IL1RL1 (interleukin 1 receptor like 1)

Gene

• Entrez ID: 9173
• Gene name: Interleukin 1 receptor like 1
• Gene symbol: IL1RL1
• Synonyms: DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1
• Chromosome: 2
• Chromosome location: 2q12.1
• Summary: The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gen

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT029172	hsa-miR-26b-5p	Microarray	19088304
MIRT1064418	hsa-miR-149	CLIP-seq
MIRT1064419	hsa-miR-3064-5p	CLIP-seq
MIRT1064420	hsa-miR-3065-5p	CLIP-seq
MIRT1064421	hsa-miR-3126-3p	CLIP-seq
MIRT1064422	hsa-miR-3164	CLIP-seq
MIRT1064423	hsa-miR-4687-3p	CLIP-seq
MIRT1064424	hsa-miR-4704-3p	CLIP-seq
MIRT1064425	hsa-miR-4794	CLIP-seq
MIRT1064426	hsa-miR-505	CLIP-seq
MIRT1064427	hsa-miR-617	CLIP-seq
MIRT1064428	hsa-miR-4434	CLIP-seq
MIRT1064429	hsa-miR-4516	CLIP-seq
MIRT2015304	hsa-miR-1237	CLIP-seq
MIRT2015305	hsa-miR-143	CLIP-seq
MIRT2015306	hsa-miR-193a-5p	CLIP-seq
MIRT2015307	hsa-miR-23a	CLIP-seq
MIRT2015308	hsa-miR-23b	CLIP-seq
MIRT2015309	hsa-miR-23c	CLIP-seq
MIRT2015310	hsa-miR-2964a-5p	CLIP-seq
MIRT2015311	hsa-miR-298	CLIP-seq
MIRT2015312	hsa-miR-3074-5p	CLIP-seq
MIRT2015313	hsa-miR-3152-5p	CLIP-seq
MIRT2015314	hsa-miR-3158-5p	CLIP-seq
MIRT2015315	hsa-miR-4297	CLIP-seq
MIRT2015316	hsa-miR-4326	CLIP-seq
MIRT2015317	hsa-miR-4426	CLIP-seq
MIRT2015318	hsa-miR-4647	CLIP-seq
MIRT2015319	hsa-miR-4659a-5p	CLIP-seq
MIRT2015320	hsa-miR-4659b-5p	CLIP-seq
MIRT2015321	hsa-miR-4662b	CLIP-seq
MIRT2015322	hsa-miR-4677-3p	CLIP-seq
MIRT2015323	hsa-miR-4722-3p	CLIP-seq
MIRT2015324	hsa-miR-4727-5p	CLIP-seq
MIRT2015325	hsa-miR-4769-3p	CLIP-seq
MIRT2015326	hsa-miR-4770	CLIP-seq
MIRT2015327	hsa-miR-4774-3p	CLIP-seq
MIRT2015328	hsa-miR-584	CLIP-seq
MIRT2015329	hsa-miR-596	CLIP-seq
MIRT2015330	hsa-miR-7	CLIP-seq
MIRT2247656	hsa-miR-1266	CLIP-seq
MIRT2247657	hsa-miR-3074-3p	CLIP-seq
MIRT2247658	hsa-miR-3130-5p	CLIP-seq
MIRT2247659	hsa-miR-3664-3p	CLIP-seq
MIRT2247660	hsa-miR-4419a	CLIP-seq
MIRT2247661	hsa-miR-4456	CLIP-seq
MIRT2247662	hsa-miR-4482	CLIP-seq
MIRT2247663	hsa-miR-4510	CLIP-seq
MIRT2247664	hsa-miR-4518	CLIP-seq
MIRT2247665	hsa-miR-4678	CLIP-seq
MIRT2247666	hsa-miR-541	CLIP-seq
MIRT2247667	hsa-miR-654-5p	CLIP-seq
MIRT2451734	hsa-miR-148a	CLIP-seq
MIRT2451735	hsa-miR-148b	CLIP-seq
MIRT2451736	hsa-miR-152	CLIP-seq
MIRT2451737	hsa-miR-1909	CLIP-seq
MIRT2451738	hsa-miR-342-3p	CLIP-seq
MIRT2451739	hsa-miR-3945	CLIP-seq
MIRT2451740	hsa-miR-4276	CLIP-seq
MIRT2451741	hsa-miR-4688	CLIP-seq
MIRT2551063	hsa-miR-124	CLIP-seq
MIRT2551064	hsa-miR-142-5p	CLIP-seq
MIRT1064418	hsa-miR-149	CLIP-seq
MIRT2551065	hsa-miR-1825	CLIP-seq
MIRT2551066	hsa-miR-1972	CLIP-seq
MIRT2551067	hsa-miR-221	CLIP-seq
MIRT2551068	hsa-miR-222	CLIP-seq
MIRT1064419	hsa-miR-3064-5p	CLIP-seq
MIRT1064421	hsa-miR-3126-3p	CLIP-seq
MIRT2551069	hsa-miR-3134	CLIP-seq
MIRT2551070	hsa-miR-3183	CLIP-seq
MIRT2551071	hsa-miR-331-5p	CLIP-seq
MIRT2551072	hsa-miR-3659	CLIP-seq
MIRT2551073	hsa-miR-3688-5p	CLIP-seq
MIRT2551074	hsa-miR-3714	CLIP-seq
MIRT2551075	hsa-miR-3910	CLIP-seq
MIRT2551076	hsa-miR-4255	CLIP-seq
MIRT2551077	hsa-miR-4266	CLIP-seq
MIRT2451740	hsa-miR-4276	CLIP-seq
MIRT2551078	hsa-miR-4302	CLIP-seq
MIRT2551079	hsa-miR-4305	CLIP-seq
MIRT2551080	hsa-miR-431	CLIP-seq
MIRT2247660	hsa-miR-4419a	CLIP-seq
MIRT2551081	hsa-miR-4501	CLIP-seq
MIRT2247663	hsa-miR-4510	CLIP-seq
MIRT2551082	hsa-miR-4534	CLIP-seq
MIRT2551083	hsa-miR-4658	CLIP-seq
MIRT1064423	hsa-miR-4687-3p	CLIP-seq
MIRT2551084	hsa-miR-4695-5p	CLIP-seq
MIRT2551085	hsa-miR-4723-3p	CLIP-seq
MIRT2551086	hsa-miR-4777-5p	CLIP-seq
MIRT2551087	hsa-miR-4779	CLIP-seq
MIRT1064425	hsa-miR-4794	CLIP-seq
MIRT2551088	hsa-miR-506	CLIP-seq
MIRT2551089	hsa-miR-511	CLIP-seq
MIRT2551090	hsa-miR-518d-5p	CLIP-seq
MIRT2551091	hsa-miR-519b-5p	CLIP-seq
MIRT2551092	hsa-miR-519c-5p	CLIP-seq
MIRT2551093	hsa-miR-520c-5p	CLIP-seq
MIRT2551094	hsa-miR-526a	CLIP-seq
MIRT2551095	hsa-miR-548v	CLIP-seq
MIRT2551096	hsa-miR-561	CLIP-seq
MIRT2551097	hsa-miR-570	CLIP-seq
MIRT2551098	hsa-miR-574-5p	CLIP-seq
MIRT1064427	hsa-miR-617	CLIP-seq
MIRT2551099	hsa-miR-642b	CLIP-seq
MIRT2551100	hsa-miR-644	CLIP-seq
MIRT2551101	hsa-miR-646	CLIP-seq
MIRT2551102	hsa-miR-890	CLIP-seq
MIRT2551101	hsa-miR-646	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
GATA1	Unknown	22865859
GATA2	Unknown	22865859

