IL33 (interleukin 33)

Gene

• Entrez ID: 90865
• Gene name: Interleukin 33
• Gene symbol: IL33
• Synonyms: C9orf26, DVS27, IL1F11, NF-HEV, NFEHEV
• Chromosome: 9
• Chromosome location: 9p24.1
• Summary: The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript vari

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017750	hsa-miR-335-5p	Microarray	18185580
MIRT736393	hsa-miR-524-3p	Western blotting, Microarray, qRT-PCR	31990904
MIRT756199	hsa-miR-181a-5p	Luciferase reporter assay, Western blotting, qRT-PCR	34978772
MIRT1064883	hsa-miR-331-3p	CLIP-seq
MIRT1064884	hsa-miR-3660	CLIP-seq
MIRT1064885	hsa-miR-4475	CLIP-seq
MIRT1064886	hsa-miR-4526	CLIP-seq
MIRT1064887	hsa-miR-4645-3p	CLIP-seq
MIRT1064888	hsa-miR-4683	CLIP-seq
MIRT1064889	hsa-miR-4686	CLIP-seq
MIRT1064890	hsa-miR-4732-3p	CLIP-seq
MIRT1064891	hsa-miR-3123	CLIP-seq
MIRT1064892	hsa-miR-3925-5p	CLIP-seq
MIRT1064893	hsa-miR-3974	CLIP-seq
MIRT1064894	hsa-miR-4494	CLIP-seq
MIRT1064895	hsa-miR-499a-5p	CLIP-seq
MIRT1064896	hsa-miR-548a-5p	CLIP-seq
MIRT1064897	hsa-miR-548ab	CLIP-seq
MIRT1064898	hsa-miR-548ak	CLIP-seq
MIRT1064899	hsa-miR-548b-5p	CLIP-seq
MIRT1064900	hsa-miR-548c-5p	CLIP-seq
MIRT1064901	hsa-miR-548d-5p	CLIP-seq
MIRT1064902	hsa-miR-548h	CLIP-seq
MIRT1064903	hsa-miR-548i	CLIP-seq
MIRT1064904	hsa-miR-548j	CLIP-seq
MIRT1064905	hsa-miR-548m	CLIP-seq
MIRT1064906	hsa-miR-548n	CLIP-seq
MIRT1064907	hsa-miR-548w	CLIP-seq
MIRT1064908	hsa-miR-548y	CLIP-seq
MIRT1064909	hsa-miR-559	CLIP-seq
MIRT1064910	hsa-miR-3646	CLIP-seq
MIRT1064911	hsa-miR-3692	CLIP-seq
MIRT1064912	hsa-miR-4519	CLIP-seq
MIRT2015432	hsa-miR-19a	CLIP-seq
MIRT2015433	hsa-miR-19b	CLIP-seq
MIRT2015434	hsa-miR-214	CLIP-seq
MIRT2015435	hsa-miR-3619-5p	CLIP-seq
MIRT2015436	hsa-miR-3665	CLIP-seq
MIRT2015437	hsa-miR-4291	CLIP-seq
MIRT2015438	hsa-miR-4421	CLIP-seq
MIRT2015439	hsa-miR-761	CLIP-seq
MIRT2015440	hsa-miR-764	CLIP-seq
MIRT2015441	hsa-miR-922	CLIP-seq
MIRT2247747	hsa-miR-4282	CLIP-seq
MIRT2451770	hsa-miR-758	CLIP-seq
MIRT2451771	hsa-miR-890	CLIP-seq
MIRT2551235	hsa-miR-105	CLIP-seq
MIRT2551236	hsa-miR-1179	CLIP-seq
MIRT2551237	hsa-miR-1225-5p	CLIP-seq
MIRT2551238	hsa-miR-1237	CLIP-seq
MIRT2551239	hsa-miR-1238	CLIP-seq
MIRT2551240	hsa-miR-1248	CLIP-seq
MIRT2551241	hsa-miR-125a-3p	CLIP-seq
MIRT2551242	hsa-miR-1271	CLIP-seq
MIRT2551243	hsa-miR-1279	CLIP-seq
MIRT2551244	hsa-miR-1282	CLIP-seq
MIRT2551245	hsa-miR-1283	CLIP-seq
MIRT2551246	hsa-miR-134	CLIP-seq
MIRT2551247	hsa-miR-142-5p	CLIP-seq
MIRT2551248	hsa-miR-145	CLIP-seq
MIRT2551249	hsa-miR-154	CLIP-seq
MIRT2551250	hsa-miR-15a	CLIP-seq
MIRT2551251	hsa-miR-15b	CLIP-seq
MIRT2551252	hsa-miR-16	CLIP-seq
