USP2 (ubiquitin specific peptidase 2)

Gene

• Entrez ID: 9099
• Gene name: Ubiquitin specific peptidase 2
• Gene symbol: USP2
• Synonyms: UBP41, USP9
• Chromosome: 11
• Chromosome location: 11q23.3
• Summary: This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nucle

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT051401	hsa-let-7f-5p	CLASH	23622248
MIRT037275	hsa-miR-877-5p	CLASH	23622248
MIRT439331	hsa-miR-493-5p	HITS-CLIP	24374217
MIRT439331	hsa-miR-493-5p	HITS-CLIP	24374217
MIRT756384	hsa-miR-1915-3p	Luciferase reporter assay, Western blotting, Immunohistochemistry (IHC)	34599680
MIRT1478308	hsa-miR-15a	CLIP-seq
MIRT1478309	hsa-miR-15b	CLIP-seq
MIRT1478310	hsa-miR-16	CLIP-seq
MIRT1478311	hsa-miR-195	CLIP-seq
MIRT1478312	hsa-miR-24	CLIP-seq
MIRT1478313	hsa-miR-331-3p	CLIP-seq
MIRT1478314	hsa-miR-3925-3p	CLIP-seq
MIRT1478315	hsa-miR-424	CLIP-seq
MIRT1478316	hsa-miR-4254	CLIP-seq
MIRT1478317	hsa-miR-4284	CLIP-seq
MIRT1478318	hsa-miR-4308	CLIP-seq
MIRT1478319	hsa-miR-4524	CLIP-seq
MIRT1478320	hsa-miR-4539	CLIP-seq
MIRT1478321	hsa-miR-4653-3p	CLIP-seq
MIRT1478322	hsa-miR-4709-3p	CLIP-seq
MIRT1478323	hsa-miR-4721	CLIP-seq
MIRT1478324	hsa-miR-497	CLIP-seq
MIRT1478325	hsa-miR-503	CLIP-seq
MIRT1478326	hsa-miR-508-5p	CLIP-seq
MIRT1478327	hsa-miR-622	CLIP-seq
MIRT1478328	hsa-miR-646	CLIP-seq
MIRT1478329	hsa-miR-1321	CLIP-seq
MIRT1478330	hsa-miR-2909	CLIP-seq
MIRT1478331	hsa-miR-3162-5p	CLIP-seq
MIRT1478332	hsa-miR-4282	CLIP-seq
MIRT1478333	hsa-miR-4739	CLIP-seq
MIRT1478334	hsa-miR-4756-5p	CLIP-seq
MIRT1478335	hsa-miR-4781-5p	CLIP-seq
MIRT1478336	hsa-miR-744	CLIP-seq
MIRT2144078	hsa-miR-1915	CLIP-seq
MIRT2144079	hsa-miR-4271	CLIP-seq
MIRT2144080	hsa-miR-4725-3p	CLIP-seq
MIRT1478313	hsa-miR-331-3p	CLIP-seq
MIRT2364278	hsa-miR-3921	CLIP-seq
MIRT2364279	hsa-miR-4653-5p	CLIP-seq
MIRT2657950	hsa-miR-1207-3p	CLIP-seq
MIRT2657951	hsa-miR-1253	CLIP-seq
MIRT2657952	hsa-miR-125a-5p	CLIP-seq
MIRT2657953	hsa-miR-125b	CLIP-seq
MIRT2657954	hsa-miR-1285	CLIP-seq
MIRT2657955	hsa-miR-1286	CLIP-seq
MIRT2657956	hsa-miR-1587	CLIP-seq
MIRT2657957	hsa-miR-1827	CLIP-seq
MIRT2657958	hsa-miR-185	CLIP-seq
MIRT2657959	hsa-miR-1908	CLIP-seq
MIRT2657960	hsa-miR-1912	CLIP-seq
MIRT2144078	hsa-miR-1915	CLIP-seq
MIRT2657961	hsa-miR-205	CLIP-seq
MIRT2657962	hsa-miR-218	CLIP-seq
MIRT1478312	hsa-miR-24	CLIP-seq
MIRT2657963	hsa-miR-2467-5p	CLIP-seq
MIRT2657964	hsa-miR-27a	CLIP-seq
MIRT2657965	hsa-miR-27b	CLIP-seq
MIRT2657966	hsa-miR-2964a-5p	CLIP-seq
MIRT2657967	hsa-miR-30a	CLIP-seq
MIRT2657968	hsa-miR-30b	CLIP-seq
MIRT2657969	hsa-miR-30c	CLIP-seq
MIRT2657970	hsa-miR-30d	CLIP-seq
