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HGS (hepatocyte growth factor-regulated tyrosine kinase substrate)

Gene

9146

Hepatocyte growth factor-regulated tyrosine kinase substrate

HGS

HRS

17q25.3

The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these prot

Show/Hide all(176)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004900	hsa-miR-296-5p	Luciferase reporter assay, Western blot	18977327
MIRT004900	hsa-miR-296-5p	Luciferase reporter assay, Western blot	18977327
MIRT004900	hsa-miR-296-5p	Luciferase reporter assay, Western blot	18977327
MIRT004900	hsa-miR-296-5p	Luciferase reporter assay, Western blot	18977327
MIRT052221	hsa-let-7b-5p	CLASH	23622248
MIRT042598	hsa-miR-423-3p	CLASH	23622248
MIRT037009	hsa-miR-877-3p	CLASH	23622248
MIRT375956	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT375956	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT004900	hsa-miR-296-5p	qRT-PCR, Western blot	26500043
MIRT1044902	hsa-miR-297	CLIP-seq
MIRT1044903	hsa-miR-3545-3p	CLIP-seq
MIRT1044904	hsa-miR-3668	CLIP-seq
MIRT1044905	hsa-miR-3687	CLIP-seq
MIRT1044906	hsa-miR-3934	CLIP-seq
MIRT1044907	hsa-miR-4255	CLIP-seq
MIRT1044908	hsa-miR-4442	CLIP-seq
MIRT1044909	hsa-miR-567	CLIP-seq
MIRT1044906	hsa-miR-3934	CLIP-seq
MIRT2009790	hsa-miR-1225-3p	CLIP-seq
MIRT2009791	hsa-miR-1253	CLIP-seq
MIRT2009792	hsa-miR-1270	CLIP-seq
MIRT2009793	hsa-miR-1273f	CLIP-seq
MIRT2009794	hsa-miR-2467-3p	CLIP-seq
MIRT2009795	hsa-miR-3117-5p	CLIP-seq
MIRT2009796	hsa-miR-3135b	CLIP-seq
MIRT2009797	hsa-miR-3154	CLIP-seq
MIRT2009798	hsa-miR-3170	CLIP-seq
MIRT2009799	hsa-miR-320e	CLIP-seq
MIRT2009800	hsa-miR-342-5p	CLIP-seq
MIRT2009801	hsa-miR-3678-3p	CLIP-seq
MIRT2009802	hsa-miR-3689d	CLIP-seq
MIRT2009803	hsa-miR-3919	CLIP-seq
MIRT2009804	hsa-miR-4251	CLIP-seq
MIRT2009805	hsa-miR-4323	CLIP-seq
MIRT2009806	hsa-miR-4417	CLIP-seq
MIRT2009807	hsa-miR-4419a	CLIP-seq
MIRT2009808	hsa-miR-4474-3p	CLIP-seq
MIRT2009809	hsa-miR-4475	CLIP-seq
MIRT2009810	hsa-miR-4510	CLIP-seq
MIRT2009811	hsa-miR-4651	CLIP-seq
MIRT2009812	hsa-miR-4664-5p	CLIP-seq
MIRT2009813	hsa-miR-4683	CLIP-seq
MIRT2009814	hsa-miR-4687-3p	CLIP-seq
MIRT2009815	hsa-miR-4786-3p	CLIP-seq
MIRT2009816	hsa-miR-541	CLIP-seq
MIRT2009817	hsa-miR-608	CLIP-seq
MIRT2009818	hsa-miR-620	CLIP-seq
MIRT2009819	hsa-miR-647	CLIP-seq
MIRT2009820	hsa-miR-654-5p	CLIP-seq
MIRT2009821	hsa-miR-769-5p	CLIP-seq
MIRT2009822	hsa-miR-877	CLIP-seq
MIRT2009823	hsa-miR-885-3p	CLIP-seq
MIRT1044904	hsa-miR-3668	CLIP-seq
MIRT1044907	hsa-miR-4255	CLIP-seq
MIRT2451141	hsa-miR-1224-5p	CLIP-seq
MIRT2451142	hsa-miR-1266	CLIP-seq
MIRT2451143	hsa-miR-1288	CLIP-seq
MIRT2451144	hsa-miR-2110	CLIP-seq
MIRT2451145	hsa-miR-3153	CLIP-seq
MIRT2451146	hsa-miR-3192	CLIP-seq
MIRT2451147	hsa-miR-3199	CLIP-seq
MIRT2451148	hsa-miR-331-3p	CLIP-seq
MIRT2009802	hsa-miR-3689d	CLIP-seq
MIRT2451149	hsa-miR-3929	CLIP-seq
MIRT2451150	hsa-miR-4271	CLIP-seq
MIRT2451151	hsa-miR-4292	CLIP-seq
MIRT2009806	hsa-miR-4417	CLIP-seq
MIRT2451152	hsa-miR-4418	CLIP-seq
MIRT2451153	hsa-miR-4419b	CLIP-seq
MIRT2451154	hsa-miR-4446-3p	CLIP-seq
MIRT2451155	hsa-miR-4478	CLIP-seq
MIRT2451156	hsa-miR-4488	CLIP-seq
MIRT2451157	hsa-miR-4492	CLIP-seq
MIRT2451158	hsa-miR-4498	CLIP-seq
MIRT2451159	hsa-miR-4505	CLIP-seq
MIRT2451160	hsa-miR-4518	CLIP-seq
MIRT2451161	hsa-miR-4667-5p	CLIP-seq
MIRT2451162	hsa-miR-4697-5p	CLIP-seq
