HTR3B (5-hydroxytryptamine receptor 3B)

Gene

• Entrez ID: 9177
• Gene name: 5-hydroxytryptamine receptor 3B
• Gene symbol: HTR3B
• Synonyms: 5-HT3B
• Chromosome: 11
• Chromosome location: 11q23.2
• Summary: The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitoge

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1057244	hsa-miR-1182	CLIP-seq
MIRT1057245	hsa-miR-129-5p	CLIP-seq
MIRT1057246	hsa-miR-193a-5p	CLIP-seq
MIRT1057247	hsa-miR-3194-3p	CLIP-seq
MIRT1057248	hsa-miR-342-5p	CLIP-seq
MIRT1057249	hsa-miR-3672	CLIP-seq
MIRT1057250	hsa-miR-431	CLIP-seq
MIRT1057251	hsa-miR-4505	CLIP-seq
MIRT1057252	hsa-miR-4651	CLIP-seq
MIRT1057253	hsa-miR-4664-5p	CLIP-seq
MIRT1057254	hsa-miR-4731-5p	CLIP-seq
MIRT1057255	hsa-miR-608	CLIP-seq
MIRT2013081	hsa-miR-1184	CLIP-seq
MIRT2013082	hsa-miR-1343	CLIP-seq
MIRT2013083	hsa-miR-203	CLIP-seq
MIRT2013084	hsa-miR-24	CLIP-seq
MIRT2013085	hsa-miR-2681	CLIP-seq
MIRT1057247	hsa-miR-3194-3p	CLIP-seq
MIRT1057248	hsa-miR-342-5p	CLIP-seq
MIRT2013086	hsa-miR-378g	CLIP-seq
MIRT2013087	hsa-miR-4284	CLIP-seq
MIRT2013088	hsa-miR-4418	CLIP-seq
MIRT2013089	hsa-miR-4437	CLIP-seq
MIRT1057251	hsa-miR-4505	CLIP-seq
MIRT1057252	hsa-miR-4651	CLIP-seq
MIRT1057253	hsa-miR-4664-5p	CLIP-seq
MIRT2013090	hsa-miR-4674	CLIP-seq
MIRT1057254	hsa-miR-4731-5p	CLIP-seq
MIRT2013091	hsa-miR-509-3-5p	CLIP-seq
MIRT2013092	hsa-miR-509-5p	CLIP-seq
MIRT1057255	hsa-miR-608	CLIP-seq
MIRT1057244	hsa-miR-1182	CLIP-seq
MIRT2013081	hsa-miR-1184	CLIP-seq
MIRT2013082	hsa-miR-1343	CLIP-seq
MIRT1057246	hsa-miR-193a-5p	CLIP-seq
MIRT2245371	hsa-miR-1976	CLIP-seq
MIRT2013083	hsa-miR-203	CLIP-seq
MIRT2013084	hsa-miR-24	CLIP-seq
MIRT2013085	hsa-miR-2681	CLIP-seq
MIRT1057247	hsa-miR-3194-3p	CLIP-seq
MIRT1057248	hsa-miR-342-5p	CLIP-seq
MIRT2245372	hsa-miR-370	CLIP-seq
MIRT2013086	hsa-miR-378g	CLIP-seq
MIRT2013087	hsa-miR-4284	CLIP-seq
MIRT1057250	hsa-miR-431	CLIP-seq
MIRT2013088	hsa-miR-4418	CLIP-seq
MIRT2013089	hsa-miR-4437	CLIP-seq
MIRT1057251	hsa-miR-4505	CLIP-seq
MIRT1057252	hsa-miR-4651	CLIP-seq
MIRT1057253	hsa-miR-4664-5p	CLIP-seq
MIRT2013090	hsa-miR-4674	CLIP-seq
MIRT1057254	hsa-miR-4731-5p	CLIP-seq
MIRT2013091	hsa-miR-509-3-5p	CLIP-seq
MIRT2013092	hsa-miR-509-5p	CLIP-seq
MIRT1057255	hsa-miR-608	CLIP-seq
MIRT2013081	hsa-miR-1184	CLIP-seq
MIRT2013083	hsa-miR-203	CLIP-seq
MIRT2013084	hsa-miR-24	CLIP-seq
MIRT2013085	hsa-miR-2681	CLIP-seq
MIRT1057248	hsa-miR-342-5p	CLIP-seq
MIRT2013087	hsa-miR-4284	CLIP-seq
MIRT2013088	hsa-miR-4418	CLIP-seq
MIRT1057251	hsa-miR-4505	CLIP-seq
MIRT1057252	hsa-miR-4651	CLIP-seq
MIRT1057253	hsa-miR-4664-5p	CLIP-seq
MIRT1057254	hsa-miR-4731-5p	CLIP-seq
MIRT2013091	hsa-miR-509-3-5p	CLIP-seq
MIRT2013092	hsa-miR-509-5p	CLIP-seq
MIRT1057255	hsa-miR-608	CLIP-seq
MIRT1057244	hsa-miR-1182	CLIP-seq
MIRT1057246	hsa-miR-193a-5p	CLIP-seq
MIRT1057247	hsa-miR-3194-3p	CLIP-seq
MIRT1057250	hsa-miR-431	CLIP-seq
MIRT1057251	hsa-miR-4505	CLIP-seq
MIRT1057254	hsa-miR-4731-5p	CLIP-seq
MIRT2013081	hsa-miR-1184	CLIP-seq
MIRT2013084	hsa-miR-24	CLIP-seq
MIRT2013085	hsa-miR-2681	CLIP-seq
MIRT1057248	hsa-miR-342-5p	CLIP-seq
MIRT2013087	hsa-miR-4284	CLIP-seq
MIRT2013088	hsa-miR-4418	CLIP-seq
MIRT1057251	hsa-miR-4505	CLIP-seq
MIRT1057252	hsa-miR-4651	CLIP-seq
MIRT1057253	hsa-miR-4664-5p	CLIP-seq
MIRT1057254	hsa-miR-4731-5p	CLIP-seq
MIRT2013091	hsa-miR-509-3-5p	CLIP-seq
MIRT2013092	hsa-miR-509-5p	CLIP-seq
MIRT1057255	hsa-miR-608	CLIP-seq
MIRT1057244	hsa-miR-1182	CLIP-seq
MIRT2013081	hsa-miR-1184	CLIP-seq
MIRT1057246	hsa-miR-193a-5p	CLIP-seq
MIRT2013084	hsa-miR-24	CLIP-seq
MIRT2013085	hsa-miR-2681	CLIP-seq
MIRT1057247	hsa-miR-3194-3p	CLIP-seq
MIRT1057248	hsa-miR-342-5p	CLIP-seq
MIRT2013087	hsa-miR-4284	CLIP-seq
MIRT1057250	hsa-miR-431	CLIP-seq
MIRT2013088	hsa-miR-4418	CLIP-seq
MIRT1057251	hsa-miR-4505	CLIP-seq
MIRT1057252	hsa-miR-4651	CLIP-seq
MIRT1057253	hsa-miR-4664-5p	CLIP-seq
MIRT1057254	hsa-miR-4731-5p	CLIP-seq
MIRT2013091	hsa-miR-509-3-5p	CLIP-seq
MIRT2013092	hsa-miR-509-5p	CLIP-seq
MIRT1057255	hsa-miR-608	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0007165	Process	Signal transduction	IBA	21873635
GO:0007210	Process	Serotonin receptor signaling pathway	IEA
GO:0007268	Process	Chemical synaptic transmission	IBA	21873635
GO:0007268	Process	Chemical synaptic transmission	TAS
GO:0009986	Component	Cell surface	IDA	16571125
GO:0022850	Function	Serotonin-gated cation-selective channel activity	IBA	21873635
GO:0022850	Function	Serotonin-gated cation-selective channel activity	IGI	9950429
GO:0030594	Function	Neurotransmitter receptor activity	IBA	21873635
GO:0034220	Process	Ion transmembrane transport	IBA	21873635
GO:0042391	Process	Regulation of membrane potential	IBA	21873635
GO:0043005	Component	Neuron projection	IBA	21873635
GO:0045202	Component	Synapse	IBA	21873635
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0050877	Process	Nervous system process	IBA	21873635
GO:1904602	Component	Serotonin-activated cation-selective channel complex	IGI	9950429