MIRT2657971	hsa-miR-30e	CLIP-seq
MIRT2657972	hsa-miR-31	CLIP-seq
MIRT2657973	hsa-miR-3123	CLIP-seq
MIRT2657974	hsa-miR-3130-5p	CLIP-seq
MIRT2657975	hsa-miR-3150a-3p	CLIP-seq
MIRT2657976	hsa-miR-3153	CLIP-seq
MIRT2657977	hsa-miR-3154	CLIP-seq
MIRT2657978	hsa-miR-3155	CLIP-seq
MIRT2657979	hsa-miR-3155b	CLIP-seq
MIRT2657980	hsa-miR-3157-3p	CLIP-seq
MIRT2657981	hsa-miR-3160-3p	CLIP-seq
MIRT2657982	hsa-miR-3169	CLIP-seq
MIRT2657983	hsa-miR-3175	CLIP-seq
MIRT2657984	hsa-miR-3177-5p	CLIP-seq
MIRT2657985	hsa-miR-3179	CLIP-seq
MIRT2657986	hsa-miR-3180	CLIP-seq
MIRT2657987	hsa-miR-3180-3p	CLIP-seq
MIRT2657988	hsa-miR-3184	CLIP-seq
MIRT2657989	hsa-miR-3187-5p	CLIP-seq
MIRT2657990	hsa-miR-3189-3p	CLIP-seq
MIRT2657991	hsa-miR-3196	CLIP-seq
MIRT2657992	hsa-miR-324-5p	CLIP-seq
MIRT2657993	hsa-miR-326	CLIP-seq
MIRT2657994	hsa-miR-330-5p	CLIP-seq
MIRT2657995	hsa-miR-362-5p	CLIP-seq
MIRT2657996	hsa-miR-3653	CLIP-seq
MIRT2364278	hsa-miR-3921	CLIP-seq
MIRT2657997	hsa-miR-3941	CLIP-seq
MIRT2657998	hsa-miR-3945	CLIP-seq
MIRT2657999	hsa-miR-423-5p	CLIP-seq
MIRT2658000	hsa-miR-4251	CLIP-seq
MIRT2658001	hsa-miR-4253	CLIP-seq
MIRT2658002	hsa-miR-4266	CLIP-seq
MIRT2658003	hsa-miR-4267	CLIP-seq
MIRT2658004	hsa-miR-4306	CLIP-seq
MIRT2658005	hsa-miR-4319	CLIP-seq
MIRT2658006	hsa-miR-4324	CLIP-seq
MIRT2658007	hsa-miR-4434	CLIP-seq
MIRT2658008	hsa-miR-4436b-3p	CLIP-seq
MIRT2658009	hsa-miR-4437	CLIP-seq
MIRT2658010	hsa-miR-4468	CLIP-seq
MIRT2658011	hsa-miR-4476	CLIP-seq
MIRT2658012	hsa-miR-4482	CLIP-seq
MIRT2658013	hsa-miR-4488	CLIP-seq
MIRT2658014	hsa-miR-4493	CLIP-seq
MIRT2658015	hsa-miR-4512	CLIP-seq
MIRT2658016	hsa-miR-4515	CLIP-seq
MIRT2658017	hsa-miR-4516	CLIP-seq
MIRT2658018	hsa-miR-4531	CLIP-seq
MIRT2658019	hsa-miR-4644	CLIP-seq
MIRT2658020	hsa-miR-4651	CLIP-seq
MIRT2364279	hsa-miR-4653-5p	CLIP-seq
MIRT2658021	hsa-miR-466	CLIP-seq
MIRT2658022	hsa-miR-4672	CLIP-seq
MIRT2658023	hsa-miR-4674	CLIP-seq
MIRT2658024	hsa-miR-4685-5p	CLIP-seq
MIRT2658025	hsa-miR-4695-5p	CLIP-seq
MIRT2658026	hsa-miR-4697-5p	CLIP-seq
MIRT2658027	hsa-miR-4716-3p	CLIP-seq
MIRT2658028	hsa-miR-4726-3p	CLIP-seq
MIRT2658029	hsa-miR-4731-5p	CLIP-seq
MIRT2658030	hsa-miR-4732-3p	CLIP-seq
MIRT2658031	hsa-miR-4738-5p	CLIP-seq
MIRT2658032	hsa-miR-4746-5p	CLIP-seq
MIRT2658033	hsa-miR-4753-5p	CLIP-seq
MIRT2658034	hsa-miR-4779	CLIP-seq
MIRT2658035	hsa-miR-4786-5p	CLIP-seq
MIRT2658036	hsa-miR-484	CLIP-seq
MIRT2658037	hsa-miR-486-3p	CLIP-seq
MIRT2658038	hsa-miR-500b	CLIP-seq
MIRT2658039	hsa-miR-501-5p	CLIP-seq
MIRT2658040	hsa-miR-513a-5p	CLIP-seq
MIRT2658041	hsa-miR-516b	CLIP-seq
