Gene
|
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
91543 |
Gene nameGene Name - the full gene name approved by the HGNC.
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Radical S-adenosyl methionine domain containing 2 |
Gene symbolGene Symbol - the official gene symbol approved by the HGNC, which is a short abbreviated form of the gene name.
|
RSAD2 |
SynonymsGene synonyms aliases
|
SAND, cig33, cig5, vig1 |
ChromosomeChromosome number
|
2 |
Chromosome locationChromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
2p25.2 |
SummarySummary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene is an interferon-inducible antiviral protein that belongs to the S-adenosyl-L-methionine (SAM) superfamily of enzymes. The protein plays a role in cellular antiviral response and innate immune signaling. Antiviral effects |
miRNAmiRNA information provided by mirtarbase database.
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Gene ontology (GO)Gene ontology information of associated ontologies with gene provided by GO database.
|
GO ID |
Ontology |
Definition |
Evidence |
Reference |
GO:0001650 |
Component |
Fibrillar center |
IDA |
|
GO:0003824 |
Function |
Catalytic activity |
IEA |
|
GO:0005515 |
Function |
Protein binding |
IPI |
21527675, 21957124, 22045669, 23638199, 24245804, 32296183 |
GO:0005739 |
Component |
Mitochondrion |
IBA |
21873635 |
GO:0005739 |
Component |
Mitochondrion |
IDA |
21527675 |
GO:0005741 |
Component |
Mitochondrial outer membrane |
IDA |
21527675 |
GO:0005743 |
Component |
Mitochondrial inner membrane |
IDA |
21527675 |
GO:0005783 |
Component |
Endoplasmic reticulum |
IBA |
21873635 |
GO:0005783 |
Component |
Endoplasmic reticulum |
IDA |
11752458, 21527675 |
GO:0005789 |
Component |
Endoplasmic reticulum membrane |
IDA |
19074433 |
GO:0005789 |
Component |
Endoplasmic reticulum membrane |
TAS |
|
GO:0005794 |
Component |
Golgi apparatus |
IEA |
|
GO:0005811 |
Component |
Lipid droplet |
ISS |
|
GO:0009615 |
Process |
Response to virus |
IDA |
21957124 |
GO:0016032 |
Process |
Viral process |
IEA |
|
GO:0034157 |
Process |
Positive regulation of toll-like receptor 7 signaling pathway |
ISS |
|
GO:0034165 |
Process |
Positive regulation of toll-like receptor 9 signaling pathway |
ISS |
|
GO:0035710 |
Process |
CD4-positive, alpha-beta T cell activation |
ISS |
|
GO:0043367 |
Process |
CD4-positive, alpha-beta T cell differentiation |
ISS |
|
GO:0043621 |
Function |
Protein self-association |
IDA |
19074433 |
GO:0045071 |
Process |
Negative regulation of viral genome replication |
IDA |
21957124 |
GO:0046872 |
Function |
Metal ion binding |
IEA |
|
GO:0050709 |
Process |
Negative regulation of protein secretion |
IDA |
19074433 |
GO:0050778 |
Process |
Positive regulation of immune response |
IBA |
21873635 |
GO:0051539 |
Function |
4 iron, 4 sulfur cluster binding |
IBA |
21873635 |
GO:0051539 |
Function |
4 iron, 4 sulfur cluster binding |
IDA |
20176015 |
GO:0051607 |
Process |
Defense response to virus |
IBA |
21873635 |
GO:0051607 |
Process |
Defense response to virus |
IDA |
9391139, 16108059, 16982913 |
GO:0060337 |
Process |
Type I interferon signaling pathway |
TAS |
|
GO:2000553 |
Process |
Positive regulation of T-helper 2 cell cytokine production |
ISS |
|
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Other IDsOther ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein
|
UniProt ID |
Q8WXG1 |
Protein name |
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (SAND) (EC 4.2.-.-) (Cytomegalovirus-induced gene 5 protein) (Radical S-adenosyl methionine domain-containing protein 2) (Virus inhibitory protein, endoplasmic reticulum-associated, interferon-in |
Protein function |
Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon (PubMed:31812350). Catalyzes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhC |
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF13353 |
Fer4_12 |
72 → 199 |
|
Domain |
PF04055 |
Radical_SAM |
77 → 266 |
Radical SAM superfamily |
Domain |
|
Sequence |
|
Sequence length |
361 |
Interactions |
View interactions |
PathwaysPathway information has different metabolic/signaling pathways associated with genes. Each record is hyperlinked to a complete information page which also includes links to the KEGG/Reactome pathway database.
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Associated diseases
|
Unknown |
Disease name |
Disease term |
dbSNP ID |
References |
Myocardial ischemia |
Myocardial Ischemia |
|
16214533 |
|