MAP3K13 (mitogen-activated protein kinase kinase kinase 13)

Gene

• Entrez ID: 9175
• Gene name: Mitogen-activated protein kinase kinase kinase 13
• Gene symbol: MAP3K13
• Synonyms: LZK, MEKK13, MLK
• Chromosome: 3
• Chromosome location: 3q27.2
• Summary: The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate and activ

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT048810	hsa-miR-93-5p	CLASH	23622248
MIRT053440	hsa-miR-203a-3p	Microarray	23807165
MIRT735627	hsa-miR-204-3p	Luciferase reporter assay	31957920
MIRT1128368	hsa-miR-105	CLIP-seq
MIRT1128369	hsa-miR-106a	CLIP-seq
MIRT1128370	hsa-miR-106b	CLIP-seq
MIRT1128371	hsa-miR-1225-3p	CLIP-seq
MIRT1128372	hsa-miR-1228	CLIP-seq
MIRT1128373	hsa-miR-1233	CLIP-seq
MIRT1128374	hsa-miR-128	CLIP-seq
MIRT1128375	hsa-miR-1293	CLIP-seq
MIRT1128376	hsa-miR-1301	CLIP-seq
MIRT1128377	hsa-miR-1304	CLIP-seq
MIRT1128378	hsa-miR-137	CLIP-seq
MIRT1128379	hsa-miR-142-5p	CLIP-seq
MIRT1128380	hsa-miR-145	CLIP-seq
MIRT1128381	hsa-miR-155	CLIP-seq
MIRT1128382	hsa-miR-17	CLIP-seq
MIRT1128383	hsa-miR-1827	CLIP-seq
MIRT1128384	hsa-miR-1912	CLIP-seq
MIRT1128385	hsa-miR-20a	CLIP-seq
MIRT1128386	hsa-miR-20b	CLIP-seq
MIRT1128387	hsa-miR-217	CLIP-seq
MIRT1128388	hsa-miR-2277-3p	CLIP-seq
MIRT1128389	hsa-miR-2467-5p	CLIP-seq
MIRT1128390	hsa-miR-25	CLIP-seq
MIRT1128391	hsa-miR-30a	CLIP-seq
MIRT1128392	hsa-miR-30b	CLIP-seq
MIRT1128393	hsa-miR-30c	CLIP-seq
MIRT1128394	hsa-miR-30d	CLIP-seq
MIRT1128395	hsa-miR-30e	CLIP-seq
MIRT1128396	hsa-miR-3122	CLIP-seq
MIRT1128397	hsa-miR-3132	CLIP-seq
MIRT1128398	hsa-miR-3188	CLIP-seq
MIRT1128399	hsa-miR-32	CLIP-seq
MIRT1128400	hsa-miR-329	CLIP-seq
MIRT1128401	hsa-miR-33a	CLIP-seq
MIRT1128402	hsa-miR-33b	CLIP-seq
MIRT1128403	hsa-miR-34a	CLIP-seq
MIRT1128404	hsa-miR-34c-5p	CLIP-seq
MIRT1128405	hsa-miR-3609	CLIP-seq
MIRT1128406	hsa-miR-3614-5p	CLIP-seq
MIRT1128407	hsa-miR-3622a-3p	CLIP-seq
MIRT1128408	hsa-miR-3622b-3p	CLIP-seq
MIRT1128409	hsa-miR-362-3p	CLIP-seq
MIRT1128410	hsa-miR-363	CLIP-seq
MIRT1128411	hsa-miR-3664-3p	CLIP-seq
MIRT1128412	hsa-miR-367	CLIP-seq
MIRT1128413	hsa-miR-3671	CLIP-seq
MIRT1128414	hsa-miR-3689a-3p	CLIP-seq
MIRT1128415	hsa-miR-3689c	CLIP-seq
MIRT1128416	hsa-miR-3913-5p	CLIP-seq
MIRT1128417	hsa-miR-3929	CLIP-seq
MIRT1128418	hsa-miR-3937	CLIP-seq
MIRT1128419	hsa-miR-3975	CLIP-seq
MIRT1128420	hsa-miR-4264	CLIP-seq
