERLFGSAANVVSAKRNRLAPAHVDEQVFLYENARSGAEAEPE DQDEGEWGLDQEQVFSLGDGVSGGFFGIRDSSFL
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Sequence length |
694 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
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Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Prostate cancer |
Malignant neoplasm of prostate |
rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 |
17199135 |
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Prostatic neoplasms |
Prostatic Neoplasms |
|
17199135 |
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