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002113	Function	Interleukin-33 binding	IBA	21873635
GO:0002114	Function	Interleukin-33 receptor activity	IBA	21873635
GO:0002826	Process	Negative regulation of T-helper 1 type immune response	IEA
GO:0004896	Function	Cytokine receptor activity	TAS	10191101
GO:0004908	Function	Interleukin-1 receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	8621446, 16286016, 25416956
GO:0005576	Component	Extracellular region	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0005925	Component	Focal adhesion	IDA
GO:0006955	Process	Immune response	NAS	10527832
GO:0007165	Process	Signal transduction	TAS	1482686
GO:0009897	Component	External side of plasma membrane	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0032689	Process	Negative regulation of interferon-gamma production	IEA
GO:0032722	Process	Positive regulation of chemokine production	IEA
GO:0032754	Process	Positive regulation of interleukin-5 production	IEA
GO:0038172	Process	Interleukin-33-mediated signaling pathway	TAS
GO:0043032	Process	Positive regulation of macrophage activation	IEA
GO:0050135	Function	NAD(P)+ nucleosidase activity	IEA
GO:0050729	Process	Positive regulation of inflammatory response	IEA
GO:0061809	Function	NAD+ nucleotidase, cyclic ADP-ribose generating	IEA

Other IDs

• MIM: 601203
• HGNC: 5998
• e!Ensembl: ENSG00000115602

Protein

• UniProt ID: Q01638
• Protein name: Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Protein ST2)
• Protein function: Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP (PubMed:35238669). Its stimulation recruits
• PDB: 4KC3
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07679	I-set	18 → 104	Immunoglobulin I-set domain	Domain
  PF01582	TIR	379 → 556	TIR domain	Family

• Sequence:

  MGFWILAILTILMYSTAAKFSKQSWGLENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQ
  ERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYS
  TVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYT
  CKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFG
  KGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQ
  YDCLALNLHGLRRHTVRLSRKNPIDHHSIYCIIAVCSVFLMLINVLVIILKMFWIEATLL
  WRDIAKPYKTRNDGKLYDAYVVYPRNYKSSTDGASRVEHFVHQILPDVLENKCGYTLCIY
  GRDMLPGEDVVTAVETNIRKSRRHIFILTPQITHNKEFAYEQEVALHCALIQNDAKVILI
  EMEALSELDMLQAEALQDSLQHLMKVQGTIKWREDHIANKRSLNSKFWKHVRYQMPVPSK
  IPRKASSLTPLAAQKQ

• Sequence length: 556

Pathways

KEGG:

Cytokine-cytokine receptor interaction

Reactome:

PIP3 activates AKT signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-33 signaling

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma, Childhood asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	27130862, 24241537, 21804549, 23028483, 20860503, 30552067, 31619474, 24388013, 30929738, 27472835, 29785011, 19198610, 31036433, 29273806, 21150878, 30578877, 29273806, 30929738, 31036433
Inflammatory bowel disease	Inflammatory Bowel Diseases	rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs139868987, rs750447828, rs368138379, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468	28067908
Leprosy	Leprosy	rs121917864, rs2239704	25642632

Unknown
Disease name	Disease term	dbSNP ID	References
Allergic rhinitis	Allergic rhinitis (disorder)		30013184
Allergic sensitization	Allergic sensitization		23817571
Crohn disease	Crohn Disease	rs2066847, rs2066844, rs886052047, rs5743265, rs111608429, rs104895438	28067908
Eczema	Eczema		30595370
Nasal polyposis	Nasal Polyps		30643255
Respiratory tract diseases	Respiratory Tract Diseases		30595370