MIRT2551253	hsa-miR-182	CLIP-seq
MIRT2551254	hsa-miR-1825	CLIP-seq
MIRT2551255	hsa-miR-186	CLIP-seq
MIRT2551256	hsa-miR-195	CLIP-seq
MIRT2551257	hsa-miR-199a-5p	CLIP-seq
MIRT2551258	hsa-miR-199b-5p	CLIP-seq
MIRT2015432	hsa-miR-19a	CLIP-seq
MIRT2015433	hsa-miR-19b	CLIP-seq
MIRT2551259	hsa-miR-204	CLIP-seq
MIRT2551260	hsa-miR-2053	CLIP-seq
MIRT2551261	hsa-miR-2054	CLIP-seq
MIRT2551262	hsa-miR-211	CLIP-seq
MIRT2015434	hsa-miR-214	CLIP-seq
MIRT2551263	hsa-miR-297	CLIP-seq
MIRT2551264	hsa-miR-3074-3p	CLIP-seq
MIRT2551265	hsa-miR-3118	CLIP-seq
MIRT1064891	hsa-miR-3123	CLIP-seq
MIRT2551266	hsa-miR-3148	CLIP-seq
MIRT2551267	hsa-miR-3149	CLIP-seq
MIRT2551268	hsa-miR-3159	CLIP-seq
MIRT2551269	hsa-miR-3164	CLIP-seq
MIRT2551270	hsa-miR-3174	CLIP-seq
MIRT2551271	hsa-miR-3176	CLIP-seq
MIRT2551272	hsa-miR-3194-3p	CLIP-seq
MIRT2551273	hsa-miR-320e	CLIP-seq
MIRT2551274	hsa-miR-323b-3p	CLIP-seq
MIRT2551275	hsa-miR-330-3p	CLIP-seq
MIRT2551276	hsa-miR-3611	CLIP-seq
MIRT2551277	hsa-miR-361-5p	CLIP-seq
MIRT2551278	hsa-miR-3617	CLIP-seq
MIRT2015435	hsa-miR-3619-5p	CLIP-seq
MIRT2551279	hsa-miR-3622a-3p	CLIP-seq
MIRT2551280	hsa-miR-3622b-3p	CLIP-seq
MIRT2551281	hsa-miR-3622b-5p	CLIP-seq
MIRT1064910	hsa-miR-3646	CLIP-seq
MIRT2551282	hsa-miR-3659	CLIP-seq
MIRT2551283	hsa-miR-3662	CLIP-seq
MIRT2551284	hsa-miR-3663-5p	CLIP-seq
MIRT2015436	hsa-miR-3665	CLIP-seq
MIRT2551285	hsa-miR-3675-3p	CLIP-seq
MIRT2551286	hsa-miR-3682-5p	CLIP-seq
MIRT2551287	hsa-miR-3688-3p	CLIP-seq
MIRT1064911	hsa-miR-3692	CLIP-seq
MIRT2551288	hsa-miR-3921	CLIP-seq
MIRT2551289	hsa-miR-3922-3p	CLIP-seq
MIRT2551290	hsa-miR-3924	CLIP-seq
MIRT2551291	hsa-miR-3925-3p	CLIP-seq
MIRT1064892	hsa-miR-3925-5p	CLIP-seq
MIRT2551292	hsa-miR-3934	CLIP-seq
MIRT2551293	hsa-miR-3942-3p	CLIP-seq
MIRT1064893	hsa-miR-3974	CLIP-seq
MIRT2551294	hsa-miR-409-3p	CLIP-seq
MIRT2551295	hsa-miR-424	CLIP-seq
MIRT2551296	hsa-miR-4253	CLIP-seq
MIRT2551297	hsa-miR-4255	CLIP-seq
MIRT2551298	hsa-miR-4257	CLIP-seq
MIRT2551299	hsa-miR-4259	CLIP-seq
MIRT2247747	hsa-miR-4282	CLIP-seq
MIRT2015437	hsa-miR-4291	CLIP-seq
MIRT2551300	hsa-miR-4292	CLIP-seq
MIRT2551301	hsa-miR-4308	CLIP-seq
MIRT2551302	hsa-miR-4311	CLIP-seq
MIRT2551303	hsa-miR-4312	CLIP-seq
MIRT2551304	hsa-miR-4318	CLIP-seq
MIRT2015438	hsa-miR-4421	CLIP-seq
MIRT2551305	hsa-miR-4423-5p	CLIP-seq
MIRT2551306	hsa-miR-4432	CLIP-seq
MIRT2551307	hsa-miR-4446-5p	CLIP-seq
MIRT1064885	hsa-miR-4475	CLIP-seq
MIRT2551308	hsa-miR-4490	CLIP-seq
MIRT1064894	hsa-miR-4494	CLIP-seq
MIRT2551309	hsa-miR-4495	CLIP-seq
MIRT2551310	hsa-miR-4517	CLIP-seq
MIRT1064912	hsa-miR-4519	CLIP-seq
MIRT2551311	hsa-miR-4524	CLIP-seq
