DYRK1B (dual specificity tyrosine phosphorylation regulated kinase 1B)

Gene

• Entrez ID: 9149
• Gene name: Dual specificity tyrosine phosphorylation regulated kinase 1B
• Gene symbol: DYRK1B
• Synonyms: AOMS3, MIRK
• Chromosome: 19
• Chromosome location: 19q13.2
• Summary: This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016969	hsa-miR-335-5p	Microarray	18185580
MIRT036171	hsa-miR-320c	CLASH	23622248
MIRT037892	hsa-miR-455-3p	CLASH	23622248
MIRT038537	hsa-miR-30c-1-3p	CLASH	23622248
MIRT043128	hsa-miR-324-5p	CLASH	23622248
MIRT044780	hsa-miR-320a	CLASH	23622248
MIRT045408	hsa-miR-149-5p	CLASH	23622248
MIRT497031	hsa-miR-6763-5p	PAR-CLIP	22291592
MIRT497032	hsa-miR-3150a-3p	PAR-CLIP	22291592
MIRT497033	hsa-miR-4460	PAR-CLIP	22291592
MIRT497034	hsa-miR-4727-3p	PAR-CLIP	22291592
MIRT497035	hsa-miR-6825-5p	PAR-CLIP	22291592
MIRT497036	hsa-miR-939-5p	PAR-CLIP	22291592
MIRT497037	hsa-miR-1343-5p	PAR-CLIP	22291592
MIRT497038	hsa-miR-3175	PAR-CLIP	22291592
MIRT497039	hsa-miR-6883-5p	PAR-CLIP	22291592
MIRT497040	hsa-miR-6785-5p	PAR-CLIP	22291592
MIRT497041	hsa-miR-4728-5p	PAR-CLIP	22291592
MIRT497042	hsa-miR-149-3p	PAR-CLIP	22291592
MIRT497043	hsa-miR-6090	PAR-CLIP	22291592
MIRT497044	hsa-miR-3926	PAR-CLIP	22291592
MIRT497045	hsa-miR-6797-5p	PAR-CLIP	22291592
MIRT497046	hsa-miR-1249-5p	PAR-CLIP	22291592
MIRT497047	hsa-miR-6133	PAR-CLIP	22291592
MIRT497048	hsa-miR-6130	PAR-CLIP	22291592
MIRT497049	hsa-miR-6129	PAR-CLIP	22291592
MIRT497050	hsa-miR-6127	PAR-CLIP	22291592
MIRT497051	hsa-miR-4510	PAR-CLIP	22291592
MIRT497052	hsa-miR-4419a	PAR-CLIP	22291592
MIRT497053	hsa-miR-1296-3p	PAR-CLIP	22291592
MIRT497054	hsa-miR-548as-3p	PAR-CLIP	22291592
MIRT497055	hsa-miR-491-5p	PAR-CLIP	22291592
MIRT734754	hsa-miR-9-5p	Luciferase reporter assay, qRT-PCR, Western blot	25696812

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003713	Function	Transcription coactivator activity	IBA	21873635
GO:0003713	Function	Transcription coactivator activity	IDA	11980910
GO:0004672	Function	Protein kinase activity	IDA	11980910
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004712	Function	Protein serine/threonine/tyrosine kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	11980910, 14500717, 14593110, 20940704, 23602568, 27705803, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005694	Component	Chromosome	IDA
GO:0006468	Process	Protein phosphorylation	IDA	11980910
GO:0007520	Process	Myoblast fusion	IEA
GO:0018105	Process	Peptidyl-serine phosphorylation	IBA	21873635
GO:0018107	Process	Peptidyl-threonine phosphorylation	IBA	21873635
GO:0018108	Process	Peptidyl-tyrosine phosphorylation	IEA
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IBA	21873635
GO:0045893	Process	Positive regulation of transcription, DNA-templated	IDA	11980910
GO:0046777	Process	Protein autophosphorylation	IEA
GO:0060612	Process	Adipose tissue development	IMP	24827035

Other IDs

• MIM: 604556
• HGNC: 3092
• e!Ensembl: ENSG00000105204

Protein

• UniProt ID: Q9Y463
• Protein name: Dual specificity tyrosine-phosphorylation-regulated kinase 1B (EC 2.7.12.1) (Minibrain-related kinase) (Mirk protein kinase)
• Protein function: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	111 → 431	Protein kinase domain	Domain

• Sequence:

  MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN
  EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG
  SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF
  MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL
  KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG
  CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT
  KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI
  SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN
  RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA
  QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR
  PPLPPPDDPATLGPHLGLRGVPQSTAASS

• Sequence length: 629

Associated diseases

Disease name	Disease term	References
	ABDOMINAL OBESITY-METABOLIC SYNDROME 3	24827035
	NON RARE IN EUROPE: Metabolic syndrome
	Coronary Stenosis
	Hypercholesterolemia
	Hypertensive disease
	Metastatic melanoma
	Myocardial Infarction
	ovarian neoplasm	20857490
	Malignant neoplasm of ovary	20857490