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CCNE2 (cyclin E2)

Gene

9134

Cyclin E2

CCNE2

CYCE2

8q22.1

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit

Show/Hide all(316)

miRTarBase ID	miRNA	Experiments	Reference
MIRT000965	hsa-miR-126-3p	Luciferase reporter assay	18834857
MIRT000768	hsa-miR-34a-5p	Review, Luciferase reporter assay	19461653
MIRT000767	hsa-miR-34b-5p	Review, Luciferase reporter assay	19461653
MIRT000766	hsa-miR-34c-5p	Review, Luciferase reporter assay	19461653
MIRT000768	hsa-miR-34a-5p	Review, Luciferase reporter assay, Western blot, Microarray	17914404
MIRT000645	hsa-miR-503-5p	Luciferase reporter assay	19956200
MIRT000768	hsa-miR-34a-5p	Review	20130964
MIRT003448	hsa-miR-34b-3p	Review	20130964
MIRT000766	hsa-miR-34c-5p	Review	20130964
MIRT000111	hsa-miR-26a-5p	Luciferase reporter assay, Western blot	19524505
MIRT000111	hsa-miR-26a-5p	Luciferase reporter assay, Western blot	19524505
MIRT006303	hsa-miR-30b-5p	Luciferase reporter assay, qRT-PCR	22384020
MIRT006303	hsa-miR-30b-5p	Luciferase reporter assay, qRT-PCR	22384020
MIRT006303	hsa-miR-30b-5p	Luciferase reporter assay, qRT-PCR	22384020
MIRT006303	hsa-miR-30b-5p	Luciferase reporter assay, qRT-PCR	22384020
MIRT006347	hsa-miR-449a	Luciferase reporter assay, Western blot	21418558
MIRT006350	hsa-miR-449b-5p	Luciferase reporter assay, Western blot	21418558
MIRT006303	hsa-miR-30b-5p	Luciferase reporter assay, qRT-PCR	22384020
MIRT006303	hsa-miR-30b-5p	Luciferase reporter assay, qRT-PCR	22384020
MIRT006303	hsa-miR-30b-5p	Luciferase reporter assay, qRT-PCR	22384020
MIRT006303	hsa-miR-30b-5p	Luciferase reporter assay, qRT-PCR	22384020
MIRT006347	hsa-miR-449a	Luciferase reporter assay, Western blot	21418558
MIRT006350	hsa-miR-449b-5p	Luciferase reporter assay, Western blot	21418558
MIRT006303	hsa-miR-30b-5p	Luciferase reporter assay, qRT-PCR	22384020
MIRT006303	hsa-miR-30b-5p	Luciferase reporter assay, qRT-PCR	22384020
MIRT006303	hsa-miR-30b-5p	Luciferase reporter assay, qRT-PCR	22384020
MIRT006303	hsa-miR-30b-5p	Luciferase reporter assay, qRT-PCR	22384020
MIRT006347	hsa-miR-449a	Luciferase reporter assay, Western blot	21418558
MIRT006350	hsa-miR-449b-5p	Luciferase reporter assay, Western blot	21418558
MIRT006665	hsa-miR-200a-3p	Luciferase reporter assay	22183793
MIRT006666	hsa-miR-200b-3p	Luciferase reporter assay	22183793
MIRT006667	hsa-miR-200c-3p	Luciferase reporter assay	22183793
MIRT028325	hsa-miR-32-5p	Sequencing	20371350
MIRT031722	hsa-miR-16-5p	Sequencing	20371350
MIRT050210	hsa-miR-25-3p	CLASH	23622248
MIRT048230	hsa-miR-196a-5p	CLASH	23622248
MIRT507854	hsa-miR-577	PAR-CLIP	20371350
MIRT507853	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT507852	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT031722	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT507851	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT507850	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT507849	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT507848	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT000645	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT507847	hsa-miR-646	PAR-CLIP	20371350
MIRT507845	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT507844	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT507854	hsa-miR-577	PAR-CLIP	21572407
MIRT507853	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT507852	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT031722	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT507851	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT507850	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT507849	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT507848	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT000645	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT507847	hsa-miR-646	PAR-CLIP	21572407
