LATS1 (large tumor suppressor kinase 1)

Gene

• Entrez ID: 9113
• Gene name: Large tumor suppressor kinase 1
• Gene symbol: LATS1
• Synonyms: WARTS, wts
• Chromosome: 6
• Chromosome location: 6q25.1
• Summary: The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs1408705745	C>A,T	Likely-pathogenic	Stop gained, genic downstream transcript variant, non coding transcript variant, 3 prime UTR variant, missense variant, coding sequence variant
rs1582867955	C>T	Likely-pathogenic	Missense variant, genic downstream transcript variant, coding sequence variant, non coding transcript variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016931	hsa-miR-335-5p	Microarray	18185580
MIRT027020	hsa-miR-103a-3p	Sequencing	20371350
MIRT030710	hsa-miR-21-5p	Microarray	18591254
MIRT031514	hsa-miR-16-5p	Sequencing	20371350
MIRT631348	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT631346	hsa-miR-3691-3p	HITS-CLIP	23824327
MIRT631345	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT631344	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT631343	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT631342	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631341	hsa-miR-1976	HITS-CLIP	23824327
MIRT631340	hsa-miR-4279	HITS-CLIP	23824327
MIRT631348	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT633521	hsa-miR-3614-3p	HITS-CLIP	23824327
MIRT631346	hsa-miR-3691-3p	HITS-CLIP	23824327
MIRT631345	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT631344	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT631343	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT631342	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631341	hsa-miR-1976	HITS-CLIP	23824327
MIRT633520	hsa-miR-4297	HITS-CLIP	23824327
MIRT633519	hsa-miR-5581-5p	HITS-CLIP	23824327
MIRT631340	hsa-miR-4279	HITS-CLIP	23824327
MIRT631348	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT631347	hsa-miR-5697	HITS-CLIP	23824327
MIRT631346	hsa-miR-3691-3p	HITS-CLIP	23824327
MIRT631345	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT631344	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT631343	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT631342	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631341	hsa-miR-1976	HITS-CLIP	23824327
MIRT631340	hsa-miR-4279	HITS-CLIP	23824327
MIRT733925	hsa-miR-25-3p	qRT-PCR	33669647
MIRT735858	hsa-miR-1184	Western blotting, qRT-PCR	32681581
MIRT735858	hsa-miR-1184	Western blotting, Immunoprecipitaion (IP), qRT-PCR	32681581
MIRT631348	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT631346	hsa-miR-3691-3p	HITS-CLIP	23824327
MIRT631345	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT631344	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT631343	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT631342	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631341	hsa-miR-1976	HITS-CLIP	23824327
MIRT631340	hsa-miR-4279	HITS-CLIP	23824327
MIRT631348	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT633521	hsa-miR-3614-3p	HITS-CLIP	23824327
MIRT631346	hsa-miR-3691-3p	HITS-CLIP	23824327
MIRT631345	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT631344	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT631343	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT631342	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631341	hsa-miR-1976	HITS-CLIP	23824327
MIRT633520	hsa-miR-4297	HITS-CLIP	23824327
MIRT633519	hsa-miR-5581-5p	HITS-CLIP	23824327
MIRT631340	hsa-miR-4279	HITS-CLIP	23824327
MIRT631348	hsa-miR-122-3p	HITS-CLIP	23824327
MIRT631347	hsa-miR-5697	HITS-CLIP	23824327
MIRT631346	hsa-miR-3691-3p	HITS-CLIP	23824327
MIRT631345	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT631344	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT631343	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT631342	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT631341	hsa-miR-1976	HITS-CLIP	23824327