MIRT1128421	hsa-miR-4278	CLIP-seq
MIRT1128422	hsa-miR-4281	CLIP-seq
MIRT1128423	hsa-miR-4326	CLIP-seq
MIRT1128424	hsa-miR-4419b	CLIP-seq
MIRT1128425	hsa-miR-4433	CLIP-seq
MIRT1128426	hsa-miR-4436b-3p	CLIP-seq
MIRT1128427	hsa-miR-4451	CLIP-seq
MIRT1128428	hsa-miR-4459	CLIP-seq
MIRT1128429	hsa-miR-4475	CLIP-seq
MIRT1128430	hsa-miR-4478	CLIP-seq
MIRT1128431	hsa-miR-4480	CLIP-seq
MIRT1128432	hsa-miR-4483	CLIP-seq
MIRT1128433	hsa-miR-449a	CLIP-seq
MIRT1128434	hsa-miR-449b	CLIP-seq
MIRT1128435	hsa-miR-450a	CLIP-seq
MIRT1128436	hsa-miR-4645-3p	CLIP-seq
MIRT1128437	hsa-miR-4649-3p	CLIP-seq
MIRT1128438	hsa-miR-4651	CLIP-seq
MIRT1128439	hsa-miR-4660	CLIP-seq
MIRT1128440	hsa-miR-4694-3p	CLIP-seq
MIRT1128441	hsa-miR-4695-5p	CLIP-seq
MIRT1128442	hsa-miR-4698	CLIP-seq
MIRT1128443	hsa-miR-4716-3p	CLIP-seq
MIRT1128444	hsa-miR-4719	CLIP-seq
MIRT1128445	hsa-miR-4722-5p	CLIP-seq
MIRT1128446	hsa-miR-4728-5p	CLIP-seq
MIRT1128447	hsa-miR-4762-5p	CLIP-seq
MIRT1128448	hsa-miR-4767	CLIP-seq
MIRT1128449	hsa-miR-4768-3p	CLIP-seq
MIRT1128450	hsa-miR-4776-3p	CLIP-seq
MIRT1128451	hsa-miR-4796-3p	CLIP-seq
MIRT1128452	hsa-miR-4797-3p	CLIP-seq
MIRT1128453	hsa-miR-4803	CLIP-seq
MIRT1128454	hsa-miR-485-5p	CLIP-seq
MIRT1128455	hsa-miR-490-3p	CLIP-seq
MIRT1128456	hsa-miR-5047	CLIP-seq
MIRT1128457	hsa-miR-510	CLIP-seq
MIRT1128458	hsa-miR-512-5p	CLIP-seq
MIRT1128459	hsa-miR-518a-5p	CLIP-seq
MIRT1128460	hsa-miR-519d	CLIP-seq
MIRT1128461	hsa-miR-520d-5p	CLIP-seq
MIRT1128462	hsa-miR-524-5p	CLIP-seq
MIRT1128463	hsa-miR-527	CLIP-seq
MIRT1128464	hsa-miR-542-3p	CLIP-seq
MIRT1128465	hsa-miR-544b	CLIP-seq
MIRT1128466	hsa-miR-548a-3p	CLIP-seq
MIRT1128467	hsa-miR-548aa	CLIP-seq
MIRT1128468	hsa-miR-548ag	CLIP-seq
MIRT1128469	hsa-miR-548ah	CLIP-seq
MIRT1128470	hsa-miR-548ai	CLIP-seq
MIRT1128471	hsa-miR-548e	CLIP-seq
MIRT1128472	hsa-miR-548f	CLIP-seq
MIRT1128473	hsa-miR-566	CLIP-seq
MIRT1128474	hsa-miR-607	CLIP-seq
MIRT1128475	hsa-miR-608	CLIP-seq
MIRT1128476	hsa-miR-621	CLIP-seq
MIRT1128477	hsa-miR-665	CLIP-seq
MIRT1128478	hsa-miR-92a	CLIP-seq
MIRT1128479	hsa-miR-92b	CLIP-seq
MIRT1128480	hsa-miR-93	CLIP-seq
MIRT1128481	hsa-miR-940	CLIP-seq
MIRT1128371	hsa-miR-1225-3p	CLIP-seq
MIRT1128373	hsa-miR-1233	CLIP-seq
MIRT1128374	hsa-miR-128	CLIP-seq
MIRT1128377	hsa-miR-1304	CLIP-seq
MIRT1128389	hsa-miR-2467-5p	CLIP-seq
MIRT1128398	hsa-miR-3188	CLIP-seq
MIRT1128406	hsa-miR-3614-5p	CLIP-seq