MIRT507846	hsa-miR-6504-3p	PAR-CLIP	21572407
MIRT106609	hsa-miR-520d-5p	PAR-CLIP	21572407
MIRT106608	hsa-miR-524-5p	PAR-CLIP	21572407
MIRT507845	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT507844	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT507843	hsa-miR-556-3p	PAR-CLIP	21572407
MIRT507854	hsa-miR-577	PAR-CLIP	21572407
MIRT507853	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT507852	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT031722	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT507851	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT507850	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT507849	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT507848	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT000645	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT507847	hsa-miR-646	PAR-CLIP	21572407
MIRT507845	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT507844	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT000768	hsa-miR-34a-5p	PAR-CLIP	23446348
MIRT006347	hsa-miR-449a	PAR-CLIP	23446348
MIRT006350	hsa-miR-449b-5p	PAR-CLIP	23446348
MIRT000766	hsa-miR-34c-5p	PAR-CLIP	23446348
MIRT507863	hsa-miR-5197-5p	PAR-CLIP	23446348
MIRT507861	hsa-miR-2115-3p	PAR-CLIP	23446348
MIRT507862	hsa-miR-219b-3p	PAR-CLIP	23446348
MIRT507860	hsa-miR-219a-2-3p	PAR-CLIP	23446348
MIRT507859	hsa-miR-6499-3p	PAR-CLIP	23446348
MIRT507858	hsa-miR-548au-3p	PAR-CLIP	23446348
MIRT507857	hsa-miR-6069	PAR-CLIP	23446348
MIRT507856	hsa-miR-1257	PAR-CLIP	23446348
MIRT507855	hsa-miR-3611	PAR-CLIP	23446348
MIRT507854	hsa-miR-577	PAR-CLIP	23446348
MIRT507853	hsa-miR-15a-5p	PAR-CLIP	23446348
MIRT507852	hsa-miR-15b-5p	PAR-CLIP	23446348
MIRT031722	hsa-miR-16-5p	PAR-CLIP	23446348
MIRT507851	hsa-miR-195-5p	PAR-CLIP	23446348
MIRT507850	hsa-miR-424-5p	PAR-CLIP	23446348
MIRT507849	hsa-miR-497-5p	PAR-CLIP	23446348
MIRT507848	hsa-miR-6838-5p	PAR-CLIP	23446348
MIRT000645	hsa-miR-503-5p	PAR-CLIP	23446348
MIRT507847	hsa-miR-646	PAR-CLIP	23446348
MIRT507846	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT106609	hsa-miR-520d-5p	PAR-CLIP	23446348
MIRT106608	hsa-miR-524-5p	PAR-CLIP	23446348
MIRT507845	hsa-miR-4524a-5p	PAR-CLIP	23446348
MIRT507844	hsa-miR-4524b-5p	PAR-CLIP	23446348
MIRT507843	hsa-miR-556-3p	PAR-CLIP	23446348
MIRT006303	hsa-miR-30b-5p	qRT-PCR, Western blot	28120942
MIRT000111	hsa-miR-26a-5p	qRT-PCR, Western blot	28120942
MIRT731697	hsa-miR-664b-5p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot	28176879
MIRT731697	hsa-miR-664b-5p	Immunofluorescence, Luciferase reporter assay, qRT-PCR, Western blot	28176879
MIRT736272	hsa-miR-30a-5p	qRT-PCR, Western blot	26555189
MIRT736272	hsa-miR-30a-5p	Flow, Immunohistochemistry, Luciferase reporter assay, qRT-PCR	27431942
MIRT734523	rno-miR-204-5p	Flow cytometry, qRT-PCR, Western blotting	32500147
MIRT736272	hsa-miR-30a-5p	Luciferase reporter assay, Western blotting, Immunoprecipitaion (IP), Immunohistochemistry (IHC)	34128973
MIRT000768	hsa-miR-34a-5p	Western blotting, Immunohistochemistry (IHC), qRT-PCR	33614246
MIRT507854	hsa-miR-577	PAR-CLIP	20371350
MIRT507853	hsa-miR-15a-5p	PAR-CLIP	20371350
MIRT507852	hsa-miR-15b-5p	PAR-CLIP	20371350
MIRT031722	hsa-miR-16-5p	PAR-CLIP	20371350
MIRT507851	hsa-miR-195-5p	PAR-CLIP	20371350
MIRT507850	hsa-miR-424-5p	PAR-CLIP	20371350
MIRT507849	hsa-miR-497-5p	PAR-CLIP	20371350
MIRT507848	hsa-miR-6838-5p	PAR-CLIP	20371350
MIRT000645	hsa-miR-503-5p	PAR-CLIP	20371350
MIRT507847	hsa-miR-646	PAR-CLIP	20371350
MIRT507845	hsa-miR-4524a-5p	PAR-CLIP	20371350
MIRT507844	hsa-miR-4524b-5p	PAR-CLIP	20371350