MIRT2451163	hsa-miR-4700-5p	CLIP-seq
MIRT2451164	hsa-miR-4725-3p	CLIP-seq
MIRT2451165	hsa-miR-4731-5p	CLIP-seq
MIRT2451166	hsa-miR-4751	CLIP-seq
MIRT2451167	hsa-miR-509-3-5p	CLIP-seq
MIRT2451168	hsa-miR-509-5p	CLIP-seq
MIRT2451169	hsa-miR-510	CLIP-seq
MIRT2009816	hsa-miR-541	CLIP-seq
MIRT2451170	hsa-miR-637	CLIP-seq
MIRT2009820	hsa-miR-654-5p	CLIP-seq
MIRT2451171	hsa-miR-762	CLIP-seq
MIRT2451141	hsa-miR-1224-5p	CLIP-seq
MIRT2451142	hsa-miR-1266	CLIP-seq
MIRT2451143	hsa-miR-1288	CLIP-seq
MIRT2545817	hsa-miR-1470	CLIP-seq
MIRT2009797	hsa-miR-3154	CLIP-seq
MIRT2009798	hsa-miR-3170	CLIP-seq
MIRT2451146	hsa-miR-3192	CLIP-seq
MIRT2451147	hsa-miR-3199	CLIP-seq
MIRT2451148	hsa-miR-331-3p	CLIP-seq
MIRT2545818	hsa-miR-342-3p	CLIP-seq
MIRT2009800	hsa-miR-342-5p	CLIP-seq
MIRT2545819	hsa-miR-3667-3p	CLIP-seq
MIRT2009802	hsa-miR-3689d	CLIP-seq
MIRT2009803	hsa-miR-3919	CLIP-seq
MIRT2451149	hsa-miR-3929	CLIP-seq
MIRT2451151	hsa-miR-4292	CLIP-seq
MIRT2009806	hsa-miR-4417	CLIP-seq
MIRT2451152	hsa-miR-4418	CLIP-seq
MIRT2451153	hsa-miR-4419b	CLIP-seq
MIRT2451154	hsa-miR-4446-3p	CLIP-seq
MIRT2451155	hsa-miR-4478	CLIP-seq
MIRT2451156	hsa-miR-4488	CLIP-seq
MIRT2451157	hsa-miR-4492	CLIP-seq
MIRT2545820	hsa-miR-4493	CLIP-seq
MIRT2451158	hsa-miR-4498	CLIP-seq
MIRT2451159	hsa-miR-4505	CLIP-seq
MIRT2451160	hsa-miR-4518	CLIP-seq
MIRT2009811	hsa-miR-4651	CLIP-seq
MIRT2009812	hsa-miR-4664-5p	CLIP-seq
MIRT2545821	hsa-miR-4667-3p	CLIP-seq
MIRT2451162	hsa-miR-4697-5p	CLIP-seq
MIRT2545822	hsa-miR-4715-3p	CLIP-seq
MIRT2451165	hsa-miR-4731-5p	CLIP-seq
MIRT2451166	hsa-miR-4751	CLIP-seq
MIRT2451167	hsa-miR-509-3-5p	CLIP-seq
MIRT2451168	hsa-miR-509-5p	CLIP-seq
MIRT2451169	hsa-miR-510	CLIP-seq
MIRT2009816	hsa-miR-541	CLIP-seq
MIRT2545823	hsa-miR-591	CLIP-seq
MIRT2009817	hsa-miR-608	CLIP-seq
MIRT2451170	hsa-miR-637	CLIP-seq
MIRT2545824	hsa-miR-642a	CLIP-seq
MIRT2009820	hsa-miR-654-5p	CLIP-seq
MIRT2451171	hsa-miR-762	CLIP-seq
MIRT2009822	hsa-miR-877	CLIP-seq
MIRT2451141	hsa-miR-1224-5p	CLIP-seq
MIRT2451142	hsa-miR-1266	CLIP-seq
MIRT2451143	hsa-miR-1288	CLIP-seq
MIRT2009797	hsa-miR-3154	CLIP-seq
MIRT2009798	hsa-miR-3170	CLIP-seq
MIRT2451146	hsa-miR-3192	CLIP-seq
MIRT2451147	hsa-miR-3199	CLIP-seq
MIRT2451148	hsa-miR-331-3p	CLIP-seq
MIRT2545818	hsa-miR-342-3p	CLIP-seq
MIRT2009800	hsa-miR-342-5p	CLIP-seq
MIRT2009802	hsa-miR-3689d	CLIP-seq
MIRT2009803	hsa-miR-3919	CLIP-seq
MIRT2451149	hsa-miR-3929	CLIP-seq
MIRT2451151	hsa-miR-4292	CLIP-seq
MIRT2009806	hsa-miR-4417	CLIP-seq
MIRT2451152	hsa-miR-4418	CLIP-seq
MIRT2451153	hsa-miR-4419b	CLIP-seq
MIRT2451154	hsa-miR-4446-3p	CLIP-seq
MIRT2009809	hsa-miR-4475	CLIP-seq
MIRT2451155	hsa-miR-4478	CLIP-seq
MIRT2451156	hsa-miR-4488	CLIP-seq
MIRT2451157	hsa-miR-4492	CLIP-seq
MIRT2545820	hsa-miR-4493	CLIP-seq
MIRT2451158	hsa-miR-4498	CLIP-seq
MIRT2451159	hsa-miR-4505	CLIP-seq
MIRT2451160	hsa-miR-4518	CLIP-seq
MIRT2009811	hsa-miR-4651	CLIP-seq
MIRT2009812	hsa-miR-4664-5p	CLIP-seq
MIRT2451162	hsa-miR-4697-5p	CLIP-seq
MIRT2545822	hsa-miR-4715-3p	CLIP-seq
MIRT2451165	hsa-miR-4731-5p	CLIP-seq
MIRT2451166	hsa-miR-4751	CLIP-seq
MIRT2451167	hsa-miR-509-3-5p	CLIP-seq
MIRT2451168	hsa-miR-509-5p	CLIP-seq
MIRT2451169	hsa-miR-510	CLIP-seq
MIRT2009816	hsa-miR-541	CLIP-seq
MIRT2545823	hsa-miR-591	CLIP-seq
MIRT2009817	hsa-miR-608	CLIP-seq
MIRT2451170	hsa-miR-637	CLIP-seq
MIRT2009820	hsa-miR-654-5p	CLIP-seq
MIRT2451171	hsa-miR-762	CLIP-seq