MIRT1128414	hsa-miR-3689a-3p	CLIP-seq
MIRT1128415	hsa-miR-3689c	CLIP-seq
MIRT1128482	hsa-miR-3926	CLIP-seq
MIRT1128419	hsa-miR-3975	CLIP-seq
MIRT1128428	hsa-miR-4459	CLIP-seq
MIRT1128483	hsa-miR-4464	CLIP-seq
MIRT1128484	hsa-miR-4476	CLIP-seq
MIRT1128446	hsa-miR-4728-5p	CLIP-seq
MIRT1128485	hsa-miR-4748	CLIP-seq
MIRT1128454	hsa-miR-485-5p	CLIP-seq
MIRT1128486	hsa-miR-548s	CLIP-seq
MIRT1128477	hsa-miR-665	CLIP-seq
MIRT1128371	hsa-miR-1225-3p	CLIP-seq
MIRT1128373	hsa-miR-1233	CLIP-seq
MIRT1128377	hsa-miR-1304	CLIP-seq
MIRT1128487	hsa-miR-223	CLIP-seq
MIRT1128389	hsa-miR-2467-5p	CLIP-seq
MIRT1128398	hsa-miR-3188	CLIP-seq
MIRT1128406	hsa-miR-3614-5p	CLIP-seq
MIRT1128411	hsa-miR-3664-3p	CLIP-seq
MIRT1128414	hsa-miR-3689a-3p	CLIP-seq
MIRT1128415	hsa-miR-3689c	CLIP-seq
MIRT1128417	hsa-miR-3929	CLIP-seq
MIRT1128419	hsa-miR-3975	CLIP-seq
MIRT1128422	hsa-miR-4281	CLIP-seq
MIRT1128424	hsa-miR-4419b	CLIP-seq
MIRT1128425	hsa-miR-4433	CLIP-seq
MIRT1128428	hsa-miR-4459	CLIP-seq
MIRT1128430	hsa-miR-4478	CLIP-seq
MIRT1128441	hsa-miR-4695-5p	CLIP-seq
MIRT1128446	hsa-miR-4728-5p	CLIP-seq
MIRT1128449	hsa-miR-4768-3p	CLIP-seq
MIRT1128454	hsa-miR-485-5p	CLIP-seq
MIRT1128457	hsa-miR-510	CLIP-seq
MIRT1128458	hsa-miR-512-5p	CLIP-seq
MIRT1128488	hsa-miR-548ac	CLIP-seq
MIRT1128489	hsa-miR-548ae	CLIP-seq
MIRT1128490	hsa-miR-548aj	CLIP-seq
MIRT1128491	hsa-miR-548am	CLIP-seq
MIRT1128492	hsa-miR-548d-3p	CLIP-seq
MIRT1128493	hsa-miR-548x	CLIP-seq
MIRT1128494	hsa-miR-548z	CLIP-seq
MIRT1128477	hsa-miR-665	CLIP-seq
MIRT1128495	hsa-miR-935	CLIP-seq
MIRT1128383	hsa-miR-1827	CLIP-seq
MIRT1128390	hsa-miR-25	CLIP-seq
MIRT1128396	hsa-miR-3122	CLIP-seq
MIRT1128399	hsa-miR-32	CLIP-seq
MIRT1128410	hsa-miR-363	CLIP-seq
MIRT1128411	hsa-miR-3664-3p	CLIP-seq
MIRT1128412	hsa-miR-367	CLIP-seq
MIRT1128414	hsa-miR-3689a-3p	CLIP-seq
MIRT1128415	hsa-miR-3689c	CLIP-seq
MIRT1128416	hsa-miR-3913-5p	CLIP-seq
MIRT1128482	hsa-miR-3926	CLIP-seq
MIRT1128417	hsa-miR-3929	CLIP-seq
MIRT1128422	hsa-miR-4281	CLIP-seq
MIRT1128424	hsa-miR-4419b	CLIP-seq
MIRT1128425	hsa-miR-4433	CLIP-seq
MIRT1128428	hsa-miR-4459	CLIP-seq
MIRT1128430	hsa-miR-4478	CLIP-seq
MIRT1128437	hsa-miR-4649-3p	CLIP-seq
MIRT2036489	hsa-miR-4667-5p	CLIP-seq
MIRT1128441	hsa-miR-4695-5p	CLIP-seq
MIRT2036490	hsa-miR-4700-5p	CLIP-seq
MIRT1128445	hsa-miR-4722-5p	CLIP-seq
MIRT1128446	hsa-miR-4728-5p	CLIP-seq