MIRT507854	hsa-miR-577	PAR-CLIP	21572407
MIRT507853	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT507852	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT031722	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT507851	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT507850	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT507849	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT507848	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT000645	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT507847	hsa-miR-646	PAR-CLIP	21572407
MIRT507846	hsa-miR-6504-3p	PAR-CLIP	21572407
MIRT106609	hsa-miR-520d-5p	PAR-CLIP	21572407
MIRT106608	hsa-miR-524-5p	PAR-CLIP	21572407
MIRT507845	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT507844	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT507843	hsa-miR-556-3p	PAR-CLIP	21572407
MIRT507854	hsa-miR-577	PAR-CLIP	21572407
MIRT507853	hsa-miR-15a-5p	PAR-CLIP	21572407
MIRT507852	hsa-miR-15b-5p	PAR-CLIP	21572407
MIRT031722	hsa-miR-16-5p	PAR-CLIP	21572407
MIRT507851	hsa-miR-195-5p	PAR-CLIP	21572407
MIRT507850	hsa-miR-424-5p	PAR-CLIP	21572407
MIRT507849	hsa-miR-497-5p	PAR-CLIP	21572407
MIRT507848	hsa-miR-6838-5p	PAR-CLIP	21572407
MIRT000645	hsa-miR-503-5p	PAR-CLIP	21572407
MIRT507847	hsa-miR-646	PAR-CLIP	21572407
MIRT507845	hsa-miR-4524a-5p	PAR-CLIP	21572407
MIRT507844	hsa-miR-4524b-5p	PAR-CLIP	21572407
MIRT000768	hsa-miR-34a-5p	PAR-CLIP	23446348
MIRT006347	hsa-miR-449a	PAR-CLIP	23446348
MIRT006350	hsa-miR-449b-5p	PAR-CLIP	23446348
MIRT000766	hsa-miR-34c-5p	PAR-CLIP	23446348
MIRT507863	hsa-miR-5197-5p	PAR-CLIP	23446348
MIRT507861	hsa-miR-2115-3p	PAR-CLIP	23446348
MIRT507862	hsa-miR-219b-3p	PAR-CLIP	23446348
MIRT507860	hsa-miR-219a-2-3p	PAR-CLIP	23446348
MIRT507859	hsa-miR-6499-3p	PAR-CLIP	23446348
MIRT507858	hsa-miR-548au-3p	PAR-CLIP	23446348
MIRT507857	hsa-miR-6069	PAR-CLIP	23446348
MIRT507856	hsa-miR-1257	PAR-CLIP	23446348
MIRT507855	hsa-miR-3611	PAR-CLIP	23446348
MIRT507854	hsa-miR-577	PAR-CLIP	23446348
MIRT507853	hsa-miR-15a-5p	PAR-CLIP	23446348
MIRT507852	hsa-miR-15b-5p	PAR-CLIP	23446348
MIRT031722	hsa-miR-16-5p	PAR-CLIP	23446348
MIRT507851	hsa-miR-195-5p	PAR-CLIP	23446348
MIRT507850	hsa-miR-424-5p	PAR-CLIP	23446348
MIRT507849	hsa-miR-497-5p	PAR-CLIP	23446348
MIRT507848	hsa-miR-6838-5p	PAR-CLIP	23446348
MIRT000645	hsa-miR-503-5p	PAR-CLIP	23446348
MIRT507847	hsa-miR-646	PAR-CLIP	23446348
MIRT507846	hsa-miR-6504-3p	PAR-CLIP	23446348
MIRT106609	hsa-miR-520d-5p	PAR-CLIP	23446348
MIRT106608	hsa-miR-524-5p	PAR-CLIP	23446348
MIRT507845	hsa-miR-4524a-5p	PAR-CLIP	23446348
MIRT507844	hsa-miR-4524b-5p	PAR-CLIP	23446348
MIRT507843	hsa-miR-556-3p	PAR-CLIP	23446348
MIRT736272	hsa-miR-30a-5p	Luciferase reporter assay, Western blotting, qRT-PCR, Flow cytometry	34589618
MIRT736272	hsa-miR-30a-5p	Luciferase reporter assay, Western blotting, qRT-PCR, Flow cytometry	34589618
MIRT871848	hsa-miR-106a	CLIP-seq
MIRT871849	hsa-miR-106b	CLIP-seq
MIRT871850	hsa-miR-1305	CLIP-seq
MIRT871851	hsa-miR-17	CLIP-seq
MIRT871852	hsa-miR-20a	CLIP-seq
MIRT871853	hsa-miR-20b	CLIP-seq
MIRT871854	hsa-miR-25	CLIP-seq
MIRT871855	hsa-miR-30a	CLIP-seq
MIRT871856	hsa-miR-30b	CLIP-seq
MIRT871857	hsa-miR-30c	CLIP-seq
MIRT871858	hsa-miR-30d	CLIP-seq
MIRT871859	hsa-miR-30e	CLIP-seq
MIRT871860	hsa-miR-3117-5p	CLIP-seq
MIRT871861	hsa-miR-3121-3p	CLIP-seq
MIRT871862	hsa-miR-3164	CLIP-seq
MIRT871863	hsa-miR-3189-3p	CLIP-seq
MIRT871864	hsa-miR-32	CLIP-seq
MIRT871865	hsa-miR-335	CLIP-seq
MIRT871866	hsa-miR-342-3p	CLIP-seq
MIRT871867	hsa-miR-34c-3p	CLIP-seq
MIRT871868	hsa-miR-3609	CLIP-seq
MIRT871869	hsa-miR-363	CLIP-seq
MIRT871870	hsa-miR-367	CLIP-seq
MIRT871871	hsa-miR-4325	CLIP-seq