MIRT631340	hsa-miR-4279	HITS-CLIP	23824327
MIRT1105137	hsa-miR-1251	CLIP-seq
MIRT1105138	hsa-miR-200b	CLIP-seq
MIRT1105139	hsa-miR-200c	CLIP-seq
MIRT1105140	hsa-miR-21	CLIP-seq
MIRT1105141	hsa-miR-3121-3p	CLIP-seq
MIRT1105142	hsa-miR-330-3p	CLIP-seq
MIRT1105143	hsa-miR-4263	CLIP-seq
MIRT1105144	hsa-miR-429	CLIP-seq
MIRT1105145	hsa-miR-4684-5p	CLIP-seq
MIRT1105146	hsa-miR-4768-5p	CLIP-seq
MIRT1105147	hsa-miR-4775	CLIP-seq
MIRT1105148	hsa-miR-4799-5p	CLIP-seq
MIRT1105149	hsa-miR-553	CLIP-seq
MIRT1105150	hsa-miR-576-5p	CLIP-seq
MIRT1105151	hsa-miR-590-5p	CLIP-seq
MIRT2029028	hsa-miR-1279	CLIP-seq
MIRT2029029	hsa-miR-135a	CLIP-seq
MIRT2029030	hsa-miR-135b	CLIP-seq
MIRT2029031	hsa-miR-3135	CLIP-seq
MIRT2029032	hsa-miR-3914	CLIP-seq
MIRT2029033	hsa-miR-4277	CLIP-seq
MIRT2029034	hsa-miR-4699-3p	CLIP-seq
MIRT1105147	hsa-miR-4775	CLIP-seq
MIRT2260006	hsa-miR-4672	CLIP-seq
MIRT1105147	hsa-miR-4775	CLIP-seq
MIRT2260007	hsa-miR-4789-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000082	Process	G1/S transition of mitotic cell cycle	IBA	21873635
GO:0000086	Process	G2/M transition of mitotic cell cycle	IDA	15122335
GO:0000287	Function	Magnesium ion binding	IDA	10518011
GO:0000819	Process	Sister chromatid segregation	IDA	15122335
GO:0000922	Component	Spindle pole	IBA	21873635
GO:0000922	Component	Spindle pole	IDA	10518011
GO:0001827	Process	Inner cell mass cell fate commitment	IEA
GO:0001828	Process	Inner cell mass cellular morphogenesis	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA	21873635
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	10518011, 20412773
GO:0004674	Function	Protein serine/threonine kinase activity	TAS
GO:0005515	Function	Protein binding	IPI	9988268, 10831611, 15220930, 18158288, 19739119, 19927127, 20303269, 20412773, 22078877, 22863277, 24012335, 24255178, 24362629, 24366813, 25026211, 25218637, 25283809, 25438054, 25751139, 28068668, 28087714, 28169360, 28514442, 32661924
GO:0005524	Function	ATP binding	IDA	10518011
GO:0005634	Component	Nucleus	ISS
GO:0005815	Component	Microtubule organizing center	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006468	Process	Protein phosphorylation	IDA	10518011
GO:0009755	Process	Hormone-mediated signaling pathway	ISS
GO:0017015	Process	Regulation of transforming growth factor beta receptor signaling pathway	ISS
GO:0018105	Process	Peptidyl-serine phosphorylation	IBA	21873635
GO:0019901	Function	Protein kinase binding	IPI	19927127
GO:0030216	Process	Keratinocyte differentiation	IEA
GO:0030331	Function	Estrogen receptor binding	IPI	28068668
GO:0030496	Component	Midbody	IEA
GO:0030833	Process	Regulation of actin filament polymerization	IDA	15220930
GO:0033138	Process	Positive regulation of peptidyl-serine phosphorylation	IDA	20412773
GO:0033146	Process	Regulation of intracellular estrogen receptor signaling pathway	IMP	28068668
GO:0034613	Process	Cellular protein localization	IEA
GO:0035329	Process	Hippo signaling	IBA	21873635
GO:0035329	Process	Hippo signaling	IDA	20412773
GO:0035329	Process	Hippo signaling	TAS
GO:0035556	Process	Intracellular signal transduction	IBA	21873635
GO:0043065	Process	Positive regulation of apoptotic process	IBA	21873635
GO:0043254	Process	Regulation of protein-containing complex assembly	IMP	20412773
GO:0045736	Process	Negative regulation of cyclin-dependent protein serine/threonine kinase activity	IDA	9988268
GO:0046620	Process	Regulation of organ growth	IBA	21873635
GO:0051220	Process	Cytoplasmic sequestering of protein	IMP	20412773
GO:0051301	Process	Cell division	IEA
GO:0060644	Process	Mammary gland epithelial cell differentiation	IMP	28068668
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IMP	20412773
GO:0106310	Function	Protein serine kinase activity	IEA
GO:0106311	Function	Protein threonine kinase activity	IEA
GO:1900181	Process	Negative regulation of protein localization to nucleus	ISS
GO:2000058	Process	Regulation of ubiquitin-dependent protein catabolic process	IMP	28068668