MIRT1128448	hsa-miR-4767	CLIP-seq
MIRT1128449	hsa-miR-4768-3p	CLIP-seq
MIRT1128454	hsa-miR-485-5p	CLIP-seq
MIRT1128457	hsa-miR-510	CLIP-seq
MIRT1128458	hsa-miR-512-5p	CLIP-seq
MIRT2036491	hsa-miR-520g	CLIP-seq
MIRT2036492	hsa-miR-520h	CLIP-seq
MIRT2036493	hsa-miR-548p	CLIP-seq
MIRT1128486	hsa-miR-548s	CLIP-seq
MIRT1128473	hsa-miR-566	CLIP-seq
MIRT2036494	hsa-miR-637	CLIP-seq
MIRT1128478	hsa-miR-92a	CLIP-seq
MIRT1128479	hsa-miR-92b	CLIP-seq
MIRT1128481	hsa-miR-940	CLIP-seq
MIRT1128390	hsa-miR-25	CLIP-seq
MIRT1128399	hsa-miR-32	CLIP-seq
MIRT1128410	hsa-miR-363	CLIP-seq
MIRT1128412	hsa-miR-367	CLIP-seq
MIRT2266760	hsa-miR-4256	CLIP-seq
MIRT1128440	hsa-miR-4694-3p	CLIP-seq
MIRT1128442	hsa-miR-4698	CLIP-seq
MIRT2266761	hsa-miR-4778-5p	CLIP-seq
MIRT1128461	hsa-miR-520d-5p	CLIP-seq
MIRT1128462	hsa-miR-524-5p	CLIP-seq
MIRT1128478	hsa-miR-92a	CLIP-seq
MIRT1128479	hsa-miR-92b	CLIP-seq
MIRT1128481	hsa-miR-940	CLIP-seq
MIRT2266762	hsa-miR-185	CLIP-seq
MIRT2266763	hsa-miR-3156-5p	CLIP-seq
MIRT2266764	hsa-miR-3163	CLIP-seq
MIRT2266765	hsa-miR-3180-5p	CLIP-seq
MIRT2266766	hsa-miR-3672	CLIP-seq
MIRT1128482	hsa-miR-3926	CLIP-seq
MIRT1128422	hsa-miR-4281	CLIP-seq
MIRT2266767	hsa-miR-4306	CLIP-seq
MIRT2266768	hsa-miR-432	CLIP-seq
MIRT1128423	hsa-miR-4326	CLIP-seq
MIRT2266769	hsa-miR-4644	CLIP-seq
MIRT2266770	hsa-miR-4695-3p	CLIP-seq
MIRT2266771	hsa-miR-520a-5p	CLIP-seq
MIRT2266772	hsa-miR-525-5p	CLIP-seq
MIRT2266773	hsa-miR-526b	CLIP-seq
MIRT1128486	hsa-miR-548s	CLIP-seq
MIRT1128481	hsa-miR-940	CLIP-seq
MIRT2438497	hsa-miR-1260	CLIP-seq
MIRT2438498	hsa-miR-1260b	CLIP-seq
MIRT2438499	hsa-miR-188-3p	CLIP-seq
MIRT2438500	hsa-miR-3156-3p	CLIP-seq
MIRT2266765	hsa-miR-3180-5p	CLIP-seq
MIRT2438501	hsa-miR-3192	CLIP-seq
MIRT2438502	hsa-miR-4301	CLIP-seq
MIRT2438503	hsa-miR-4314	CLIP-seq
MIRT2438504	hsa-miR-4646-5p	CLIP-seq
MIRT2438505	hsa-miR-4747-5p	CLIP-seq
MIRT2266771	hsa-miR-520a-5p	CLIP-seq
MIRT2266772	hsa-miR-525-5p	CLIP-seq
MIRT2266766	hsa-miR-3672	CLIP-seq
MIRT2566337	hsa-miR-1183	CLIP-seq
MIRT2566338	hsa-miR-3124-3p	CLIP-seq
MIRT2566339	hsa-miR-4725-5p	CLIP-seq
MIRT1128453	hsa-miR-4803	CLIP-seq
MIRT2566340	hsa-miR-504	CLIP-seq
MIRT1128391	hsa-miR-30a	CLIP-seq
MIRT1128392	hsa-miR-30b	CLIP-seq
MIRT1128393	hsa-miR-30c	CLIP-seq
MIRT1128394	hsa-miR-30d	CLIP-seq
MIRT1128395	hsa-miR-30e	CLIP-seq
MIRT2566338	hsa-miR-3124-3p	CLIP-seq