MIRT871872	hsa-miR-4652-3p	CLIP-seq
MIRT871873	hsa-miR-4705	CLIP-seq
MIRT871874	hsa-miR-4712-5p	CLIP-seq
MIRT871875	hsa-miR-4775	CLIP-seq
MIRT871876	hsa-miR-4796-3p	CLIP-seq
MIRT871877	hsa-miR-498	CLIP-seq
MIRT871878	hsa-miR-513a-3p	CLIP-seq
MIRT871879	hsa-miR-514	CLIP-seq
MIRT871880	hsa-miR-514b-3p	CLIP-seq
MIRT871881	hsa-miR-519d	CLIP-seq
MIRT871882	hsa-miR-548ah	CLIP-seq
MIRT871883	hsa-miR-548b-3p	CLIP-seq
MIRT871884	hsa-miR-590-3p	CLIP-seq
MIRT871885	hsa-miR-617	CLIP-seq
MIRT871886	hsa-miR-770-5p	CLIP-seq
MIRT871887	hsa-miR-92a	CLIP-seq
MIRT871888	hsa-miR-92b	CLIP-seq
MIRT871889	hsa-miR-93	CLIP-seq
MIRT871860	hsa-miR-3117-5p	CLIP-seq
MIRT1958736	hsa-miR-374c	CLIP-seq
MIRT1958737	hsa-miR-4452	CLIP-seq
MIRT1958738	hsa-miR-655	CLIP-seq
MIRT871848	hsa-miR-106a	CLIP-seq
MIRT871849	hsa-miR-106b	CLIP-seq
MIRT2195467	hsa-miR-1243	CLIP-seq
MIRT2195468	hsa-miR-1253	CLIP-seq
MIRT2195469	hsa-miR-1284	CLIP-seq
MIRT2195470	hsa-miR-1287	CLIP-seq
MIRT2195471	hsa-miR-1290	CLIP-seq
MIRT2195472	hsa-miR-132	CLIP-seq
MIRT2195473	hsa-miR-1323	CLIP-seq
MIRT2195474	hsa-miR-141	CLIP-seq
MIRT2195475	hsa-miR-151-3p	CLIP-seq
MIRT871851	hsa-miR-17	CLIP-seq
MIRT2195476	hsa-miR-200a	CLIP-seq
MIRT871852	hsa-miR-20a	CLIP-seq
MIRT871853	hsa-miR-20b	CLIP-seq
MIRT2195477	hsa-miR-212	CLIP-seq
MIRT2195478	hsa-miR-219-2-3p	CLIP-seq
MIRT2195479	hsa-miR-23a	CLIP-seq
MIRT2195480	hsa-miR-23b	CLIP-seq
MIRT2195481	hsa-miR-23c	CLIP-seq
MIRT2195482	hsa-miR-2467-5p	CLIP-seq
MIRT2195483	hsa-miR-2964a-3p	CLIP-seq
MIRT871855	hsa-miR-30a	CLIP-seq
MIRT871856	hsa-miR-30b	CLIP-seq
MIRT871857	hsa-miR-30c	CLIP-seq
MIRT871858	hsa-miR-30d	CLIP-seq
MIRT871859	hsa-miR-30e	CLIP-seq
MIRT871860	hsa-miR-3117-5p	CLIP-seq
MIRT2195484	hsa-miR-3120-3p	CLIP-seq
MIRT871861	hsa-miR-3121-3p	CLIP-seq
MIRT871862	hsa-miR-3164	CLIP-seq
MIRT2195485	hsa-miR-3167	CLIP-seq
MIRT2195486	hsa-miR-3168	CLIP-seq
MIRT2195487	hsa-miR-3188	CLIP-seq
MIRT871866	hsa-miR-342-3p	CLIP-seq
MIRT2195488	hsa-miR-34a	CLIP-seq
MIRT871868	hsa-miR-3609	CLIP-seq
MIRT2195489	hsa-miR-3617	CLIP-seq
MIRT2195490	hsa-miR-3652	CLIP-seq
MIRT2195491	hsa-miR-370	CLIP-seq
MIRT2195492	hsa-miR-3975	CLIP-seq
MIRT2195493	hsa-miR-4263	CLIP-seq
MIRT2195494	hsa-miR-4277	CLIP-seq
MIRT2195495	hsa-miR-4430	CLIP-seq
MIRT2195496	hsa-miR-4434	CLIP-seq
MIRT2195497	hsa-miR-4436b-3p	CLIP-seq
MIRT1958737	hsa-miR-4452	CLIP-seq
MIRT2195498	hsa-miR-4463	CLIP-seq
MIRT2195499	hsa-miR-4499	CLIP-seq
MIRT2195500	hsa-miR-449b	CLIP-seq
MIRT2195501	hsa-miR-4516	CLIP-seq
MIRT2195502	hsa-miR-455-3p	CLIP-seq
MIRT2195503	hsa-miR-4668-3p	CLIP-seq
MIRT2195504	hsa-miR-4719	CLIP-seq
MIRT2195505	hsa-miR-4761-3p	CLIP-seq
MIRT871875	hsa-miR-4775	CLIP-seq
MIRT871876	hsa-miR-4796-3p	CLIP-seq
MIRT2195506	hsa-miR-4802-5p	CLIP-seq
MIRT2195507	hsa-miR-4803	CLIP-seq
MIRT2195508	hsa-miR-485-3p	CLIP-seq
MIRT2195509	hsa-miR-485-5p	CLIP-seq
MIRT2195510	hsa-miR-488	CLIP-seq
MIRT871878	hsa-miR-513a-3p	CLIP-seq
MIRT2195511	hsa-miR-513b	CLIP-seq
MIRT871881	hsa-miR-519d	CLIP-seq
MIRT2195512	hsa-miR-548a-3p	CLIP-seq
MIRT871882	hsa-miR-548ah	CLIP-seq
MIRT2195513	hsa-miR-548e	CLIP-seq
MIRT2195514	hsa-miR-548f	CLIP-seq
MIRT2195515	hsa-miR-548o	CLIP-seq
MIRT2195516	hsa-miR-576-5p	CLIP-seq
MIRT871884	hsa-miR-590-3p	CLIP-seq
MIRT871885	hsa-miR-617	CLIP-seq
MIRT2195517	hsa-miR-641	CLIP-seq
MIRT2195518	hsa-miR-765	CLIP-seq
MIRT2195519	hsa-miR-802	CLIP-seq
MIRT2195520	hsa-miR-876-5p	CLIP-seq
MIRT871889	hsa-miR-93	CLIP-seq
MIRT2195484	hsa-miR-3120-3p	CLIP-seq
MIRT2385710	hsa-miR-511	CLIP-seq
MIRT871855	hsa-miR-30a	CLIP-seq
MIRT871856	hsa-miR-30b	CLIP-seq
MIRT871857	hsa-miR-30c	CLIP-seq
MIRT871858	hsa-miR-30d	CLIP-seq
MIRT871859	hsa-miR-30e	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
CHD8	Activation	19255092