MIRT2658042	hsa-miR-539	CLIP-seq
MIRT2658043	hsa-miR-608	CLIP-seq
MIRT2658044	hsa-miR-612	CLIP-seq
MIRT2658045	hsa-miR-625	CLIP-seq
MIRT2658046	hsa-miR-635	CLIP-seq
MIRT2658047	hsa-miR-661	CLIP-seq
MIRT2658048	hsa-miR-663	CLIP-seq
MIRT2658049	hsa-miR-670	CLIP-seq
MIRT2658050	hsa-miR-760	CLIP-seq
MIRT2658051	hsa-miR-766	CLIP-seq
MIRT2658052	hsa-miR-874	CLIP-seq
MIRT2658053	hsa-miR-938	CLIP-seq
MIRT2658054	hsa-miR-939	CLIP-seq
MIRT2658055	hsa-miR-942	CLIP-seq
MIRT2657951	hsa-miR-1253	CLIP-seq
MIRT2657952	hsa-miR-125a-5p	CLIP-seq
MIRT2657953	hsa-miR-125b	CLIP-seq
MIRT2657954	hsa-miR-1285	CLIP-seq
MIRT2657955	hsa-miR-1286	CLIP-seq
MIRT2657956	hsa-miR-1587	CLIP-seq
MIRT2657957	hsa-miR-1827	CLIP-seq
MIRT2657959	hsa-miR-1908	CLIP-seq
MIRT2657960	hsa-miR-1912	CLIP-seq
MIRT2144078	hsa-miR-1915	CLIP-seq
MIRT1478312	hsa-miR-24	CLIP-seq
MIRT2657963	hsa-miR-2467-5p	CLIP-seq
MIRT2657964	hsa-miR-27a	CLIP-seq
MIRT2657965	hsa-miR-27b	CLIP-seq
MIRT2657966	hsa-miR-2964a-5p	CLIP-seq
MIRT2657967	hsa-miR-30a	CLIP-seq
MIRT2657968	hsa-miR-30b	CLIP-seq
MIRT2657969	hsa-miR-30c	CLIP-seq
MIRT2657970	hsa-miR-30d	CLIP-seq
MIRT2657971	hsa-miR-30e	CLIP-seq
MIRT2657972	hsa-miR-31	CLIP-seq
MIRT2657973	hsa-miR-3123	CLIP-seq
MIRT2657974	hsa-miR-3130-5p	CLIP-seq
MIRT2657976	hsa-miR-3153	CLIP-seq
MIRT2657977	hsa-miR-3154	CLIP-seq
MIRT2657978	hsa-miR-3155	CLIP-seq
MIRT2657979	hsa-miR-3155b	CLIP-seq
MIRT2657980	hsa-miR-3157-3p	CLIP-seq
MIRT2657981	hsa-miR-3160-3p	CLIP-seq
MIRT2657982	hsa-miR-3169	CLIP-seq
MIRT2657984	hsa-miR-3177-5p	CLIP-seq
MIRT2657985	hsa-miR-3179	CLIP-seq
MIRT2657986	hsa-miR-3180	CLIP-seq
MIRT2657987	hsa-miR-3180-3p	CLIP-seq
MIRT2657988	hsa-miR-3184	CLIP-seq
MIRT2657989	hsa-miR-3187-5p	CLIP-seq
MIRT2657990	hsa-miR-3189-3p	CLIP-seq
MIRT2657991	hsa-miR-3196	CLIP-seq
MIRT2657992	hsa-miR-324-5p	CLIP-seq
MIRT2657993	hsa-miR-326	CLIP-seq
MIRT2657994	hsa-miR-330-5p	CLIP-seq
MIRT2657996	hsa-miR-3653	CLIP-seq
MIRT2657997	hsa-miR-3941	CLIP-seq
MIRT2657998	hsa-miR-3945	CLIP-seq
MIRT2657999	hsa-miR-423-5p	CLIP-seq
MIRT2658000	hsa-miR-4251	CLIP-seq
MIRT2658001	hsa-miR-4253	CLIP-seq
MIRT2658002	hsa-miR-4266	CLIP-seq
MIRT2658003	hsa-miR-4267	CLIP-seq
MIRT2658005	hsa-miR-4319	CLIP-seq
MIRT2658006	hsa-miR-4324	CLIP-seq
MIRT2658007	hsa-miR-4434	CLIP-seq
MIRT2658008	hsa-miR-4436b-3p	CLIP-seq
MIRT2658009	hsa-miR-4437	CLIP-seq
MIRT2658011	hsa-miR-4476	CLIP-seq
MIRT2658012	hsa-miR-4482	CLIP-seq
MIRT2658013	hsa-miR-4488	CLIP-seq
MIRT2658014	hsa-miR-4493	CLIP-seq
MIRT2658015	hsa-miR-4512	CLIP-seq
MIRT2658016	hsa-miR-4515	CLIP-seq
MIRT2658017	hsa-miR-4516	CLIP-seq
MIRT2658018	hsa-miR-4531	CLIP-seq