MIRT2551312	hsa-miR-4536	CLIP-seq
MIRT2551313	hsa-miR-4539	CLIP-seq
MIRT2551314	hsa-miR-4639-5p	CLIP-seq
MIRT2551315	hsa-miR-4642	CLIP-seq
MIRT2551316	hsa-miR-4643	CLIP-seq
MIRT1064887	hsa-miR-4645-3p	CLIP-seq
MIRT2551317	hsa-miR-4652-3p	CLIP-seq
MIRT2551318	hsa-miR-4653-5p	CLIP-seq
MIRT2551319	hsa-miR-4658	CLIP-seq
MIRT2551320	hsa-miR-4660	CLIP-seq
MIRT2551321	hsa-miR-4661-5p	CLIP-seq
MIRT2551322	hsa-miR-4670-3p	CLIP-seq
MIRT2551323	hsa-miR-4677-3p	CLIP-seq
MIRT2551324	hsa-miR-4679	CLIP-seq
MIRT2551325	hsa-miR-4682	CLIP-seq
MIRT1064888	hsa-miR-4683	CLIP-seq
MIRT1064889	hsa-miR-4686	CLIP-seq
MIRT2551326	hsa-miR-4694-5p	CLIP-seq
MIRT2551327	hsa-miR-4699-3p	CLIP-seq
MIRT2551328	hsa-miR-4699-5p	CLIP-seq
MIRT2551329	hsa-miR-4709-3p	CLIP-seq
MIRT2551330	hsa-miR-4715-5p	CLIP-seq
MIRT2551331	hsa-miR-4720-3p	CLIP-seq
MIRT2551332	hsa-miR-4738-3p	CLIP-seq
MIRT2551333	hsa-miR-4753-3p	CLIP-seq
MIRT2551334	hsa-miR-4755-5p	CLIP-seq
MIRT2551335	hsa-miR-4761-3p	CLIP-seq
MIRT2551336	hsa-miR-4774-3p	CLIP-seq
MIRT2551337	hsa-miR-4774-5p	CLIP-seq
MIRT2551338	hsa-miR-4778-3p	CLIP-seq
MIRT2551339	hsa-miR-4778-5p	CLIP-seq
MIRT2551340	hsa-miR-4786-3p	CLIP-seq
MIRT2551341	hsa-miR-4789-5p	CLIP-seq
MIRT2551342	hsa-miR-4797-3p	CLIP-seq
MIRT2551343	hsa-miR-4797-5p	CLIP-seq
MIRT2551344	hsa-miR-4804-3p	CLIP-seq
MIRT2551345	hsa-miR-490-3p	CLIP-seq
MIRT2551346	hsa-miR-494	CLIP-seq
MIRT2551347	hsa-miR-495	CLIP-seq
MIRT2551348	hsa-miR-496	CLIP-seq
MIRT2551349	hsa-miR-497	CLIP-seq
MIRT1064895	hsa-miR-499a-5p	CLIP-seq
MIRT2551350	hsa-miR-503	CLIP-seq
MIRT2551351	hsa-miR-513a-5p	CLIP-seq
MIRT2551352	hsa-miR-515-5p	CLIP-seq
MIRT2551353	hsa-miR-520a-5p	CLIP-seq
MIRT2551354	hsa-miR-525-5p	CLIP-seq
MIRT2551355	hsa-miR-532-5p	CLIP-seq
MIRT2551356	hsa-miR-543	CLIP-seq
MIRT1064896	hsa-miR-548a-5p	CLIP-seq
MIRT1064897	hsa-miR-548ab	CLIP-seq
MIRT1064898	hsa-miR-548ak	CLIP-seq
MIRT1064899	hsa-miR-548b-5p	CLIP-seq
MIRT1064900	hsa-miR-548c-5p	CLIP-seq
MIRT1064901	hsa-miR-548d-5p	CLIP-seq
MIRT1064902	hsa-miR-548h	CLIP-seq
MIRT1064903	hsa-miR-548i	CLIP-seq
MIRT1064904	hsa-miR-548j	CLIP-seq
MIRT2551357	hsa-miR-548k	CLIP-seq
MIRT2551358	hsa-miR-548l	CLIP-seq
MIRT1064905	hsa-miR-548m	CLIP-seq
MIRT1064906	hsa-miR-548n	CLIP-seq
MIRT2551359	hsa-miR-548t	CLIP-seq
MIRT2551360	hsa-miR-548u	CLIP-seq
MIRT1064907	hsa-miR-548w	CLIP-seq
MIRT1064908	hsa-miR-548y	CLIP-seq
MIRT1064909	hsa-miR-559	CLIP-seq
MIRT2551361	hsa-miR-561	CLIP-seq
MIRT2551362	hsa-miR-569	CLIP-seq
MIRT2551363	hsa-miR-570	CLIP-seq
MIRT2551364	hsa-miR-574-5p	CLIP-seq
MIRT2551365	hsa-miR-576-3p	CLIP-seq
MIRT2551366	hsa-miR-577	CLIP-seq
MIRT2551367	hsa-miR-579	CLIP-seq