Other IDs

• MIM: 604654
• HGNC: 5298
• e!Ensembl: ENSG00000149305

Protein

• UniProt ID: O95264
• Protein name: 5-hydroxytryptamine receptor 3B (5-HT3-B) (5-HT3B) (Serotonin receptor 3B)
• Protein function: Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons. {ECO:0000269|PubMed:10521471, ECO:0000269|PubMed:12867984, ECO:0000269|PubMed:17392525,
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02931	Neur_chan_LBD	32 → 239	Neurotransmitter-gated ion-channel ligand binding domain	Family
  PF02932	Neur_chan_memb	246 → 340	Neurotransmitter-gated ion-channel transmembrane region	Family

• Sequence:

  MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVY
  LDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIII
  NEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTV
  EDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRHPL
  VYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTP
  LIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQPFLCLRGDTDADRPRVEPRAQRA
  VVTESSLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSY
  LFMLGIYTITLCSLWALWGGV

• Sequence length: 441

Pathways

KEGG:

Serotonergic synapse
Taste transduction

Reactome:

Neurotransmitter receptors and postsynaptic signal transmission

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Myopathy	Myopathy	rs137854521, rs386834236, rs121908557, rs121909092, rs111033570, rs104894299, rs104894294, rs121909273, rs121909274, rs121909275, rs199474699, rs199476140, rs118192165, rs118192169, rs118192166, rs193922856, rs281865489, rs397514675, rs397514676, rs397514677, rs367543058, rs118192117, rs193922837, rs118192129, rs118192143, rs118192153, rs118192133, rs118192156, rs118192149, rs118192148, rs118192183, rs118192147, rs118192123, rs118192127, rs118192142, rs118192144, rs118192178, rs118192151, rs118192150, rs118192184, rs118192154, rs118192134, rs118192155, rs193922893, rs118192132, rs118192146, rs193922867, rs193922884, rs587777528, rs527236030, rs587777672, rs587777673, rs587777674, rs587777675, rs587783343, rs2754158, rs786204796, rs748277951, rs797046047, rs797046064, rs797046060, rs797045479, rs797045931, rs797045932, rs797045934, rs797045935, rs797045477, rs797045478, rs1057518851, rs1057518855, rs1057518773, rs1057518866, rs1555322610, rs1555806119, rs761483896, rs144071404, rs1198364572, rs1568614042, rs978984063, rs1568604308, rs1332371891, rs1601842249, rs777176261, rs1249621033, rs1278804520, rs1568613962, rs1568510406, rs1597512576, rs193922887, rs371455345, rs1603452200, rs1599634685, rs1575065895, rs1575201712, rs139715157, rs1974129338	17600820
Prostate cancer	Prostate carcinoma	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	25217961, 29892016
Schizophrenia	Schizophrenia	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	20356718

Unknown
Disease name	Disease term	dbSNP ID	References
Bipolar disorder	Bipolar Disorder		22832903, 15389765
Mental depression	Mental Depression, Depressive disorder, Unipolar Depression, Major Depressive Disorder	rs587778876, rs587778877	19741568, 16487942, 18184810, 18184810, 16487942