MIRT2266766	hsa-miR-3672	CLIP-seq
MIRT2566341	hsa-miR-4775	CLIP-seq
MIRT1128453	hsa-miR-4803	CLIP-seq
MIRT1128467	hsa-miR-548aa	CLIP-seq
MIRT2566342	hsa-miR-579	CLIP-seq
MIRT1128390	hsa-miR-25	CLIP-seq
MIRT1128399	hsa-miR-32	CLIP-seq
MIRT1128410	hsa-miR-363	CLIP-seq
MIRT1128412	hsa-miR-367	CLIP-seq
MIRT2266766	hsa-miR-3672	CLIP-seq
MIRT2566342	hsa-miR-579	CLIP-seq
MIRT1128478	hsa-miR-92a	CLIP-seq
MIRT1128479	hsa-miR-92b	CLIP-seq
MIRT1128369	hsa-miR-106a	CLIP-seq
MIRT1128370	hsa-miR-106b	CLIP-seq
MIRT2566337	hsa-miR-1183	CLIP-seq
MIRT2684476	hsa-miR-1224-3p	CLIP-seq
MIRT1128371	hsa-miR-1225-3p	CLIP-seq
MIRT1128372	hsa-miR-1228	CLIP-seq
MIRT1128373	hsa-miR-1233	CLIP-seq
MIRT2684477	hsa-miR-1271	CLIP-seq
MIRT2684478	hsa-miR-1273d	CLIP-seq
MIRT2684479	hsa-miR-1273f	CLIP-seq
MIRT1128374	hsa-miR-128	CLIP-seq
MIRT2684480	hsa-miR-1286	CLIP-seq
MIRT2684481	hsa-miR-1295	CLIP-seq
MIRT2684482	hsa-miR-1303	CLIP-seq
MIRT1128379	hsa-miR-142-5p	CLIP-seq
MIRT1128380	hsa-miR-145	CLIP-seq
MIRT1128382	hsa-miR-17	CLIP-seq
MIRT2684483	hsa-miR-182	CLIP-seq
MIRT1128383	hsa-miR-1827	CLIP-seq
MIRT2684484	hsa-miR-187	CLIP-seq
MIRT2684485	hsa-miR-188-5p	CLIP-seq
MIRT2684486	hsa-miR-208a	CLIP-seq
MIRT2684487	hsa-miR-208b	CLIP-seq
MIRT1128385	hsa-miR-20a	CLIP-seq
MIRT1128386	hsa-miR-20b	CLIP-seq
MIRT2684488	hsa-miR-2116	CLIP-seq
MIRT2684489	hsa-miR-2278	CLIP-seq
MIRT1128391	hsa-miR-30a	CLIP-seq
MIRT1128392	hsa-miR-30b	CLIP-seq
MIRT1128393	hsa-miR-30c	CLIP-seq
MIRT1128394	hsa-miR-30d	CLIP-seq
MIRT1128395	hsa-miR-30e	CLIP-seq
MIRT2684490	hsa-miR-3117-5p	CLIP-seq
MIRT1128396	hsa-miR-3122	CLIP-seq
MIRT2566338	hsa-miR-3124-3p	CLIP-seq
MIRT2684491	hsa-miR-3138	CLIP-seq
MIRT2684492	hsa-miR-3140-3p	CLIP-seq
MIRT2684493	hsa-miR-3157-5p	CLIP-seq
MIRT2438501	hsa-miR-3192	CLIP-seq
MIRT2684494	hsa-miR-324-5p	CLIP-seq
MIRT1128400	hsa-miR-329	CLIP-seq
MIRT2684495	hsa-miR-337-3p	CLIP-seq
MIRT2684496	hsa-miR-3607-3p	CLIP-seq
MIRT1128405	hsa-miR-3609	CLIP-seq
MIRT1128406	hsa-miR-3614-5p	CLIP-seq
MIRT2684497	hsa-miR-3618	CLIP-seq
MIRT1128407	hsa-miR-3622a-3p	CLIP-seq
MIRT1128408	hsa-miR-3622b-3p	CLIP-seq
MIRT1128409	hsa-miR-362-3p	CLIP-seq
MIRT2684498	hsa-miR-3646	CLIP-seq
MIRT2684499	hsa-miR-3647-3p	CLIP-seq
MIRT2684500	hsa-miR-3662	CLIP-seq
MIRT1128411	hsa-miR-3664-3p	CLIP-seq
MIRT2684501	hsa-miR-3667-3p	CLIP-seq
MIRT1128413	hsa-miR-3671	CLIP-seq
MIRT2266766	hsa-miR-3672	CLIP-seq