MIRT2551368	hsa-miR-582-3p	CLIP-seq
MIRT2551369	hsa-miR-582-5p	CLIP-seq
MIRT2551370	hsa-miR-590-3p	CLIP-seq
MIRT2551371	hsa-miR-593	CLIP-seq
MIRT2551372	hsa-miR-623	CLIP-seq
MIRT2551373	hsa-miR-641	CLIP-seq
MIRT2551374	hsa-miR-643	CLIP-seq
MIRT2551375	hsa-miR-645	CLIP-seq
MIRT2551376	hsa-miR-646	CLIP-seq
MIRT2551377	hsa-miR-654-3p	CLIP-seq
MIRT2551378	hsa-miR-671-5p	CLIP-seq
MIRT2451770	hsa-miR-758	CLIP-seq
MIRT2551379	hsa-miR-760	CLIP-seq
MIRT2015439	hsa-miR-761	CLIP-seq
MIRT2015440	hsa-miR-764	CLIP-seq
MIRT2551380	hsa-miR-765	CLIP-seq
MIRT2551381	hsa-miR-766	CLIP-seq
MIRT2551382	hsa-miR-767-3p	CLIP-seq
MIRT2551383	hsa-miR-873	CLIP-seq
MIRT2551384	hsa-miR-888	CLIP-seq
MIRT2551385	hsa-miR-889	CLIP-seq
MIRT2451771	hsa-miR-890	CLIP-seq
MIRT2015441	hsa-miR-922	CLIP-seq
MIRT2551386	hsa-miR-96	CLIP-seq
MIRT2551235	hsa-miR-105	CLIP-seq
MIRT2551238	hsa-miR-1237	CLIP-seq
MIRT2551240	hsa-miR-1248	CLIP-seq
MIRT2551245	hsa-miR-1283	CLIP-seq
MIRT2551248	hsa-miR-145	CLIP-seq
MIRT2551249	hsa-miR-154	CLIP-seq
MIRT2551254	hsa-miR-1825	CLIP-seq
MIRT2551255	hsa-miR-186	CLIP-seq
MIRT2551257	hsa-miR-199a-5p	CLIP-seq
MIRT2551258	hsa-miR-199b-5p	CLIP-seq
MIRT2015432	hsa-miR-19a	CLIP-seq
MIRT2015433	hsa-miR-19b	CLIP-seq
MIRT2551260	hsa-miR-2053	CLIP-seq
MIRT2015434	hsa-miR-214	CLIP-seq
MIRT2551264	hsa-miR-3074-3p	CLIP-seq
MIRT1064891	hsa-miR-3123	CLIP-seq
MIRT2551266	hsa-miR-3148	CLIP-seq
MIRT2551268	hsa-miR-3159	CLIP-seq
MIRT2551271	hsa-miR-3176	CLIP-seq
MIRT2551272	hsa-miR-3194-3p	CLIP-seq
MIRT2551274	hsa-miR-323b-3p	CLIP-seq
MIRT2551276	hsa-miR-3611	CLIP-seq
MIRT2551277	hsa-miR-361-5p	CLIP-seq
MIRT2551278	hsa-miR-3617	CLIP-seq
MIRT2015435	hsa-miR-3619-5p	CLIP-seq
MIRT2551279	hsa-miR-3622a-3p	CLIP-seq
MIRT2551280	hsa-miR-3622b-3p	CLIP-seq
MIRT2551281	hsa-miR-3622b-5p	CLIP-seq
MIRT1064910	hsa-miR-3646	CLIP-seq
MIRT2551282	hsa-miR-3659	CLIP-seq
MIRT2551283	hsa-miR-3662	CLIP-seq
MIRT2551284	hsa-miR-3663-5p	CLIP-seq
MIRT2015436	hsa-miR-3665	CLIP-seq
MIRT2551285	hsa-miR-3675-3p	CLIP-seq
MIRT2551287	hsa-miR-3688-3p	CLIP-seq
MIRT1064911	hsa-miR-3692	CLIP-seq
MIRT2551288	hsa-miR-3921	CLIP-seq
MIRT2551289	hsa-miR-3922-3p	CLIP-seq
MIRT2551291	hsa-miR-3925-3p	CLIP-seq
MIRT1064892	hsa-miR-3925-5p	CLIP-seq
MIRT1064893	hsa-miR-3974	CLIP-seq
MIRT2551294	hsa-miR-409-3p	CLIP-seq
MIRT2551296	hsa-miR-4253	CLIP-seq
MIRT2015437	hsa-miR-4291	CLIP-seq
MIRT2551302	hsa-miR-4311	CLIP-seq
MIRT2015438	hsa-miR-4421	CLIP-seq
MIRT2551305	hsa-miR-4423-5p	CLIP-seq
MIRT1064885	hsa-miR-4475	CLIP-seq
MIRT2551308	hsa-miR-4490	CLIP-seq
MIRT1064894	hsa-miR-4494	CLIP-seq
MIRT2551310	hsa-miR-4517	CLIP-seq
