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RSAD2 (radical S-adenosyl methionine domain containing 2)

Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
91543
Gene nameGene Name - the full gene name approved by the HGNC.
Radical S-adenosyl methionine domain containing 2
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
RSAD2
SynonymsGene synonyms aliases
SAND, cig33, cig5, vig1
ChromosomeChromosome number
2
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p25.2
SummarySummary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is an interferon-inducible antiviral protein that belongs to the S-adenosyl-L-methionine (SAM) superfamily of enzymes. The protein plays a role in cellular antiviral response and innate immune signaling. Antiviral effects
miRNAmiRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT021222 hsa-miR-146a-5p Microarray 18057241
MIRT028788 hsa-miR-26b-5p Microarray 19088304
MIRT1320867 hsa-miR-106a CLIP-seq
MIRT1320868 hsa-miR-106b CLIP-seq
MIRT1320869 hsa-miR-1185 CLIP-seq
Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001650 Component Fibrillar center IDA
GO:0003824 Function Catalytic activity IEA
GO:0005515 Function Protein binding IPI 21527675, 21957124, 22045669, 23638199, 24245804, 32296183
GO:0005739 Component Mitochondrion IBA 21873635
GO:0005739 Component Mitochondrion IDA 21527675
Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM
HGNC
e!Ensembl
Protein
UniProt ID Q8WXG1
Protein name S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (SAND) (EC 4.2.-.-) (Cytomegalovirus-induced gene 5 protein) (Radical S-adenosyl methionine domain-containing protein 2) (Virus inhibitory protein, endoplasmic reticulum-associated, interferon-in
Protein function Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon (PubMed:31812350). Catalyzes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhC
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13353 Fer4_12
72 199
Domain
PF04055 Radical_SAM
77 266
Radical SAM superfamily
Domain
Sequence
MWVLTPAAFAGKLLSVFRQPLSSLWRSLVPLFCWLRATFWLLATKRRKQQLVLRGPDETK
EEEEDPPLPTTPTSVNYHFTRQCNYKCGFCFHTAKTSFVLPLEEAKRGLLLLKEAGMEKI
NFSGGEPFLQDRGEYLGKLVRFCKVELRLPSVSIVSNGSLIRERWFQNYGEYLDILAISC
DSFDEEVNVLIGRGQGKKN
HVENLQKLRRWCRDYRVAFKINSVINRFNVEEDMTEQIKAL
NPVRWKVFQCLLIEGENCGEDALREA
ERFVIGDEEFERFLERHKEVSCLVPESNQKMKDS
YLILDEYMRFLNCRKGRKDPSKSILDVGVEEAIKFSGFDEKMFLKRGGKYIWSKADLKLD
W
Sequence length 361
Interactions View interactions
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
 
KEGG
 
Reactome
  Hepatitis C
Influenza A
  Interferon alpha/beta signaling
Associated diseases
Unknown
Disease name Disease term dbSNP ID References
Myocardial ischemia Myocardial Ischemia 16214533

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