MIRT2684502	hsa-miR-3686	CLIP-seq
MIRT1128414	hsa-miR-3689a-3p	CLIP-seq
MIRT1128415	hsa-miR-3689c	CLIP-seq
MIRT2684503	hsa-miR-3689d	CLIP-seq
MIRT2684504	hsa-miR-3692	CLIP-seq
MIRT1128416	hsa-miR-3913-5p	CLIP-seq
MIRT1128482	hsa-miR-3926	CLIP-seq
MIRT1128417	hsa-miR-3929	CLIP-seq
MIRT1128418	hsa-miR-3937	CLIP-seq
MIRT2684505	hsa-miR-4254	CLIP-seq
MIRT2684506	hsa-miR-4260	CLIP-seq
MIRT2684507	hsa-miR-4263	CLIP-seq
MIRT2684508	hsa-miR-4273	CLIP-seq
MIRT1128422	hsa-miR-4281	CLIP-seq
MIRT2684509	hsa-miR-4283	CLIP-seq
MIRT2684510	hsa-miR-4308	CLIP-seq
MIRT2684511	hsa-miR-4310	CLIP-seq
MIRT2684512	hsa-miR-4330	CLIP-seq
MIRT1128424	hsa-miR-4419b	CLIP-seq
MIRT2684513	hsa-miR-4432	CLIP-seq
MIRT1128425	hsa-miR-4433	CLIP-seq
MIRT1128428	hsa-miR-4459	CLIP-seq
MIRT1128430	hsa-miR-4478	CLIP-seq
MIRT2684514	hsa-miR-4489	CLIP-seq
MIRT2684515	hsa-miR-4495	CLIP-seq
MIRT2684516	hsa-miR-4514	CLIP-seq
MIRT2684517	hsa-miR-4519	CLIP-seq
MIRT2684518	hsa-miR-4534	CLIP-seq
MIRT2684519	hsa-miR-4536	CLIP-seq
MIRT1128436	hsa-miR-4645-3p	CLIP-seq
MIRT1128437	hsa-miR-4649-3p	CLIP-seq
MIRT2684520	hsa-miR-4652-5p	CLIP-seq
MIRT2684521	hsa-miR-4662a-3p	CLIP-seq
MIRT2684522	hsa-miR-4662a-5p	CLIP-seq
MIRT2684523	hsa-miR-4668-3p	CLIP-seq
MIRT2684524	hsa-miR-4676-5p	CLIP-seq
MIRT2684525	hsa-miR-4677-5p	CLIP-seq
MIRT2684526	hsa-miR-4691-3p	CLIP-seq
MIRT2684527	hsa-miR-4692	CLIP-seq
MIRT1128440	hsa-miR-4694-3p	CLIP-seq
MIRT1128441	hsa-miR-4695-5p	CLIP-seq
MIRT2684528	hsa-miR-4704-5p	CLIP-seq
MIRT1128444	hsa-miR-4719	CLIP-seq
MIRT1128445	hsa-miR-4722-5p	CLIP-seq
MIRT2566339	hsa-miR-4725-5p	CLIP-seq
MIRT2684529	hsa-miR-4727-5p	CLIP-seq
MIRT1128446	hsa-miR-4728-5p	CLIP-seq
MIRT2684530	hsa-miR-4755-3p	CLIP-seq
MIRT1128447	hsa-miR-4762-5p	CLIP-seq
MIRT1128449	hsa-miR-4768-3p	CLIP-seq
MIRT2684531	hsa-miR-4769-3p	CLIP-seq
MIRT2684532	hsa-miR-4780	CLIP-seq
MIRT2684533	hsa-miR-4786-3p	CLIP-seq
MIRT1128451	hsa-miR-4796-3p	CLIP-seq
MIRT2684534	hsa-miR-4802-5p	CLIP-seq
MIRT1128453	hsa-miR-4803	CLIP-seq
MIRT1128454	hsa-miR-485-5p	CLIP-seq
MIRT1128455	hsa-miR-490-3p	CLIP-seq
MIRT2684535	hsa-miR-495	CLIP-seq
MIRT2684536	hsa-miR-499-5p	CLIP-seq
MIRT2684537	hsa-miR-500a	CLIP-seq
MIRT2566340	hsa-miR-504	CLIP-seq
MIRT1128457	hsa-miR-510	CLIP-seq
MIRT1128458	hsa-miR-512-5p	CLIP-seq
MIRT1128460	hsa-miR-519d	CLIP-seq
MIRT1128465	hsa-miR-544b	CLIP-seq