MIRT1064912	hsa-miR-4519	CLIP-seq
MIRT2551312	hsa-miR-4536	CLIP-seq
MIRT1064887	hsa-miR-4645-3p	CLIP-seq
MIRT2551318	hsa-miR-4653-5p	CLIP-seq
MIRT2551319	hsa-miR-4658	CLIP-seq
MIRT2551321	hsa-miR-4661-5p	CLIP-seq
MIRT2551322	hsa-miR-4670-3p	CLIP-seq
MIRT2551323	hsa-miR-4677-3p	CLIP-seq
MIRT2551324	hsa-miR-4679	CLIP-seq
MIRT2551325	hsa-miR-4682	CLIP-seq
MIRT1064888	hsa-miR-4683	CLIP-seq
MIRT1064889	hsa-miR-4686	CLIP-seq
MIRT2551326	hsa-miR-4694-5p	CLIP-seq
MIRT2551328	hsa-miR-4699-5p	CLIP-seq
MIRT2551329	hsa-miR-4709-3p	CLIP-seq
MIRT2551332	hsa-miR-4738-3p	CLIP-seq
MIRT2551333	hsa-miR-4753-3p	CLIP-seq
MIRT2551335	hsa-miR-4761-3p	CLIP-seq
MIRT2551336	hsa-miR-4774-3p	CLIP-seq
MIRT2551337	hsa-miR-4774-5p	CLIP-seq
MIRT2551338	hsa-miR-4778-3p	CLIP-seq
MIRT2551339	hsa-miR-4778-5p	CLIP-seq
MIRT2551341	hsa-miR-4789-5p	CLIP-seq
MIRT2551343	hsa-miR-4797-5p	CLIP-seq
MIRT2551345	hsa-miR-490-3p	CLIP-seq
MIRT2551347	hsa-miR-495	CLIP-seq
MIRT1064895	hsa-miR-499a-5p	CLIP-seq
MIRT2551352	hsa-miR-515-5p	CLIP-seq
MIRT2551356	hsa-miR-543	CLIP-seq
MIRT1064896	hsa-miR-548a-5p	CLIP-seq
MIRT1064897	hsa-miR-548ab	CLIP-seq
MIRT1064898	hsa-miR-548ak	CLIP-seq
MIRT1064899	hsa-miR-548b-5p	CLIP-seq
MIRT1064900	hsa-miR-548c-5p	CLIP-seq
MIRT1064901	hsa-miR-548d-5p	CLIP-seq
MIRT1064902	hsa-miR-548h	CLIP-seq
MIRT1064903	hsa-miR-548i	CLIP-seq
MIRT1064904	hsa-miR-548j	CLIP-seq
MIRT1064905	hsa-miR-548m	CLIP-seq
MIRT1064906	hsa-miR-548n	CLIP-seq
MIRT1064907	hsa-miR-548w	CLIP-seq
MIRT1064908	hsa-miR-548y	CLIP-seq
MIRT1064909	hsa-miR-559	CLIP-seq
MIRT2551362	hsa-miR-569	CLIP-seq
MIRT2551363	hsa-miR-570	CLIP-seq
MIRT2551364	hsa-miR-574-5p	CLIP-seq
MIRT2551368	hsa-miR-582-3p	CLIP-seq
MIRT2551370	hsa-miR-590-3p	CLIP-seq
MIRT2551371	hsa-miR-593	CLIP-seq
MIRT2551373	hsa-miR-641	CLIP-seq
MIRT2551374	hsa-miR-643	CLIP-seq
MIRT2551375	hsa-miR-645	CLIP-seq
MIRT2551379	hsa-miR-760	CLIP-seq
MIRT2015439	hsa-miR-761	CLIP-seq
MIRT2015440	hsa-miR-764	CLIP-seq
MIRT2551380	hsa-miR-765	CLIP-seq
MIRT2551381	hsa-miR-766	CLIP-seq
MIRT2551382	hsa-miR-767-3p	CLIP-seq
MIRT2551383	hsa-miR-873	CLIP-seq
MIRT2551385	hsa-miR-889	CLIP-seq
MIRT2451771	hsa-miR-890	CLIP-seq
MIRT2015441	hsa-miR-922	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	17185418
GO:0001819	Process	Positive regulation of cytokine production	IBA	21873635
GO:0002112	Function	Interleukin-33 receptor binding	IEA
GO:0002282	Process	Microglial cell activation involved in immune response	IEA
GO:0002638	Process	Negative regulation of immunoglobulin production	IEA
GO:0002639	Process	Positive regulation of immunoglobulin production	IEA
GO:0002686	Process	Negative regulation of leukocyte migration	IEA