Show/Hide all(35)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	10861283, 12802020, 15611048, 16084064, 16189514, 17853893, 18675823, 19278655, 20150893, 21070952, 22046132, 22458338, 24790097, 25416956, 25588945, 25910212, 26871637, 29892012, 29997244, 31467278, 31515488, 32296183, 32814053
GO:0005764	Component	Lysosome	IDA
GO:0005768	Component	Endosome	IDA	15611048
GO:0005769	Component	Early endosome	IDA	10861283
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006622	Process	Protein targeting to lysosome	IMP	18767904
GO:0007165	Process	Signal transduction	TAS	9407053
GO:0008285	Process	Negative regulation of cell population proliferation	TAS	9407053
GO:0010324	Process	Membrane invagination	IMP	18767904
GO:0010628	Process	Positive regulation of gene expression	IMP	18767904
GO:0010642	Process	Negative regulation of platelet-derived growth factor receptor signaling pathway	IMP	18977327
GO:0016197	Process	Endosomal transport	NAS	10861283
GO:0016197	Process	Endosomal transport	TAS
GO:0016236	Process	Macroautophagy	TAS	20588296
GO:0016525	Process	Negative regulation of angiogenesis	IMP	18977327
GO:0016579	Process	Protein deubiquitination	TAS
GO:0019904	Function	Protein domain specific binding	IPI	11984006
GO:0030948	Process	Negative regulation of vascular endothelial growth factor receptor signaling pathway	IMP	18977327
GO:0031901	Component	Early endosome membrane	IEA
GO:0032585	Component	Multivesicular body membrane	IEA
GO:0033565	Component	ESCRT-0 complex	IDA	24790097
GO:0033565	Component	ESCRT-0 complex	TAS	20588296
GO:0036258	Process	Multivesicular body assembly	TAS	20588296
GO:0042059	Process	Negative regulation of epidermal growth factor receptor signaling pathway	TAS
GO:0042176	Process	Regulation of protein catabolic process	TAS	15611048
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0043405	Process	Regulation of MAP kinase activity	IMP	17714434
GO:0044389	Function	Ubiquitin-like protein ligase binding	IPI	24790097
GO:0046426	Process	Negative regulation of receptor signaling pathway via JAK-STAT	IDA	12444102
GO:0046872	Function	Metal ion binding	IEA
GO:0061024	Process	Membrane organization	TAS
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0072657	Process	Protein localization to membrane	IMP	18767904
GO:1903543	Process	Positive regulation of exosomal secretion	IMP	24105262

