Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
91584 |
Gene nameGene Name - the full gene name approved by the HGNC.
|
Plexin A4 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
PLXNA4 |
SynonymsGene synonyms aliases
|
FAYV2820, PLEXA4, PLXNA4A, PLXNA4B, PRO34003 |
ChromosomeChromosome number
|
7 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
7q32.3 |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
Q9HCM2 |
Protein name |
Plexin-A4 |
Protein function |
Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin a |
PDB |
4E74
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF01403 |
Sema |
53 → 488 |
Sema domain |
Family |
PF01437 |
PSI |
509 → 559 |
Plexin repeat |
Family |
PF17960 |
TIG_plexin |
564 → 654 |
TIG domain |
Domain |
PF01437 |
PSI |
655 → 702 |
Plexin repeat |
Family |
PF18020 |
TIG_2 |
708 → 802 |
TIG domain found in plexin |
Domain |
PF01833 |
TIG |
858 → 951 |
IPT/TIG domain |
Domain |
PF01833 |
TIG |
954 → 1036 |
IPT/TIG domain |
Domain |
PF01833 |
TIG |
1040 → 1138 |
IPT/TIG domain |
Domain |
PF01833 |
TIG |
1142 → 1227 |
IPT/TIG domain |
Domain |
PF08337 |
Plexin_cytopl |
1311 → 1864 |
Plexin cytoplasmic RasGAP domain |
Family |
|
Sequence |
|
Sequence length |
1894 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
|
Causal |
Disease name |
Disease term |
dbSNP ID |
References |
Alzheimer disease |
Alzheimer`s Disease |
rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs145518263, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316 |
25043464 |
Chronic obstructive pulmonary disease |
Chronic Obstructive Airway Disease |
rs2227956, rs1008438, rs1043618, rs562047, rs1061581, rs2763979, rs6457452, rs13147758, rs1828591, rs13118928 |
26503814 |
Inflammatory bowel disease |
Inflammatory Bowel Diseases |
rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs139868987, rs750447828, rs368138379, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468 |
29603369 |
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