GO:0002826	Process	Negative regulation of T-helper 1 type immune response	IEA
GO:0002830	Process	Positive regulation of type 2 immune response	IEA
GO:0005125	Function	Cytokine activity	IBA	21873635
GO:0005125	Function	Cytokine activity	IDA	19841166
GO:0005515	Function	Protein binding	IPI	16286016, 18688256, 29045903
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IEA
GO:0005634	Component	Nucleus	IDA	18787100, 18836528, 21357533, 22215666
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005737	Component	Cytoplasm	IDA	22215666
GO:0010186	Process	Positive regulation of cellular defense response	ISS
GO:0010628	Process	Positive regulation of gene expression	ISS
GO:0016579	Process	Protein deubiquitination	TAS
GO:0030133	Component	Transport vesicle	IEA
GO:0032436	Process	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA
GO:0032689	Process	Negative regulation of interferon-gamma production	IEA
GO:0032722	Process	Positive regulation of chemokine production	IDA	19841166
GO:0032736	Process	Positive regulation of interleukin-13 production	IEA
GO:0032753	Process	Positive regulation of interleukin-4 production	IEA
GO:0032754	Process	Positive regulation of interleukin-5 production	IEA
GO:0032755	Process	Positive regulation of interleukin-6 production	ISS
GO:0032760	Process	Positive regulation of tumor necrosis factor production	ISS
GO:0038172	Process	Interleukin-33-mediated signaling pathway	ISS
GO:0038172	Process	Interleukin-33-mediated signaling pathway	TAS
GO:0043032	Process	Positive regulation of macrophage activation	IDA	19841166
GO:0043032	Process	Positive regulation of macrophage activation	ISS
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0045345	Process	Positive regulation of MHC class I biosynthetic process	IEA
GO:0045348	Process	Positive regulation of MHC class II biosynthetic process	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	ISS	19841166
GO:0050729	Process	Positive regulation of inflammatory response	IBA	21873635
GO:0050729	Process	Positive regulation of inflammatory response	ISS	19841166
GO:0051607	Process	Defense response to virus	IEA
GO:0051770	Process	Positive regulation of nitric-oxide synthase biosynthetic process	ISS
GO:0061518	Process	Microglial cell proliferation	IEA
GO:0097191	Process	Extrinsic apoptotic signaling pathway	IEA
GO:0120042	Process	Negative regulation of macrophage proliferation	ISS
GO:0150078	Process	Positive regulation of neuroinflammatory response	TAS	26753638
GO:0150142	Process	Positive regulation of CD86 production	ISS
GO:0150145	Process	Positive regulation of CD80 production	ISS