Other IDs

• MIM: 603473
• HGNC: 6514
• e!Ensembl: ENSG00000131023

Protein

• UniProt ID: O95835
• Protein name: Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
• Protein function: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:10518011, PubMed:10831611, PubMed:18158288, PubMed:26437
• PDB: 4ZRK, 5B5W, 5BRK, 7LWH
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00627	UBA	101 → 138	UBA/TS-N domain	Domain
  PF00069	Pkinase	705 → 1010	Protein kinase domain	Domain

• Sequence:

  MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSKPSDAAKAEHNMSKMSTE
  DPRQVRNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVNPQMLQDLQAAGFDEDMVI
  QALQKTNNRSIEAAIEFISKMSYQDPRREQMAAAAARPINASMKPGNVQQSVNRKQSWKG
  SKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGSGISAFVQAHPSNGQRVNPPPPP
  QVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGY
  PPPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQSSSKFNFPSGRPGMQNGTGQTDFMIHQ
  NVVPAGTVNRQPPPPYPLTAANGQSPSALQTGGSAAPSSYTNGSIPQSMMVPNRNSHNME
  LYNISVPGLQTNWPQSSSAPAQSSPSSGHEIPTWQPNIPVRSNSFNNPLGNRASHSANSQ
  PSATTVTAITPAPIQQPVKSMRVLKPELQTALAPTHPSWIPQPIQTVQPSPFPEGTASNV
  TVMPPVAEAPNYQGPPPPYPKHLLHQNPSVPPYESISKPSKEDQPSLPKEDESEKSYENV
  DSGDKEKKQITTSPITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHR
  KKQLENEMMRVGLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVC
  LARKVDTKALYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYF
  VMDYIPGGDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDG
  HIKLTDFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAAR
  QHQRCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQM
  KVINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLR
  QQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHAFYEFTF
  RRFFDDNGYPYNYPKPIEYEYINSQGSEQQSDEDDQNTGSEIKNRDLVYV

• Sequence length: 1130

Pathways

KEGG:

Hippo signaling pathway
Hippo signaling pathway - multiple species

Reactome:

