DOK2 (docking protein 2)

Gene

• Entrez ID: 9046
• Gene name: Docking protein 2
• Gene symbol: DOK2
• Synonyms: p56DOK, p56dok-2
• Chromosome: 8
• Chromosome location: 8p21.3
• Summary: The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein wh

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT041270	hsa-miR-193b-3p	CLASH	23622248
MIRT498423	hsa-miR-365a-3p	PAR-CLIP	22291592
MIRT498422	hsa-miR-365b-3p	PAR-CLIP	22291592
MIRT498421	hsa-miR-155-5p	PAR-CLIP	22291592
MIRT498420	hsa-miR-4715-3p	PAR-CLIP	22291592
MIRT498423	hsa-miR-365a-3p	PAR-CLIP	22291592
MIRT498422	hsa-miR-365b-3p	PAR-CLIP	22291592
MIRT498421	hsa-miR-155-5p	PAR-CLIP	22291592
MIRT498420	hsa-miR-4715-3p	PAR-CLIP	22291592
MIRT2214388	hsa-miR-103b	CLIP-seq
MIRT2214389	hsa-miR-1226	CLIP-seq
MIRT2214390	hsa-miR-153	CLIP-seq
MIRT2214391	hsa-miR-298	CLIP-seq
MIRT2214392	hsa-miR-4459	CLIP-seq
MIRT2214393	hsa-miR-448	CLIP-seq
MIRT2214394	hsa-miR-4530	CLIP-seq
MIRT2214395	hsa-miR-4662a-5p	CLIP-seq
MIRT2214396	hsa-miR-4690-3p	CLIP-seq
MIRT2214397	hsa-miR-4733-3p	CLIP-seq
MIRT2214398	hsa-miR-4786-3p	CLIP-seq
MIRT2214399	hsa-miR-634	CLIP-seq
MIRT2214400	hsa-miR-765	CLIP-seq
MIRT2214401	hsa-miR-922	CLIP-seq
MIRT2387071	hsa-miR-4779	CLIP-seq
MIRT2214388	hsa-miR-103b	CLIP-seq
MIRT2214390	hsa-miR-153	CLIP-seq
MIRT2214393	hsa-miR-448	CLIP-seq
MIRT2214395	hsa-miR-4662a-5p	CLIP-seq
MIRT2214396	hsa-miR-4690-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005068	Function	Transmembrane receptor protein tyrosine kinase adaptor activity	IEA
GO:0005515	Function	Protein binding	IPI	21044950, 32296183
GO:0005829	Component	Cytosol	TAS
GO:0007165	Process	Signal transduction	TAS	9478921, 10799545
GO:0007166	Process	Cell surface receptor signaling pathway	TAS	10799545
GO:0007169	Process	Transmembrane receptor protein tyrosine kinase signaling pathway	IEA
GO:0007265	Process	Ras protein signal transduction	IEA
GO:0007411	Process	Axon guidance	TAS
GO:0016032	Process	Viral process	IEA
GO:0050900	Process	Leukocyte migration	TAS

Other IDs

• MIM: 604997
• HGNC: 2991
• e!Ensembl: ENSG00000147443

Protein

• UniProt ID: O60496
• Protein name: Docking protein 2 (Downstream of tyrosine kinase 2) (p56(dok-2))
• Protein function: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3.
• PDB: 2D9W, 2DLW
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02174	IRS	147 → 247	PTB domain (IRS-1 type)	Domain

• Sequence:

  MGDGAVKQGFLYLQQQQTFGKKWRRFGASLYGGSDCALARLELQEGPEKPRRCEAARKVI
  RLSDCLRVAEAGGEASSPRDTSAFFLETKERLYLLAAPAAERGDWVQAICLLAFPGQRKE
  LSGPEGKQSRPCMEENELYSSAVTVGPHKEFAVTMRPTEASERCHLRGSYTLRAGESALE
  LWGGPEPGTQLYDWPYRFLRRFGRDKVTFSFEAGRRCVSGEGNFEFETRQGNEIFLALEE
  AISAQKNAAPATPQPQPATIPASLPRPDSPYSRPHDSLPPPSPTTPVPAPRPRGQEGEYA
  VPFDAVARSLGKNFRGILAVPPQLLADPLYDSIEETLPPRPDHIYDEPEGVAALSLYDSP
  QEPRGEAWRRQATADRDPAGLQHVQPAGQDFSASGWQPGTEYDNVVLKKGPK

• Sequence length: 412

Pathways

Reactome:

Tie2 Signaling
RET signaling

Associated diseases

Causal
Disease name	Disease term	dbSNP ID	References
Lung cancer	Malignant neoplasm of lung	rs121913530, rs121913529, rs878855122, rs1057519784, rs770315135	20139980

Unknown
Disease name	Disease term	dbSNP ID	References
Lung neoplasms	Lung Neoplasms		20139980