MIRT2658020	hsa-miR-4651	CLIP-seq
MIRT2658021	hsa-miR-466	CLIP-seq
MIRT2658022	hsa-miR-4672	CLIP-seq
MIRT2658023	hsa-miR-4674	CLIP-seq
MIRT2658024	hsa-miR-4685-5p	CLIP-seq
MIRT2658025	hsa-miR-4695-5p	CLIP-seq
MIRT2658026	hsa-miR-4697-5p	CLIP-seq
MIRT2658027	hsa-miR-4716-3p	CLIP-seq
MIRT2658028	hsa-miR-4726-3p	CLIP-seq
MIRT2658030	hsa-miR-4732-3p	CLIP-seq
MIRT2658031	hsa-miR-4738-5p	CLIP-seq
MIRT2658032	hsa-miR-4746-5p	CLIP-seq
MIRT2658033	hsa-miR-4753-5p	CLIP-seq
MIRT2658034	hsa-miR-4779	CLIP-seq
MIRT2658035	hsa-miR-4786-5p	CLIP-seq
MIRT2658036	hsa-miR-484	CLIP-seq
MIRT2658037	hsa-miR-486-3p	CLIP-seq
MIRT2658040	hsa-miR-513a-5p	CLIP-seq
MIRT2658041	hsa-miR-516b	CLIP-seq
MIRT2658042	hsa-miR-539	CLIP-seq
MIRT2658043	hsa-miR-608	CLIP-seq
MIRT2658044	hsa-miR-612	CLIP-seq
MIRT2658045	hsa-miR-625	CLIP-seq
MIRT2658046	hsa-miR-635	CLIP-seq
MIRT2658047	hsa-miR-661	CLIP-seq
MIRT2658048	hsa-miR-663	CLIP-seq
MIRT2658049	hsa-miR-670	CLIP-seq
MIRT2658050	hsa-miR-760	CLIP-seq
MIRT2658051	hsa-miR-766	CLIP-seq
MIRT2658052	hsa-miR-874	CLIP-seq
MIRT2658053	hsa-miR-938	CLIP-seq
MIRT2658055	hsa-miR-942	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	17290220
GO:0004197	Function	Cysteine-type endopeptidase activity	TAS	9827704
GO:0004843	Function	Thiol-dependent ubiquitin-specific protease activity	IDA	17290220
GO:0004843	Function	Thiol-dependent ubiquitin-specific protease activity	IMP	19917254
GO:0005515	Function	Protein binding	IPI	16189514, 17290220, 19838211, 22024150, 25416956, 31515488, 32296183
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005813	Component	Centrosome	IEA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0007049	Process	Cell cycle	IEA
GO:0007517	Process	Muscle organ development	IEA
GO:0016020	Component	Membrane	IEA
GO:0016579	Process	Protein deubiquitination	IDA	17290220, 19838211, 19917254
GO:0016579	Process	Protein deubiquitination	TAS
GO:0018215	Process	Protein phosphopantetheinylation	IEA
GO:0030332	Function	Cyclin binding	IPI	19917254
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	17290220
GO:0032922	Process	Circadian regulation of gene expression	ISS
GO:0042802	Function	Identical protein binding	IEA
GO:0043153	Process	Entrainment of circadian clock by photoperiod	ISS
GO:0045475	Process	Locomotor rhythm	ISS
GO:0045931	Process	Positive regulation of mitotic cell cycle	IMP	17290220
GO:0046872	Function	Metal ion binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0048512	Process	Circadian behavior	ISS
GO:0050821	Process	Protein stabilization	IDA	17290220
GO:0050821	Process	Protein stabilization	IMP	19838211