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000079	Process	Regulation of cyclin-dependent protein serine/threonine kinase activity	IBA	21873635
GO:0000082	Process	G1/S transition of mitotic cell cycle	IBA	21873635
GO:0000082	Process	G1/S transition of mitotic cell cycle	TAS
GO:0000307	Component	Cyclin-dependent protein kinase holoenzyme complex	IBA	21873635
GO:0000723	Process	Telomere maintenance	IEA
GO:0005515	Function	Protein binding	IPI	9840943, 15232106, 23455922, 23602568, 24358021, 25852190, 26496610, 28514442, 30833792, 32814053
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005813	Component	Centrosome	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0006270	Process	DNA replication initiation	IEA
GO:0007129	Process	Homologous chromosome pairing at meiosis	IEA
GO:0016538	Function	Cyclin-dependent protein serine/threonine kinase regulator activity	IBA	21873635
GO:0019901	Function	Protein kinase binding	IEA
GO:0044772	Process	Mitotic cell cycle phase transition	IBA	21873635
GO:0051301	Process	Cell division	IEA
GO:0097134	Component	Cyclin E1-CDK2 complex	IBA	21873635
GO:0097135	Component	Cyclin E2-CDK2 complex	IBA	21873635
GO:0097135	Component	Cyclin E2-CDK2 complex	IDA	18305109
GO:1903827	Process	Regulation of cellular protein localization	IEA