MIRT1128466	hsa-miR-548a-3p	CLIP-seq
MIRT1128469	hsa-miR-548ah	CLIP-seq
MIRT2684538	hsa-miR-548c-3p	CLIP-seq
MIRT1128471	hsa-miR-548e	CLIP-seq
MIRT1128472	hsa-miR-548f	CLIP-seq
MIRT2036493	hsa-miR-548p	CLIP-seq
MIRT1128486	hsa-miR-548s	CLIP-seq
MIRT2684539	hsa-miR-552	CLIP-seq
MIRT2684540	hsa-miR-555	CLIP-seq
MIRT1128473	hsa-miR-566	CLIP-seq
MIRT2684541	hsa-miR-575	CLIP-seq
MIRT1128474	hsa-miR-607	CLIP-seq
MIRT2684542	hsa-miR-623	CLIP-seq
MIRT1128477	hsa-miR-665	CLIP-seq
MIRT2684543	hsa-miR-767-3p	CLIP-seq
MIRT1128480	hsa-miR-93	CLIP-seq
MIRT2684544	hsa-miR-934	CLIP-seq
MIRT1128481	hsa-miR-940	CLIP-seq
MIRT2684545	hsa-miR-96	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000186	Process	Activation of MAPKK activity	IDA	11726277
GO:0004672	Function	Protein kinase activity	IBA	21873635
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	9353328
GO:0004706	Function	JUN kinase kinase kinase activity	IBA	21873635
GO:0004706	Function	JUN kinase kinase kinase activity	ISS
GO:0004709	Function	MAP kinase kinase kinase activity	IDA	11726277
GO:0005515	Function	Protein binding	IPI	11726277, 12492477
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0006468	Process	Protein phosphorylation	IDA	9353328, 11726277
GO:0007254	Process	JNK cascade	IDA	9353328, 11726277
GO:0007256	Process	Activation of JNKK activity	ISS
GO:0007257	Process	Activation of JUN kinase activity	IBA	21873635
GO:0007257	Process	Activation of JUN kinase activity	ISS
GO:0014042	Process	Positive regulation of neuron maturation	ISS
GO:0016020	Component	Membrane	IDA	9353328
GO:0018105	Process	Peptidyl-serine phosphorylation	ISS
GO:0019899	Function	Enzyme binding	IPI	12492477
GO:0019901	Function	Protein kinase binding	ISS	9353328
GO:0042802	Function	Identical protein binding	IPI	11163770
GO:0042803	Function	Protein homodimerization activity	IDA	11163770
GO:0045773	Process	Positive regulation of axon extension	ISS
GO:0046777	Process	Protein autophosphorylation	IDA	9353328
GO:0046872	Function	Metal ion binding	IEA
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IBA	21873635
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IDA	12492477
GO:0106137	Function	IkappaB kinase complex binding	IDA	12492477
GO:0150012	Process	Positive regulation of neuron projection arborization	ISS
GO:1905492	Process	Positive regulation of branching morphogenesis of a nerve	ISS