MIM	HGNC	e!Ensembl
604375	4897	ENSG00000185359

Protein

UniProt ID

O14964

Protein name

Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)

Protein function

Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via

PDB

2D3G , 3F1I , 3OBQ , 3ZYQ , 4AVX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00790	VHS	3 → 139	VHS domain	Domain
PF01363	FYVE	158 → 221	FYVE zinc finger	Domain
PF12210	Hrs_helical	407 → 501	Hepatocyte growth factor-regulated tyrosine kinase substrate	Domain

Sequence

MGRGSGTFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHV
ALYALEVMESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFR
NEPKYKVVQDTYQIMKVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVMTRKH
HCRACGQIFCGKCSSKYSTIPKFGIEKEVRVCEPCYEQLNRKAEGKATSTTELPPEYLTS
PLSQQSQLPPKRDETALQEEEELQLALALSQSEAEEKERLRQKSTYTSYPKAEPMPSASS
APPASSLYSSPVNSSAPLAEDIDPELARYLNRNYWEKKQEEARKSPTPSAPVPLTEPAAQ
PGEGHAAPTNVVENPLPETDSQPIPPSGGPFSEPQFHNGESEESHEQFLKALQNAVTTFV
NRMKSNHMRGRSITNDSAVLSLFQSINGMHPQLLELLNQLDERRLYYEGLQDKLAQIRDA
RGALSALREEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQE
KERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPAAGGVLYQPSGPASFPSTFSPAGSVE
GSPMHGVYMSQPAPAAGPYPSMPSTAADPSMVSAYMYPAGATGAQAAPQAQAGPTASPAY
SSYQPTPTAGYQNVASQAPQSLPAISQPPQSSTMGYMGSQSVSMGYQPYNMQNLMTTLPS
QDASLPPQQPYIAGQQPMYQQMAPSGGPPQQQPPVAQQPQAQGPPAQGSEAQLISFD

Sequence length

777

Interactions

View interactions

	KEGG		Reactome
	Viral life cycle - HIV-1 Endocytosis Phagosome		EGFR downregulation Lysosome Vesicle Biogenesis Ub-specific processing proteases Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Endosomal Sorting Complex Required For Transport (ESCRT) Inhibition of membrane repair Prevention of phagosomal-lysosomal fusion

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Schizophrenia	Schizophrenia, Childhood	rs74315508, rs74315509, rs13447324, rs1558507406, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313	26508570

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