MIM	HGNC	e!Ensembl
603775	1590	ENSG00000175305

Protein

UniProt ID

O96020

Protein name

G1/S-specific cyclin-E2

Protein function

Essential for the control of the cell cycle at the late G1 and early S phase.

PDB

8HN9

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00134	Cyclin_N	112 → 239	Cyclin, N-terminal domain	Domain
PF02984	Cyclin_C	241 → 363	Cyclin, C-terminal domain	Domain

Sequence

MSRRSSRLQAKQQPQPSQTESPQEAQIIQAKKRKTTQDVKKRREEVTKKHQYEIRNCWPP
VLSGGISPCIIIETPHKEIGTSDFSRFTNYRFKNLFINPSPLPDLSWGCSKEVWLNMLKK
ESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDI
NKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEEDILRMELIILKALKWELCP
VTIISWLNLFLQVDALKDAPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILTAAA
LCHFTSIEVVKKASGLEWDSISECVDWMVPFVNVVKSTSPVKLKTFKKIPMEDRHNIQTH
TNYLAMLEEVNYINTFRKGGQLSPVCNGGIMTPPKSTEKPPGKH

Sequence length

404

Interactions

View interactions

	KEGG		Reactome
	Cell cycle Oocyte meiosis p53 signaling pathway PI3K-Akt signaling pathway Cellular senescence Cushing syndrome Hepatitis B Measles Human papillomavirus infection Human T-cell leukemia virus 1 infection Epstein-Barr virus infection Pathways in cancer Viral carcinogenesis MicroRNAs in cancer Prostate cancer Small cell lung cancer Gastric cancer		G0 and Early G1 SCF(Skp2)-mediated degradation of p27/p21 DNA Damage/Telomere Stress Induced Senescence TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition p53-Dependent G1 DNA Damage Response

Associated diseases

Show/Hide Causal Diseases (1)

Causal
Disease name	Disease term	dbSNP ID	References
Carcinoma of the head and neck	Squamous cell carcinoma of the head and neck	rs121909237, rs121909250, rs121909251, rs121909252, rs28934571, rs28934574, rs28934576, rs28934578, rs121912664, rs397516436, rs121912666, rs397514495, rs587782705, rs193920774, rs730882001, rs786201838, rs587782144, rs866775781, rs730882008, rs1567549584, rs1597371666, rs1597365075	29464035

Show/Hide Unknown Diseases (5)

Unknown
Disease name	Disease term	dbSNP ID	References
Endometrioma	Endometrioma		20864642
Endometriosis	Endometriosis	rs1800629, rs1143634	20864642
Malignant mesothelioma	Malignant mesothelioma		25756049
Sclerocystic ovaries	Sclerocystic Ovaries		21411543
Polycystic ovary syndrome	Polycystic Ovary Syndrome		21411543

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