Other IDs

• MIM: 604915
• HGNC: 6852
• e!Ensembl: ENSG00000073803

Protein

• UniProt ID: O43283
• Protein name: Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Leucine zipper-bearing kinase) (Mixed lineage kinase) (MLK)
• Protein function: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07714	PK_Tyr_Ser-Thr	168 → 407	Protein tyrosine and serine/threonine kinase	Domain

• Sequence:

  MANFQEHLSCSSSPHLPFSESKTFNGLQDELTAMGNHPSPKLLEDQQEKGMVRTELIESV
  HSPVTTTVLTSVSEDSRDQFENSVLQLREHDESETAVSQGNSNTVDGESTSGTEDIKIQF
  SRSGSGSGGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQG
  AVFLGKFRAEEVAIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQ
  LYEVLRAGRKITPRLLVDWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGT
  SKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSA
  IIWGVGSNSLHLPVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLDIASADVLATPQE
  TYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERAN
  NLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPH
  KSGMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHS
  DFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHG
  QDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGP
  WGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENE
  FSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCIS
  SCQSYSTFSSENFSVSDGEEGNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDIS
  SHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSDGECSDATVRTNKH
  YSSATW

• Sequence length: 966

Pathways

KEGG:

MAPK signaling pathway

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Breast adenocarcinoma	Breast adenocarcinoma	rs28934874, rs112445441, rs121913279, rs121913286, rs104886003, rs121434592
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243
Breast carcinoma	Breast Carcinoma	rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451, rs397507859, rs80359709, rs80359742, rs80359205, rs80357627, rs80357004, rs80357571, rs80357767, rs80357653, rs80358086, rs80357608, rs28897696, rs41293465, rs146650273, rs63751017, rs63750617, rs63750726, rs63750199, rs63749848, rs398122618, rs398122653, rs397509211, rs80357791, rs121912666, rs587778541, rs121908698, rs536907995, rs587781302, rs140342925, rs587781506, rs587782652, rs587782849, rs587783057, rs10520699, rs11852999, rs139770721, rs374950566, rs786202800, rs863224451, rs377153250, rs747727055, rs876658804, rs780001540, rs760815829, rs878854926, rs775248597, rs886040658, rs886040192, rs786203523, rs886040319, rs397508006, rs587782011, rs1060502772, rs1555461727, rs1553333072, rs1114167702, rs1257401983, rs886040950, rs1060502759, rs774684620, rs142947311, rs1555580883, rs748513310, rs376170600, rs863224499, rs1593909229, rs748453607, rs1294578913, rs1574737047, rs1593909960, rs2081922847, rs2082559544, rs2053694038

Unknown
Disease name	Disease term	dbSNP ID	References
Metastatic melanoma	Metastatic melanoma