Other IDs

• MIM: 608678
• HGNC: 16028
• e!Ensembl: ENSG00000137033

Protein

• UniProt ID: O95760
• Protein name: Interleukin-33 (IL-33) (Interleukin-1 family member 11) (IL-1F11) (Nuclear factor from high endothelial venules) (NF-HEV) [Cleaved into: Interleukin-33 (95-270); Interleukin-33 (99-270); Interleukin-33 (109-270)]
• Protein function: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016, PubMed:19841166). Involved in the maturation of Th2 cells inducing the secretion
• PDB: 2KLL, 4KC3
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15095	IL33	5 → 268	Interleukin 33	Family

• Sequence:

  MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYF
  RRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPIT
  EYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGK
  MLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFI
  GVKDNHLALIKVDSSENLCTENILFKLSET

• Sequence length: 270

Pathways

KEGG:

Cytokine-cytokine receptor interaction
Necroptosis
Cytosolic DNA-sensing pathway
Influenza A

Reactome:

PIP3 activates AKT signaling
Ub-specific processing proteases
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Interleukin-33 signaling

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Asthma	Asthma, Childhood asthma	rs324981, rs121912630, rs150116809, rs4950928, rs708494, rs1581842283	29067999, 31619474, 21804549, 27472835, 29785011, 24241537, 19198610, 20860503, 29273806
Dermatitis	Dermatitis, Atopic	rs61816761, rs150597413, rs138726443, rs201356558, rs149484917, rs372754256, rs747301529, rs567795279, rs745915174	18249437
Kidney disease	Kidney Diseases	rs74315342, rs749740335, rs757649673, rs112417755, rs35138315	21949094
Lung carcinoma	Small cell carcinoma of lung	rs1805076, rs121909071, rs121913530, rs112445441, rs121913529, rs121913535, rs121913297, rs121913279, rs104886003, rs397516975, rs11554290, rs121913364, rs121913351, rs121913369, rs121913355, rs121912470, rs121913273, rs121913281, rs121913348, rs727503093, rs121913353, rs397516890, rs397516896, rs121913378, rs397516897, rs397516977, rs397516978, rs397516979, rs397516980, rs397516981, rs397516982, rs121913240, rs17851045, rs397517086, rs121913428, rs397517094, rs397517098, rs397517106, rs121913465, rs397517108, rs397517111, rs397517112, rs397517114, rs397517116, rs1554350366, rs397517127, rs397517200, rs397517202, rs121913283, rs121913370, rs121913357, rs727503106, rs121913238, rs727503108, rs397517040, rs397516976, rs1555618025, rs1057519729, rs1584238193	28604730

Unknown
Disease name	Disease term	dbSNP ID	References
Eczema	Eczema, Infantile		18249437
Endometriosis	Endometriosis	rs1800629, rs1143634	23472165