Signaling by Hippo

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Astrocytoma	Astrocytoma, Subependymal Giant Cell Astrocytoma, Juvenile Pilocytic Astrocytoma, Diffuse Astrocytoma, Pilocytic Astrocytoma, Childhood Cerebral Astrocytoma, Cerebral Astrocytoma	rs555607708	17049657
Neoplasm	Neoplasms, Glandular and Epithelial	rs137854562, rs137854565, rs137854568, rs137854574, rs121434220, rs121909218, rs121909222, rs587776667, rs606231169, rs587776701, rs121913388, rs137852578, rs137852216, rs121912651, rs28934575, rs28934571, rs121912654, rs11540652, rs28934573, rs28934576, rs28934578, rs121912667, rs104893810, rs121913530, rs121913301, rs79184941, rs121908595, rs11554290, rs121434596, rs121913364, rs121434592, rs121913502, rs11554273, rs121913495, rs121913479, rs121913412, rs121913407, rs80338964, rs377767360, rs387906650, rs121913272, rs63750393, rs587776935, rs121913250, rs121913237, rs397516436, rs121913343, rs397516439, rs397516981, rs121913240, rs121913529, rs121913428, rs121913465, rs397517199, rs397517201, rs45446594, rs45481400, rs80358042, rs146650273, rs63750087, rs398123117, rs201744589, rs587778833, rs587778867, rs587778850, rs587778825, rs587776783, rs587780070, rs587780071, rs587780073, rs587777476, rs587781255, rs587781288, rs587781392, rs587781558, rs80358870, rs587781694, rs587781807, rs587782018, rs587782206, rs121913344, rs587782529, rs587782664, rs587782682, rs587782705, rs121913500, rs121913291, rs587783697, rs587783690, rs587783502, rs193920774, rs724159946, rs730880472, rs564652222, rs730882029, rs730882005, rs730882025, rs730882019, rs869025192, rs768922431, rs786203485, rs786202918, rs398123329, rs786201059, rs121912657, rs786201090, rs786204910, rs786204853, rs121913293, rs121913332, rs797044942, rs121913333, rs863224491, rs863224451, rs863224499, rs760043106, rs863225332, rs864622636, rs864622451, rs779707422, rs879255270, rs875989848, rs876661244, rs876660754, rs746235533, rs876659384, rs587778720, rs483352697, rs876658694, rs121913331, rs55863639, rs786203650, rs879254171, rs80359365, rs886040960, rs886042002, rs886041779, rs1057516620, rs1057517302, rs1057517544, rs1057517992, rs1057518134, rs985033810, rs1057517840, rs587777613, rs147001633, rs377577594, rs121913499, rs121909224, rs1057519724, rs1057519729, rs121913503, rs1057519742, rs121913294, rs121913538, rs121913287, rs121913284, rs74535574, rs1057519757, rs397516790, rs121913285, rs121913387, rs121913236, rs1057519893, rs1057519906, rs1057519929, rs772110575, rs1057519941, rs786202962, rs764146326, rs1057519989, rs121912656, rs1057519992, rs866775781, rs1057519996, rs765848205, rs138729528, rs786201057, rs864622237, rs1057520672, rs1060500766, rs587781702, rs866380588, rs11540654, rs770776262, rs1057519984, rs121913321, rs1064793022, rs1064794276, rs112431538, rs1064794311, rs1064794618, rs1064796632, rs750318549, rs1554897889, rs1554900675, rs1114167568, rs587783031, rs1114167621, rs1114167629, rs1114167657, rs1131690863, rs11575996, rs1131691039, rs1131691026, rs1131690921, rs1131691082, rs863225313, rs1554085846, rs1553647989, rs1554898074, rs764735889, rs553257776, rs1554898067, rs1555615472, rs1060500352, rs1555526131, rs1057519990, rs1270783041, rs1019340046, rs1057523347, rs1553332772, rs1555525429, rs1060500345, rs1554730670, rs1555526469, rs11575997, rs1554069710, rs1555610903, rs1565400045, rs1565486028, rs1569061768, rs1114167577, rs1561588104, rs751448371, rs1564568473, rs1567556930, rs1567555934, rs1559587104, rs1569293373, rs1568498107, rs141798398, rs1597359215, rs757274881, rs1567556123, rs1555525367, rs1202793339, rs1568504941, rs1587330312, rs1060501207, rs1589596415, rs1595314951, rs1598173737, rs1597375294, rs1567555445, rs1595331264, rs1593060859, rs1859977029, rs1217977493, rs1961431691, rs2073243450, rs1724674149, rs1820531050	21447609
Carcinoma	Carcinoma, Basal Cell	rs121912654, rs555607708, rs786202962, rs1564055259	26950094
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382
Lung carcinoma	Large cell carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193
Peritoneal mesothelioma	Malignant Mesothelioma of Peritoneum	rs1408705745, rs1565941245

Unknown
Disease name	Disease term	dbSNP ID	References
Anaplastic astrocytoma	Anaplastic astrocytoma		17049657
Epithelioma	Epithelioma		21447609
Fibrillary astrocytoma	Fibrillary Astrocytoma		17049657
Gemistocytic astrocytoma	Gemistocytic astrocytoma		17049657
Glandular neoplasms	Glandular Neoplasms		21447609
Grade i astrocytoma	Grade I Astrocytoma		17049657
Intracranial astrocytoma	Intracranial Astrocytoma		17049657
Oligoastrocytoma	Mixed oligoastrocytoma		17049657
Protoplasmic astrocytoma	Protoplasmic astrocytoma		17049657