Other IDs

• MIM: 604725
• HGNC: 12618
• e!Ensembl: ENSG00000036672

Protein

• UniProt ID: O75604
• Protein name: Ubiquitin carboxyl-terminal hydrolase 2 (EC 3.4.19.12) (41 kDa ubiquitin-specific protease) (Deubiquitinating enzyme 2) (Ubiquitin thioesterase 2) (Ubiquitin-specific-processing protease 2)
• Protein function: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1 (PubMed:17290220, PubMed:19838211, PubMed:19917254). Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities (By
• PDB: 2HD5, 2IBI, 3NHE, 3V6C, 3V6E, 5XU8, 5XVE, 6DGF
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00443	UCH	267 → 596	Ubiquitin carboxyl-terminal hydrolase	Family

• Sequence:

  MSQLSSTLKRYTESARYTDAHYAKSGYGAYTPSSYGANLAASLLEKEKLGFKPVPTSSFL
  TRPRTYGPSSLLDYDRGRPLLRPDITGGGKRAESQTRGTERPLGSGLSGGSGFPYGVTNN
  CLSYLPINAYDQGVTLTQKLDSQSDLARDFSSLRTSDSYRIDPRNLGRSPMLARTRKELC
  TLQGLYQTASCPEYLVDYLENYGRKGSASQVPSQAPPSRVPEIISPTYRPIGRYTLWETG
  KGQAPGPSRSSSPGRDGMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLY
  MRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQE
  FLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLK
  SSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCR
  GRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAV
  YNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELAS
  PPSRM

• Sequence length: 605

Pathways

Reactome:

TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases
Regulation of TP53 Degradation

Associated diseases

Unknown
Disease name	Disease term	dbSNP ID	References
Liver carcinoma	Liver carcinoma		21147110